WO2009028649A1 - アミノ酸高含量固形製剤の低容量化製法 - Google Patents

アミノ酸高含量固形製剤の低容量化製法 Download PDF

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Publication number
WO2009028649A1
WO2009028649A1 PCT/JP2008/065500 JP2008065500W WO2009028649A1 WO 2009028649 A1 WO2009028649 A1 WO 2009028649A1 JP 2008065500 W JP2008065500 W JP 2008065500W WO 2009028649 A1 WO2009028649 A1 WO 2009028649A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
solid preparation
volume
acid content
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065500
Other languages
English (en)
French (fr)
Inventor
Kunikazu Suzuki
Kazuhiro Takanosu
Satoru Watano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP2009530195A priority Critical patent/JP5454142B2/ja
Publication of WO2009028649A1 publication Critical patent/WO2009028649A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glanulating (AREA)

Abstract

　１回の摂取量が増大しつつあるアミノ酸製剤のさらなる低容量化方法および製剤の提供。 　アミノ酸を有効成分とする固形製剤の製造方法であって、アミノ酸を含有する粉体および結合剤を容器に収容し、当該容器内で一工程で混練および造粒する工程を含む製造方法、ならびに前記製造方法により製造されるアミノ酸高含量固形製剤。
PCT/JP2008/065500 2007-08-31 2008-08-29 アミノ酸高含量固形製剤の低容量化製法 Ceased WO2009028649A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009530195A JP5454142B2 (ja) 2007-08-31 2008-08-29 アミノ酸高含量固形製剤の低容量化製法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-225585 2007-08-31
JP2007225585 2007-08-31

Publications (1)

Publication Number Publication Date
WO2009028649A1 true WO2009028649A1 (ja) 2009-03-05

Family

ID=40387360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065500 Ceased WO2009028649A1 (ja) 2007-08-31 2008-08-29 アミノ酸高含量固形製剤の低容量化製法

Country Status (2)

Country Link
JP (1) JP5454142B2 (ja)
WO (1) WO2009028649A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013193974A (ja) * 2012-03-19 2013-09-30 Fancl Corp アミノ酸高含有錠剤
JP2013223483A (ja) * 2012-03-19 2013-10-31 Fancl Corp 高分岐環状構造を持つデキストリンを含有するアミノ酸高含有錠剤
CN105249133A (zh) * 2015-10-27 2016-01-20 无锡金维氨生物科技有限公司 一种支链氨基酸添加剂
EP2719290B1 (en) * 2012-10-12 2017-03-22 Innobio Limited A microencapsulated amino acid composition and method of manufacturing microencapsulated amino acid composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09278534A (ja) * 1996-04-05 1997-10-28 Matsushita Electric Ind Co Ltd セラミック顆粒の製造方法
JP2003212768A (ja) * 2002-01-24 2003-07-30 Ajinomoto Co Inc 分岐鎖アミノ酸含有顆粒の製造方法
JP2004081010A (ja) * 2002-08-22 2004-03-18 Fancl Corp 食品組成物
WO2006085677A1 (en) * 2005-02-09 2006-08-17 Shinagawa Machinery Works Co., Ltd Kneading and granulating machine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09278534A (ja) * 1996-04-05 1997-10-28 Matsushita Electric Ind Co Ltd セラミック顆粒の製造方法
JP2003212768A (ja) * 2002-01-24 2003-07-30 Ajinomoto Co Inc 分岐鎖アミノ酸含有顆粒の製造方法
JP2004081010A (ja) * 2002-08-22 2004-03-18 Fancl Corp 食品組成物
WO2006085677A1 (en) * 2005-02-09 2006-08-17 Shinagawa Machinery Works Co., Ltd Kneading and granulating machine

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013193974A (ja) * 2012-03-19 2013-09-30 Fancl Corp アミノ酸高含有錠剤
JP2013223483A (ja) * 2012-03-19 2013-10-31 Fancl Corp 高分岐環状構造を持つデキストリンを含有するアミノ酸高含有錠剤
EP2719290B1 (en) * 2012-10-12 2017-03-22 Innobio Limited A microencapsulated amino acid composition and method of manufacturing microencapsulated amino acid composition
CN105249133A (zh) * 2015-10-27 2016-01-20 无锡金维氨生物科技有限公司 一种支链氨基酸添加剂

Also Published As

Publication number Publication date
JPWO2009028649A1 (ja) 2010-12-02
JP5454142B2 (ja) 2014-03-26

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