WO2009048119A1 - 高機能化キメラ蛋白質を含有する医薬組成物 - Google Patents

高機能化キメラ蛋白質を含有する医薬組成物 Download PDF

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Publication number
WO2009048119A1
WO2009048119A1 PCT/JP2008/068413 JP2008068413W WO2009048119A1 WO 2009048119 A1 WO2009048119 A1 WO 2009048119A1 JP 2008068413 W JP2008068413 W JP 2008068413W WO 2009048119 A1 WO2009048119 A1 WO 2009048119A1
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WO
WIPO (PCT)
Prior art keywords
medicinal composition
amino acid
acid sequence
chimeric protein
fgf2
Prior art date
Application number
PCT/JP2008/068413
Other languages
English (en)
French (fr)
Inventor
Toru Imamura
Kaori Motomura
Akiko Kuramochi
Yoshiro Hanyu
Masashi Suzuki
Masahiro Asada
Akiko Hagiwara
Fumiaki Nakayama
Makoto Akashi
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National Institute Of Advanced Industrial Science And Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Advanced Industrial Science And Technology filed Critical National Institute Of Advanced Industrial Science And Technology
Priority to US12/682,568 priority Critical patent/US20100286042A1/en
Priority to EP08837820.3A priority patent/EP2213296B1/en
Priority to JP2008548787A priority patent/JP5004250B2/ja
Publication of WO2009048119A1 publication Critical patent/WO2009048119A1/ja
Priority to US13/439,693 priority patent/US20120214740A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　FGF1蛋白質のアミノ酸配列において、４１～８３位の配列のうち少なくとも６２～８３位の配列を含む部分配列が、FGF2蛋白質のアミノ酸配列における対応する位置の部分配列に置換されており、他の領域はFGF1のアミノ酸配列から構成されているキメラ蛋白質を有効成分とするFGF2代替用医薬組成物を提供する。特に、創傷治癒及び放射線障害の予防と治療用の医薬組成物として、FGF2医薬組成物以上に優れた薬理作用を示し、かつ製剤化もしやすい。
PCT/JP2008/068413 2007-10-12 2008-10-10 高機能化キメラ蛋白質を含有する医薬組成物 WO2009048119A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/682,568 US20100286042A1 (en) 2007-10-12 2008-10-10 Medicinal Composition Containing Highly Functionalized Chimeric Protein
EP08837820.3A EP2213296B1 (en) 2007-10-12 2008-10-10 Fgf1/fgf2 chimeric protein and uses thereof
JP2008548787A JP5004250B2 (ja) 2007-10-12 2008-10-10 高機能化キメラ蛋白質を含有する医薬組成物
US13/439,693 US20120214740A1 (en) 2007-10-12 2012-04-04 Medicinal Compositions Containing Highly Functionalized Chimeric Protein

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007267000 2007-10-12
JP2007-267000 2007-10-12
JP2007275496 2007-10-23
JP2007-275496 2007-10-23
JP2008-184952 2008-07-16
JP2008184952 2008-07-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/439,693 Division US20120214740A1 (en) 2007-10-12 2012-04-04 Medicinal Compositions Containing Highly Functionalized Chimeric Protein

Publications (1)

Publication Number Publication Date
WO2009048119A1 true WO2009048119A1 (ja) 2009-04-16

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ID=40549262

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PCT/JP2008/068413 WO2009048119A1 (ja) 2007-10-12 2008-10-10 高機能化キメラ蛋白質を含有する医薬組成物

Country Status (4)

Country Link
US (2) US20100286042A1 (ja)
EP (1) EP2213296B1 (ja)
JP (2) JP5004250B2 (ja)
WO (1) WO2009048119A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014037365A (ja) * 2012-08-15 2014-02-27 National Institute Of Advanced Industrial & Technology 放射線被ばく後の自己反応性ｔ細胞増殖阻害剤
JP2014100141A (ja) * 2012-10-23 2014-06-05 National Institute Of Advanced Industrial & Technology 多能性幹細胞培養方法
JP2016079178A (ja) * 2014-10-14 2016-05-16 訊聯生物科技股▲分▼有限公司 スキンケア用組成物、その製造方法および該組成物を含有する医薬品
JP2018524005A (ja) * 2015-07-15 2018-08-30 プロージット ソウル バイオテクノロジー （ベイジン） カンパニー リミテッド 融合ポリペプチドおよび使用方法
WO2021125177A1 (ja) * 2019-12-16 2021-06-24 Jsr株式会社 オルガノイドの製造方法

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CA2796459C (en) 2010-04-16 2016-05-24 Salk Institute For Biological Studies Methods for treating metabolic disorders using fgf-1
US8435525B1 (en) * 2010-04-16 2013-05-07 Andrew B. Bush FGF modulation of in vivo antibody production and humoral immunity
US9226960B2 (en) 2010-04-16 2016-01-05 Andrew B. Bush FGF modulation of in vivo antibody production and humoral immunity
WO2013131091A1 (en) 2012-03-02 2013-09-06 New York University Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders
US9464126B2 (en) * 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
CN105828833A (zh) 2013-10-21 2016-08-03 萨克生物研究学院 突变的成纤维细胞生长因子（fgf）1及使用方法
WO2015061331A1 (en) * 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
WO2015061351A1 (en) * 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
JP2018535964A (ja) 2015-10-30 2018-12-06 ソーク インスティテュート フォー バイオロジカル スタディーズ 線維芽細胞増殖因子（ｆｇｆ）１アナログによるステロイド誘導性高血糖の処置
US10385113B2 (en) 2016-03-30 2019-08-20 The Board Of Trustees Of The University Of Arkansas Engineered FGF compositions and methods of use thereof
US11267855B2 (en) 2018-03-16 2022-03-08 The Board Of Trustees Of The University Of Arkansas Engineered FGF1 and FGF2 compositions and methods of use thereof
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
EP4365192A1 (en) * 2022-11-04 2024-05-08 DSM IP Assets B.V. Microbial production of growth factors

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014037365A (ja) * 2012-08-15 2014-02-27 National Institute Of Advanced Industrial & Technology 放射線被ばく後の自己反応性ｔ細胞増殖阻害剤
JP2014100141A (ja) * 2012-10-23 2014-06-05 National Institute Of Advanced Industrial & Technology 多能性幹細胞培養方法
JP2016079178A (ja) * 2014-10-14 2016-05-16 訊聯生物科技股▲分▼有限公司 スキンケア用組成物、その製造方法および該組成物を含有する医薬品
JP2018524005A (ja) * 2015-07-15 2018-08-30 プロージット ソウル バイオテクノロジー （ベイジン） カンパニー リミテッド 融合ポリペプチドおよび使用方法
US11020454B2 (en) 2015-07-15 2021-06-01 Prosit Sole Biotechnology (Beijing) Co. Ltd Fusion polypeptides and methods of use
WO2021125177A1 (ja) * 2019-12-16 2021-06-24 Jsr株式会社 オルガノイドの製造方法

Also Published As

Publication number Publication date
JP2012143234A (ja) 2012-08-02
US20120214740A1 (en) 2012-08-23
JP5414078B2 (ja) 2014-02-12
JPWO2009048119A1 (ja) 2011-02-24
EP2213296A4 (en) 2012-06-20
JP5004250B2 (ja) 2012-08-22
EP2213296B1 (en) 2015-04-15
EP2213296A1 (en) 2010-08-04
US20100286042A1 (en) 2010-11-11

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