WO2009090082A3 - Bakteriophagenpräparation und verwendung - Google Patents

Bakteriophagenpräparation und verwendung Download PDF

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Publication number
WO2009090082A3
WO2009090082A3 PCT/EP2009/000249 EP2009000249W WO2009090082A3 WO 2009090082 A3 WO2009090082 A3 WO 2009090082A3 EP 2009000249 W EP2009000249 W EP 2009000249W WO 2009090082 A3 WO2009090082 A3 WO 2009090082A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacteriophage
bacteriophage preparation
relates
preparation
alkaline
Prior art date
Application number
PCT/EP2009/000249
Other languages
English (en)
French (fr)
Other versions
WO2009090082A2 (de
Inventor
Neithard Dahlen
Gabriele Ruppert-Seipp
Original Assignee
Innovations-Transfer Uphoff Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovations-Transfer Uphoff Gmbh & Co. Kg filed Critical Innovations-Transfer Uphoff Gmbh & Co. Kg
Priority to CA2740010A priority Critical patent/CA2740010A1/en
Priority to EP09701705A priority patent/EP2234497A2/de
Priority to JP2010542583A priority patent/JP2011509964A/ja
Priority to US12/863,459 priority patent/US20100291041A1/en
Publication of WO2009090082A2 publication Critical patent/WO2009090082A2/de
Publication of WO2009090082A3 publication Critical patent/WO2009090082A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40—Viruses, e.g. bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00051—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Agronomy & Crop Science (AREA)
  • Biotechnology (AREA)
  • Dentistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die Erfindung zeigt eine Bakteriophagenpräparation mit mindestens einem gegen mindestens einen Bakterienstamm spezifisch wirksamen Bakteriophagen in alkalischer Pufferlösung in Kombination mit mindestens einem oberflächenaktiven Mittel, das vorzugsweise ein im alkalischen Bereich zwischen pH 7,5 und pH 9,0 stabilisiertes Polyhexamethylbiguanid (Polyhexanid) ist. Weiter zeigt die Erfindung die Verwendung einer solchen Bakteriophagenpräparation zur Herstellung eines Arzneimittels, insbesondere für therapeutische, präventive und desinfizierende antibakterielle Anwendung. Schließlich zeigt die Erfindung ein Desinfektionsverfahren unter Verwendung der Bakteriophagenpräparation mit niederfrequentem Ultraschall.
PCT/EP2009/000249 2008-01-18 2009-01-16 Bakteriophagenpräparation und verwendung WO2009090082A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2740010A CA2740010A1 (en) 2008-01-18 2009-01-16 Bacteriophage preparation and use
EP09701705A EP2234497A2 (de) 2008-01-18 2009-01-16 Bakteriophagenpräparation und verwendung
JP2010542583A JP2011509964A (ja) 2008-01-18 2009-01-16 バクテリオファージ製剤およびその用途
US12/863,459 US20100291041A1 (en) 2008-01-18 2009-01-16 Bacteriophage preparation and use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008005193.4 2008-01-18
DE102008005193A DE102008005193A1 (de) 2008-01-18 2008-01-18 Bakteriophagenpräparation und Verwendung

Publications (2)

Publication Number Publication Date
WO2009090082A2 WO2009090082A2 (de) 2009-07-23
WO2009090082A3 true WO2009090082A3 (de) 2010-07-15

Family

ID=40785905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/000249 WO2009090082A2 (de) 2008-01-18 2009-01-16 Bakteriophagenpräparation und verwendung

Country Status (6)

Country Link
US (1) US20100291041A1 (de)
EP (1) EP2234497A2 (de)
JP (1) JP2011509964A (de)
CA (1) CA2740010A1 (de)
DE (1) DE102008005193A1 (de)
WO (1) WO2009090082A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120276612A1 (en) * 2009-08-12 2012-11-01 Tzu Chi Buddhist General Hospital Phage of acinetobacter baumannii
DE102009049505A1 (de) * 2009-10-15 2011-04-21 Schülke & Mayr GmbH Desinfektionsverfahren mit gleichzeitiger Ultraschallbehandlung
DE102012007212A1 (de) 2012-04-11 2013-10-17 Merz Pharma Gmbh & Co. Kgaa Zubereitung zur topischen Anwendung auf Schleimhäuten mit Polyhexanid als Wirkstoff
DE102013106455A1 (de) 2013-06-20 2014-12-24 Airbus Defence and Space GmbH Verfahren zur Dekontamination von bakteriologischen Verunreinigungen
BR112016022112B1 (pt) 2014-03-31 2022-05-10 Kimberly-Clark Worldwide, Inc Composição para proteger uma superfície de organismos patogênicos
US20170157186A1 (en) * 2015-12-02 2017-06-08 Smart Phage, Inc. Phage to treat bacteria on skin
CN112646785B (zh) * 2020-12-30 2022-03-18 瑞科盟(青岛)生物工程有限公司 一株耐高温烈性变形杆菌噬菌体rdp-sa-20018及其应用
CN113699121B (zh) * 2021-09-03 2024-05-03 青岛农业大学 一种高压静电场协同1,3-甘油二酯和胶原蛋白肽提高t4噬菌体效价的方法
EP4302787A1 (de) * 2022-07-08 2024-01-10 Phatec Gmbh Hydroxyethycellulosegelzusammensetzungen mit bakteriophagen

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414304A2 (de) * 1989-08-21 1991-02-27 Unilever N.V. Wässrige Zusammensetzung auf der Basis eines Tensids und eines Bacteriophagen
WO1995001154A1 (en) * 1993-07-01 1995-01-12 Unilever N.V. Oral care compositions
EP0700249B1 (de) * 1993-05-26 1998-07-22 Fresenius AG Antiinfektivum
EP1041141A1 (de) * 1999-03-30 2000-10-04 Council Of Scientific And Industrial Research Neuer Bakteriophage, Verfahren zur Isolierung und dafür geeignetes universales Wachstumsmedium
DE10012026A1 (de) * 2000-03-11 2001-09-20 Prontomed Gmbh Medizinisches Gel und dessen Verwendung
US20020058246A1 (en) * 1995-09-07 2002-05-16 Peter Markvardsen Phage display for detergent enzyme activity
US20040029250A1 (en) * 2000-01-11 2004-02-12 Alexander Sulakvelidze Method and device for sanitation using bacteriophages
US20040208853A1 (en) * 2000-01-11 2004-10-21 Intralytix, Inc. Method and device for sanitation using bacteriophages

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020001590A1 (en) 2000-04-20 2002-01-03 Mount Sinai Hospital Antibacterial therapy for multi-drug resistant bacteria
US20070196496A1 (en) * 2002-04-16 2007-08-23 Michael Farber Delivery systems for functional ingredients

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0414304A2 (de) * 1989-08-21 1991-02-27 Unilever N.V. Wässrige Zusammensetzung auf der Basis eines Tensids und eines Bacteriophagen
EP0700249B1 (de) * 1993-05-26 1998-07-22 Fresenius AG Antiinfektivum
WO1995001154A1 (en) * 1993-07-01 1995-01-12 Unilever N.V. Oral care compositions
US20020058246A1 (en) * 1995-09-07 2002-05-16 Peter Markvardsen Phage display for detergent enzyme activity
EP1041141A1 (de) * 1999-03-30 2000-10-04 Council Of Scientific And Industrial Research Neuer Bakteriophage, Verfahren zur Isolierung und dafür geeignetes universales Wachstumsmedium
US20040029250A1 (en) * 2000-01-11 2004-02-12 Alexander Sulakvelidze Method and device for sanitation using bacteriophages
US20040208853A1 (en) * 2000-01-11 2004-10-21 Intralytix, Inc. Method and device for sanitation using bacteriophages
DE10012026A1 (de) * 2000-03-11 2001-09-20 Prontomed Gmbh Medizinisches Gel und dessen Verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GROMAN N B ET AL: "The inhibition of adsorption of Corynebacterium diphtheriae phage by Tween 80", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 1, no. 3, 1 September 1955 (1955-09-01), pages 313 - 323, XP023051980, ISSN: 0042-6822, [retrieved on 19550901] *
KLEIN, MORTON ET AL: "The Action of Synthetic Detergents Upon Certain Strains of Bacteriophage and Virus", THE JOURNAL OF IMMUNOLOGY, vol. 51, 1945, US, pages 389 - 395, XP002571978, ISSN: 0022-1767 *
MAILLARD J -Y ET AL: "Energy dispersive analysis of X-rays study of the distribution of chlorhexidine diacetate and cetylpyridinium chloride on the Pseudomonas aeruginosa bacteriophage F116", LETTERS IN APPLIED MICROBIOLOGY, vol. 20, no. 6, 1995, pages 357 - 360, XP002571979, ISSN: 0266-8254 *

Also Published As

Publication number Publication date
EP2234497A2 (de) 2010-10-06
WO2009090082A2 (de) 2009-07-23
JP2011509964A (ja) 2011-03-31
US20100291041A1 (en) 2010-11-18
CA2740010A1 (en) 2009-07-23
DE102008005193A1 (de) 2009-07-23

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