WO2009069776A1 - 糖鎖分析による肝疾患の診断方法 - Google Patents

糖鎖分析による肝疾患の診断方法 Download PDF

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Publication number
WO2009069776A1
WO2009069776A1 PCT/JP2008/071709 JP2008071709W WO2009069776A1 WO 2009069776 A1 WO2009069776 A1 WO 2009069776A1 JP 2008071709 W JP2008071709 W JP 2008071709W WO 2009069776 A1 WO2009069776 A1 WO 2009069776A1
Authority
WO
WIPO (PCT)
Prior art keywords
sugar chain
hepatic disease
diagnostic
chain analysis
serum
Prior art date
Application number
PCT/JP2008/071709
Other languages
English (en)
French (fr)
Inventor
Shin-Ichiro Nishimura
Satoru Todo
Original Assignee
National University Corporation Hokkaido University
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Hokkaido University, Shionogi & Co., Ltd. filed Critical National University Corporation Hokkaido University
Priority to JP2009543886A priority Critical patent/JPWO2009069776A1/ja
Priority to EP08853570A priority patent/EP2224235A4/en
Priority to US12/734,879 priority patent/US20100301203A1/en
Publication of WO2009069776A1 publication Critical patent/WO2009069776A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　本発明は、肝疾患、特にＨＣＣの新しい診断方法の提供を目的とする。本発明者らは血清中糖鎖発現量の定量的発現プロファイルをもとに各罹患状態との関連性を解析して、肝疾患の進行に伴って変動する糖鎖を見出し、新たなバイオマーカーとなる血清糖鎖を提供した。
PCT/JP2008/071709 2007-11-30 2008-11-28 糖鎖分析による肝疾患の診断方法 WO2009069776A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009543886A JPWO2009069776A1 (ja) 2007-11-30 2008-11-28 糖鎖分析による肝疾患の診断方法
EP08853570A EP2224235A4 (en) 2007-11-30 2008-11-28 DIAGNOSTIC METHOD OF HEPATIC DISEASE BY SUGAR CHAIN ANALYSIS
US12/734,879 US20100301203A1 (en) 2007-11-30 2008-11-28 Method of diagnostic heparic disease by sugar chain analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-310285 2007-11-30
JP2007310285 2007-11-30

Publications (1)

Publication Number Publication Date
WO2009069776A1 true WO2009069776A1 (ja) 2009-06-04

Family

ID=40678665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071709 WO2009069776A1 (ja) 2007-11-30 2008-11-28 糖鎖分析による肝疾患の診断方法

Country Status (4)

Country Link
US (1) US20100301203A1 (ja)
EP (2) EP2224235A4 (ja)
JP (1) JPWO2009069776A1 (ja)
WO (1) WO2009069776A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5737761B2 (ja) * 2009-09-18 2015-06-17 大学共同利用機関法人自然科学研究機構 肝細胞癌マーカー
WO2021010349A1 (ja) * 2019-07-12 2021-01-21 国立大学法人北海道大学 非アルコール性脂肪肝炎の血中線維化マーカーの開発

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113311056B (zh) * 2021-05-10 2022-06-21 中国医学科学院北京协和医院 用于遗传性血管水肿的标志物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007278803A (ja) * 2006-04-05 2007-10-25 Glyence Co Ltd 肝細胞癌マーカー及び肝細胞癌の検査法

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JP2579497B2 (ja) * 1987-09-07 1997-02-05 オリエンタル酵母工業株式会社 肝臓疾患診断剤
ES2498369T3 (es) * 2002-04-16 2014-09-24 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Un marcador para medir cirrosis hepática
US7860656B2 (en) * 2005-02-03 2010-12-28 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of hepatic steatosis using biochemical markers
FI20055417A0 (fi) * 2005-07-20 2005-07-20 Glykos Finland Oy Syöpäpesifiset glykaanit ja niiden käyttö
US9012162B2 (en) * 2006-09-08 2015-04-21 The Chancellor, Masters And Scholars Of The University Of Oxford Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers
AU2008263899A1 (en) * 2007-06-14 2008-12-18 Universiteit Gent Diagnostic test for the detection of early stage liver cancer
WO2009117666A1 (en) * 2008-03-21 2009-09-24 Indiana University Research And Technology Corporation Glycan markers of hepatocellular carcinoma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007278803A (ja) * 2006-04-05 2007-10-25 Glyence Co Ltd 肝細胞癌マーカー及び肝細胞癌の検査法

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
COLLIER ET AL., VIRAL HEPATITIS REVIEWS, vol. 4, 1998, pages 31 - 41
KOGO ET AL.: "Alcohol-sei Kanshogai Marker", RINSHO SHOKAKI NAIKA, vol. 10, no. 8, 1995, pages 1287 - 1294 *
LEVY ET AL., ANN. SURG., vol. 234, 2001, pages 206 - 209
MURAKAMI ET AL.: "Detectability of hypervascularhepatocellular carcinoma by arterial phase images of MR and spiral CT", ACTA RADIOL, vol. 36, 1995, pages 372 - 376
NAKAGAWA H. ET AL.: "Identification of Neutral and Sialyl N-Linked Oligosaccharide Structures from Human Serum Glycoproteins Using Three Kinds of High-Performance Liquid Chromatography", ANALYTICAL BIOCHEMISTRY, vol. 226, no. 1, 1995, pages 130 - 138 *
NISHIMURA, S; K NIIKURA; M KUROGOCHI; T MATSUSHITA; M FUMOTO; H HINOU; R KAMITANI; H NAKAGAWA; K DEGUCHI; N MIURA: "High-Throughput Protein Glycomics: Combined Use of Chemoselective Glycoblotting and Maldi-Tof/Tof Mass Spectrometry.", ANGEW CHEM INT ED ENGL, vol. 44, no. 1, 2004, pages 91 - 96
SCOW ET AL., PROTEOMICS, vol. 1, 2001, pages 1249 - 1263
See also references of EP2224235A4 *
SHERMAN, J., HEPATOL., vol. 34, 2001, pages 603 - 605
TAKETA, HEPATOLOGY, vol. 12, 1990, pages 1420 - 1432
TREVISANI ET AL., J. HEPATOL., vol. 34, 2001, pages 570 - 575
YOSHIAKI MIURA ET AL.: "BlotGlycoABC?, an Integrated Glycoblotting Technique for Rapid and Large Scale Clinical Glycomics", MOLECULAR & CELLULAR PROTEOMICS, vol. 7, February 2008 (2008-02-01), pages 370 - 377 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5737761B2 (ja) * 2009-09-18 2015-06-17 大学共同利用機関法人自然科学研究機構 肝細胞癌マーカー
WO2021010349A1 (ja) * 2019-07-12 2021-01-21 国立大学法人北海道大学 非アルコール性脂肪肝炎の血中線維化マーカーの開発

Also Published As

Publication number Publication date
EP2224235A4 (en) 2011-04-20
JPWO2009069776A1 (ja) 2011-04-21
EP2508888A1 (en) 2012-10-10
EP2224235A1 (en) 2010-09-01
US20100301203A1 (en) 2010-12-02

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