WO2009034431A3 - Formes posologiques à libération contrôlée de la varenicline - Google Patents
Formes posologiques à libération contrôlée de la varenicline Download PDFInfo
- Publication number
- WO2009034431A3 WO2009034431A3 PCT/IB2008/002311 IB2008002311W WO2009034431A3 WO 2009034431 A3 WO2009034431 A3 WO 2009034431A3 IB 2008002311 W IB2008002311 W IB 2008002311W WO 2009034431 A3 WO2009034431 A3 WO 2009034431A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- varenicline
- controlled
- dosage forms
- release dosage
- antioxidant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention porte sur une composition pharmaceutique à libération contrôlée de la varenicline ou d'un sel pharmaceutiquement acceptable de cette dernière, ladite composition pharmaceutique à libération contrôlée comprenant un enrobage et un antioxydant, l'antioxydant étant présent dans une quantité égale à un pourcentage en poids compris entre environ 0,1% et 55 de la couche d'enrobage.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97101707P | 2007-09-10 | 2007-09-10 | |
US60/971,017 | 2007-09-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009034431A2 WO2009034431A2 (fr) | 2009-03-19 |
WO2009034431A3 true WO2009034431A3 (fr) | 2009-11-19 |
Family
ID=40032575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2008/002311 WO2009034431A2 (fr) | 2007-09-10 | 2008-08-29 | Formes posologiques à libération contrôlée de la varenicline |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009034431A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3400964A4 (fr) * | 2016-01-08 | 2019-08-21 | CTC Bio, Inc. | Préparation pharmaceutique à usage oral et goût masqué contenant de la varénicline ou un sel pharmaceutiquement acceptable de celle-ci |
KR20180058644A (ko) * | 2016-11-24 | 2018-06-01 | 에스케이케미칼 주식회사 | 바레니클린 서방성 제제 및 이의 제조 방법 |
GB2561333B (en) | 2017-02-17 | 2020-06-03 | Bo Soederpalm | Treatment of alcohol use disorder |
WO2018154395A2 (fr) | 2018-06-11 | 2018-08-30 | Alvogen Malta Operations (Row) Ltd | Composition pharmaceutique à libération contrôlée de varénicline |
KR102235848B1 (ko) * | 2019-11-20 | 2021-04-05 | 충북대학교 산학협력단 | 바레니클린 또는 이의 약학적으로 허용가능한 염의 지연 방출용 정제 |
CN117479927A (zh) * | 2021-06-25 | 2024-01-30 | 汉达医药股份有限公司 | 稳定的伐尼克兰剂型 |
EP4169516A1 (fr) * | 2021-11-05 | 2023-04-26 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Prévention de la conversion d'agents pharmaceutiques en composés n-nitrosamine toxiques |
WO2023012376A2 (fr) * | 2021-11-05 | 2023-02-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Prévention de la conversion d'agents pharmaceutiques en composés de n-nitrosamine toxiques |
KR20230068877A (ko) * | 2021-11-11 | 2023-05-18 | 주식회사 아울바이오 | 고용량 바레니클린을 포함하는 미립구 및 이의 제조방법 및 이를 포함하는 약학적 조성물 |
CN114088843B (zh) * | 2021-11-26 | 2024-01-30 | 上海皓鸿生物医药科技有限公司 | 一种伐伦克林中间体中亚硝胺类基因毒性杂质的检测方法 |
WO2023275413A2 (fr) * | 2021-12-23 | 2023-01-05 | Medichem, S.A. | Formulations pharmaceutiques solides de varénicline |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040235850A1 (en) * | 2003-05-20 | 2004-11-25 | Pfizer Inc | Pharmaceutical compositions of varenicline |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
US4093105A (en) | 1977-10-19 | 1978-06-06 | N. T. Gates Company | Plastic container with vent means |
US5612059A (en) | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
US6133361A (en) | 1996-02-03 | 2000-10-17 | Mitsubishi Gas Chemical Company, Inc. | Oxygen-absorbing composition, oxygen-absorbing resin composition, packing material, multi-layered packing, oxygen absorber packet, packing method and preservation method |
EA002482B1 (ru) | 1997-07-01 | 2002-06-27 | Пфайзер Инк. | Соли сертралина и лекарственные формы с длительным высвобождением сертралина |
US6605610B1 (en) | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
US6410550B1 (en) | 1997-12-31 | 2002-06-25 | Pfizer Inc | Aryl fused azapolycyclic compounds |
CA2420535A1 (fr) | 2000-08-30 | 2002-03-07 | Mary Tanya Am Ende | Formulations a liberation prolongee pour les secretagogues de l'hormone de croissance |
EP1243524A3 (fr) | 2001-03-16 | 2004-04-07 | Pfizer Products Inc. | Trousse pharmaceutique pour médicaments sensibles a l'oxygène |
AU2002351008B2 (en) | 2001-11-30 | 2007-07-12 | Pfizer Products Inc. | Pharmaceutical compositions of 5,8,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]-hexadeca-2(11)3,5,7,9-pentaene |
-
2008
- 2008-08-29 WO PCT/IB2008/002311 patent/WO2009034431A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040235850A1 (en) * | 2003-05-20 | 2004-11-25 | Pfizer Inc | Pharmaceutical compositions of varenicline |
Non-Patent Citations (3)
Title |
---|
KENNETH C WATERMAN ET AL: "N-methylation and N-formylation of a secondary amine drug (varenicline) in an osmotic tablet", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, WASHINGTON, US, vol. 97, no. 4, 1 April 2008 (2008-04-01), pages 1499 - 1507, XP008111696, ISSN: 0022-3549 * |
PUZ MICHAEL J ET AL: "Use of the antioxidant BHT in asymmetric membrane tablet coatings to stabilize the core to the acid catalyzed peroxide oxidation of a thioether drug.", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY 2005, vol. 10, no. 1, 2005, pages 115 - 125, XP002546552, ISSN: 1083-7450 * |
WATERMAN ET AL.: "N-methylation and N-formylation of a secondary amine drug (varenicline) in an osmotic tablet", J PHARM SCI, vol. 97, no. 4, 21 August 2007 (2007-08-21), pages 1499 - 1507, XP002546561, Retrieved from the Internet <URL:http://www3.interscience.wiley.com/journal/115805949/abstract?CRETRY=1&SRETRY=0> [retrieved on 20090909] * |
Also Published As
Publication number | Publication date |
---|---|
WO2009034431A2 (fr) | 2009-03-19 |
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