WO2009097934A1 - Dispositif d'injection avec moyen de pré-activation - Google Patents

Dispositif d'injection avec moyen de pré-activation Download PDF

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Publication number
WO2009097934A1
WO2009097934A1 PCT/EP2008/067057 EP2008067057W WO2009097934A1 WO 2009097934 A1 WO2009097934 A1 WO 2009097934A1 EP 2008067057 W EP2008067057 W EP 2008067057W WO 2009097934 A1 WO2009097934 A1 WO 2009097934A1
Authority
WO
WIPO (PCT)
Prior art keywords
activation means
manually operable
drive member
medicament
injection device
Prior art date
Application number
PCT/EP2008/067057
Other languages
English (en)
Inventor
Katja Kunze
Istvan Bartha
Original Assignee
Shl Group Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shl Group Ab filed Critical Shl Group Ab
Publication of WO2009097934A1 publication Critical patent/WO2009097934A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals

Definitions

  • the present invention relates to an injection device and in particular to an injection device capable of dispensing a number of preset doses of medicament.
  • Injection devices that are capable of dispensing certain amounts of medicament are becoming more and more popular.
  • the aim of the present invention is to remedy the drawbacks with the state of the art injectors. This aim is obtained by an injection device comprising the features of the independent claim. Preferable embodiments of the present invention are the subject of the dependent patent claims.
  • an injection device for delivering preset doses of medicament, comprising: a front housing and a rear housing; a medicament container disposed within the front housing, wherein the container has a front opening with or for an injection needle for delivering the medicament therethrough and a movable stopper therein; medicament delivery drive means comprising a threaded plunger rod having its front end in contact with said movable stopper, a rotatable drive member rotatably locked to said plunger rod, and preset dose surfaces arranged on the circumference of said rotatable drive member; activation means operably connected to said medicament delivery drive means; and a manually operable pre-activation means operably connected to said activation means, and arranged to be movable between an inactivated position and an activated position; wherein said activation means are arranged to be movable between an idle position in which said activation means are completely arranged within said rear housing and an engaged position in which a rear part of said activation means protrudes
  • said preset dose surfaces comprises a predetermined number of degrees to each other corresponding to a predetermined amount of medicament to be delivered
  • said medicament delivery drive means further comprises priming surfaces arranged on the circumference of said rotatable drive member, and wherein said priming surfaces comprises a predetermined number of degrees between each preset dose surface and each priming surface corresponding to a predetermined amount of medicament to be primed.
  • said medicament delivery drive means comprises a spring force means acting on said drive member and wherein said manually operable pre-activation means is operably connected to said drive member through a locking mechanism, such that when said manually operable pre-activation means is moved between its inactivated position and its activated position said spring force means is tensioned and held tensioned.
  • the advantages with the present invention are several.
  • the injector is very easy to use because of the simple handling of the manually operable pre-activation means and that the pop-up button only becomes active when a preset dose has been set.
  • the user thus obtains an indication that the injector is ready to use because the pop-up button is protruded and could in this respect have an alternative colour that indicates that the injector is ready for injection.
  • the manually operable pre-activation means only is capable of being turned or moved a certain preset distance, the user cannot set a wrong dose; he or she simply turns the manually operable pre-activation means until it cannot be moved any further. There is thus no need for indications or scales that the user has to look at when setting the dose.
  • Another advantage with the present invention is the preferable use of a torsion spring, preferably helical, that is tensioned when the manually operable pre-activation means is turned. This provides a compact solution with few components in that the handling of the functions of the device is done by turning or rotating components of the device.
  • Fig. 1 is a perspective view of an injector according to the present invention
  • Fig. 2 is a perspective view of the injector of Fig. 1 with a protective cap removed
  • Fig. 3 is an exploded view of a first embodiment
  • Fig. 4 is a cross-sectional view of the first embodiment
  • Fig. 5 is a perspective view of manually operable pre-activation means comprised in the first embodiment
  • Fig. 6 is a cross-sectional view of a second embodiment when the injector has its activation means in an idle position
  • Fig. 7 is a cross-sectional view of a second embodiment when the injector has its activation means in an engaged position
  • Fig. 8 is a perspective view of the inner surface of the rear housing comprised in the second embodiment
  • Fig. 9 is a perspective view of a component of the activation means comprised in the second embodiment.
  • Fig. 10 is a perspective view of a component of the medicament delivery drive means comprised in the second embodiment
  • Figs. 1 1a and l ib are perspective views of a component of the activation means comprised in the second embodiment.
  • the present invention relates to an injection device for delivering preset doses of medicament, comprising: a front housing 10 and a rear housing 12; a medicament container 16 disposed within the front housing, wherein the container has a front opening with or for an injection needle for delivering the medicament therethrough and a movable stopper therein; medicament delivery drive means comprising a threaded plunger rod 18 having its front end in contact with said movable stopper, a rotatable drive member 28 rotatably locked to said plunger rod, and preset dose surfaces 34 arranged on the circumference of said rotatable drive member; activation means operably connected to said medicament delivery drive means; and a manually operable pre- activation means 44 operably connected to said activation means, and arranged to be movable between an inactivated position and an activated position; wherein said activation means are arranged to be movable between an idle position in which said activation means are completely arranged within said rear housing and an engaged position in which a rear part of said activation means protrudes from
  • Both housings 10, 12 are of elongated shapes, forming a pen-like injector.
  • the front housing is further arranged with a protective cover 14 when the injector is not used.
  • the threaded plunger rod 18 is threaded into a threaded passage of a nut 22.
  • the outer surface of the nut is arranged with splines 24, which mate with corresponding splines on the inner surface of the rear housing.
  • the nut is further in contact with a wall 26 of the rear housing.
  • a rotatable drive member 28 is arranged.
  • the rotatable drive member 28 is elongated rod-like having an inner passage, which houses the plunger rod.
  • the plunger rod is arranged with an elongated groove 30, which mates with corresponding protrusions (not shown) in the passage, whereby the plunger rod is rotatably fixed in relation to the dose wheel, but axially movable.
  • the front part of the rotatable drive member 28 is arranged with the preset dose surfaces 34 which comprise a predetermined number of degrees to each other corresponding to a predetermined amount of medicament to be delivered.
  • Said medicament delivery drive means further comprises priming surfaces 36 arranged on the circumference of said rotatable drive member, and wherein said priming surfaces comprises a predetermined number of degrees between each preset dose surface and each priming surface corresponding to a predetermined amount of medicament to be primed. Said dose surfaces are determined during the manufacturing of the device.
  • Said medicament delivery drive means further comprises a spring force means 38 acting on said rotatable drive member 28, in the embodiment shown in Fig. 3 and Fig. 4, a helical torsion spring.
  • a front pin 40 of the spring is placed in a fixation hole provided in a circumferential ledge of the rotatable drive member.
  • a rear pin 42 of the spring is placed in a fixation hole in a circumferential ledge of the manually operable pre- activation means 44.
  • the manually operable pre-activation means 44 has a sleeve-like rear part 46 provided with a circumferential protrusion 48 that fits onto a circumferential groove 50 of the rear housing such that the sleeve-like part 46 may be turned in relation to the rear housing.
  • the manually operable pre-activation means 44 is further arranged with a tubular part 52 extending around the drive member, and wherein the rear end surface has a pointed shape which cooperates with a recess in an end wall of the manually operable pre-activation means, the function of which is to reduce friction between the drive member and the manually operable pre-activation means 44.
  • the activation means comprises a sleeve 54 and a rotating member 64 which are connected together in such a form that the rotating member 64 is rotatable in relation to said sleeve 54.
  • the sleeve 54 partially surrounds the rotatable drive member 28 and the drive spring.
  • a number of inwardly directed protrusions 56 are attached, which protrusions cooperate with the preset dose surfaces 34 and/ or the priming surfaces 36 in a manner that will be described hereinbelow.
  • the rear part of the sleeve 54 is arranged with a number of flexible arms 58 arranged with inwardly directed ledges 60.
  • ledges cooperate with an outwardly directed circumferential ledge 62 that is attached to the front end of the rotating member 64, hereafter named rotator.
  • the outer surface of the rotator is provided with a groove 66 that runs along its circumference.
  • the groove has a certain shape with a repeated pattern, comprising a straight part 66a directed in the longitudinal direction of the device and an inclined part 66b.
  • the groove 66 cooperates with a fixed guide 67 arranged on the inner surface of the rear housing in a manner that will be described below.
  • the upper part of the rotator is provided with two opposite cut-outs, whereby two arms 68 are formed.
  • the arms extend through passages in the manually operable pre-activation means 44 such that the rotator is rotationally locked to said manually operable pre-activation means 44 but axially slidable.
  • the arms are arranged with holes 70, into which inwardly extending protrusions of a pop-up button 72 are placed.
  • the pop-up button provided with a circumferential protrusion that fits completely into a circumferential groove of the sleeve-like rear part 46 such that the pop-up button may be longitudinally displaced in relation to the housing.
  • the manually operable pre-activation means 44 is operably connected to said drive member 28 through a locking mechanism, such that when said manually operable pre-activation means is moved between its inactivated position and its activated position said spring force means is tensioned and held tensioned.
  • the locking mechanism comprises a ring 90 with at least one ridge or ledge arranged on mating ridges or ledges on the tubular part 52 of the manually operable pre-activation means, and a spring 74 arranged between said ring 90 and a circumferential elevation 92 the tubular part 52 of the manually operable pre-activation means.
  • the ring 90 is arranged with at least one bevelled protrusion 91 arranged to be in contact with one of a number of equally distributed bevelled recesses (not shown) arranged on said drive member 28, such that when said manually operable pre-activation means 44 is moved between its inactivated position and its activated position, said at least one bevelled protrusion 91 is moved along said equally distributed bevelled recesses arranged on said drive member 28.
  • the device is intended to function as follows. When the device is delivered to the intended user, as shown in Fig. 1 , the protective cover is removed, an injection needle is attached.
  • the activation means is in its idle position when the inwardly directed protrusions 56 of the sleeve 54 are disposed in contact with the preset dose surfaces 34.
  • the activation means are moved from its idle position to its engaged position when the manually operable pre-activation means 44 is turned in relation to the rear housing 12. Because the rotator and the pop-up button are rotatably connected to the manually operable pre-activation means 44, the rotator will also rotate. This causes the fixed guide 67 of the housing to move along the groove 66 of the rotator.
  • the rotator and pop-up button is forced towards protruding somewhat out from the rear housing.
  • the movement of the rotator causes the sleeve 54 to be moved linearly toward the rear end of the injector wherein the protrusions 56 of the sleeve 54 comes out of contact with the preset dose surfaces 34 allowing the drive member 28 to rotate somewhat until the protrusions 56 comes into contact with the priming surfaces 36.
  • the short rotational displacement of drive member 28 forces the plunger rod to move longitudinally towards the front end of the injector, pressing the stopper for priming the container.
  • the drive member Since the protrusions 56 of the sleeve 54 are in contact with the priming surfaces 36, the drive member is held in a fixed rotational position when continuing the turning of the manually operable pre- activation means 44 and allows the torsion spring 38 to be tensioned because of its attachment between drive member 28 and the manually operable pre-activation means 44.
  • the least one bevelled protrusion 91 of the ring 90 is resiliently moved along said equally distributed bevelled recesses arranged on the drive member 28 whereby the drive member 28 is rotationally locked and the torsion spring 38 is held a tensioned state.
  • the protrusions 67 leave the inclined part 66b of the groove and reaches the vertical part 66a.
  • the injector is then primed, armed and ready to use, and the activation means is in its engaged position which is indicated by the pop-up button now protruding outside the rear housing of the injector, Fig. 2.
  • the side surface of the popup button may be of another colour, perhaps also bright, indicating that the injector is armed.
  • the activation means are movable between its engaged position and its idle position for activating said medicament delivery drive means by pressing the pop-up button into the circumferential groove of the sleeve-like rear part 46.
  • This causes the vertical part 66a of the groove to be displaced on the fixed guide 67 of the housing.
  • the sleeve 54 moves also vertically towards the front of the injector. This causes the protrusions 56 of the sleeve 54 to move out of contact of the priming surfaces 36, whereby the drive member 28 is free to rotate due to the force of the torsion spring 38.
  • the rotation of the drive member causes the plunger rod to rotate due to the rotational locking between them.
  • the needle When the injection is completed, the needle is manually withdrawn from the injection site.
  • the protective cover 14 can now be reattached, possibly after the used needle has been discarded and a new sterile needle is mounted.
  • the injector is ready for a subsequent injection.
  • the injector is thus used a number of times according to the above description until the container is emptied.
  • the injector may now be disassembled and a new container be introduced.
  • the nut 24 with the plunger rod 18 is removed from the injector and the plunger rod is threaded back to its original position. The nut and the plunger rod are then mounted back in the injector.
  • the nut 24 may be arranged with teeth on its rear surface co-acting with corresponding teeth on the forwardly facing surface of the fixed wall 26.
  • a resilient means e.g. a spring, is further arranged between the nut and the wall.
  • the injector comprises a front housing 1 10 and a rear housing 1 12; a medicament container disposed within the front housing, wherein the container has a front opening with or for an injection needle for delivering the medicament therethrough and a movable stopper therein; medicament delivery drive means comprising a threaded plunger rod 146 having its front end in contact with said movable stopper, a rotatable drive member 148 rotatably locked to said plunger rod, and preset dose surfaces 156 arranged on the circumference of said rotatable drive member; activation means operably connected to said medicament delivery drive means and a manually operable pre-activation means operably connected to said activation means, and arranged to be movable between an inactivated position and an activated position; wherein said activation means are arranged to be movable between an idle position in which said activation means are completely arranged within said rear housing and an engaged position in which a rear part of said activation means protrudes from said rear housing when said manually operable pre- activ
  • the rear housing is further arranged with a central passage arranged with threads 144 and ramps 152 through which the threaded plunger rod 146 is arranged, Fig, 8.
  • the drive member 148 is arranged adjacent the threaded passage.
  • the plunger rod extends through the drive member in a rotationally locked, but slidable manner with the help of a spline design.
  • the front end surface of the drive member is arranged with a ratchet interface having inclined ramps 150 co-acting with a surface surrounding the central passage with corresponding ramps 152 of the rear housing, the function of which will be described below.
  • a rear end of the drive member has a somewhat larger diameter and is arranged with a number of outwardly preset dose surfaces 156 on its circumference which comprise a predetermined number of degrees to each other corresponding to a predetermined amount of medicament to be delivered and where the preset dose surfaces have somewhat inclined surfaces 158, Figs. 9 and 10.
  • the preset dose surfaces have somewhat inclined surfaces 158, Figs. 9 and 10.
  • the activation means comprises a thumb button 1 14 and toggle sleeve 160 operably connected to each other and wherein the toggle sleeve is arranged to co-act with the drive member 148.
  • the front end of the toggle sleeve is arranged with a circumferential ledge 162 having a number of cut-outs 164, which mate with longitudinal ridges 166 on the inner surface of the rear housing, Fig. 1 Ia.
  • inclined ridges 168 are arranged, Fig. l ib, which cooperate with the inclined surfaces 158 of the preset dose surfaces 156 in a manner that will be explained.
  • the rear end surface 170 of the toggle sleeve 160 is arranged with inclined surfaces 172, Fig. 1 1a, which surfaces co-act with corresponding surfaces 176 of a tubular part 178 of the thumb button 1 14.
  • the front end surface of the thumb button is arranged with a number of inclined surfaces 188 and stop ledges 190.
  • a resilient means 192 e.g. a spring, is arranged between an inner surface of the thumb button and the rear end of the drive member, Fig. 7.
  • the manually operable pre-activation means comprises a prolonged part of the rear housing and a locking mechanism (not shown), e.g. a flexible ring, a flexible land or the like, operably connected to the prolonged part of the rear housing and to the thumb button 1 14, such that when said manually operable pre-activation means is in an inactivated position said locking mechanism is engaged with said thumb button holding said thumb button within the rear housing and when said manually operable pre-activation means is in an activated position said locking mechanism is released from said thumb button such that said thumb button protrudes somewhat from the rear housing.
  • the device is intended to function as follows. When the device is delivered to the user, an end cover is removed by pulling it off the injector.
  • the manually operable pre-activation means is moved from its inactivated position to its activated position such that the thumb button protrudes somewhat from the rear housing.
  • the force from the resilient means 192 will force the activation means from its idle position to its engaged position by forcing the toggle sleeve towards the rear end of the injector and allowing the toggle sleeve to slightly rotate due to the ramps 172 on the rear end of the toggle sleeve working with the mating ramps 176 on the thumb button such that the inclined ridges 168 of the toggle sleeve are in position to act on the preset dose surfaces 156 of the drive member.
  • the activation means is then in its engaged position which is indicated by the thumb button now protruding outside the rear housing of the injector.
  • the side surface of the thumb button may be of another colour, perhaps also bright, indicating that the injector is armed.
  • the skin is now penetrated by the needle at the injection site.
  • the activation means are movable between its engaged position and its idle position for activating said medicament delivery drive means by pressing the thumb button which causes the toggle sleeve 160 to move forward. This in turn will cause the drive member 148 to rotate because of the inclined ridges 68 of the toggle sleeve acting on the end surfaces 158 of the preset dose surfaces 156 of the drive member.
  • the rotation of the drive member is transmitted to the plunger rod 146 because of the rotational lock between them, and due to the threads of the plunger rod cooperating with the threads of the rear housing; the plunger rod will move forward and thus press the stopper towards the front end of the device.
  • the ratchet interface between the drive member and the rear housing is such that the ramps 150, 152 falls into the next indexed position and the preset dose is completed.
  • the ramps providing the indexed positions prevent any backdriving of the drive member.
  • the locking mechanism of the manually operable pre-activation means hold the thumb button in within the rear housing until it is released for a subsequent injection.
  • the needle When the injection is completed, the needle is manually withdrawn from the injection site.
  • the protective cover can now be reattached, possibly after the used needle has been discarded and a new sterile needle is mounted.
  • the injector is ready for a subsequent injection.
  • the injector is thus used a number of times according to the above description until the container is emptied.
  • the injector may now be disassembled and a new container be introduced.

Abstract

L'invention porte sur un dispositif d'injection pour administrer des doses préréglées de médicament, comportant un boîtier ; un contenant de médicament ; un moyen de commande d'administration du médicament ; un moyen d'activation (72) relié de façon fonctionnelle audit moyen de commande d'administration de médicament ; et un moyen de pré-activation (46) actionnable manuellement, relié de façon fonctionnelle audit moyen d'activation et agencé pour être déplaçable entre une position inactivée et une position activée, ledit moyen d'activation étant agencé pour être déplaçable entre une position libre, dans laquelle ledit moyen d'activation est complètement disposé à l'intérieur dudit boîtier arrière, et une position en contact, dans laquelle une partie arrière dudit moyen d'activation fait saillie dudit boîtier arrière lorsque ledit moyen de pré-activation actionnable manuellement est activé de sa position inactivée à sa position activée pour indiquer que l'injecteur est armé, et ledit moyen d'activation étant également agencé pour être déplaçable entre sa position en contact et sa position libre pour activer ledit moyen de commande d'administration de médicament.
PCT/EP2008/067057 2008-02-05 2008-12-09 Dispositif d'injection avec moyen de pré-activation WO2009097934A1 (fr)

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SE0800266-9 2008-02-05
SE0800266 2008-02-05

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WO2011039219A3 (fr) * 2009-09-30 2011-08-11 Sanofi-Aventis Deutschland Gmbh Dispositif de délivrance de médicaments, ensemble de dispositif de délivrance de médicaments et procédé de montage d'un dispositif de délivrance de médicaments
JP2013539695A (ja) * 2010-10-13 2013-10-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 用量設定機構及びそれを使用する方法
EP2722065A1 (fr) * 2012-10-18 2014-04-23 Sanofi-Aventis Deutschland GmbH Auto-injecteur
WO2014139839A1 (fr) * 2013-03-12 2014-09-18 Carebay Europe Ltd Dispositif de distribution de médicament
CN104349807A (zh) * 2012-05-30 2015-02-11 赛诺菲-安万特德国有限公司 用于药物输送装置的驱动机构和药物输送装置
WO2015101669A1 (fr) 2014-01-03 2015-07-09 Novo Nordisk A/S Dispositif d'auto-injection avec activation par bouton
US9415165B2 (en) 2009-10-16 2016-08-16 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
WO2017009284A1 (fr) * 2015-07-10 2017-01-19 Alk-Abelló A/S Injecteur comportant une goupille de sécurité
EP2588163A4 (fr) * 2009-06-05 2017-12-20 SHL Group AB Dispositif d'administration de médicament
EP2640447A4 (fr) * 2010-11-18 2018-01-17 SHL Group AB Dispositif de distribution de médicament
RU2793052C1 (ru) * 2022-10-05 2023-03-28 Общество с ограниченной ответственностью "Комарик" Автоматизированный инъектор для введения лекарственных средств

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EP2588163A4 (fr) * 2009-06-05 2017-12-20 SHL Group AB Dispositif d'administration de médicament
WO2011039219A3 (fr) * 2009-09-30 2011-08-11 Sanofi-Aventis Deutschland Gmbh Dispositif de délivrance de médicaments, ensemble de dispositif de délivrance de médicaments et procédé de montage d'un dispositif de délivrance de médicaments
US9555192B2 (en) 2009-09-30 2017-01-31 Sanofi-Aventis Deutschland Gmbh Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device
US9415165B2 (en) 2009-10-16 2016-08-16 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US11819668B2 (en) 2009-10-16 2023-11-21 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US11033690B2 (en) 2009-10-16 2021-06-15 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US10806865B2 (en) 2009-10-16 2020-10-20 Owen Mumford Limited Injector apparatus having a clutch to inhibit forward movement of the plunger
US9517308B2 (en) 2010-10-13 2016-12-13 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism and method of setting a dose
JP2013539695A (ja) * 2010-10-13 2013-10-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 用量設定機構及びそれを使用する方法
EP2640447A4 (fr) * 2010-11-18 2018-01-17 SHL Group AB Dispositif de distribution de médicament
CN104349807A (zh) * 2012-05-30 2015-02-11 赛诺菲-安万特德国有限公司 用于药物输送装置的驱动机构和药物输送装置
US9700679B2 (en) 2012-05-30 2017-07-11 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
CN104853788A (zh) * 2012-10-18 2015-08-19 赛诺菲-安万特德国有限公司 自助注射器
US10384007B2 (en) 2012-10-18 2019-08-20 Sanofi-Aventis Deutschland Gmbh Auto-injector
WO2014060216A1 (fr) * 2012-10-18 2014-04-24 Sanofi-Aventis Deutschland Gmbh Auto-injecteur
EP2722065A1 (fr) * 2012-10-18 2014-04-23 Sanofi-Aventis Deutschland GmbH Auto-injecteur
US10881807B2 (en) 2013-03-12 2021-01-05 Shl Medical Ag Medicament delivery device
TWI594782B (zh) * 2013-03-12 2017-08-11 卡貝歐洲有限公司 藥物輸送裝置
US20210069424A1 (en) * 2013-03-12 2021-03-11 Shl Medical Ag Medicament delivery device
WO2014139839A1 (fr) * 2013-03-12 2014-09-18 Carebay Europe Ltd Dispositif de distribution de médicament
US11872380B2 (en) 2013-03-12 2024-01-16 Shl Medical Ag Medicament delivery device
WO2015101669A1 (fr) 2014-01-03 2015-07-09 Novo Nordisk A/S Dispositif d'auto-injection avec activation par bouton
WO2017009284A1 (fr) * 2015-07-10 2017-01-19 Alk-Abelló A/S Injecteur comportant une goupille de sécurité
US11020527B2 (en) 2015-07-10 2021-06-01 Alk-Abelló A/S Injector comprising a safety pin
RU2793052C1 (ru) * 2022-10-05 2023-03-28 Общество с ограниченной ответственностью "Комарик" Автоматизированный инъектор для введения лекарственных средств

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