WO2009096817A2 - Produit réduisant le degré d’intoxication aigue par l’alcool (d’ébriété) et procédé d'utilisation correspondant - Google Patents
Produit réduisant le degré d’intoxication aigue par l’alcool (d’ébriété) et procédé d'utilisation correspondant Download PDFInfo
- Publication number
- WO2009096817A2 WO2009096817A2 PCT/RU2009/000033 RU2009000033W WO2009096817A2 WO 2009096817 A2 WO2009096817 A2 WO 2009096817A2 RU 2009000033 W RU2009000033 W RU 2009000033W WO 2009096817 A2 WO2009096817 A2 WO 2009096817A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alcohol
- intoxication
- hangover
- agent
- degree
- Prior art date
Links
- 206010001605 Alcohol poisoning Diseases 0.000 title claims abstract description 28
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 18
- 206010019133 Hangover Diseases 0.000 claims description 46
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 28
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 25
- 229930091371 Fructose Natural products 0.000 claims description 24
- 239000005715 Fructose Substances 0.000 claims description 24
- 230000001154 acute effect Effects 0.000 claims description 20
- 231100000566 intoxication Toxicity 0.000 claims description 18
- 230000035987 intoxication Effects 0.000 claims description 18
- 229960001153 serine Drugs 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 87
- 235000019441 ethanol Nutrition 0.000 abstract description 66
- 239000000654 additive Substances 0.000 abstract description 8
- 230000009471 action Effects 0.000 abstract description 4
- 230000000996 additive effect Effects 0.000 abstract description 4
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 2
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 abstract 1
- 230000002075 anti-alcohol Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 23
- 241000699670 Mus sp. Species 0.000 description 19
- 230000014759 maintenance of location Effects 0.000 description 19
- 150000003839 salts Chemical class 0.000 description 17
- WQABCVAJNWAXTE-UHFFFAOYSA-N dimercaprol Chemical compound OCC(S)CS WQABCVAJNWAXTE-UHFFFAOYSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 229940024606 amino acid Drugs 0.000 description 13
- 235000001014 amino acid Nutrition 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 13
- 229960001051 dimercaprol Drugs 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 10
- 230000006977 prepulse inhibition Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- -1 L-serine Chemical class 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 206010044565 Tremor Diseases 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- 230000001953 sensory effect Effects 0.000 description 8
- 229920002307 Dextran Polymers 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 239000003085 diluting agent Substances 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000000969 carrier Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 229920001059 synthetic polymer Polymers 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 239000002547 new drug Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 239000008223 sterile water Substances 0.000 description 4
- 206010001623 Alcoholic hangover Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 231100001133 acute intoxication condition Toxicity 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 229940126601 medicinal product Drugs 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000000375 suspending agent Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 201000007930 alcohol dependence Diseases 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 208000037849 arterial hypertension Diseases 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 229940088679 drug related substance Drugs 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229960002737 fructose Drugs 0.000 description 2
- 238000011990 functional testing Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000037023 motor activity Effects 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- RGHNJXZEOKUKBD-NRXMZTRTSA-N (2r,3r,4r,5s)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-NRXMZTRTSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 description 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 241000878128 Malleus Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241001279827 Sipha Species 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241000718541 Tetragastris balsamifera Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 150000001495 arsenic compounds Chemical class 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229940093797 bioflavonoids Drugs 0.000 description 1
- 230000000035 biogenic effect Effects 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229940095643 calcium hydroxide Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical class CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229940093920 gynecological arsenic compound Drugs 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 235000006486 human diet Nutrition 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229940006116 lithium hydroxide Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000006742 locomotor activity Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 229960000816 magnesium hydroxide Drugs 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 210000002331 malleus Anatomy 0.000 description 1
- 150000002690 malonic acid derivatives Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012907 medicinal substance Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical class [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 150000008143 steroidal glycosides Chemical class 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000005622 tetraalkylammonium hydroxides Chemical class 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000005490 tosylate group Chemical group 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Definitions
- the invention relates to a new tool that reduces the degree of acute alcohol intoxication (intoxication) and / or has an anti-hangover effect, a biologically active additive, a pharmaceutical composition, a drug that can weaken an alcoholic hangover caused by excessive consumption of products containing ethyl alcohol.
- Hangover syndrome affects about 50% of the population who consume alcohol in significant doses, which causes economic damage, since during this period there is a significant decrease in human performance [Smith, S M .; Varpes, GM Sigps apd smartphones of hapgiver: rewaleps apd relatiopshir to also us and the advanced adul. Drug Alcohol Direp. 11: 249-269; 1983].
- the economic damage associated with the deterioration of performance due to a hangover in 2000 in the United States amounted to about $ 148 billion [Wi convinced Thannnencion, JG; Shlirak, MG; Wroper, WS The alcohol hapgover. Arm.Ipterp.Med. 132: 897-902; 2000].
- the hangover syndrome develops within a few hours after the end of acute alcohol intoxication against the background of the restoration of general motor activity, thinking and memory [Streufert, S .; Rogash, R .; Braig, D .; Gipgrireteh, D .; Kapper, A .; Lapdis, R .; Lopardi, L .; Roache, J .; Severs, W. Alcohol hapver apd maperial effestivess. Alcohol CHn. Exp Res. 19: 1141-1146; 1995. Salimov, RM; Markpa, NV; Rerelkipa, O. V .; Maskii, A. L; Rolletaeva, 1. 1.
- a hangover condition is characterized by a complex set of subjective discomfort and impaired sensory-motor coordination, which are objectively recorded, in particular, as violation of the filtration of sensory information in the brain [Grillop, Sipha, O'Malleu, 1994; Grillop et al., 2000] and difficulty maintaining the balance of the body.
- Violation of the filtration of sensory information and difficulty maintaining equilibrium have a homologous manifestation in humans and different types of mammals and can be measured in an animal experiment by evaluating prepulse inhibition of trembling in response to an acoustic stimulus [Maysky A.I., Salimov R.M. Guidelines for preclinical evaluation of drugs for the treatment of alcoholism.
- dimercaprol which is an antidote for poisoning with arsenic compounds, heavy metal salts, cardiac glycosides, and also improves lipid peroxidation in the period after alcohol intoxication [US20060148898 Al. ⁇ uripg apd rorhulastis agept arrlid duri ⁇ g th Canal us founded procedure for alcohol apd psuskhoastive substapses. 2006.07.06].
- the ability of dimercaprol to restore the processes of sensory filtration and muscle coordination disrupted by alcohol is not known.
- contraindications that limit the use of dimercaprol include liver failure and arterial hypertension [Drug Register.
- Dimercaprol http://www.rlsnet.ru/mnn_dimerkaprol.html; US Dearttep of Nalth & Nutrition Services. Dietersarrol, http://www.remm.nlm.gov/dimercaprol.htm].
- These contraindications are of particular importance when dimercaprol is used in combination with alcohol, which in turn creates an additional burden on the detoxifying function of the liver and can provoke arterial hypertension [Gorelik, P. B. Alcohol apd ströke. Stroke. 18: 268-271; 1987; Tirelli, S. R .; Leope, AF; Sölho, E. B .; Resstel, L.
- the active ingredient contains succinic acid and / or its salts, fumaric acid and / or its salts, fructose, dry extract of St. John's wort grass (Nurerisum), sources of magnesium ions and sources of potassium ions, which, when used after alcohol, can increase the time retention of animals on a rotating rod, although its ability to improve sensory filtration performance is not shown [RU2250778. An agent that reduces the adverse effects of acute alcohol intoxication. 2004.02.26]. This product does not contain the amino acids tianin and series.
- amino acid means a natural amino acid or a non-natural amino acid.
- Preferred amino acids are amino acids containing an ⁇ or ⁇ amino group. Examples of natural amino acids are alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan, methionine, glycine, series, tianine, threonine and cysteine.
- Bioly active additives means substances of natural origin (their concentrates, solutions, mixtures, etc.) or biologically active substances of synthetic, semisynthetic or biotechnological origin and their analogues that are free of drugs and intended for use with food or regardless of its intake, as well as for introduction into food. Supplements are used to enrich the human diet and give it special preventive and health-improving properties. Traditionally, dietary supplements are divided into three main groups: nutraceuticals, eubiotics (probiotics) and parapharmaceuticals. Parapharmaceuticals mean dietary supplements used for prophylaxis, adjuvant therapy, and maintaining the physiological boundaries of the functional activity of organs and systems. Parapharmaceuticals are organic acids, bioflavonoids, biogenic amines, alkaloids, oligosaccharides, polynucleotides, etc. Parapharmaceuticals can increase the adaptive capacity of the body in extreme conditions.
- Medical substance (drug substance, drug substitution) means a physiologically active substance of synthetic or other (biotechnological, plant, animal, microbial and other) origin, having pharmacological activity and is the active principle of the pharmaceutical composition used for the manufacture and manufacture of a medicinal product ( facilities).
- “Medicinal product (preparation)” a substance (or a mixture of substances in the form of a pharmaceutical composition) in the form of tablets, capsules, injections, ointments and other formulations intended to restore, correct or alter physiological functions in humans and animals, as well as for treatment and disease prevention, diagnosis, anesthesia, contraception, cosmetology and more.
- “Therapeutic cocktail” is a simultaneously administered combination of two or more drugs with different a mechanism of pharmacological action and aimed at various biological targets involved in the pathogenesis of the disease.
- “Pharmaceutical composition” means a composition comprising a drug substance (substance) and at least one of the components selected from the group consisting of pharmaceutically acceptable and pharmacologically compatible excipients, solvents, diluents, carriers, excipients, distributing and perceiving agents delivery vehicles such as preservatives, stabilizers, fillers, grinders, moisturizers, emulsifiers, suspending agents, thickeners, sweeteners, perfumes, flavors, anti-tank terial agents, fungicides, lubricants, prolonged delivery regulators, the choice and ratio of which depends on the nature and method of administration and dosage.
- pharmaceutically acceptable and pharmacologically compatible excipients such as preservatives, stabilizers, fillers, grinders, moisturizers, emulsifiers, suspending agents, thickeners, sweeteners, perfumes, flavors, anti-tank terial agents, fungicides, lubricants, prolonged delivery regulators, the choice and
- suspending agents examples include ethoxylated isostearyl alcohol, polyoxyethylene, sorbitol and sorbitol ether, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar and tragacanth, as well as mixtures of these substances. Protection against the action of microorganisms can be achieved using a variety of antibacterial and antifungal agents, for example, parabens, chlorobutanol, sorbic acid and the like.
- the composition may also include isotonic agents, for example, sugars, sodium chloride and the like.
- the prolonged action of the composition can be achieved using agents that slow down the absorption of the active principle, for example, aluminum monostearate and gelatin.
- suitable carriers, solvents, diluents and delivery vehicles are water, ethanol, polyalcohols, and also mixtures thereof, vegetable oils (such as olive oil) and injectable organic esters (such as ethyl oleate).
- excipients are lactose, milk sugar, sodium citrate, calcium carbonate, calcium phosphate and the like.
- grinders and distributors are starch, alginic acid and its salts, silicates.
- lubricants are magnesium stearate, sodium lauryl sulfate, talc, and high molecular weight polyethylene glycol.
- the pharmaceutical composition for oral, sublingual, transdermal, intramuscular, intravenous, subcutaneous, local or rectal administration of the active principle, alone or in combination with another active principle, can be administered to animals and humans in a standard administration form, in the form of a mixture with traditional pharmaceutical carriers.
- Suitable unit dosage forms include oral forms such as tablets, gelatin capsules, pills, powders, granules, chewing gums and oral solutions or suspensions, for example, therapeutic shakes, sublingual and buccal administration forms, aerosols, implants, local, transdermal, subcutaneous, intramuscular, intravenous, intranasal or intraocular administration forms and rectal forms introduction.
- “Pharmaceutically acceptable salt” means the relatively non-toxic organic and inorganic salts of the acids and bases of the present invention. These salts can be prepared in situ during the synthesis, isolation or purification of compounds or prepared specially. In particular, base salts can be prepared specifically based on the purified free base of the claimed compound and a suitable organic or inorganic acid.
- salts thus obtained are hydrochlorides, hydrobromides, sulfates, bisulfates, phosphates, nitrates, acetates, oxalates, valeriates, oleates, palmitates, stearates, laurates, borates, benzoates, lactates, tosylates, citrates, maleates, fumarates, succinates, tartrates mesylates, malonates, salicylates, propionates, ethanesulfonates, benzenesulfonates, sulfamates and the like.
- Salts of the claimed acids can also be specially prepared by reacting the purified acid with a suitable base, and metal and amine salts can be synthesized.
- Metal salts include sodium, potassium, calcium, barium, zinc, magnesium, lithium and aluminum salts, the most desirable of which are sodium and potassium salts.
- Suitable inorganic bases from which metal salts can be obtained are hydroxide, carbonate, sodium bicarbonate and hydride, potassium hydroxide and bicarbonate, potash, lithium hydroxide, calcium hydroxide, magnesium hydroxide, zinc hydroxide.
- amines and amino acids are selected that are sufficiently basic to form a stable salt and are suitable for medical use (in particular, they should have low toxicity).
- amines include ammonia, methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, triethylamine, benzylamine, dibenzylamine, dicyclohexylamine, piperazine, ethylpiperidine, tris (hydroxymethyl) aminomethane and the like.
- tetraalkylammonium hydroxides for example, such as choline, tetramethylammonium, tetraethylammonium and the like, can be used for salt formation.
- amino acids can be used basic amino acids - lysine, ornithine and arginine.
- composition of the new CCEF together with a natural, synthetic or semi-synthetic polymer suitable for oral administration further reduces the degree of acute alcohol intoxication (intoxication).
- the purpose of this invention is to create a new tool, biologically active additives, pharmaceutical compositions and medicines that reduce the degree of acute alcohol intoxication (intoxication) and / or have anti-hangover effects and are able to weaken the alcohol hangover caused by excessive consumption of products containing ethyl alcohol.
- This goal is achieved by a means with anti-hangover, containing as active components L-serine, tianine and fructose and / or a polymer suitable for oral administration, in a mass ratio of (12-18): (0.8-l, 2): (40-60) :( 0-14), respectively.
- an agent that reduces the degree of acute alcohol intoxication (intoxication) and has an anti-hangover effect containing as active components L-serine, L-tianine, fructose and a natural, synthetic or semi-synthetic polymer suitable for oral administration in the ratio (12- 18) :( 0,8-l, 2) :( 40-60) :( 8-14), respectively.
- a natural, synthetic or semi-synthetic polymer suitable for oral administration is used, for example, cellulose derivatives, starch derivatives (in particular hydroxyethyl starch), gelatin and its derivatives, dextran, polyvinylpyrrolidone, chitosan, cyclodextrins, , agar, guar gum and several others.
- the subject of this invention is also a biologically active additive comprising an agent that reduces the degree of acute alcohol intoxication (intoxication) and has an anti-hangover effect, containing, as active components, L-serine, fructose, tianine and / or a polymer suitable for oral administration.
- a more preferred biologically active additive includes an agent that reduces the degree of acute alcohol intoxication (intoxication) and / or has an anti-hangover effect, containing L-serine, tianine, fructose, and / or a polymer suitable for oral administration in a weight ratio of ( 12-18) :( 0.8-1.2) :( 40-60) :( 0-14), respectively.
- a dietary supplement may include diluents, auxiliary agents and / or carriers.
- a dietary supplement along with the agent of the present invention may include other active agents and / or dietary supplements, provided that they do not cause undesirable effects, for example, allergic reactions.
- the subject of this invention is also a pharmaceutical composition that reduces the degree of acute alcohol intoxication (intoxication) and / or has an anti-hangover effect, containing L-serine, tianine, fructose and / or a polymer suitable for oral administration and an inert excipient and / or solvent.
- a more preferred pharmaceutical composition having an anti-hangover effect contains L-serine, tianine, fructose and / or a polymer suitable for oral administration in a weight ratio of (12-18): (0.8-l, 2) :( 40-60 ) :( 0-14), respectively, and an inert filler and / or solvent.
- the pharmaceutical composition may include pharmaceutically acceptable excipients.
- pharmaceutically acceptable excipients are meant diluents, excipients and / or carriers used in the pharmaceutical field.
- the pharmaceutical composition along with the agent of the present other active agents may also be included in the invention, provided that they do not cause undesirable effects, for example, allergic reactions.
- Carriers which are used in the pharmaceutical field to produce oral forms of a medicinal product are binders, lubricants, disintegrants, solvents, diluents, stabilizers, suspending agents, colorless agents, flavoring agents; antiseptic agents, solubilizers, stabilizers are used in injection forms of the drug; in local forms of the drug, bases, diluents, lubricants, antiseptic agents are used.
- the aim of the present invention is also a method for producing a pharmaceutical composition.
- the goal is achieved by mixing the means of the present invention with an inert filler and / or solvent.
- This goal is also achieved by dissolving the agent in water, freeze drying the resulting solution and mixing the resulting composition with an inert filler and / or solvent.
- the subject of this invention is also a medicament in the form of tablets, capsules or injections, placed in a pharmaceutically acceptable package, comprising an agent or a new pharmaceutical composition intended to reduce the degree of acute alcohol intoxication (intoxication) and / or the reduction of alcohol hangover caused by excessive consumption of products containing ethyl alcohol.
- the drug may be administered orally.
- the clinical dosage can be adjusted depending on: therapeutic efficacy and bioavailability of the active ingredients in the body, their metabolic rate and excretion from the body, and also depending on the patient’s age, gender and stage of illness. In accordance with the instructions of a doctor or pharmacist, these drugs can be taken several times during certain periods of time (preferably from one to six times).
- FIG. 1 the influence of 25% ethyl alcohol on locomotor activity (time spent in the center and in the arms of the closed cruciform labyrinth until the mice made 12 visits to the arms) of male SHK mice when they were given a dose of 4.5 g / kg inside 1.5 or 3 hours before the test. * - difference from the group receiving placebo (sterile water); FIG.
- FIG. 3 the effect of 25% ethanol on the retention time of male SHK mice on a rotating rod when they introduced a dose of 4.5 g / kg 3 hours before the test, (initial rotation speed 5 rpm, acceleration 0.5 rpm every 10 seconds).
- FIG. 4 the effect of 25% ethyl alcohol on prepulse inhibition of flinching in response to an acoustic stimulus, when a dose of 4.5 g / kg was administered to male SHK mice 3 hours before the test.
- * - difference from the placebo group sterile water.
- Example 1 A study of the effectiveness of anti-hangover and the ability to weaken the alcohol hangover of a new drug and drug, based on it, was carried out in comparison with the reference drug (dimercaprol) in experiments on male SHK mice.
- the subnarcotic dose of alcohol was determined when administered orally (re ments), using a probe, in the form of a 25% solution of ethyl alcohol, which turned out to be 4.5 g / kg for the used mouse line and the termination period of acute intoxication (intoxication), which started about 3 hours after the introduction of alcohol.
- 10 SHK mice were used.
- mice A study of the effect of the new agent on hangover indicators in mice was carried out in comparison with the closest competitor, the well-known drug dimercaprol in a therapeutic dose of 4.2 mg / kg.
- a subnarcotic dose of alcohol of 4.5 g / kg in the form of a 25% solution of ethyl alcohol was injected into the mice using a probe inside (re-s) 3 hours before the tests used.
- Dimercaprol, series, tianin, fructose and mixtures of serine, tianin and fructose were administered orally 2.5 hours after the introduction of alcohol. In each group, 10 SHK mice were used.
- the table shows the test data on the effect of funds on hangover indicators in mice 2.5 hours after the administration of 4500 mg / g of alcohol to male SHK mice.
- the hangover impaired inhibition of trembling by an acoustic stimulus was estimated in%.
- the hangover of coordination of mouse movements was evaluated by the duration of retention on a rotating rod.
- the new drug, composition and drug based on it are more preferable compared to the known drug dimercaprol, because they do not have contraindications (liver function insufficiency and hypertension, especially when dimercaprol is used in combination with alcohol), characteristic of the latter [Register medicines. Dimercaprol, http://www.rlsnet.ru/in ⁇ i_dimerkaprol.html; U.S. Dearttep of Nalth & Nutap Servises. Dietersarrol, http://www.remm.nlm.gov/dimercaprol.htm. Gorelisk, P. B. Alcohol apd stroke. Stroke. 18: 268-271; 1987; Tirelli, S.
- Example 2 At the beginning of the experiments, a sub-narcotic dose of alcohol was determined when it was introduced in the form of a 25% solution of ethyl alcohol using a probe inside (re works), which turned out to be 4.5 g / kg for the used mouse line, the beginning of the period of acute intoxication (intoxication) , which was observed approximately 2 hours after the introduction of alcohol, and the period of termination of acute intoxication, which began approximately 3 hours after the introduction of alcohol. The experiments were carried out on male SHK mice.
- the assessment of acute alcohol intoxication was carried out 2 hours after the introduction of the indicated dose of alcohol according to the criterion of gross movement disorders - by the ability to stay on a rotating rod, as well as by slowing down the study of the cruciform maze by mice.
- the mouse was placed in a Rotamex-5 installation ( ⁇ olutbus Ipstrupts, USA) on a rod, which first rotated at a speed of 5 rpm and accelerated rotation by 0.5 rpm every 10 seconds.
- the mouse was placed in the central compartment of the labyrinth and, in a semi-automatic mode, the sequence of its transitions from one sleeve to the other was recorded. The time during which 12 such transitions occurred was recorded.
- mice were injected into the esophagus with one of the following formulations in a volume of 10 ml / kg: 1) sterilized water, 2) 25% solution of ethyl alcohol, 3) 25% solution of ethyl alcohol + dextran (85 mg / kg), 4 ) 25% solution of ethyl alcohol + IIK-1 composition, including dextran (85 mg / kg), tianine (10 mg / kg) and series (100 mg / kg), + fructose (500 mg / kg), 5) 25% ethanol solution + PC composition, including dextran (140 mg / kg), tianine (10 mg / kg) and series (100 mg / kg), + fructose (500 mg / kg); 6) 25% solution of ethyl alcohol + Alkoklin mixture, including tianine (10 mg / kg), series (100 mg / kg) and fructose (500 mg / kg).
- Symptoms of an alcoholic hangover observed 3 hours after the introduction of alcohol, are characterized by a violation of the filtering ability of the brain (impaired prepulse inhibition of the startle reaction to sound) and fine coordination of movements necessary to maintain balance (reducing the duration of retention on a rotating rod).
- Dextran during alcohol intoxication does not affect retention on a rotating rod and improves the speed of movement in the maze, and in the hangover period does not affect the studied parameters.
- Composition IIK-1 during alcohol intoxication does not affect retention on a rotating rod and improves the speed of movement in the maze, and in the hangover period improves prepulse inhibition of trembling and retention on a rotating rod.
- Composition PC during alcohol intoxication improves retention on a rotating rod and improves the speed of movement in the maze, and in the hangover period improves prepulse inhibition of trembling and retention on a rotating rod.
- composition "Alkocline” when administered simultaneously with alcohol during alcohol intoxication does not affect the retention on the rotating rod and the speed of movement in the labyrinth, and in the hangover - does not affect prepulse inhibition of trembling and retention on the rotating rod.
- the composition “Alkoklin”, when administered 30 minutes before the start of the functional test during alcohol intoxication does not affect the retention on the rotating rod and the speed of movement in the maze, and in the hangover it improves prepulse inhibition of trembling and retention on the rotating rod.
- Example 3 Obtaining biologically active additives. Thoroughly mix L-serine, L-tianine and fructose in a weight ratio of 15: 1: 50. The resulting powdery mixture is packaged in 300 mg in a suitable size gelatin capsule.
- Example 4. Obtaining a drug in the form of tablets. 1600 mg of starch, 1600 mg of ground lactose, 400 mg of talc and 1000 mg of a mixture of L-serine, L-thianine and fructose are mixed in a weight ratio of 15: 1: 50 and pressed into a block. The resulting bar is crushed into granules and sieved through sieves, collecting granules with a size of 14-16 mesh. The granules obtained are tabletted into a suitable tablet form weighing 560 mg each.
- Example 5 Obtaining biologically active additives.
- 0.14 g of a natural, synthetic or semi-synthetic polymer suitable for oral administration for example, dextran, 0.10 g of L-serine, 0.01 g of tianine and 0.50 g of fructose are dissolved in 14 ml of distilled water. The resulting solution was incubated for 20 minutes at room temperature, filtered and dried, for example, in a freeze dryer. The resulting powder mixture is packaged in 300 mg in a suitable size gelatin capsule.
- Example 6 Obtaining funds in the form of a drink.
- 1.4 g of a natural, synthetic or semi-synthetic polymer suitable for oral administration, for example, dextran, 1.0 g of L-serine, 0.1 g of tianine and 5.0 g of fructose are dissolved in 140 ml of distilled water.
- the resulting solution was incubated for 20 minutes at room temperature, filtered and dried, for example, in a freeze dryer.
- the resulting powdery mixture is dissolved in water, flavoring agents, for example citric acid, are added if necessary, and the beverage is used in an effective amount.
- the invention can be used in medicine, veterinary medicine, biochemistry.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L’invention concerne un nouveau produit réduisant le degré d’intoxication aigue par l’alcool (d’ébriété) et possédant une action « anti-gueule de bois », un additif bioactif, une composition pharmaceutique, un médicament capable de réduire l’effet « gueule de bois » provoqué par l’abus de l’alcool.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008103155/04A RU2358723C1 (ru) | 2008-01-31 | 2008-01-31 | Средство, обладающее антипохмельным действием, биологически активная добавка, фармацевтическая композиция, лекарственное средство и способ получения |
RU2008103155 | 2008-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009096817A2 true WO2009096817A2 (fr) | 2009-08-06 |
WO2009096817A3 WO2009096817A3 (fr) | 2009-09-24 |
Family
ID=40913450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2009/000033 WO2009096817A2 (fr) | 2008-01-31 | 2009-01-29 | Produit réduisant le degré d’intoxication aigue par l’alcool (d’ébriété) et procédé d'utilisation correspondant |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2358723C1 (fr) |
WO (1) | WO2009096817A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2557960C1 (ru) * | 2014-07-01 | 2015-07-27 | Аллан Герович Бениашвили | Ородисперсная таблетка дегидроэпиандростерона и/или комбинации дегидроэпиандростерона и l-тианина |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989004165A1 (fr) * | 1987-10-19 | 1989-05-18 | Haklitch Joseph A | Complement alimentaire de desintoxication |
US5585467A (en) * | 1990-12-04 | 1996-12-17 | Il-Yang Pharmaceutical Co., Ltd. | Proteoglycan(G009) effective in enhancing antitumor immunity |
RU2160589C1 (ru) * | 2000-05-18 | 2000-12-20 | Алекс Кашлинский | Средство для снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома и способ снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома с использованием этого средства |
CA2453159A1 (fr) * | 2001-07-10 | 2003-01-23 | Penam Investments Pty Ltd | Preparation et ses utilisations pour combattre la xylostomiase |
US20070213400A1 (en) * | 2004-05-06 | 2007-09-13 | Taiyokagaku Co., Ltd. | Alcohol-metabolism enhancing composition and ingesta containing the same |
-
2008
- 2008-01-31 RU RU2008103155/04A patent/RU2358723C1/ru active IP Right Revival
-
2009
- 2009-01-29 WO PCT/RU2009/000033 patent/WO2009096817A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989004165A1 (fr) * | 1987-10-19 | 1989-05-18 | Haklitch Joseph A | Complement alimentaire de desintoxication |
US5585467A (en) * | 1990-12-04 | 1996-12-17 | Il-Yang Pharmaceutical Co., Ltd. | Proteoglycan(G009) effective in enhancing antitumor immunity |
RU2160589C1 (ru) * | 2000-05-18 | 2000-12-20 | Алекс Кашлинский | Средство для снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома и способ снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома с использованием этого средства |
CA2453159A1 (fr) * | 2001-07-10 | 2003-01-23 | Penam Investments Pty Ltd | Preparation et ses utilisations pour combattre la xylostomiase |
US20070213400A1 (en) * | 2004-05-06 | 2007-09-13 | Taiyokagaku Co., Ltd. | Alcohol-metabolism enhancing composition and ingesta containing the same |
Also Published As
Publication number | Publication date |
---|---|
RU2358723C1 (ru) | 2009-06-20 |
WO2009096817A3 (fr) | 2009-09-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2573990C2 (ru) | Препарат, содержащий аминокислоты и растения, и его активность при алкогольной детоксикации | |
CN106456583B (zh) | 用于治疗神经障碍的巴氯芬、阿坎酸和中链甘油三酯的组合 | |
CZ20033066A3 (cs) | Kapalná farmaceutická směs | |
RU2501808C1 (ru) | Композиция для улучшения функции мозга и способ улучшения функции мозга | |
JP2002544241A (ja) | 生体活性剤の改良された細胞取り込み | |
IE903717A1 (en) | S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset hastened enhanced analgesics | |
HU230031B1 (hu) | Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény | |
CA2891362C (fr) | Comprime effervescent | |
RU2396076C1 (ru) | Средство, уменьшающее степень острой алкогольной интоксикации (опьянения) и обладающее антипохмельным действием, биологически активная добавка, фармацевтическая композиция, лекарственное средство и способ получения | |
WO2005102320A1 (fr) | Medicament pour traiter des infections virales | |
JPS5938203B2 (ja) | 補酵素qを主成分とする脳循環障害治療剤 | |
RU2358723C1 (ru) | Средство, обладающее антипохмельным действием, биологически активная добавка, фармацевтическая композиция, лекарственное средство и способ получения | |
RU2240784C1 (ru) | Лекарственное средство на основе арбидола | |
WO2022103639A1 (fr) | Méthodes de traitement de maladies auto-immunes ou inflammatoires avec du cannabidiol ou ses dérivés/analogues | |
JP2018188377A (ja) | 医薬組成物 | |
US8344101B2 (en) | Composition for improving brain function and method for improving brain function | |
WO2007107835A2 (fr) | Formulations liquides stables d'agents anti-epileptiques | |
WO2012036191A1 (fr) | Composition destinée à l'amélioration de la fonction cérébrale et méthode d'amélioration de la fonction cérébrale | |
TW201216977A (en) | Compositions and methods for improving brain function | |
JP7291380B2 (ja) | 鼻水又は鼻づまりの口腔粘膜投与用即効性改善剤 | |
RU2276982C2 (ru) | Средство, обладающее противовоспалительным, анальгетическим, жаропонижающим действием в форме таблетки | |
EP1518554B1 (fr) | Composition pharmaceutique pour le traitement de l'hyperhomocystéinémie | |
UA126659C2 (uk) | Фармацевтичний склад, що містить бензокаїн з посиленою стабільністю | |
US8343924B2 (en) | Composition for improving brain function and method for improving brain function | |
CN111166868A (zh) | 一种用于治疗神经疾病和障碍的组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09706073 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase in: |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 09706073 Country of ref document: EP Kind code of ref document: A2 |