WO2009078348A1 - Method of producing liquid earthworm extract and method of producing dry earthworm powder - Google Patents

Method of producing liquid earthworm extract and method of producing dry earthworm powder Download PDF

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Publication number
WO2009078348A1
WO2009078348A1 PCT/JP2008/072607 JP2008072607W WO2009078348A1 WO 2009078348 A1 WO2009078348 A1 WO 2009078348A1 JP 2008072607 W JP2008072607 W JP 2008072607W WO 2009078348 A1 WO2009078348 A1 WO 2009078348A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
earthworm
extract
liquid
incubated
Prior art date
Application number
PCT/JP2008/072607
Other languages
French (fr)
Japanese (ja)
Inventor
Hisashi Mihara
Tadahiko Inukai
Original Assignee
Mihara L R Institute Co.Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mihara L R Institute Co.Ltd filed Critical Mihara L R Institute Co.Ltd
Publication of WO2009078348A1 publication Critical patent/WO2009078348A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)

Abstract

[PROBLEMS] To provide a method of producing a liquid earthworm extract which scarcely suffers from jamming in filtration or a failure in recovering the supernatant in centrifugation, shows favorable handling properties and facilitates the removal of water-insoluble matters, and a method of producing a dry earthworm powder from the liquid earthworm extract obtained by the above method. [MEANS FOR SOLVING PROBLEMS] Living earthworms, which have been optionally ground, are incubated to give a liquid extract. It is preferable that the above-described living earthworms, which have been optionally ground, are incubated in the coexistence of a paste of a plant belonging to the family Alliaceae, a liquid extract thereof or a paste of the above-described plant belonging to the family Alliaceae from which insoluble matters have been removed. The incubation temperature preferably ranges from 10oC to 65oC. It is preferable that the living earthworms, which have been optionally ground, to be incubated are employed in a frozen state.
PCT/JP2008/072607 2007-12-14 2008-12-12 Method of producing liquid earthworm extract and method of producing dry earthworm powder WO2009078348A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007322899A JP2009143845A (en) 2007-12-14 2007-12-14 Method for producing earthworm extract, and method for producing earthworm dry powder
JP2007-322899 2007-12-14

Publications (1)

Publication Number Publication Date
WO2009078348A1 true WO2009078348A1 (en) 2009-06-25

Family

ID=40795464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072607 WO2009078348A1 (en) 2007-12-14 2008-12-12 Method of producing liquid earthworm extract and method of producing dry earthworm powder

Country Status (2)

Country Link
JP (1) JP2009143845A (en)
WO (1) WO2009078348A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029453A1 (en) * 2008-09-10 2010-03-18 Pt.Dexa Medica Composition of thrombolytic agent and anti thrombosis and also its production method
CN112889756A (en) * 2019-12-03 2021-06-04 泰州市春光生态农业发展有限公司 Novel high-efficiency method for extracting living earthworm mucus
CN116712462A (en) * 2023-06-13 2023-09-08 江西济民可信药业有限公司 Preparation method of dry earthworm powder capable of retaining activity of earthworms

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115843564A (en) * 2022-11-18 2023-03-28 中国热带农业科学院环境与植物保护研究所 Method for increasing gibberellin content of crops

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5728007A (en) * 1980-07-29 1982-02-15 Mitsuo Ishikura Preparation of colorless, transparent and tasteless earthworm extract
JPS58148824A (en) * 1982-02-27 1983-09-05 Amano Pharmaceut Co Ltd Preparation of fibrinolytic active substance
JP2004292402A (en) * 2003-03-28 2004-10-21 Mihara Lr Kenkyusho:Kk Method for producing dried earthworm powder
JP2006096673A (en) * 2004-09-28 2006-04-13 Mihara Lr Kenkyusho:Kk Method for producing earthworm product

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5728007A (en) * 1980-07-29 1982-02-15 Mitsuo Ishikura Preparation of colorless, transparent and tasteless earthworm extract
JPS58148824A (en) * 1982-02-27 1983-09-05 Amano Pharmaceut Co Ltd Preparation of fibrinolytic active substance
JP2004292402A (en) * 2003-03-28 2004-10-21 Mihara Lr Kenkyusho:Kk Method for producing dried earthworm powder
JP2006096673A (en) * 2004-09-28 2006-04-13 Mihara Lr Kenkyusho:Kk Method for producing earthworm product

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MIHARA H.: "Mimizu no Sen'yo Kassei Busshitsu to sono Yuyosei", JOURNAL OF THE PHYSIOLOGICAL SOCIETY OF JAPAN, vol. 53, no. 7, 1991, pages 231 - 243 *
NAKAJIMA N. ET AL.: "Mimizu (Lumbricus rubellus) Saibochu ni Hakken sareta Kiwamete Antei na Sen'yo Koso (sono 2)", OKAYAMA KENRITSU TANKI DAIGAKU KENKYU KIYO, vol. 36, 1991, pages 71 - 76 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029453A1 (en) * 2008-09-10 2010-03-18 Pt.Dexa Medica Composition of thrombolytic agent and anti thrombosis and also its production method
CN112889756A (en) * 2019-12-03 2021-06-04 泰州市春光生态农业发展有限公司 Novel high-efficiency method for extracting living earthworm mucus
CN112889756B (en) * 2019-12-03 2023-03-24 泰州市春光生态农业发展有限公司 Method for extracting live earthworm mucus
CN116712462A (en) * 2023-06-13 2023-09-08 江西济民可信药业有限公司 Preparation method of dry earthworm powder capable of retaining activity of earthworms
CN116712462B (en) * 2023-06-13 2023-12-15 江西济民可信药业有限公司 Preparation method of dry earthworm powder capable of retaining activity of earthworms

Also Published As

Publication number Publication date
JP2009143845A (en) 2009-07-02

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