WO2009098404A8 - Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation - Google Patents

Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation Download PDF

Info

Publication number
WO2009098404A8
WO2009098404A8 PCT/FR2008/001661 FR2008001661W WO2009098404A8 WO 2009098404 A8 WO2009098404 A8 WO 2009098404A8 FR 2008001661 W FR2008001661 W FR 2008001661W WO 2009098404 A8 WO2009098404 A8 WO 2009098404A8
Authority
WO
WIPO (PCT)
Prior art keywords
macromolecules
amphiphilic molecules
nanoparticles based
preparing nanoparticles
functional amphiphilic
Prior art date
Application number
PCT/FR2008/001661
Other languages
English (en)
Other versions
WO2009098404A3 (fr
WO2009098404A2 (fr
Inventor
Philippe Barthelemy
Michel Camplo
Nathalie Campins
Bruno Chauffert
Florence Bouyer
Original Assignee
Universite Victor Segalen Bordeaux 2
Universite De Bourgogne
Universite De La Mediterranee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Victor Segalen Bordeaux 2, Universite De Bourgogne, Universite De La Mediterranee filed Critical Universite Victor Segalen Bordeaux 2
Priority to US12/745,670 priority Critical patent/US20110059180A1/en
Priority to CA2706812A priority patent/CA2706812A1/fr
Priority to CN2008801260085A priority patent/CN101932310B/zh
Priority to JP2010535425A priority patent/JP5719594B2/ja
Priority to EP08872219A priority patent/EP2231132A2/fr
Publication of WO2009098404A2 publication Critical patent/WO2009098404A2/fr
Publication of WO2009098404A3 publication Critical patent/WO2009098404A3/fr
Publication of WO2009098404A8 publication Critical patent/WO2009098404A8/fr
Priority to US14/208,978 priority patent/US9533049B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles, éventuellement en présence d'au moins un colipide, permettant Pencapsulation d'agents thérapeutiques, en particulier d'agents anti-tumoraux, et leur utilisation pour le transport et la vectorisation d'agents thérapeutiques, en particulier d'agents anti-tumoraux.
PCT/FR2008/001661 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation WO2009098404A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/745,670 US20110059180A1 (en) 2007-11-30 2008-11-28 Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
CA2706812A CA2706812A1 (fr) 2007-11-30 2008-11-28 Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation
CN2008801260085A CN101932310B (zh) 2007-11-30 2008-11-28 制备基于官能两亲分子或者大分子的纳米颗粒的方法和其用途
JP2010535425A JP5719594B2 (ja) 2007-11-30 2008-11-28 機能性両親媒性の分子又は巨大分子を基とするナノ粒子の調製方法及びその使用
EP08872219A EP2231132A2 (fr) 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation
US14/208,978 US9533049B2 (en) 2007-11-30 2014-03-13 Method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR07/08399 2007-11-30
FR0708399A FR2924430B1 (fr) 2007-11-30 2007-11-30 Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/745,670 A-371-Of-International US20110059180A1 (en) 2007-11-30 2008-11-28 Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
US14/208,978 Division US9533049B2 (en) 2007-11-30 2014-03-13 Method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, and the use thereof

Publications (3)

Publication Number Publication Date
WO2009098404A2 WO2009098404A2 (fr) 2009-08-13
WO2009098404A3 WO2009098404A3 (fr) 2009-11-12
WO2009098404A8 true WO2009098404A8 (fr) 2010-01-28

Family

ID=39638675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001661 WO2009098404A2 (fr) 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation

Country Status (7)

Country Link
US (2) US20110059180A1 (fr)
EP (1) EP2231132A2 (fr)
JP (3) JP5719594B2 (fr)
CN (1) CN101932310B (fr)
CA (1) CA2706812A1 (fr)
FR (1) FR2924430B1 (fr)
WO (1) WO2009098404A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945946B1 (fr) * 2009-05-29 2011-08-26 Univ Victor Segalen Bordeaux 2 Formulations a compartiments multiples a base de molecules ou macromolecules amphiphiles fonctionnelles
EP3085360A1 (fr) 2015-04-20 2016-10-26 Universite De Bordeaux Compositions de nanovecteurs à base de lipide chargées avec des nanoparticules métalliques et agent thérapeutique
JP2019532027A (ja) 2016-08-17 2019-11-07 ソルスティス バイオロジクス，リミティッド ポリヌクレオチド構築物
WO2019006455A1 (fr) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. Auxiliaires de phosphoramidites chiraux et leurs procédés d'utilisation
EP3502684A1 (fr) 2017-12-22 2019-06-26 Universite De Bordeaux Procédé de détection d'ions métalliques dans des solutions aqueuses au moyen de composés nucléolipides
EP3505178A1 (fr) 2017-12-29 2019-07-03 Universite De Bordeaux Formulations de gel de bio-encres comprenant un composé à base de nucléolipides
FR3078064A1 (fr) 2018-02-22 2019-08-23 Universite de Bordeaux Procede de decontamination d'un milieu liquide aqueux contenant des micropolluants
CA3150779A1 (fr) * 2019-08-12 2021-02-18 Integrated Nanotherapeutics Inc. Lipides pour l'administration d'un materiau charge, leurs formulations et leur procede de fabrication

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696590B2 (ja) * 1985-04-16 1994-11-30 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
DK86988A (da) * 1987-02-25 1988-08-26 Takeda Chemical Industries Ltd Liposompraeparat og anvendelse deraf
US6001817A (en) * 1998-01-12 1999-12-14 Unitech Pharmaceuticals, Inc. Pharmaceutical composition comprised of cisplatin, and processes for making and using same
GB9813535D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
AU2158401A (en) * 1999-11-05 2001-05-14 Seed Capital Investments-2 (Sci-2) B.V. Method for the formulation of substances having a low water-solubility and lipophilicity and formulation thus obtained
AU2002359918A1 (en) * 2001-12-28 2003-07-24 Terumo Kabushiki Kaisha Blood bag system and method of inactivating pathogenic microorganisms
FR2869616B1 (fr) * 2004-04-29 2008-10-24 Univ D Avignon Et Des Pays Du Nouveaux composes amphiphiles, leur procede de preparation et leurs applications notamment a la transfection
CN103735560A (zh) * 2005-06-07 2014-04-23 耶鲁大学 使用克来夫定和替比夫定治疗癌症和其它病症或疾病状态的方法
FR2945946B1 (fr) * 2009-05-29 2011-08-26 Univ Victor Segalen Bordeaux 2 Formulations a compartiments multiples a base de molecules ou macromolecules amphiphiles fonctionnelles

Also Published As

Publication number Publication date
JP2011504920A (ja) 2011-02-17
FR2924430A1 (fr) 2009-06-05
JP2017014243A (ja) 2017-01-19
JP5719594B2 (ja) 2015-05-20
JP2015044815A (ja) 2015-03-12
WO2009098404A3 (fr) 2009-11-12
CA2706812A1 (fr) 2009-08-13
CN101932310A (zh) 2010-12-29
JP6280167B2 (ja) 2018-02-14
US20110059180A1 (en) 2011-03-10
US9533049B2 (en) 2017-01-03
FR2924430B1 (fr) 2010-03-19
CN101932310B (zh) 2013-11-13
EP2231132A2 (fr) 2010-09-29
US20140308343A1 (en) 2014-10-16
WO2009098404A2 (fr) 2009-08-13

Similar Documents

Publication Publication Date Title
WO2009098404A3 (fr) Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation
CY1116622T1 (el) Αντισωματα anti-cd22, τα ανοσοσυζευγματα τους και χρησεις αυτων
SI1909843T1 (sl) Protitumorski biokonjugati hialuronske kisline ali njenih derivatov, dobljeni z indirektno kemijsko konjugacijo, in njihova uporaba na farmacevtskem področju
WO2009120247A3 (fr) Compositions de nanoparticules de lipides et procédés de préparation et d’utilisation de celles-ci
WO2010069532A8 (fr) Anticorps dirigés contre l'angiopoïétine 2 humaine
WO2008030211A3 (fr) Procédés de fabrication d'une dispersion de nanomatériaux et produits issus de celle-ci
DK1943016T3 (da) Kompositnanopartikler, nanopartikler og fremgangsmåder til fremstilling heraf
WO2007118653A3 (fr) Nanoparticules contenant de la nicotine et/ou de la cotinine, dispersions et leur utilisation
WO2010013224A3 (fr) Nanoparticules de curcumine et leurs procédés de production
WO2007047498A3 (fr) Formation et encapsulation de membranes moleculaires monocouches et bicouches
WO2008033300A8 (fr) Formulation de bis (thiohydrazide amides)
WO2008120998A3 (fr) Particules administrant des médicaments acoustiquement sensibles
IL201730A (en) History 1h - Benzaimidazole – 2 – Il – Profile – Methyl – Amino – Ethyl – 5 – Aryl – Bicyclo [2.2.2] Oct – 5 – Ann – 2 – All, Pharmaceutical preparations containing them and their use in the preparation of drugs
DE602005014718D1 (de) Aktor und Transportvorrichtung, bewegliches Gerät sowie Vorrichtung ausgestattet mit dem Aktor
FR2895412B1 (fr) Procede de preparation de nanoparticules en feuillets et nanoparticules obtenues.
ZA201009097B (en) C-ring-substituted pregn-4-ene-21,17-carbolactone,and pharmaceutical preparations comprising the latter
ATE531715T1 (de) 1,3-dihydro-2h-pyrroloä3.2-büpyridin-2-onderiva e,deren herstellung und deren therapeutische verwendungen
EP2266619A4 (fr) Composition pharmaceutique à base d'hépatoprotecteur et de prébiotique, fabrication et utilisation de celle-ci
BRPI0812871A2 (pt) " recipiente, e, método para formar o mesmo ".
HK1120417A1 (en) Stable nanoparticle formulations
WO2008110374A3 (fr) Granulés contenant une substance pharmaceutique, procédés de fabrication et utilisation de ceux-ci
EP2193789A4 (fr) Utilisation du 3,5-dihydrotoluène ou de ses dérivés dans la préparation de médicaments ou de nourriture fonctionnelle destinés au traitement ou à la prévention de la dépression
AP2010005435A0 (en) 1,4-Naphthoquinone derivatives and therapeutic usethereof.
SG148120A1 (en) An oral pharmaceutical and an oral care product
PL1835917T3 (pl) Środki zawierające kwas foliowy, witaminę B6 i witaminę B12 oraz ich zastosowanie

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880126008.5

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08872219

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2706812

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2010535425

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 4453/DELNP/2010

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2008872219

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12745670

Country of ref document: US