WO2009060963A1 - ４-ヒドロキシイソロイシン又は２-アミノ－３－メチル－４－ケトペンタン酸の製造法 - Google Patents

４-ヒドロキシイソロイシン又は２-アミノ－３－メチル－４－ケトペンタン酸の製造法 Download PDF

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Publication number
WO2009060963A1
WO2009060963A1 PCT/JP2008/070356 JP2008070356W WO2009060963A1 WO 2009060963 A1 WO2009060963 A1 WO 2009060963A1 JP 2008070356 W JP2008070356 W JP 2008070356W WO 2009060963 A1 WO2009060963 A1 WO 2009060963A1
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WO
WIPO (PCT)
Prior art keywords
isoleucine
hydroxyisoleucine
amino
methyl
ketopentanoic acid
Prior art date
Application number
PCT/JP2008/070356
Other languages
English (en)
French (fr)
Inventor
Tomohiro Kodera
Sakayu Shimizu
Jun Ogawa
Makoto Hibi
Sergey Vasilievich Smirnov
Natalia Nikolaevna Samsonova
Veronika Aleksandrovna Kotoliarova
Natalia Yurievna Rushkevich
Yury Ivanovich Kozlov
Original Assignee
Ajinomoto Co., Inc.
Kozlov, Ivan Yakovlevich
Arsatyants, Raisa Aleksandrovna
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2007140878/13A external-priority patent/RU2392323C2/ru
Priority claimed from RU2007140881/13A external-priority patent/RU2395578C2/ru
Application filed by Ajinomoto Co., Inc., Kozlov, Ivan Yakovlevich, Arsatyants, Raisa Aleksandrovna filed Critical Ajinomoto Co., Inc.
Publication of WO2009060963A1 publication Critical patent/WO2009060963A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

　２-アミノ-３-メチル-４-ケトペンタン酸から４-ヒドロキシイソロイシンを生成する、微生物由来の酵素の存在下で２-アミノ-３-メチル-４-ケトペンタン酸またはその塩を還元反応に供し４-ヒドロキシイソロイシンを生成させる工程を含むことを特徴とする、４-ヒドロキシイソロイシン又はその塩の製造方法。Ｌ－イソロイシンジオキシゲナーゼ及び４－ヒドロキシ－Ｌ－イソロイシンデヒドロゲナーゼの存在下で、Ｌ－イソロイシンを反応させる工程を含む、２－アミノ－３－メチル－４－ケトペンタン酸又はその塩を製造する方法。４－ヒドロキシ－Ｌ－イソロイシンデヒドロゲナーゼの活性が低減又は欠失するように改変されている、Ｌ－イソロイシンジオキシゲナーゼ活性を有する細菌の存在下で、Ｌ－イソロイシンから（２Ｓ，３Ｒ，４Ｓ）－４－ヒドロキシ－Ｌ－イソロイシン又はその塩を製造する方法。
PCT/JP2008/070356 2007-11-07 2008-11-07 ４-ヒドロキシイソロイシン又は２-アミノ－３－メチル－４－ケトペンタン酸の製造法 WO2009060963A1 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
RU2007140878/13A RU2392323C2 (ru) 2007-11-07 2007-11-07 Способ продукции 2-амино-3-метил-4-кетопентаноата
JP2007-290136 2007-11-07
RU2007140878 2007-11-07
JP2007290136 2007-11-07
RU2007140881/13A RU2395578C2 (ru) 2007-11-07 2007-11-07 Способ продукции (2s,3r,4s)-4-гидрокси-l-изолейцина с использованием бактерии, в которой разрушена активность 4-гидрокси-l-изолейциндегидрогеназы
RU2007140881 2007-11-07

Publications (1)

Publication Number Publication Date
WO2009060963A1 true WO2009060963A1 (ja) 2009-05-14

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ID=40625847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070356 WO2009060963A1 (ja) 2007-11-07 2008-11-07 ４-ヒドロキシイソロイシン又は２-アミノ－３－メチル－４－ケトペンタン酸の製造法

Country Status (2)

Country Link
JP (1) JP2009131254A (ja)
WO (1) WO2009060963A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017119514A1 (ja) * 2016-01-08 2017-07-13 株式会社バイオシンクタンク ４－ヒドロキシイソロイシンの（２ｓ，３ｒ，４ｓ）体及び（２ｓ，３ｓ，４ｒ）体の製造方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119575A1 (en) * 2006-03-24 2007-10-25 Ajinomoto Co., Inc. Novel aldolase and production process of 4-hydroxy-l-isoleucine
WO2008044614A1 (en) * 2006-09-28 2008-04-17 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119575A1 (en) * 2006-03-24 2007-10-25 Ajinomoto Co., Inc. Novel aldolase and production process of 4-hydroxy-l-isoleucine
WO2008044614A1 (en) * 2006-09-28 2008-04-17 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI [online] 14 January 2007 (2007-01-14), "3-oxoacyl-[acyl-carrier protein] reductase.", retrieved from http://www.ncbi.nlm.nih.gov/ entrez/viewer.fcgi?db=protein&id=122601979 Database accession no. Q3EZTO *
DATABASE NCBI [online] 20 January 2007 (2007-01-20), "3-oxoacyl-[acyl-carrier protein] reductase.", retrieved from http://www.ncbi.nlm.nih.gov/ entrez/viewer.fcgi?81714738:CAGE_DDBJ:14039327 Database accession no. Q81GW9 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017119514A1 (ja) * 2016-01-08 2017-07-13 株式会社バイオシンクタンク ４－ヒドロキシイソロイシンの（２ｓ，３ｒ，４ｓ）体及び（２ｓ，３ｓ，４ｒ）体の製造方法

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