WO2009044899A1 - 細胞の増殖を制御する核酸 - Google Patents

細胞の増殖を制御する核酸 Download PDF

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Publication number
WO2009044899A1
WO2009044899A1 PCT/JP2008/068109 JP2008068109W WO2009044899A1 WO 2009044899 A1 WO2009044899 A1 WO 2009044899A1 JP 2008068109 W JP2008068109 W JP 2008068109W WO 2009044899 A1 WO2009044899 A1 WO 2009044899A1
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WIPO (PCT)
Prior art keywords
cell
proliferation
nucleic acid
regulating
acid capable
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PCT/JP2008/068109
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English (en)
French (fr)
Inventor
Haruo Nakano
Tatsuya Miyazawa
Yoji Yamada
Tetsuo Yoshida
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
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Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Priority to EP08835543A priority Critical patent/EP2208499A4/en
Priority to US12/681,417 priority patent/US20100305188A1/en
Priority to JP2009536125A priority patent/JPWO2009044899A1/ja
Publication of WO2009044899A1 publication Critical patent/WO2009044899A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring

Abstract

　細胞の増殖抑制剤または増殖促進剤、細胞の増殖異常に起因する疾患の診断薬または治療薬、アポトーシス誘導剤、マイクロＲＮＡなどの核酸の標的遺伝子の発現抑制剤または発現促進剤、細胞の増殖抑制方法または増殖促進方法に関する。
PCT/JP2008/068109 2007-10-03 2008-10-03 細胞の増殖を制御する核酸 WO2009044899A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08835543A EP2208499A4 (en) 2007-10-03 2008-10-03 NUCLEIC ACID FOR REGULATING CELL PROLIFERATION
US12/681,417 US20100305188A1 (en) 2007-10-03 2008-10-03 Nucleic acid capable of regulating the proliferation of cell
JP2009536125A JPWO2009044899A1 (ja) 2007-10-03 2008-10-03 細胞の増殖を制御する核酸

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007260393 2007-10-03
JP2007-260393 2007-10-03

Publications (1)

Publication Number Publication Date
WO2009044899A1 true WO2009044899A1 (ja) 2009-04-09

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Application Number Title Priority Date Filing Date
PCT/JP2008/068109 WO2009044899A1 (ja) 2007-10-03 2008-10-03 細胞の増殖を制御する核酸

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US (1) US20100305188A1 (ja)
EP (1) EP2208499A4 (ja)
JP (1) JPWO2009044899A1 (ja)
WO (1) WO2009044899A1 (ja)

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WO2011111715A1 (ja) * 2010-03-09 2011-09-15 協和発酵キリン株式会社 細胞周期を制御する核酸
WO2012161124A1 (ja) * 2011-05-20 2012-11-29 国立大学法人愛媛大学 マイクロｒｎａ又はその発現系を含む組成物
JP2013091611A (ja) * 2011-10-25 2013-05-16 Gifu Univ 間葉系細胞の分化調節剤およびこれを用いた医薬、並びに間葉系細胞への分化調節作用を有する物質のスクリーニング方法
WO2014126233A1 (ja) * 2013-02-15 2014-08-21 国立大学法人東京医科歯科大学 マイクロｒｎａの測定方法、並びに、がん治療剤及びこれを含有するがん治療のための医薬組成物
US9441222B2 (en) 2011-01-11 2016-09-13 Interna Technologies B.V. MiRNA for treating diseases and conditions associated with neo-angiogenesis
US9682095B2 (en) 2010-07-06 2017-06-20 Interna Technologies B.V. MiRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway
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