WO2008035359A3 - Acide oxyminophénoxyalcanoïque et dérivés de l'acide phenylalcanoïque - Google Patents
Acide oxyminophénoxyalcanoïque et dérivés de l'acide phenylalcanoïque Download PDFInfo
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- WO2008035359A3 WO2008035359A3 PCT/IN2007/000226 IN2007000226W WO2008035359A3 WO 2008035359 A3 WO2008035359 A3 WO 2008035359A3 IN 2007000226 W IN2007000226 W IN 2007000226W WO 2008035359 A3 WO2008035359 A3 WO 2008035359A3
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- Prior art keywords
- acid
- oximinophenoxyalkanoic
- phenylalkanoic
- derivatives
- preparation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/52—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne un acide oxyminophénoxyalcanoïque et l'acide phénylalcanoïque de la formule générale (I) leurs formes tautomères, leurs stéréoisomères, leurs sels pharmaceutiquement acceptables, les compositions pharmaceutiques les contenant, leurs procédés de préparation, l'utilisation de ces composés en médicine et les intermédiaires impliqués dans leur préparation.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN913/MUM/2006 | 2006-06-12 | ||
IN913MU2006 | 2006-06-12 | ||
IN2167MU2006 | 2006-12-29 | ||
IN2167/MUM/2006 | 2006-12-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008035359A2 WO2008035359A2 (fr) | 2008-03-27 |
WO2008035359A3 true WO2008035359A3 (fr) | 2008-05-15 |
Family
ID=39032144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2007/000226 WO2008035359A2 (fr) | 2006-06-12 | 2007-06-05 | Acide oxyminophénoxyalcanoïque et dérivés de l'acide phenylalcanoïque |
Country Status (1)
Country | Link |
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WO (1) | WO2008035359A2 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
EA201170615A1 (ru) * | 2008-10-27 | 2011-12-30 | Кадила Хелзкэр Лимитед | Лиганды рецептора тиреоидного гормона |
ES2403120T3 (es) | 2008-12-24 | 2013-05-14 | Cadila Healthcare Limited | Nuevos derivados de oxima |
JP2012116753A (ja) * | 2009-03-26 | 2012-06-21 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
KR101510975B1 (ko) * | 2010-12-28 | 2015-04-10 | 카딜라 핼쓰캐어 리미티드 | 이상지질혈증의 치료에 적절한 헤테로시클릭 화합물 |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
WO2014192023A1 (fr) * | 2013-05-22 | 2014-12-04 | Cadila Healthcare Limited | Nouveaux composés appropriés pour le traitement de la dyslipidémie |
EP3083587B1 (fr) * | 2013-12-16 | 2018-04-04 | Cadila Healthcare Limited | Dérivés d'oximino pour le traitement de la dyslipidémie |
KR20200072795A (ko) * | 2018-12-13 | 2020-06-23 | 고려대학교 산학협력단 | 옥시이미노메틸벤젠 유도체를 유효성분으로 포함하는 일주기 연관성 질환의 예방 또는 치료용 약학적 조성물 |
KR102209201B1 (ko) * | 2020-06-29 | 2021-02-01 | 고려대학교 산학협력단 | 옥시이미노메틸벤젠 유도체 |
Citations (16)
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DE2003430A1 (de) * | 1969-01-31 | 1970-09-03 | Fournier Gmbh Lab | Phenoxy-alkyl-carbonsaeurederivate |
GB1352723A (en) * | 1970-09-10 | 1974-05-08 | Merck & Co Inc | 2-phenyl-benzoxazoles and their production and use |
DE2065956A1 (de) * | 1969-01-31 | 1977-07-14 | Fournier Gmbh Lab | P-acyloxim-phenoxyessigsaeuren und ihre derivate, ihre herstellung sowie pharmazeutische mittel |
EP0002666A1 (fr) * | 1977-11-21 | 1979-07-11 | Hoechst Aktiengesellschaft | Acides 1,2-benzisoxazolyloxy (ou thio) acétiques et dérives apparentés, leurs procédés de préparation et médicaments les contenant |
US4259509A (en) * | 1977-02-14 | 1981-03-31 | Albert Rolland S.A. | 2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof |
US4999345A (en) * | 1988-06-04 | 1991-03-12 | Basf Aktiengesellschaft | Sulfonamide derivatives and drugs obtained therefrom |
EP0656348A2 (fr) * | 1993-12-03 | 1995-06-07 | F. Hoffmann-La Roche Ag | Dérivés d'acide acérique comme médicaments |
WO1995019976A1 (fr) * | 1994-01-25 | 1995-07-27 | Biocode S.A. | Derives chemoluminescents heterocycliques |
US6355796B1 (en) * | 1999-02-16 | 2002-03-12 | Basf Aktiengesellschaft | Processes and intermediate compounds for the preparation of 2-(N,N-disubstituted) amino-4-(perfluoroalkyl)-1, 3- oxazin-6-one and 6-(perfluoroalkyl) uracil compounds |
WO2002096894A1 (fr) * | 2001-05-31 | 2002-12-05 | Glaxo Group Limited | Derives de thiazole ou d'oxazole pouvant etre utilises dans le traitement des maladies cardiovasculaires et apparentees |
US6518290B1 (en) * | 1999-12-02 | 2003-02-11 | Michael Lawrence Sierra | Substituted oxazoles and thiazoles derivatives as HPPAr alpha activators |
EP1310494A1 (fr) * | 2000-08-11 | 2003-05-14 | Nippon Chemiphar Co., Ltd. | ACTIVATEURS DE PPAR (delta) |
WO2005035495A2 (fr) * | 2003-10-08 | 2005-04-21 | Nicholas Piramal India Limited | Antagonistes du recepteur du fibrinogene et leur utilisation |
WO2005113519A1 (fr) * | 2004-05-14 | 2005-12-01 | Irm Llc | Composes et compositions en tant que modulateurs de ppar |
WO2006011669A1 (fr) * | 2004-07-28 | 2006-02-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux composés apparentés à l'acide cinnamique |
WO2007028424A1 (fr) * | 2005-02-15 | 2007-03-15 | F. Hoffmann-La Roche Ag | Dérivés d'amides en tant qu’activateurs de ppar |
-
2007
- 2007-06-05 WO PCT/IN2007/000226 patent/WO2008035359A2/fr active Application Filing
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DE2003430A1 (de) * | 1969-01-31 | 1970-09-03 | Fournier Gmbh Lab | Phenoxy-alkyl-carbonsaeurederivate |
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DE2065956A1 (de) * | 1969-01-31 | 1977-07-14 | Fournier Gmbh Lab | P-acyloxim-phenoxyessigsaeuren und ihre derivate, ihre herstellung sowie pharmazeutische mittel |
GB1352723A (en) * | 1970-09-10 | 1974-05-08 | Merck & Co Inc | 2-phenyl-benzoxazoles and their production and use |
US4259509A (en) * | 1977-02-14 | 1981-03-31 | Albert Rolland S.A. | 2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof |
EP0002666A1 (fr) * | 1977-11-21 | 1979-07-11 | Hoechst Aktiengesellschaft | Acides 1,2-benzisoxazolyloxy (ou thio) acétiques et dérives apparentés, leurs procédés de préparation et médicaments les contenant |
US4999345A (en) * | 1988-06-04 | 1991-03-12 | Basf Aktiengesellschaft | Sulfonamide derivatives and drugs obtained therefrom |
EP0656348A2 (fr) * | 1993-12-03 | 1995-06-07 | F. Hoffmann-La Roche Ag | Dérivés d'acide acérique comme médicaments |
WO1995019976A1 (fr) * | 1994-01-25 | 1995-07-27 | Biocode S.A. | Derives chemoluminescents heterocycliques |
US6355796B1 (en) * | 1999-02-16 | 2002-03-12 | Basf Aktiengesellschaft | Processes and intermediate compounds for the preparation of 2-(N,N-disubstituted) amino-4-(perfluoroalkyl)-1, 3- oxazin-6-one and 6-(perfluoroalkyl) uracil compounds |
US6518290B1 (en) * | 1999-12-02 | 2003-02-11 | Michael Lawrence Sierra | Substituted oxazoles and thiazoles derivatives as HPPAr alpha activators |
EP1310494A1 (fr) * | 2000-08-11 | 2003-05-14 | Nippon Chemiphar Co., Ltd. | ACTIVATEURS DE PPAR (delta) |
WO2002096894A1 (fr) * | 2001-05-31 | 2002-12-05 | Glaxo Group Limited | Derives de thiazole ou d'oxazole pouvant etre utilises dans le traitement des maladies cardiovasculaires et apparentees |
WO2005035495A2 (fr) * | 2003-10-08 | 2005-04-21 | Nicholas Piramal India Limited | Antagonistes du recepteur du fibrinogene et leur utilisation |
WO2005113519A1 (fr) * | 2004-05-14 | 2005-12-01 | Irm Llc | Composes et compositions en tant que modulateurs de ppar |
WO2006011669A1 (fr) * | 2004-07-28 | 2006-02-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux composés apparentés à l'acide cinnamique |
WO2007028424A1 (fr) * | 2005-02-15 | 2007-03-15 | F. Hoffmann-La Roche Ag | Dérivés d'amides en tant qu’activateurs de ppar |
Non-Patent Citations (10)
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