WO2009050365A3 - Procede de preparation de derives ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux - Google Patents
Procede de preparation de derives ( poly) aminoalkylaminoacetamide d ' epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux Download PDFInfo
- Publication number
- WO2009050365A3 WO2009050365A3 PCT/FR2008/051700 FR2008051700W WO2009050365A3 WO 2009050365 A3 WO2009050365 A3 WO 2009050365A3 FR 2008051700 W FR2008051700 W FR 2008051700W WO 2009050365 A3 WO2009050365 A3 WO 2009050365A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- epipodophyllotoxin
- poly
- preparing
- therapeutics
- anticancer agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La présente invention a pour objet un nouveau procédé de préparation des dérivés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine et de leurs sels caractérisé en ce qu'il comprend une étape de couplage peptidique de la 4 amino 4' déméthylépipodophyllotoxine avec un réactif aminé comportant des groupements protecteurs.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08839817A EP2203456A2 (fr) | 2007-09-25 | 2008-09-23 | Procede de preparation de derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux |
US12/733,864 US8664409B2 (en) | 2007-09-25 | 2008-09-23 | Process for the preparation of (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin useful for their applications in therapeutics as anticancer agent |
JP2010526342A JP5346026B2 (ja) | 2007-09-25 | 2008-09-23 | 抗ガン剤として治療への応用に有効な、エピポドフィロトキシンの(ポリ)アミノアルキルアミノアセトアミド誘導体の調製方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0706693 | 2007-09-25 | ||
FR0706693A FR2921369B1 (fr) | 2007-09-25 | 2007-09-25 | Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux. |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009050365A2 WO2009050365A2 (fr) | 2009-04-23 |
WO2009050365A3 true WO2009050365A3 (fr) | 2009-10-29 |
Family
ID=39399036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2008/051700 WO2009050365A2 (fr) | 2007-09-25 | 2008-09-23 | Nouveau procede de preparation de derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine, utiles pour leurs applications en therapeutique comme agent anticancereux. |
Country Status (5)
Country | Link |
---|---|
US (1) | US8664409B2 (fr) |
EP (1) | EP2203456A2 (fr) |
JP (1) | JP5346026B2 (fr) |
FR (1) | FR2921369B1 (fr) |
WO (1) | WO2009050365A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2935143B1 (fr) | 2008-08-19 | 2010-12-03 | Pf Medicament | Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998034910A1 (fr) * | 1997-02-10 | 1998-08-13 | Transgene S.A. | Composes glycerolipidiques utiles pour le transfert d'une substance active dans une cellule cible |
WO2004073375A2 (fr) * | 2003-02-18 | 2004-09-02 | Ranbaxy Laboratories Limited | Derives de podophyllotoxine utiles comme agents antitumoraux |
WO2005100363A1 (fr) * | 2004-04-16 | 2005-10-27 | Pierre Fabre Medicament | Derives de polyaminoacetamide d'epipodophyllotoxine, leurs methodes de preparation et leurs utilisation sous forme d'agents therapeutiques anticancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999038821A2 (fr) * | 1998-01-30 | 1999-08-05 | Aventis Pharma S.A. | Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications |
US6566393B1 (en) * | 2002-06-21 | 2003-05-20 | The University Of North Carolina At Chapel Hill | Etoposide analogs and methods of use thereof |
-
2007
- 2007-09-25 FR FR0706693A patent/FR2921369B1/fr not_active Expired - Fee Related
-
2008
- 2008-09-23 US US12/733,864 patent/US8664409B2/en not_active Expired - Fee Related
- 2008-09-23 JP JP2010526342A patent/JP5346026B2/ja not_active Expired - Fee Related
- 2008-09-23 EP EP08839817A patent/EP2203456A2/fr not_active Withdrawn
- 2008-09-23 WO PCT/FR2008/051700 patent/WO2009050365A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998034910A1 (fr) * | 1997-02-10 | 1998-08-13 | Transgene S.A. | Composes glycerolipidiques utiles pour le transfert d'une substance active dans une cellule cible |
WO2004073375A2 (fr) * | 2003-02-18 | 2004-09-02 | Ranbaxy Laboratories Limited | Derives de podophyllotoxine utiles comme agents antitumoraux |
WO2005100363A1 (fr) * | 2004-04-16 | 2005-10-27 | Pierre Fabre Medicament | Derives de polyaminoacetamide d'epipodophyllotoxine, leurs methodes de preparation et leurs utilisation sous forme d'agents therapeutiques anticancer |
Non-Patent Citations (3)
Title |
---|
BYK G ET AL: "One Pot Synthesis of Unsymmetrically Functionalized Polyamines by a Solid Phase Strategy Starting from their Symmetrical Polyamine-Counterparts", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 38, no. 18, 5 May 1997 (1997-05-05), pages 3219 - 3222, XP004059812, ISSN: 0040-4039 * |
CHRISTOPHE JACOPIN ET AL.: "Glycosidation of alkylamino-alkan-1-ol. A simple and convenient synthesis of glycosylated cationic lipids", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, GBOXFORD, pages 1447 - 1450, XP002481454 * |
KAMAL A ET AL: "Synthesis of 4-beta-Amido and 4-beta-Sulphonamido Analogues of Podophyllotoxin as Potential Antitumor Agents", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 11, no. 23, 17 November 2003 (2003-11-17), pages 5135 - 5142, XP002281030, ISSN: 0968-0896 * |
Also Published As
Publication number | Publication date |
---|---|
US8664409B2 (en) | 2014-03-04 |
WO2009050365A2 (fr) | 2009-04-23 |
FR2921369B1 (fr) | 2014-07-11 |
JP5346026B2 (ja) | 2013-11-20 |
FR2921369A1 (fr) | 2009-03-27 |
EP2203456A2 (fr) | 2010-07-07 |
JP2010540506A (ja) | 2010-12-24 |
US20120022273A1 (en) | 2012-01-26 |
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