WO2009063992A1 - 縮合ピリジン誘導体およびその用途 - Google Patents

縮合ピリジン誘導体およびその用途 Download PDF

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Publication number
WO2009063992A1
WO2009063992A1 PCT/JP2008/070809 JP2008070809W WO2009063992A1 WO 2009063992 A1 WO2009063992 A1 WO 2009063992A1 JP 2008070809 W JP2008070809 W JP 2008070809W WO 2009063992 A1 WO2009063992 A1 WO 2009063992A1
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WO
WIPO (PCT)
Prior art keywords
therapeutic agent
preventive
activating
pyridine derivative
5ht2c receptor
Prior art date
Application number
PCT/JP2008/070809
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English (en)
French (fr)
Inventor
Takahiro Matsumoto
Hiroyuki Nagamiya
Hironobu Maezaki
Tomokazu Kusumoto
Kyoko Yoshikawa
Hideki Furukawa
Izumi Kamo
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to JP2009541194A priority Critical patent/JP5520051B2/ja
Priority to US12/742,781 priority patent/US20100266504A1/en
Priority to EP08851020A priority patent/EP2216023A4/en
Publication of WO2009063992A1 publication Critical patent/WO2009063992A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders

Abstract

　セロトニン５－ＨＴ２Ｃ受容体活性化作用等を有する縮合ピリジン誘導体、および当該縮合ピリジン誘導体を含む下部尿路症状、肥満および／または臓器脱等の疾患の予防または治療剤、膀胱内圧上昇時の漏出時圧を増大する物質、または腹圧性尿失禁予防または治療薬のスクリーニング方法、セロトニン５-ＨＴ２Ｃ受容体を活性化する物質を含有してなる膀胱瘤および小腸瘤の予防または治療薬及び動物の下腹神経および陰部神経を両側切断した状態において膀胱内圧を上昇せしめて、その時観察される尿道、直腸、または膣における閉鎖反応を測定することを特徴とする、膀胱瘤および小腸瘤の治療薬のスクリーニング方法を提供すること。式： ［式中、各記号は明細書中と同義を示す］で表される化合物またはその塩を含有してなるセロトニン５－ＨＴ２ｃ受容体活性化剤。
PCT/JP2008/070809 2007-11-15 2008-11-14 縮合ピリジン誘導体およびその用途 WO2009063992A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009541194A JP5520051B2 (ja) 2007-11-15 2008-11-14 縮合ピリジン誘導体およびその用途
US12/742,781 US20100266504A1 (en) 2007-11-15 2008-11-14 Condensed pyridine derivative and use thereof
EP08851020A EP2216023A4 (en) 2007-11-15 2008-11-14 CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007297170 2007-11-15
JP2007-297170 2007-11-15

Publications (1)

Publication Number Publication Date
WO2009063992A1 true WO2009063992A1 (ja) 2009-05-22

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Country Status (4)

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US (1) US20100266504A1 (ja)
EP (2) EP2789338A3 (ja)
JP (1) JP5520051B2 (ja)
WO (1) WO2009063992A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513233A (ja) * 2008-02-22 2011-04-28 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
US8314088B2 (en) 2009-06-15 2012-11-20 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
WO2013133325A1 (ja) * 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
US8916549B2 (en) 2009-08-04 2014-12-23 Takeda Pharmaceutical Company Limited Thienooxazepine derivative
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3033142A1 (en) * 2016-08-19 2018-02-22 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2023205196A1 (en) * 2022-04-21 2023-10-26 Merck Sharp & Dohme Llc Process for preparing agglomerated crystalline medium-chain fatty acid sodium salts
CN115634220B (zh) * 2022-12-23 2023-04-07 中国人民解放军军事科学院军事医学研究院 二甲双胍在制备预防和/或治疗电磁辐射致生殖损伤的产品中的应用

Citations (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3253989A (en) 1963-02-11 1966-05-31 American Cyanamid Co Process for producing anorexia
US3652588A (en) 1969-10-23 1972-03-28 Upjohn Co 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles
US3676558A (en) 1970-08-28 1972-07-11 Upjohn Co Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment
US4082844A (en) 1976-02-09 1978-04-04 Merck & Co., Inc. 6-chloro-2-(1-piperazinyl)pyrazine
JPS5857379A (ja) 1981-10-01 1983-04-05 Nippon Kayaku Co Ltd ５，６，７，８−テトラヒドロ−１，６−ナフチリジン誘導体およびその製造法
US4971969A (en) 1988-11-24 1990-11-20 Akzo N.V. Pharmaceutical composition containing 1-(mono- or bis(trifluoromethyl)-2-pyridinyl)piperazines
EP0572863A1 (de) 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
US5494928A (en) 1993-01-22 1996-02-27 Hoffmann-La Roche Inc. Indole derivatives
US5646173A (en) 1993-10-22 1997-07-08 Hoffmann-La Roche Inc. Tricyclic pyrrole derivatives useful as 5-HT selective agents
JPH09263545A (ja) 1995-06-05 1997-10-07 Takeda Chem Ind Ltd 骨形成促進医薬組成物
WO1997042183A1 (en) 1996-05-03 1997-11-13 F. Hoffmann-La Roche Ag Benzofuryl derivatives and their use
WO1998030546A1 (en) 1997-01-08 1998-07-16 F. Hoffmann-La Roche Ag TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES
WO1998030548A1 (fr) 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE
WO1998033504A1 (en) 1997-02-03 1998-08-06 Akzo Nobel N.V. Treatment of urinary incontinence
EP0863136A1 (en) 1997-02-25 1998-09-09 Akzo Nobel N.V. Derivatives of azetidine and pyrrolidine
WO1999002159A1 (en) 1997-07-09 1999-01-21 Nortran Pharmaceuticals Inc. Aroylpiperazines for modulating sexual activity
WO2000012475A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indoline derivatives as 5-ht2b and/or 5-ht2c receptor ligands
WO2000012481A2 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity________________
WO2000012502A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Pyrroloquinolines for treatment of obesity
WO2000012482A2 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity
WO2000012510A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists
WO2000017170A2 (en) 1998-09-23 2000-03-30 Vernalis Research Limited N1-substituted benzopyrazoles as inhibitors of 5-ht2 receptors
WO2000016761A2 (en) 1998-09-18 2000-03-30 Alcon Laboratories, Inc. Serotonergic 5ht2 agonists for treating glaucoma
WO2000028993A1 (en) 1998-11-19 2000-05-25 Nortran Pharmaceuticals, Inc. Serotonin ligands as pro-erectile compounds
WO2000035922A1 (en) 1998-12-17 2000-06-22 American Home Products Corporation 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists
WO2000044753A1 (en) 1999-01-29 2000-08-03 Vernalis Research Limited Pirazino(aza)indole derivatives
WO2000044737A1 (en) 1999-01-27 2000-08-03 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists
WO2000064899A1 (en) 1999-04-23 2000-11-02 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds as 5-ht receptor ligands
WO2000077002A1 (en) 1999-06-15 2000-12-21 Du Pont Pharmaceuticals Company Substituted heterocycle fused gamma-carbolines
WO2000076984A2 (en) 1999-05-21 2000-12-21 Biovitrum Ab Novel compounds, their use and preparation
WO2001009123A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Benzofurylpiperazine serotonin agonists
WO2001009126A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzothiophenes
WO2001009111A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists
WO2001009122A2 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzofurans
WO2001012603A1 (en) 1999-08-11 2001-02-22 Vernalis Research Limited Indole derivatives, process for their preparation, pharmaceutical compositions containing them and their medicinal application
WO2001012602A1 (en) 1999-08-11 2001-02-22 Vernalis Research Limited Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands
WO2001040183A1 (en) 1999-12-03 2001-06-07 Alcon Universal Ltd. 1-aminoalkyl-1h-indoles for treating glaucoma
US6281243B1 (en) 1998-02-26 2001-08-28 Akzo Nobel N.V. Derivatives of azetidine and pyrrolidine
WO2001066548A1 (en) 2000-03-06 2001-09-13 F. Hoffmann-La Roche Ag New aza-indolyl derivatives
WO2001070207A2 (en) 2000-03-17 2001-09-27 Alcon, Inc. 5ht2 agonists for controlling iop and treating glaucoma
WO2001070223A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
WO2001072752A2 (en) 2000-03-14 2001-10-04 Pharmacia & Upjohn Company 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-a]INDOLE COMPOUNDS
US6310208B1 (en) 1997-01-08 2001-10-30 Hoffmann-La Roche Inc. Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines
WO2001083487A1 (fr) 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derive de froindazole
WO2002004457A1 (en) 2000-07-06 2002-01-17 Pharmacia & Upjohn Company Azepino[4,5-b]pyrano[3,2-e]indoles
WO2002008178A1 (en) 2000-07-21 2002-01-31 Biovitrum Ab New combination of serotonin agonist (5ht2) and antagonist (5ht6)as pharmaceutical formulation
WO2002010169A1 (en) 2000-07-31 2002-02-07 F. Hoffmann-La Roche Ag Piperazine derivatives
WO2002024701A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company Substituted azepino[4,5b)indole derivatives
US6372745B1 (en) 1999-12-06 2002-04-16 American Home Products Corporation 2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
WO2002036596A2 (en) 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002040456A1 (en) 2000-11-20 2002-05-23 Biovitrum Ab Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
WO2002040457A1 (en) 2000-11-20 2002-05-23 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
WO2002042304A2 (en) 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
WO2002044152A1 (en) 2000-10-16 2002-06-06 F. Hoffmann-La Roche Ag Indoline derivatives and their use as 5-ht2 receptor ligands
EP1213017A2 (en) 2000-12-05 2002-06-12 Akzo Nobel N.V. Use of a 5-HT2C receptor agonist for the treatment of hot flushes
WO2002048124A2 (en) 2000-12-15 2002-06-20 F. Hoffmann-La Roche Ag Piperazine derivatives
WO2002051849A1 (fr) 2000-12-26 2002-07-04 Daiichi Pharmaceutical Co., Ltd. Inhibiteurs cdk4
WO2002059124A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
WO2002059127A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Pharma Company Pyrazinoquinoxaline derivatives as serotonin agonists and antagonists
WO2002059129A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
WO2002072584A2 (en) 2001-03-13 2002-09-19 F. Hoffmann-La Roche Ag Tetrahydro-pyrazino (1,2-a) indoles for the treatment of central nervous disorders
WO2002074746A1 (fr) 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Derives de benzazepine
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
WO2002098350A2 (en) 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
WO2002098860A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
WO2002098400A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
WO2003000666A1 (en) 2001-06-21 2003-01-03 Pfizer Products Inc. 5-ht receptor ligands and uses thereof
WO2003004501A2 (en) 2001-07-05 2003-01-16 Pharmacia & Upjohn Company (hetero) aryl substituted benzofurans as 5-ht ligands
WO2003006466A1 (en) 2001-07-13 2003-01-23 Pharmacia & Upjohn Company Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands
WO2003011281A1 (en) 2001-08-02 2003-02-13 Vernalis Research Limited Treatment of attention deficit hyperactivity disorder or attention deficit disorder
WO2003014125A1 (en) 2001-08-06 2003-02-20 Pharmacia & Upjohn Company Therapeutically useful tetracyclic ligands
WO2003014118A1 (en) 2001-08-08 2003-02-20 Pharmacia & Upjohn Company THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES
WO2003024976A2 (en) 2001-09-21 2003-03-27 Pharmacia & Upjohn Company Tricyclic indole derivatives as 5-ht ligands
WO2003028733A1 (en) 2001-08-06 2003-04-10 Pharmacia & Upjohn Company Tetracyclic indole derivatives as 5-ht receptor ligands
WO2003033497A1 (en) 2001-10-18 2003-04-24 Pharmacia & Upjohn Company Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity
WO2003057213A2 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003057161A2 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation BENZOTHIENO [3,2-c]PYRAZOLYL AND BENZOFURANO [3,2-c] PYRAZOLYL COMPOUNDS, THEIR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR AND INTERMEDIATE COMPOUNDS THEREOF
WO2003057673A1 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003057674A1 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 4-sulfide / sulfoxide / sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003062205A1 (en) 2001-12-21 2003-07-31 Smithkline Beecham P.L.C. 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment of cns disorders
WO2003064423A1 (en) 2002-01-29 2003-08-07 F. Hoffmann-La Roche Ag Aza-arylpiperazines
US6610685B2 (en) 2000-12-27 2003-08-26 Hoffmann-La Roche Inc. Fused indole derivatives
WO2003076427A1 (en) 2002-03-14 2003-09-18 Pfizer Limited Quinazoline compounds useful in therapy
WO2003087086A2 (de) 2002-04-16 2003-10-23 Merck Patent Gmbh Substituierte indole und deren verwendung als 5ht-wiederaufnahme inhibitoren und als 5ht liganden
WO2003086306A2 (en) 2002-04-12 2003-10-23 Arena Pharmaceuticals, Inc. 5ht2c receptor modulators
WO2003089409A1 (en) 2002-04-19 2003-10-30 Glaxo Group Limited Compounds having affinity at 5ht2c receptor and use thereof in therapy
WO2003091250A1 (en) 2002-04-25 2003-11-06 Wyeth [1,4]diazepino[6,7,1-ij]quinoline derivatives as anti psychotic and antiobesity agents
WO2003091257A1 (en) 2002-04-25 2003-11-06 Wyeth [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS
WO2003091251A1 (en) 2002-04-25 2003-11-06 Wyeth 1,2,3,4,7,8-hexahydro-6h-[1,4]diazepino[6,7,1-1j]quinoline derivatives as antipsychotic and antiobesity agents
WO2003097636A1 (en) 2002-05-17 2003-11-27 Biovitrum Ab Novel compounds and their use
US6667303B1 (en) 2001-07-30 2003-12-23 Wyeth Aryl substituted 1,4-diazepanes and method of use thereof
WO2004000829A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel process
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
JP2004159919A (ja) * 2002-11-13 2004-06-10 Takeda Chem Ind Ltd 腹圧性尿失禁予防治療薬のスクリーニング方法
WO2004056324A2 (en) 2002-12-19 2004-07-08 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
WO2004069162A2 (en) 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004078718A1 (en) 2003-03-05 2004-09-16 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
WO2004081010A1 (en) 2003-03-11 2004-09-23 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
US20040192754A1 (en) 2003-03-24 2004-09-30 Shapira Nathan Andrew Methods for treating idiopathic hyperhidrosis and associated conditions
WO2004087662A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
WO2004087156A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
WO2004087692A1 (de) 2003-04-04 2004-10-14 Merck Patent Gmbh Chromenonindole
WO2004089897A1 (en) 2003-04-07 2004-10-21 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
WO2004096196A2 (en) 2003-04-25 2004-11-11 Pfizer Limited Treatment of incontinence with 5htc2 agonists
WO2004096201A1 (en) 2003-04-29 2004-11-11 Orexigen Therapeutics, Inc. Compositions for affecting weight loss
WO2004112769A1 (en) 2003-06-23 2004-12-29 EGIS Gyógyszergyár Rt. Use of bicyclo[2.2.1]heptane derivatives for the preparation of neuroprotective pharmaceutical compositions
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
WO2005000849A1 (en) 2003-06-26 2005-01-06 F. Hoffmann-La Roche Ag 5ht2c receptor agonists for the treatment of diabetes and obesity
WO2005003096A1 (en) 2003-06-17 2005-01-13 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
EP1500391A1 (en) 2003-07-24 2005-01-26 Neuro3D Therapeutic use of bicycloheptane derivatives
WO2005016902A1 (en) 2003-06-20 2005-02-24 Arena Pharmaceuticals, Inc. N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005019179A2 (en) 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
WO2005019180A1 (en) 2003-08-11 2005-03-03 Eli Lilly And Company 6-(2,2,2-TRIFLUOROETHYLAMINO)-7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINE AS A 5-HT2c RECEPTOR AGONIST
US20050080074A1 (en) 2003-10-07 2005-04-14 Wacker Dean A. Modulators of serotonin receptors
WO2005040146A1 (en) 2003-10-24 2005-05-06 Wyeth Dihydrobenzofuranyl alkanamines and pharmaceutical compositions containing them
WO2005042490A1 (en) 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005041856A2 (en) 2003-11-03 2005-05-12 Pliva-Istrazivacki Institut D.O.O. Use of 2-thia-dibenzo[e, h]azulenes for the treatment and prevention of central nervous system diseases and disorders
WO2005044812A1 (en) 2003-10-24 2005-05-19 Wyeth A Corporation Of The State Of Delaware Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists
WO2005049623A1 (en) 2003-11-21 2005-06-02 Pliva-Istrazivacki Institut D.O.O. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
WO2005082859A1 (en) 2004-02-25 2005-09-09 Eli Lilly And Company 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2005105082A1 (en) 2004-04-14 2005-11-10 Bristol-Myers Squibb Company Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
WO2005109987A2 (en) 2004-05-11 2005-11-24 Egis Gyógyszergyár Nyrt. 3-(((4-phenyl)-piperazine-1-yl)-alkyl)-3-alkyl-1, 3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders
WO2005113535A2 (en) 2004-05-21 2005-12-01 Pfizer Products Inc. Pyrazinylmethyl lactam derivatives
WO2005121113A1 (en) 2004-06-14 2005-12-22 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives
US20060003990A1 (en) 2004-06-30 2006-01-05 Athersys, Inc. Substituted azepine derivatives as serotonin receptor modulators
WO2006000902A1 (en) 2004-06-25 2006-01-05 Pfizer Products Inc. Dihydrobenzofuran compounds and uses thereof
US20060014777A1 (en) 2004-07-14 2006-01-19 Fevig John M Pyrrolo(oxo)isoquinolines as 5HT ligands
US20060014778A1 (en) 2004-07-14 2006-01-19 Fevig John M Pyrrolo(oxo)quinolines as 5HT ligands
US20060025601A1 (en) 2004-07-29 2006-02-02 Athersys, Inc. Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
WO2006020817A1 (en) 2004-08-13 2006-02-23 Omeros Corporation Novel serotonin receptor ligands and their uses thereof
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2006022420A1 (ja) * 2004-08-25 2006-03-02 Takeda Pharmaceutical Company Limited 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
WO2006028961A2 (en) 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
WO2006044762A2 (en) 2004-10-15 2006-04-27 Bayer Pharmaceuticals Corporation Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor
WO2006047032A2 (en) 2004-09-27 2006-05-04 Organix, Inc. Indole compounds useful as serotonin selective agents
WO2006047228A1 (en) 2004-10-21 2006-05-04 Wyeth Asymmetric synthesis of substituted dihydrobenzofurans
WO2006050007A2 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as cns agents
WO2006052887A1 (en) 2004-11-05 2006-05-18 Wyeth Formulations of [1,4]diazepino[6,7,1-ij]quinoline derivatives
WO2006065600A2 (en) 2004-12-13 2006-06-22 Arena Pharmaceuticals, Inc. N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto
WO2006077025A2 (en) 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
WO2006103511A1 (en) 2005-03-31 2006-10-05 Pfizer Products Inc. Cyclopentapyridine and tetrahydroquinoline derivatives
US20060241172A1 (en) 2005-04-22 2006-10-26 Wyeth Benzodioxane and benzodioxolane derivatives and uses thereof
US20060241176A1 (en) 2005-04-22 2006-10-26 Wyeth Dihydrobenzofuran derivatives and uses thereof
WO2006116170A1 (en) 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
WO2006116165A1 (en) 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
WO2006116169A2 (en) 2005-04-24 2006-11-02 Wyeth Methods for modulating bladder function
WO2006116218A1 (en) 2005-04-22 2006-11-02 Wyeth Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
WO2006116136A1 (en) 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
WO2006116151A1 (en) 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
WO2006116171A1 (en) 2005-04-22 2006-11-02 Wyeth Treatment of pain
WO2006116148A2 (en) 2005-04-22 2006-11-02 Wyeth (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse
WO2006117304A1 (en) 2005-05-03 2006-11-09 F. Hoffmann-La Roche Ag Tetracyclic azapyrazinoindolines as 5-ht2 ligands
US20070032481A1 (en) 2005-08-04 2007-02-08 Dvorak Curt A Pyrimidine compounds as serotonin receptor modulators
US20070049613A1 (en) 2005-08-24 2007-03-01 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
WO2007025144A1 (en) 2005-08-24 2007-03-01 University Of Illinois - Chicago 5-ht2c receptor agonists as anorectic agents
WO2007028082A1 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-substituted- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028083A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028132A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
WO2007028131A1 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
WO2007030150A1 (en) 2005-04-22 2007-03-15 Wyeth Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists
WO2007084622A2 (en) 2006-01-19 2007-07-26 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
WO2007106349A2 (en) * 2006-03-10 2007-09-20 Neurogen Corporation Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
WO2007132841A1 (ja) * 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
WO2007140213A1 (en) 2006-05-26 2007-12-06 Forest Laboratories Holdings Limited Pyridoazepine derivatives
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
WO2008007664A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique bicycique et son utilisation
WO2008010073A1 (en) 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
WO2008009125A1 (en) 2006-07-20 2008-01-24 Cascade Therapeutics Inc. Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands
WO2008052086A1 (en) 2006-10-24 2008-05-02 Wyeth Benzodioxane derivatives and uses thereof
WO2008052087A1 (en) 2006-10-24 2008-05-02 Wyeth Chromane derivatives and uses thereof
WO2008052075A2 (en) 2006-10-24 2008-05-02 Wyeth Benzoxazine derivatives and uses thereof
WO2008052088A1 (en) 2006-10-25 2008-05-02 Wyeth Chromane derivatives, synthesis thereof, and intermediates thereto
WO2008052078A2 (en) 2006-10-24 2008-05-02 Wyeth Benzoxathiine and benzoxathiole derivatives and uses thereof
US20080146583A1 (en) 2003-05-15 2008-06-19 Pfizer Inc Treatment of Incontinence
WO2008117169A1 (en) 2007-03-23 2008-10-02 Pfizer Limited Pyrimido [4, 5-d] azepine derivatives as 5-ht2c agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004164A1 (en) 2003-04-30 2005-01-06 Caggiano Thomas J. 2-Cyanopropanoic acid amide and ester derivatives and methods of their use
JP4678329B2 (ja) 2006-04-28 2011-04-27 富士ゼロックス株式会社 画像形成装置

Patent Citations (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3253989A (en) 1963-02-11 1966-05-31 American Cyanamid Co Process for producing anorexia
US3652588A (en) 1969-10-23 1972-03-28 Upjohn Co 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles
US3676558A (en) 1970-08-28 1972-07-11 Upjohn Co Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment
US4082844A (en) 1976-02-09 1978-04-04 Merck & Co., Inc. 6-chloro-2-(1-piperazinyl)pyrazine
JPS5857379A (ja) 1981-10-01 1983-04-05 Nippon Kayaku Co Ltd ５，６，７，８−テトラヒドロ−１，６−ナフチリジン誘導体およびその製造法
US4971969A (en) 1988-11-24 1990-11-20 Akzo N.V. Pharmaceutical composition containing 1-(mono- or bis(trifluoromethyl)-2-pyridinyl)piperazines
EP0572863A1 (de) 1992-06-05 1993-12-08 F. Hoffmann-La Roche Ag ZNS Pyrazinoindole
US5494928A (en) 1993-01-22 1996-02-27 Hoffmann-La Roche Inc. Indole derivatives
US5646173A (en) 1993-10-22 1997-07-08 Hoffmann-La Roche Inc. Tricyclic pyrrole derivatives useful as 5-HT selective agents
JPH09263545A (ja) 1995-06-05 1997-10-07 Takeda Chem Ind Ltd 骨形成促進医薬組成物
WO1997042183A1 (en) 1996-05-03 1997-11-13 F. Hoffmann-La Roche Ag Benzofuryl derivatives and their use
WO1998030546A1 (en) 1997-01-08 1998-07-16 F. Hoffmann-La Roche Ag TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES
US6310208B1 (en) 1997-01-08 2001-10-30 Hoffmann-La Roche Inc. Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines
WO1998030548A1 (fr) 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE
WO1998033504A1 (en) 1997-02-03 1998-08-06 Akzo Nobel N.V. Treatment of urinary incontinence
EP0863136A1 (en) 1997-02-25 1998-09-09 Akzo Nobel N.V. Derivatives of azetidine and pyrrolidine
WO1999043647A1 (en) 1997-02-25 1999-09-02 Akzo Nobel N.V. Derivatives of azetidine and pyrrolidine
WO1999002159A1 (en) 1997-07-09 1999-01-21 Nortran Pharmaceuticals Inc. Aroylpiperazines for modulating sexual activity
US6281243B1 (en) 1998-02-26 2001-08-28 Akzo Nobel N.V. Derivatives of azetidine and pyrrolidine
WO2000012481A2 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity________________
US6552062B1 (en) 1998-09-01 2003-04-22 Vernalis Research Limited Indazole derivatives with 5-HT2 receptor activity
WO2000012510A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists
WO2000012482A2 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity
WO2000012475A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Indoline derivatives as 5-ht2b and/or 5-ht2c receptor ligands
WO2000012502A1 (en) 1998-09-01 2000-03-09 Vernalis Research Limited Pyrroloquinolines for treatment of obesity
US6365598B1 (en) 1998-09-01 2002-04-02 Vernalis Research Limited Pyrroloquinolines for treatment of obesity
US6380238B1 (en) 1998-09-01 2002-04-30 Vernalis Research Limited Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands
US6433175B1 (en) 1998-09-01 2002-08-13 Vernalis Research Limited Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists
WO2000016761A2 (en) 1998-09-18 2000-03-30 Alcon Laboratories, Inc. Serotonergic 5ht2 agonists for treating glaucoma
WO2000017170A2 (en) 1998-09-23 2000-03-30 Vernalis Research Limited N1-substituted benzopyrazoles as inhibitors of 5-ht2 receptors
WO2000028993A1 (en) 1998-11-19 2000-05-25 Nortran Pharmaceuticals, Inc. Serotonin ligands as pro-erectile compounds
WO2000035922A1 (en) 1998-12-17 2000-06-22 American Home Products Corporation 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists
WO2000044737A1 (en) 1999-01-27 2000-08-03 Eli Lilly And Company Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists
WO2000044753A1 (en) 1999-01-29 2000-08-03 Vernalis Research Limited Pirazino(aza)indole derivatives
WO2000064899A1 (en) 1999-04-23 2000-11-02 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds as 5-ht receptor ligands
WO2000076984A2 (en) 1999-05-21 2000-12-21 Biovitrum Ab Novel compounds, their use and preparation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
WO2000077002A1 (en) 1999-06-15 2000-12-21 Du Pont Pharmaceuticals Company Substituted heterocycle fused gamma-carbolines
WO2000077001A1 (en) 1999-06-15 2000-12-21 Du Pont Pharmaceuticals Company Substituted heterocycle fused gamma-carbolines
WO2000077010A2 (en) 1999-06-15 2000-12-21 Du Pont Pharmaceuticals Company Substituted heterocycle fused gamma-carbolines
WO2001009122A2 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzofurans
WO2001009126A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Serotonergic benzothiophenes
WO2001009111A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists
US6638936B1 (en) 1999-07-29 2003-10-28 Eli Lilly And Company Benzofurylpiperazine serotonin agonists
WO2001009123A1 (en) 1999-07-29 2001-02-08 Eli Lilly And Company Benzofurylpiperazine serotonin agonists
WO2001012602A1 (en) 1999-08-11 2001-02-22 Vernalis Research Limited Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands
US6706750B1 (en) 1999-08-11 2004-03-16 Vernalis Research Limited Indole derivatives process for their preparation, pharmaceutical compositions containing them and their medicinal application
WO2001012603A1 (en) 1999-08-11 2001-02-22 Vernalis Research Limited Indole derivatives, process for their preparation, pharmaceutical compositions containing them and their medicinal application
WO2001040183A1 (en) 1999-12-03 2001-06-07 Alcon Universal Ltd. 1-aminoalkyl-1h-indoles for treating glaucoma
US6372745B1 (en) 1999-12-06 2002-04-16 American Home Products Corporation 2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
US6583134B2 (en) 2000-03-06 2003-06-24 Hoffman-La Roche Inc. Aza- indolyl derivatives for treating obesity
WO2001066548A1 (en) 2000-03-06 2001-09-13 F. Hoffmann-La Roche Ag New aza-indolyl derivatives
US6734301B2 (en) 2000-03-14 2004-05-11 Pharmacia & Upjohn Company 2,3,4,5-Tetrahydro-1H-[1,4]diazepino[1,7-a]indole compounds
WO2001072752A2 (en) 2000-03-14 2001-10-04 Pharmacia & Upjohn Company 2,3,4,5-TETRAHYDRO-1H-[1,4]DIAZEPINO[1,7-a]INDOLE COMPOUNDS
WO2001070223A1 (en) 2000-03-17 2001-09-27 Alcon, Inc. Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
WO2001070207A2 (en) 2000-03-17 2001-09-27 Alcon, Inc. 5ht2 agonists for controlling iop and treating glaucoma
WO2001083487A1 (fr) 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derive de froindazole
WO2002004456A1 (en) 2000-07-06 2002-01-17 Pharmacia & Upjohn Company SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES
WO2002004457A1 (en) 2000-07-06 2002-01-17 Pharmacia & Upjohn Company Azepino[4,5-b]pyrano[3,2-e]indoles
WO2002008178A1 (en) 2000-07-21 2002-01-31 Biovitrum Ab New combination of serotonin agonist (5ht2) and antagonist (5ht6)as pharmaceutical formulation
WO2002010169A1 (en) 2000-07-31 2002-02-07 F. Hoffmann-La Roche Ag Piperazine derivatives
WO2002024700A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
WO2002024701A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company Substituted azepino[4,5b)indole derivatives
WO2002044152A1 (en) 2000-10-16 2002-06-06 F. Hoffmann-La Roche Ag Indoline derivatives and their use as 5-ht2 receptor ligands
US6479534B1 (en) 2000-10-16 2002-11-12 Hoffmann La Roche Indoline derivatives and method of treating obesity
WO2002042304A2 (en) 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
WO2002036596A2 (en) 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002040456A1 (en) 2000-11-20 2002-05-23 Biovitrum Ab Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor
WO2002040457A1 (en) 2000-11-20 2002-05-23 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
EP1213017A2 (en) 2000-12-05 2002-06-12 Akzo Nobel N.V. Use of a 5-HT2C receptor agonist for the treatment of hot flushes
WO2002048124A2 (en) 2000-12-15 2002-06-20 F. Hoffmann-La Roche Ag Piperazine derivatives
WO2002059129A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
WO2002059124A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Company Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
WO2002059127A2 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Pharma Company Pyrazinoquinoxaline derivatives as serotonin agonists and antagonists
WO2002051849A1 (fr) 2000-12-26 2002-07-04 Daiichi Pharmaceutical Co., Ltd. Inhibiteurs cdk4
US6610685B2 (en) 2000-12-27 2003-08-26 Hoffmann-La Roche Inc. Fused indole derivatives
WO2002072584A2 (en) 2001-03-13 2002-09-19 F. Hoffmann-La Roche Ag Tetrahydro-pyrazino (1,2-a) indoles for the treatment of central nervous disorders
WO2002074746A1 (fr) 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Derives de benzazepine
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
WO2002098350A2 (en) 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
WO2002098400A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
WO2002098860A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
WO2003000663A1 (en) 2001-06-21 2003-01-03 Pfizer Products Inc. 5-ht receptor ligands and uses thereof
WO2003000666A1 (en) 2001-06-21 2003-01-03 Pfizer Products Inc. 5-ht receptor ligands and uses thereof
WO2003004501A2 (en) 2001-07-05 2003-01-16 Pharmacia & Upjohn Company (hetero) aryl substituted benzofurans as 5-ht ligands
WO2003006466A1 (en) 2001-07-13 2003-01-23 Pharmacia & Upjohn Company Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands
US6667303B1 (en) 2001-07-30 2003-12-23 Wyeth Aryl substituted 1,4-diazepanes and method of use thereof
WO2003011281A1 (en) 2001-08-02 2003-02-13 Vernalis Research Limited Treatment of attention deficit hyperactivity disorder or attention deficit disorder
WO2003028733A1 (en) 2001-08-06 2003-04-10 Pharmacia & Upjohn Company Tetracyclic indole derivatives as 5-ht receptor ligands
WO2003014125A1 (en) 2001-08-06 2003-02-20 Pharmacia & Upjohn Company Therapeutically useful tetracyclic ligands
WO2003014118A1 (en) 2001-08-08 2003-02-20 Pharmacia & Upjohn Company THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES
WO2003024976A2 (en) 2001-09-21 2003-03-27 Pharmacia & Upjohn Company Tricyclic indole derivatives as 5-ht ligands
WO2003033497A1 (en) 2001-10-18 2003-04-24 Pharmacia & Upjohn Company Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity
WO2003062205A1 (en) 2001-12-21 2003-07-31 Smithkline Beecham P.L.C. 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment of cns disorders
WO2003057161A2 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation BENZOTHIENO [3,2-c]PYRAZOLYL AND BENZOFURANO [3,2-c] PYRAZOLYL COMPOUNDS, THEIR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR AND INTERMEDIATE COMPOUNDS THEREOF
WO2003057674A1 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 4-sulfide / sulfoxide / sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003057673A1 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003057213A2 (en) 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003064423A1 (en) 2002-01-29 2003-08-07 F. Hoffmann-La Roche Ag Aza-arylpiperazines
WO2003076427A1 (en) 2002-03-14 2003-09-18 Pfizer Limited Quinazoline compounds useful in therapy
WO2003086306A2 (en) 2002-04-12 2003-10-23 Arena Pharmaceuticals, Inc. 5ht2c receptor modulators
WO2003087086A2 (de) 2002-04-16 2003-10-23 Merck Patent Gmbh Substituierte indole und deren verwendung als 5ht-wiederaufnahme inhibitoren und als 5ht liganden
WO2003089409A1 (en) 2002-04-19 2003-10-30 Glaxo Group Limited Compounds having affinity at 5ht2c receptor and use thereof in therapy
WO2003091257A1 (en) 2002-04-25 2003-11-06 Wyeth [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS
WO2003091251A1 (en) 2002-04-25 2003-11-06 Wyeth 1,2,3,4,7,8-hexahydro-6h-[1,4]diazepino[6,7,1-1j]quinoline derivatives as antipsychotic and antiobesity agents
WO2003091250A1 (en) 2002-04-25 2003-11-06 Wyeth [1,4]diazepino[6,7,1-ij]quinoline derivatives as anti psychotic and antiobesity agents
WO2003097636A1 (en) 2002-05-17 2003-11-27 Biovitrum Ab Novel compounds and their use
WO2004000829A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel process
WO2004000830A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
JP2004159919A (ja) * 2002-11-13 2004-06-10 Takeda Chem Ind Ltd 腹圧性尿失禁予防治療薬のスクリーニング方法
WO2004056324A2 (en) 2002-12-19 2004-07-08 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
WO2004069162A2 (en) 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
WO2004078718A1 (en) 2003-03-05 2004-09-16 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
WO2004081010A1 (en) 2003-03-11 2004-09-23 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
US20040192754A1 (en) 2003-03-24 2004-09-30 Shapira Nathan Andrew Methods for treating idiopathic hyperhidrosis and associated conditions
WO2004087662A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
WO2004087156A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
WO2004087692A1 (de) 2003-04-04 2004-10-14 Merck Patent Gmbh Chromenonindole
WO2004089897A1 (en) 2003-04-07 2004-10-21 Glaxo Group Limited Compounds having activity at 5ht2c receptor and uses thereof
WO2004096196A2 (en) 2003-04-25 2004-11-11 Pfizer Limited Treatment of incontinence with 5htc2 agonists
WO2004096201A1 (en) 2003-04-29 2004-11-11 Orexigen Therapeutics, Inc. Compositions for affecting weight loss
US20080146583A1 (en) 2003-05-15 2008-06-19 Pfizer Inc Treatment of Incontinence
WO2005003096A1 (en) 2003-06-17 2005-01-13 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
WO2005019179A2 (en) 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5ht2c receptor associated diseases
WO2005016902A1 (en) 2003-06-20 2005-02-24 Arena Pharmaceuticals, Inc. N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2004112769A1 (en) 2003-06-23 2004-12-29 EGIS Gyógyszergyár Rt. Use of bicyclo[2.2.1]heptane derivatives for the preparation of neuroprotective pharmaceutical compositions
WO2005000849A1 (en) 2003-06-26 2005-01-06 F. Hoffmann-La Roche Ag 5ht2c receptor agonists for the treatment of diabetes and obesity
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
EP1500391A1 (en) 2003-07-24 2005-01-26 Neuro3D Therapeutic use of bicycloheptane derivatives
WO2005019180A1 (en) 2003-08-11 2005-03-03 Eli Lilly And Company 6-(2,2,2-TRIFLUOROETHYLAMINO)-7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINE AS A 5-HT2c RECEPTOR AGONIST
US20050080074A1 (en) 2003-10-07 2005-04-14 Wacker Dean A. Modulators of serotonin receptors
WO2005042490A1 (en) 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005044812A1 (en) 2003-10-24 2005-05-19 Wyeth A Corporation Of The State Of Delaware Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists
WO2005040146A1 (en) 2003-10-24 2005-05-06 Wyeth Dihydrobenzofuranyl alkanamines and pharmaceutical compositions containing them
WO2005041856A2 (en) 2003-11-03 2005-05-12 Pliva-Istrazivacki Institut D.O.O. Use of 2-thia-dibenzo[e, h]azulenes for the treatment and prevention of central nervous system diseases and disorders
WO2005049623A1 (en) 2003-11-21 2005-06-02 Pliva-Istrazivacki Institut D.O.O. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
WO2005082859A1 (en) 2004-02-25 2005-09-09 Eli Lilly And Company 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2005105082A1 (en) 2004-04-14 2005-11-10 Bristol-Myers Squibb Company Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
WO2005109987A2 (en) 2004-05-11 2005-11-24 Egis Gyógyszergyár Nyrt. 3-(((4-phenyl)-piperazine-1-yl)-alkyl)-3-alkyl-1, 3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders
WO2005111036A1 (en) 2004-05-12 2005-11-24 Pfizer Limited Tetrahydronaphthyridine derivatives useful as histamine h3 receptor ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
WO2005113535A2 (en) 2004-05-21 2005-12-01 Pfizer Products Inc. Pyrazinylmethyl lactam derivatives
WO2005121113A1 (en) 2004-06-14 2005-12-22 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives
WO2006000902A1 (en) 2004-06-25 2006-01-05 Pfizer Products Inc. Dihydrobenzofuran compounds and uses thereof
US20060003990A1 (en) 2004-06-30 2006-01-05 Athersys, Inc. Substituted azepine derivatives as serotonin receptor modulators
WO2006004931A2 (en) 2004-06-30 2006-01-12 Athersys, Inc. Substituted azepine derivatives as serotonin receptor modulators
US20060014777A1 (en) 2004-07-14 2006-01-19 Fevig John M Pyrrolo(oxo)isoquinolines as 5HT ligands
US20060014778A1 (en) 2004-07-14 2006-01-19 Fevig John M Pyrrolo(oxo)quinolines as 5HT ligands
WO2006019940A2 (en) 2004-07-14 2006-02-23 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5ht ligands
WO2006020049A2 (en) 2004-07-15 2006-02-23 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20060025601A1 (en) 2004-07-29 2006-02-02 Athersys, Inc. Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators
WO2006020817A1 (en) 2004-08-13 2006-02-23 Omeros Corporation Novel serotonin receptor ligands and their uses thereof
WO2006022420A1 (ja) * 2004-08-25 2006-03-02 Takeda Pharmaceutical Company Limited 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
WO2006028961A2 (en) 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
WO2006047032A2 (en) 2004-09-27 2006-05-04 Organix, Inc. Indole compounds useful as serotonin selective agents
WO2006044762A2 (en) 2004-10-15 2006-04-27 Bayer Pharmaceuticals Corporation Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor
WO2006047228A1 (en) 2004-10-21 2006-05-04 Wyeth Asymmetric synthesis of substituted dihydrobenzofurans
WO2006050007A2 (en) 2004-11-01 2006-05-11 Wyeth Substituted indolizines and derivatives as cns agents
WO2006052887A1 (en) 2004-11-05 2006-05-18 Wyeth Formulations of [1,4]diazepino[6,7,1-ij]quinoline derivatives
WO2006065600A2 (en) 2004-12-13 2006-06-22 Arena Pharmaceuticals, Inc. N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto
WO2006077025A2 (en) 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
WO2006103511A1 (en) 2005-03-31 2006-10-05 Pfizer Products Inc. Cyclopentapyridine and tetrahydroquinoline derivatives
WO2006116170A1 (en) 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
WO2007030150A1 (en) 2005-04-22 2007-03-15 Wyeth Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists
WO2006116165A1 (en) 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
WO2006116218A1 (en) 2005-04-22 2006-11-02 Wyeth Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
WO2006116136A1 (en) 2005-04-22 2006-11-02 Wyeth Dihydrobenzofuran derivatives and uses thereof
WO2006116151A1 (en) 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
WO2006116171A1 (en) 2005-04-22 2006-11-02 Wyeth Treatment of pain
WO2006116148A2 (en) 2005-04-22 2006-11-02 Wyeth (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse
US20060241176A1 (en) 2005-04-22 2006-10-26 Wyeth Dihydrobenzofuran derivatives and uses thereof
US20060241172A1 (en) 2005-04-22 2006-10-26 Wyeth Benzodioxane and benzodioxolane derivatives and uses thereof
WO2006116169A2 (en) 2005-04-24 2006-11-02 Wyeth Methods for modulating bladder function
WO2006117304A1 (en) 2005-05-03 2006-11-09 F. Hoffmann-La Roche Ag Tetracyclic azapyrazinoindolines as 5-ht2 ligands
US20070032481A1 (en) 2005-08-04 2007-02-08 Dvorak Curt A Pyrimidine compounds as serotonin receptor modulators
US20070049613A1 (en) 2005-08-24 2007-03-01 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
WO2007025144A1 (en) 2005-08-24 2007-03-01 University Of Illinois - Chicago 5-ht2c receptor agonists as anorectic agents
WO2007028083A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028132A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
WO2007028131A1 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
WO2007028082A1 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-substituted- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
US20080255092A1 (en) 2005-09-01 2008-10-16 John Gordon Allen 6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists
US20080269196A1 (en) 2005-09-01 2008-10-30 Karin Briner 6-Arylalkylamino-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepines as 5-Ht2c Receptor Agonists
WO2007084622A2 (en) 2006-01-19 2007-07-26 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-ht2c receptor ligands and uses thereof
WO2007106349A2 (en) * 2006-03-10 2007-09-20 Neurogen Corporation Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
WO2007132841A1 (ja) * 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
WO2007140213A1 (en) 2006-05-26 2007-12-06 Forest Laboratories Holdings Limited Pyridoazepine derivatives
WO2008007664A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique bicycique et son utilisation
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
WO2008010073A1 (en) 2006-07-14 2008-01-24 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
WO2008009125A1 (en) 2006-07-20 2008-01-24 Cascade Therapeutics Inc. Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands
WO2008052075A2 (en) 2006-10-24 2008-05-02 Wyeth Benzoxazine derivatives and uses thereof
WO2008052078A2 (en) 2006-10-24 2008-05-02 Wyeth Benzoxathiine and benzoxathiole derivatives and uses thereof
WO2008052087A1 (en) 2006-10-24 2008-05-02 Wyeth Chromane derivatives and uses thereof
WO2008052086A1 (en) 2006-10-24 2008-05-02 Wyeth Benzodioxane derivatives and uses thereof
WO2008052088A1 (en) 2006-10-25 2008-05-02 Wyeth Chromane derivatives, synthesis thereof, and intermediates thereto
WO2008117169A1 (en) 2007-03-23 2008-10-02 Pfizer Limited Pyrimido [4, 5-d] azepine derivatives as 5-ht2c agonists

Non-Patent Citations (27)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF PHYSIOLOGY RENAL PHYSIOLOGY, vol. 287, 2004, pages 434 - 441
AMERICAN JOURNAL OF PHYSIOLOGY RENAL PHYSIOLOGY, vol. 287, 2004, pages F434 - 441
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, vol. 285, 2003, pages R356 - R365
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, vol. 293, 2007, pages F920 - F926
BIORG. MED. CHEM. LETT., vol. 9, 1999, pages 2329
BRITISH JOURNAL OF CANCER, vol. 68, 1993, pages 314 - 318
BRITISH JOURNAL OF UROLOGY, vol. 73, 1994, pages 413 - 417
CHEMICAL REVIEWS, vol. 95, 1995, pages 2457
EUR. J. PHARMACOL., vol. 483, 2004, pages 37 - 43
EUROPEAN UROLOGY, vol. 51, 2007, pages 884 - 886
EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 15, 2006, pages 257 - 266
INTERNATIONAL UROGYNECOLOGY JOURNAL INCLUDING PELVIC FLOOR DYSFUNCTION, vol. 16, 2005, pages 359 - 363
J. AM. CHEM. SOC., vol. 125, 2003, pages 6653
J. AM. SOC. CHEM., vol. 119, 1997, pages 3395
J. ORG. CHEM., vol. 65, 2000, pages 1174
J. ORG. CHEM., vol. 71, 2006, pages 1732
J. PHARMACOL. EXP. THER., vol. 286, 1998, pages 913 - 924
JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
JOURNAL OF UROLOGY, vol. 166, 2001, pages 311 - 317
LANCET, vol. 369, 2007, pages 1027 - 38
NEUROSCIENCE, vol. 92, 1999, pages 1523 - 1537
PHARMACOLOGY BIOCHEMISTRY BEHAVIOR, vol. 71, 2002, pages 533 - 554
THE JOURNAL OF FAMILY PRACTICE, vol. 14, 1982, pages 935 - 936
THE JOURNAL OF UROLOGY, vol. 127, 1982, pages 1202 - 1206
THE JOURNAL OF UROLOGY, vol. 166, 2001, pages 311 - 317
THE JOURNAL OF UROLOGY, vol. 176, 2006, pages 819 - 823
UROLOGY, vol. 52, 1998, pages 143 - 151

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
JP2011513233A (ja) * 2008-02-22 2011-04-28 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物
US8314088B2 (en) 2009-06-15 2012-11-20 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
US8318722B2 (en) 2009-06-15 2012-11-27 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
US8324201B2 (en) 2009-06-15 2012-12-04 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
US9115139B2 (en) 2009-06-15 2015-08-25 Takeda Pharmaceutical Company Limited Pyrazinooxazepine derivatives
US8916549B2 (en) 2009-08-04 2014-12-23 Takeda Pharmaceutical Company Limited Thienooxazepine derivative
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2013133325A1 (ja) * 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
US9556200B2 (en) 2012-03-06 2017-01-31 Takeda Pharmaceutical Company Limited Tricyclic compound
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

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