WO2009019227A2 - Article pour le soin des plaies, présentant des polymères super-absorbants sous forme de fibres et/ou de fils - Google Patents

Article pour le soin des plaies, présentant des polymères super-absorbants sous forme de fibres et/ou de fils Download PDF

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Publication number
WO2009019227A2
WO2009019227A2 PCT/EP2008/060169 EP2008060169W WO2009019227A2 WO 2009019227 A2 WO2009019227 A2 WO 2009019227A2 EP 2008060169 W EP2008060169 W EP 2008060169W WO 2009019227 A2 WO2009019227 A2 WO 2009019227A2
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WO
WIPO (PCT)
Prior art keywords
wound
care article
wound care
fibers
superabsorbent polymers
Prior art date
Application number
PCT/EP2008/060169
Other languages
German (de)
English (en)
Other versions
WO2009019227A3 (fr
Inventor
Birgit Riesinger
Original Assignee
Birgit Riesinger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Birgit Riesinger filed Critical Birgit Riesinger
Publication of WO2009019227A2 publication Critical patent/WO2009019227A2/fr
Publication of WO2009019227A3 publication Critical patent/WO2009019227A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/15577—Apparatus or processes for manufacturing
    • A61F13/15617—Making absorbent pads from fibres or pulverulent material with or without treatment of the fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/06—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings
    • A61F13/064—Bandages or dressings; Absorbent pads specially adapted for feet or legs; Corn-pads; Corn-rings for feet
    • A61F13/069—Decubitus ulcer bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00119—Wound bandages elastic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00463—Plasters use haemostatic
    • A61F2013/00472—Plasters use haemostatic with chemical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00727—Plasters means for wound humidity control
    • A61F2013/00731—Plasters means for wound humidity control with absorbing pads
    • A61F2013/0074—Plasters means for wound humidity control with absorbing pads containing foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00727—Plasters means for wound humidity control
    • A61F2013/00748—Plasters means for wound humidity control with hydrocolloids or superabsorbers

Definitions

  • Wound care articles comprising superabsorbent polymers in fiber and / or yarn form
  • the invention relates to a wound care article according to the preamble of claim 1.
  • Such a wound care article is particularly suitable for receiving exudate from chronic wounds, such as e.g. in diabetes, leg ulcers and similar diseases.
  • exudate refers to a wound fluid derived from the blood plasma via the inflammatory processes of wound edema.
  • the exudate serves in a similar way the supply of the wound bed and the healing processes running in it.
  • it contains a wide range of components, resulting in a specific weight that is slightly above that of water. This is also different from the transudate, which is derived from non-inflammatory processes and has a significantly lower specific gravity with a low cell and protein content.
  • exudate coordinates the various processes of wound healing both temporally and spatially through its high content of growth factors and cytokines.
  • growth factors and cytokines are mainly formed by platelets, keratinocytes, macrophages and fibroblasts. They influence the motility, migration and proliferation of the various cells involved in wound healing.
  • the infiltration of cells into the wound base is promoted as well as the supply of the newly formed granulation tissue by angiogenesis.
  • the wound cleansing will supported by the exudate. It contains various serine, cysteine and aspartate proteases as well as matrix metalloproteases, which in their activity severely regulate irreversibly damaged tissue and thus prepare the wound bed for the subsequent phases of healing.
  • Components of the physiological exudate are in particular salts, glucose, cytokines and growth factors, plasma proteins, proteases (in particular matrix metalloproteases), granulocytes and macrophages.
  • the normally healing-promoting exudate loses its positive effect in chronic wounds.
  • the content of inflammatory cytokines and proteases is significantly increased in pathological exudate.
  • the content of growth factors is reduced.
  • a particularly serious difference arises with regard to the activity of the matrix-metalloproteases zuvo addressed.
  • they are also involved in the subsequent remodeling of the granulation to the scar tissue.
  • These enzymes are normally formed as an inactive pre-enzyme and are regulated in their activation by appropriate inhibitors (tissue inhibitors of metalloproteases, TIMPs), which at the same time have a positive effect on cell growth.
  • a wound care article of the type mentioned in the beginning serves, in particular, to absorb said chronic exudate and thus promote wound healing.
  • particulate superabsorbent polymers in wound care articles has a number of disadvantages:
  • these particles can not be brought close to the wound because they are not absorbable, so it is not excluded that particles get into the wound, remain there and lead to inflammation. For this reason, these particles must always be separated from the wound by a particle-tight sheath.
  • the particles must always be arranged in a carrier matrix, e.g. in a mat of an airlaid.
  • the proportion of superabsorbent materials in such a wound care article is thus always reduced by the proportion of the airlaid, which impairs the maximum absorption capacity.
  • Particles can not direct or direct liquid flows. In this way, it may u.U. come to a Wundrandmazeration.
  • Particles often have a high abrasiveness and can - at least in the dry state - cause an unpleasant feeling on the skin.
  • the object of the present invention is to provide a wound care article which avoids the disadvantages mentioned.
  • a wound care article comprising at least a portion of superabsorbent polymers, said superabsorbent polymers being in fiber and / or yarn form.
  • superabsorbent polymers are plastics that are able to absorb many times their own weight - up to 1000 times - in liquids. Chemically, this is a copolymer of acrylic acid (propionic acid, C3H4O2) and sodium acrylate (sodium salt of acrylic acid, NaCsHsO 2 ), whereby the ratio of the two monomers can vary to one another.
  • core crosslinker CXL
  • CXL core-crosslinker
  • Superabsorbent polymers are usually in the form of granules or powder, and are e.g. in this form for use in wound dressings from WO03094813, WO2007051599 and WO0152780 of the applicant of the present invention.
  • the disclosure content of said documents is fully attached to the disclosure content of this document.
  • the wound dressing described therein may preferably comprise a substantially flat material portion of absorbent material, e.g. consists of an absorbent fleece of said fibers with superabsorbent polymers dispersed therein. These are preferably present in the form of a granulate or a powder as described, but may also be in the form of a bed, a compact, a foam, in the form of fibers, a Fasergewirkes, -laid or fleece and / or a fiber wadding.
  • absorbent material e.g. consists of an absorbent fleece of said fibers with superabsorbent polymers dispersed therein.
  • These are preferably present in the form of a granulate or a powder as described, but may also be in the form of a bed, a compact, a foam, in the form of fibers, a Fasergewirkes, -laid or fleece and / or a fiber wadding.
  • said fibers or yarns have a wicking effect.
  • the liquid streams can direct.
  • a wound edge maceration can be prevented.
  • Unlike particulate superabsorbent polymers they can be made into nonwovens, fabrics or the like. In this way, for example, the shell of a Wound dressing can be made of these fibers or yarns, and the superabsorbent properties can be brought so much closer to the wound base.
  • Said fibers or yarns can be made into a structure without the need for an adhesive or a welding process, as is required with particulate superabsorbent polymers. This has significant advantages in terms of product purity as well as pharmacology and potential allergenicity. viii) In contrast to particulate superabsorbent polymers, the dimensioning of said fibers or yarns can be controlled and controlled much more precisely, which on the one hand leads to the prevention of dusts which frequently arise when using particulate superabsorbent polymers, and, on the other hand, the product quality (Homogeneity and reproducibility) substantially increased, ix) Due to the lack of formation of dusts, it may be possible to dispense with the use of a separate shell, x).
  • Said yarns or fibers may be air-laid in known from the prior art, the particulate superabsorbent Containing polymers that replace the carrier fibers of the airlaid, so as to increase the proportion of superabsorbent materials in a wound care article and thus the total absorption capacity -.
  • Any two- or three-dimensional arrangement of the fibers or yarns is conceivable here.
  • the fibers or yarns may be directional or non-directional (Wirr-Warr), in multiple layers or otherwise.
  • Superabsorbent fibers of polyacrylates are e.g. marketed and sold by the company Technical Absorbents under the trade name "Oasis Super Absorbent Fiber.” Like all superabsorbent polyacrylates, they have a very high absorption capacity for liquids, for example in the form of a fleece, an airlaid, a fabric, a fabric Airlaids and / or a nonwoven are present Such fibers are known for example from DE 69807337
  • the said fibers of superabsorbent material are, however, usually very brittle, since the polyacrylate material used has a high brittleness. For this reason, the fibers can not exceed a certain length and therefore can not be easily processed into a yarn.
  • WO 106047 describes yarns comprising superabsorbent polymers. These yarns are based on a special production process in which the abovementioned superabsorbent fibers are mixed with supporting fibers of a stronger material and then spun into a yarn. Said supporting fibers are e.g. to fibers of polyester, polypropylene, nylon, cotton, viscose or similar material. The yarn thus produced can then be made into a woven, scrim, knit and / or knitted fabric. Likewise, the fibers can also be processed with elastic fibers, such as spandex.
  • the superabsorbent polymers present in fiber form are present at least partially in the form of a wadding, a fleece, an airlaid and / or a nonwoven.
  • fibers are used with average lengths of 5 - 50 mm.
  • the preparation is carried out by known methods, such as carding or the Airlaid method.
  • the superabsorbent fibers may be the sole constituent of the respective material.
  • the wound care article additionally has a proportion of supporting fibers which ensure the integrity of the wound dressing even when moist, wherein said fibers are selected from the group comprising
  • cellulose fibers a) cellulose fibers, b) viscose fibers, c) alginate fibers, and / or d) polyester, polyolefin, polyurethane, polyvinyl alcohol or polymaid fibers, or mixtures or copolymers thereof
  • the fibers mentioned absorb only relatively little moisture and therefore retain their structural integrity for longer. So they form, so to speak, the "backbone" of the wound care article of the invention, so that this, when it has absorbed moisture, can be removed as a whole from the wound.
  • a fabric in which e.g. the warp threads are made from superabsorbent yarns, while the weft threads are made from other yarns, e.g. containing supporting fibers according to the above list.
  • a fabric has directional hydroactive properties, i. it absorbs fluid in one direction and passes it on.
  • Viscose fibers are fibers that consist of the base material cellulose and are processed using a chemical finishing process. The cellulose is first mixed with sodium hydroxide solution, swells and forms sodium cellulose. These can be carbon disulphide (CS 2 ) act. This produces sodium xanthate (xanthate), which is soluble in aqueous, dilute NaOH solution and forms a viscous solution. Both before the reaction with CS 2 and after dissolving in sodium hydroxide solution, the soda-cellulose or the spun-viscose is given time for the respective chemical reactions.
  • CS 2 carbon disulphide
  • the dope has the appropriate viscosity and the appropriate degree of ripeness - reactivity with respect to the spinning bath - to be subsequently spun can.
  • a sulfuric acid spinning bath which additionally contains sodium sulphate and a small amount of zinc sulphate, almost to the saturation limit, for retarding the cellulose precipitation reaction.
  • Viskosepinnmasse is pressed by gear pumps through the spinnerets.
  • the typical hole diameter of a single hole of the spinnerets is about 50 microns.
  • the fiber thus obtained differs from classical cellulose fibers by a very smooth surface, which prevents any adhesion to the wound, as well as a higher tear resistance. Viscose is available under the trade name Rayon
  • Alginates are obtained from the brown algae and can be processed in fiber form into a nonwoven or woven fabric. Chemically, it is polysaccharides, namely calcium and / or Natrimsalze the alginic acids. Alginates can absorb up to 20 times their own weight of liquid, whereby the wound exudate is stored in the cavities. The Ca 2+ ions contained in the alginate lattice are exchanged with the Na + ions from the exudate until the degree of saturation of Na ions in the alginate is reached. Swelling of the wound dressing and transformation of the alginate fiber into a gel body by swelling of the fibers occur.
  • the wound care article contains, in addition to said yarns or fibers, at least one further constituent selected from the group comprising
  • hydroactive polymers a) hydroactive polymers, and / or b) particulate superabsorbent polymers
  • hydroactive polymers is understood in the following to mean polymers which have moisture-binding properties.
  • Modified starch as well as cellulose and cellulose ethers, e.g.
  • the hydroactive polymers mentioned take up aqueous wound exudates and likewise form a moist surface. Possibly. assume a gelatinous form.
  • the moist surface or the gel form contributes to the tendency of the wound care article to become sore so that it can be detached atraumatic and painless after use. Due to the gel form, the wound care article has a cooling and thus jelly-reducing effect.
  • the gel form allows the formation of a wound healing moisturizing climate.
  • the hydroactive polymers are particularly preferably in the form of fibers.
  • These fibers may be of the type that retain their structural integrity upon absorption of water or exudate, or may be of the type that lose their fibrous shape upon absorption of exudate and become a structureless gel or solution. The latter applies especially to fibers of methylcellulose and their derivatives.
  • the absorption properties of the superabsorbent yarns or fibers and the hydroactive polymers used differ.
  • a wound care article having a high-absorbency core and a low-absorbency shell. This configuration ensures a wound care article that always has a dry surface.
  • Mineral ion exchangers such as zeolites, bentonites or montmarylinites, may also be part of the wound care article, in particular its mat.
  • Zeolites can u. a. Absorb pollutants, such as heavy metals.
  • the wound exudate absorbing body comprises at least one material selected from the group consisting of a mat, in particular an airlaid of said yarns or fibers of superabsorbent polymers with incorporated superabsorbent polymers, and / or a loose filling of superabsorbent polymers.
  • Said Airlaid mat may preferably have a substantially flat material portion of absorbent material, the z. B. consists of an absorbent fleece of said fibers with superabsorbent polymers distributed therein.
  • This wound exudate absorbent body with the exception that fibers or yarns of superabsorbent polymers are used here instead of cellulose fibers, correspond to the absorbent pad contained in a wound dressing of the applicant of the present invention, as described, for example, in WO03094813, WO2007051599 and WOO 152780 and sold under the trade name "sorbion sachet.”
  • the disclosure content of said documents is fully incorporated in the disclosure of this document.
  • the wound-absorbent body can likewise form a core which-optionally flake-like-has fibers or yarns of superabsorbent polymers and superabsorbent polymers in granular form, the granules being adhesively bonded or welded to the fibers or yarns at several heights , and the granules are distributed over more than 50% of the total height of at least a portion of the core, wherein there are mixed areas of granules and fibers.
  • the proportion by weight of the superabsorbent polymers may preferably be in the range between 10 and 25% by weight. Similar constructions are known from conventional incontinence materials and known as sanitary napkins for their cushioning properties.
  • Around said core may be disposed a sheath which is overlapped in areas and which may be e.g. an adhesive seam is covered or part of the same.
  • a section of a hydrophobic and / or water-repellent or water-impermeable material may be provided inside the sheath, which acts as a soaking or protecting agent.
  • the wound exudate absorbent body may also include at least one flat layer comprising fibers or yarns of superabsorbent polymers to which superabsorbent polymers in granule form are adhered.
  • a structure of the body having at least three layers, wherein two cover layers surrounding a layer having superabsorbent polymers.
  • the possibly provided multiple layers may also be physically compacted together by rolling, pressing, calendering or similar processes.
  • the body may have repetitive patterns or grains, such as a checked pattern, a punching pattern, or the like.
  • the said wound exudate absorbing body may also have an envelope of a permeable material, if necessary; This may have different connections or seams in their edge regions, which are produced in particular by adhesions.
  • connection area between the two sides of the sheath on at least one side of the wound exudate absorbing body - preferably in the longitudinal direction - is designed narrower than at least one other side, so that in the former case, unlike in the latter case a foldable supernatant results.
  • Said casing may preferably consist of a polypropylene nonwoven having an area weight of 10 to 40 g / m 2 .
  • the wound exudate absorbent body thus described is fixed to at least one inner side of the surrounding sheath, preferably by bonding.
  • the superabsorbent polymers present in yarn form be present at least partially in the form of a woven fabric, a fabric, a knitted fabric and / or a knitted fabric.
  • the individual yarns can also be welded together in the form of a grid.
  • the superabsorbent yarns may e.g. act as a cover of a wound dressing.
  • a dressing similar to a gauze bandage can be made.
  • the superabsorbent yarns may be the sole constituent of the respective material, but they may also be used in combination with other fibers, e.g. with pulp, viscose, cotton and / or polyolefin fibers.
  • a wound care article which is characterized in that the superabsorbent polymers present in fiber and / or yarn form part of a flat mat and / or a flat wound dressing.
  • a wound care article which is characterized in that the superabsorbent polymers present in fiber and / or yarn form part of a three-dimensional absorption body.
  • a wound care article which is characterized in that the superabsorbent polymers present in fiber and / or yarn form part of an envelope of a wound dressing.
  • the superabsorbent polymers present in fiber and / or yarn form part of a foam.
  • This foam may be e.g. a material selected from the group consisting of thermoplastic flexible foams, such as
  • Polyurethane, polyamide or polyether foam, silicone foam and cellulose foam or natural sponge is.
  • Natural sponges for example of the horn-pebble sponges (Demospongiae), have a capacity to absorb liquids, similar to technical foams. In addition, they have growth-inhibiting properties against microorganisms to protect against sedimentation of sessile organisms. These properties may also be useful in the context of wound care to prevent bacterial growth in the wound dressing and / or wound. Likewise, these sponges have growth-inhibiting properties against fungi and unicellulars. In addition, such sponges are able to absorb liquids and are therefore highly suitable for the absorption of exudates.
  • Said natural sponge can in thin slices, the z. B. generated by thermal cutting, be placed on the wound.
  • the flexible foam may optionally be configured in multiple layers, wherein the individual layers may preferably have thicknesses between 0.5 mm and 10 mm.
  • the flexible foam may be open-celled and closed-celled. In particular, in the latter case can be provided that the material has punches and / or perforations, which accelerate the liquid inlet and passage in or through the flexible foam.
  • the flexible foam can also be designed as integral foam.
  • the superabsorbent fibers or yarns may be incorporated into the starting material prior to foaming the foam. Alternatively, they can also be pressed into the finished foam material by means of pressure.
  • the absorption capacity of the wound care article according to the invention is further increased.
  • the fibers or yarns may have a wicking effect. This is advantageous in that it ensures that the surface of the wound care article remains dry and absorbed exudate is rapidly forwarded inwards.
  • the superabsorbent polymers present in fiber and / or yarn form are applied to a carrier layer.
  • the fibers in a jumble arrangement are optionally spread on both sides to a layer which has been previously coated with an adhesive material.
  • an adhesive material This may be e.g. to trade paraffin or glycerin.
  • a fabric having superabsorbent yarn may be applied to said layer.
  • Several of these layers may e.g. be superimposed in a wound care article according to the invention.
  • the superabsorbent constituents present in fibrous and / or yarn form are a bandage or a wrap which optionally has elastic properties.
  • the fibers have been processed in the manner described above with elastic fibers to form a yarn.
  • a wound care article according to the invention for the treatment of chronic wounds, acutely bleeding wounds and traumatically produced wounds is provided.
  • a wound care article according to the invention for surgical or postoperative care or for military purposes is provided.
  • kits for acute, emergency or military medical or chronic care comprising a wound care article according to the invention.
  • a possibly provided casing consists at least partially of a hydrophobic material, for example of polypropylene or of a hydrophobically finished natural material, such as cotton.
  • a hydrophobic material for example of polypropylene or of a hydrophobically finished natural material, such as cotton.
  • the hydrophobic properties of the sheath prevent it from sticking to the wound surface and help the wound exudate to reach the inside of the sheath more quickly.
  • the casing may also be made of another plastic, in particular a polyurethane or polyethylene film or of artificial spider silk film.
  • the material of the sheath may be structured such that the sheath has a rough inner surface and a smooth outer surface.
  • the rough inner surface of the sheath is formed by funnel-shaped perforations, each tapering towards the inner surface and terminating in a free opening edge ("projection") .
  • This rough inner surface counteracts the displacements of the contents of the sheath such that it is adhered with adhesive dots
  • the smooth outer surface of the sheath material may be formed by curved portions of material extending between the perforations, such sheath material may be referred to as "three-dimensional" as opposed to a bilaterally planar one, and is made of, for example: from the DE 102006017194 the applicant of the present application, the disclosure content of which is fully referenced here.
  • the wound care article also has at least one nutritive active ingredient and / or active ingredient complex which has at least one disinfecting or decontaminating and / or at least one protease inhibiting action.
  • the disinfectant active ingredient and / or active substance complex may be, for example, a composition of at least one vitamin or vitamin derivative, a metal ion and a detergent. It may also be an BLIS (bacteriocin like inhibitory substance) or coated magnetic particles.
  • the nutritive active ingredient and / or active ingredient complex may be a composition containing at least the components of an enteral and / or parenteral dietetics. It may also be at least one active element selected from the group containing insulin, recombinant insulin, proinsulin, an insulin-like growth factor (IGF), an insulin mimetic and / or a diabetic-specific, non-glucose- or sucrose-based energy carrier ,
  • the protease-inhibiting active substance and / or active substance complex may be at least one active element selected from the group comprising protease inhibitors, superabsorbent polymers, chelators for divalent cations, collagen, coated magnetic particles, acids, buffers, non-pathogenic acid-producing microorganisms, probiotics and / or symbiotics.
  • DE 102007030931 Further relationships and background to the nutritive, a disinfecting or decontaminating and / or proteases inhibiting agents and / or active substance complexes are described in the DE 102007030931 the applicant of the present application, the contents of which reference is made here in their entirety. DE 102007030931 also describes further nutritive, disinfecting or decontaminating and / or protease-inhibiting active substances and / or active substance complexes which are likewise to be regarded as disclosed in this application.
  • the wound care article may be added substances that can increase the osmotic pressure.
  • the substances include z. B. Osmodiuretics, such as mannitol.
  • Mineral ion exchangers such as zeolites, bentonites or montmarylinites, may also be part of the wound care article, in particular its mat.
  • Zeolites can, inter alia, absorb pollutants, such as heavy metals. Moreover, they develop a hemostatic effect.
  • the wound care article according to the invention can also be introduced into a wound care system for wound drainage using negative pressure.
  • Such systems are disclosed, for example, in the publications DE202004017052, WO2006048246 and DE202004018245 by the applicant of the present invention, the disclosure content of which is considered to belong to the present invention.
  • a device for wound treatment using negative pressure comprising a gastight wound covering element, which forms a space remaining between the respective wound and the wound covering element in the state applied to the body of the patient, and at least one connection point which coincides with the space in Contact is and over which the air in the room can be evacuated, wherein the wound covering element is underlaid by at least one area, the Wundsekrete receiving wound care article whose volume increases in the course of the absorption process, so that the absorbed wound secretions within the wound care article and thus below the wound covering element remain until removal of the wound care article from the body of the patient, the wound care article is at least one layer of a superabsorbent enriched textile section, which is surrounded by a liquid-permeable shell, and di e layer in plan view on its flat side has a surface that is 3% to 90% smaller than that of the shell, so that the wound care article can approach in the vicinity of its entire filling capacity in the cross section of a circular shape.
  • a multi-component dressing for wound treatment of the human or animal body using negative pressure comprising: a wound covering element for attachment to the skin and mucosal surface, at least one connection point which is in contact with the wound space and over which the substances located in the wound space can be evacuated which comprises superabsorbent polymers, wherein the absorbed wound secretions remain bound to polymers in the wound space until they are removed from the wound space, the polymers, by virtue of their binding capacity, assisting mutual synergies with the subatmospheric pressures.
  • a drainage device for wound treatment using negative pressure comprising a gas-tight, consisting of sheet-like material wound covering element, which in the applied to the body of the patient state on the Hautoberflä- is adhesively secured around the wound area and forms a sealed space remaining between the respective wound and the wound covering element, at least one drainage tube insertable into the space through which the substances in the space can be evacuated and at least one within the space At least one layer of a superabsorbent-enriched textile section surrounded by a liquid-permeable sheath, wherein the absorbed wound secretions within the wound care article and thus below the wound covering element until removal of the wound care article from the body of the wound Patients remain, and wherein the Wundabde- ckungselement has a gas-tight sealable treatment opening through which the wound care article can be inserted into the room and removed from the room.
  • the wound care article of the invention may moreover have a shape adapted to anatomical conditions.
  • he can e.g. be designed in the form of a cuff; which can be slipped over the one arm or a leg or a joint, or in the form of an adapted to the heel, the elbow joint or the like Association.
  • the wound care article according to the invention may also be designed so that it is suitable for transfer around a surgically applied line.
  • the wound care article may e.g. at least one slit, which makes it possible to transfer the bandage on the body of a patient by a conduit (eg a drainage line or a catheter), the wound care article is associated with a second, also planar wound care article, which is at a distance from the first wound care article, wherein the distance is bridged by a connecting strip or web.
  • a wound care article is e.g. from the DE202006005966 the applicant of the present invention, the contents of which should be fully added to the disclosure of the present description.
  • the wound care article has at least one agent which can restrict the bleeding or bleeding tendency.
  • Said agent may be at least one chemically and / or physiologically acting active substance or active substance complex or at least one physically acting active element.
  • a wound care article is known, for example, from DE 10 2007 030 931 of the applicant of the present application.
  • the wound care article for example
  • substantially flat material section comprising absorption material which is formed from an absorbent fleece with superabsorbent polymers distributed therein and at least one chemically and / or physiologically active agent or complex of active substances,
  • Wound dressing arranged secondary wound dressing, which contains superabsorbent polymers, wherein if necessary a diffusion barrier is arranged between them,
  • a bandage packet comprising a primary wound dressing with at least one chemically and / or physiologically acting active substance or active substance complex and a wound section arranged on the wound dressing, which has superabsorbent polymers at least in sections, and / or
  • the material section having a longitudinal extent comprising absorbent material, the material section having elastically deformable properties, and wherein the material section has superabsorbent polymers and optionally at least one chemically and / or physiologically acting active substance or active substance complex
  • the chemically and / or physiologically acting active ingredient or active substance complex is preferably at least one substance or a composition which has haemostatic properties. These substances are known under the generic term "hemostats”.
  • the chemically and / or physiologically acting active ingredient or active substance complex is preferably at least one substance or a composition which has haemostatic properties. These substances are known under the generic term "hemostats”.
  • the physically acting active element is, for example, a setting, a pressure pad, a compression bandage or a compression bandage. definitions
  • wound care article is intended in particular to designate a wound dressing, preferably a flat wound dressing or a wound care cloth.
  • Said wound dressing can be designed to be both absorbent and non-absorbent or only insubstantially absorbent.
  • wound care article may also be understood as an ensemble of various products placed in a given arrangement on the wound to be treated. This ensemble can form a physical unit by the various products are combined in a common shell or - if necessary, without a shell - are adhesively bonded together.
  • the ensemble may also be in the form of a kit in which the various products are placed on the wound to be treated by means of a coil in the given arrangement.
  • the wound care article acts as a rinsing body.
  • a physiological solution for example, 0.9% saline, Ringer's solution or the like
  • Such a wound care article continuously releases liquid to the wound during use, rinses it, and absorbs exudate, cell debris, necrotic components, bacteria, debris, and the like.
  • This type of toilet bowl is known under the brand name TenderWet.
  • nonwoven refers to a textile fabric of individual fibers which, unlike woven fabrics, knitted fabrics and knitted fabrics, is not made of yarns Nonwovens tend to retain their structural integrity as a result of the adhesion of the individual fibers and are referred to as “nonwovens”. and eg made by swaging the fibers.
  • airlaid refers to a special nonwoven fabric made of cellulose and polyolefins, in which superabsorbent polymers are embedded, if necessary.
  • exudate refers to a wound fluid derived from the blood plasma via the inflammatory processes of wound edema.
  • the exudate serves in a similar way the supply of the wound bed and the healing processes running in it.
  • the transudate which is derived from non-inflammatory processes and has a significantly lower specific gravity with a low cell and protein content.
  • exudate coordinates the various processes of wound healing both temporally and spatially through its high content of growth factors and cytokines. These are mainly formed by platelets, keratinocytes, macrophages and fibroblasts. They influence the motility, migration and proliferation of the various cells involved in wound healing. Thus, the infiltration of cells into the wound base is just as required as the supply of the newly formed granulation tissue by angiogenesis.
  • the wound cleansing is also supported by the exudate. It contains various serine, cysteine and aspartate proteases as well as matrix metalloproteases, which in their activity strictly regulate irreversibly damaged tissue and thus prepare the wound bed for the subsequent phases of healing.
  • Components of the physiological exudate are in particular salts, glucose, cytokines and growth factors, plasma proteins, proteases (in particular matrix metalloproteases), granulocytes and macrophages.
  • active ingredient complex is to be understood below not only a complex in the chemical sense, but in particular a composition synergistically an effect-inducing agents.
  • the term "physically acting active element” is to be understood in the following to mean an active element which is able to restrict the bleeding or tendency to bleed by physical means, ie by the exertion of pressure, tension, cold and the like.
  • the term “ligature” is to be understood in the following an emergency medical measure, which is able to stop the arterial blood flow, for example, in a limb, so as to prevent an unacceptable loss of blood in a wound. Indications for such a ligation are usually traumatic effects that lead to injuries of at least one artery.
  • chronic wounds should be understood to mean wounds that are not primarily due to traumatic effects. Although traumatic effects may have been the original cause of such a wound, the chronic wound is characterized mainly by delayed wound healing. Chronic wounds often show only slight bleeding, if at all, and often a strong exudation.
  • tissue hemorrhage is to be understood as a bleeding that is not of arterial origin, but possibly of venous origin or of interstitial or capillary origin, and which in any case is so mild that it is not directly or indirectly life-threatening.
  • acute bleeding wounds should be understood to mean those wounds that lead to large blood losses. As a rule, arterial haemorrhages are responsible for this, e.g. caused by traumatic effects. Acute bleeding wounds may u.U. be directly or life threatening. For this reason bleeding is a very high priority in acute bleeding wounds.
  • compression bandage is to be understood in the following the known from emergency medicine pressure bandage, This consists of a not too hard, non-absorbent article (pressure pad) without sharp or hard edges, which is applied to an already covered wound and using a wrap is attached with a moderate draft. The pressure exerted reduces the circulation of the affected part of the body and the traumatically opened blood vessels are closed again.
  • non-absorbent or only slightly absorbent wound dressing is intended to mean a wound dressing which has a low absorption capacity for liquids. Overall, the absorption capacity should be less than 60% by weight, preferably less than 20% by weight, of the dry weight of the wound dressing. Primary task of a Therefore, it is not the uptake of blood or exudates that is involved in the wound dressing, but the delivery of haemostatic agents in the context of the present invention.
  • compression bandage as a rule is understood to mean a bandage which acts in a similar way to a compression bandage, but dispenses with the aforementioned pressure pad.
  • the pressure or the compression on the wound is exerted exclusively by the winding.
  • the wrapping material can be elastic.
  • Alginates are extracted from brown algae and woven into a fibrous web. Chemically, they are polysaccharides, calcium and / or sodium salts of alginic acids. Alginates can absorb up to 20 times their own weight of liquid, while the wound exudate is stored in the cavities. The Ca 2+ ions contained in the alginate lattice are exchanged with the Na + ions from the exudate until the degree of saturation of Na ions in the alginate is reached. This leads to a swelling of the wound dressing and the conversion of the alginate fiber into a gel body by swelling of the fibers.
  • Carboxymethylcellulose in particular is in the form of sodium carboxymethylcellulose and is commercially available under the name "Hydro Faser".
  • the fibers are converted into a planar matrix.
  • the fibers are gradually transformed into a gel pad that holds the liquid and does not release it again.
  • the fibers are constructed so that the wound exudate is absorbed only in the vertical direction. This means that, as long as the capacity is sufficient, the exudate does not flow over the edge of the wound. In this way, wound edge maceration can be effectively prevented.
  • FIG. 1 shows a first embodiment of the wound care article, with a nonwoven absorbent body, in a schematic sectional view
  • Figures 2a and 2b show a second embodiment of the wound care article, with a covered, tissue-like absorbent body, in a schematic sectional view;
  • FIG. 3 shows a tissue section, in a perspective view
  • FIG. 4 shows a tube-like wound care article, made of the fabric according to FIG. 3, in a perspective view;
  • FIG. 5 shows another embodiment of the wound care article, with a fleece-like absorbent body and a foam-like sheath, likewise in a schematic sectional representation
  • Fig. 6 shows another embodiment of the wound care article according to Fig.l, but with a sandwich-like absorbent nonwoven core and
  • FIG. 7 shows a wound care article according to FIG. 2a, but with an additional liquid-impermeable insert.
  • a wound care article 100 comprising a liquid-permeable cover 2 made of polypropylene film of a basis weight 25 g / m 2 .
  • the shell 2 is in plan view rectangular on its flat side (see Fig. 2b) and includes an absorbent body 1 which completely surrounds. In a further, not shown embodiment, the shell 2 is circular.
  • the shell 2 is composed of two congruent shell walls 2.1, 2.2, which are welded together at their periphery with an ultrasonic seam 16.
  • the absorbent body 1 is in the form of a loose, airy nonwoven layer 11 consisting of superabsorbent short cut fibers (staple fibers). The properties of the high-absorbency short fibers are evident, for example, from the datasheet published by the manufacturer, Technical Absorbents, Grimsby, Great Britain.
  • the short cut fibers of an average length of about 8 to 10 mm interlock with each other, thereby enabling the formation of the cotton-like nonwoven layer 11.
  • the liquid-permeable cover 2 is fine-pored and allows penetration of the wound exudate into the absorbent body 1. This fine-pored structure also acts as a barrier to the individual short fibers.
  • the product can be placed on the wound with both its "left" and "right” flat sides.
  • FIG. 5 A similar wound care article (reference numeral 200) is shown in FIG. 5.
  • the absorbent, cotton-like absorbent body 1 is surrounded by a foam-like sheath 12 whose sheath walls 12.1, 12.2 are likewise congruently connected to one another by means of the peripheral ultrasonic seam 16.
  • superabsorbent powdery particles 15 are interspersed.
  • the two forms of the superabsorbent material (powder or granules and short fibers) contribute to a significantly increased absorption capacity of the body 3.
  • As a material for the shell 12 is fine-pored, therapeutically effective polyurethane foam provided.
  • FIG. 6 shows a further embodiment (reference numeral 300) of the wound care article, in which an absorbent body 3 is present in a shape resembling the known airlaid mat.
  • the sandwich-like body 3 consists of a nonwoven core 13 of superabsorbent short fibers and two cellulosic cover layers 14.1, 14.2.
  • the body 3 surrounds the shell 2 already described.
  • the nonwoven core 13 may also include other textile fibers, such as CMC fibers (not shown).
  • the superabsorbent short fibers can be spun into a yarn made, for example, by said company Technical Absorbents, Grimsby. It is preferred to use the superabsorbent yarn of a diameter of 0.3 mm to 1.0 mm for the preparation of wound dressings. It should be noted that the increasing yarn diameter corresponds to the increasing absorption capacity.
  • a use of yarns 10 is described in the following Figures 2a, 2b, 3, 4 and 7.
  • a superabsorbent fabric 17 from yarns 10 of 0.5 mm in diameter, a superabsorbent fabric 17 (see Fig. 3) is made whose stitches are about 2 to 3 mm in size.
  • the superabsorbent fabric 17 is adhesively bonded to a covering film 18 over the entire surface. A pointwise bonding is also possible.
  • the fabric 17 with the cover sheet 18 laid thereon forms a wound care article 400 which, if applied to a wound, not shown, is preferably backed by a wound spacer grid.
  • a fabric hose 19 is shown, which is made of the yarn 10 of an exemplary diameter of 0.3 mm.
  • the fabric tube 19 has 2 to 3 mm meshes 21, which can increase accordingly when used on the wound, if the fabric tube 19 via a limb, z. B. lower leg of the patient is everted and expands.
  • the superabsorbent fabric hose 19 can also fulfill a fixing function.
  • the superabsorbent fabric tube 19 represents a wound care article 500 for extremities.
  • an absorbent body 4 is accommodated inside the sheath 2, comprising the superabsorbent tissue 17 described in FIG. 3.
  • the two components form a wound care article 600.
  • the superabsorbent tissue 17 is shown in plan view on its flat side (cf. Fig. 2b) is also rectangular and has about 25% - smaller dimensions than that of the shell 2, so that the tissue can unfold unhindered during the absorption process.
  • FIG. 7 shows a further superabsorbent wound care article 700, comprising the sheath 2 according to FIG. 1, an absorbent body 4 (tissue 17) according to FIGS. 2 a and 2 b and one between the tissue 17 and the wound dressing.
  • the film section 22 fulfills the laundry protection function here.

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  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
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  • Materials For Medical Uses (AREA)
  • Artificial Filaments (AREA)
  • Multicomponent Fibers (AREA)

Abstract

L'objet de la présente invention est un article pour le soin des plaies, présentant une proportion de polymères super-absorbants, lesdits polymères super-absorbants se présentant sous forme de fibres et/ou de fils.
PCT/EP2008/060169 2007-08-03 2008-08-01 Article pour le soin des plaies, présentant des polymères super-absorbants sous forme de fibres et/ou de fils WO2009019227A2 (fr)

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DE102007036758 2007-08-03
DE102007036757 2007-08-03
DE102007036755.6 2007-08-03
DE102007036758.0 2007-08-03
DE102007036755 2007-08-03
DE102007036757.2 2007-08-03
DE102007049429A DE102007049429A1 (de) 2007-08-03 2007-10-14 Wundpflegeartikel, aufweisend superabsorbierende Polymere in Faser- und/oder Garnform
DE102007049429.9 2007-10-14

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DE102010004478A1 (de) 2010-01-12 2011-07-14 Riesinger, Birgit, 48346 Neue Technologien zur Verwendung in Wundauflagen mit superabsorbierenden Polymeren
DE102012100842A1 (de) 2012-02-01 2013-08-14 Birgit Riesinger Wundpflegeartikel, aufweisend mindestens eine Oberfläche mit abrasiven Eigenschaften
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US11058587B2 (en) 2010-04-27 2021-07-13 Smith & Nephew Plc Wound dressing and method of use
US11090195B2 (en) 2010-04-27 2021-08-17 Smith & Nephew Plc Wound dressing and method of use
USRE47645E1 (en) 2010-10-15 2019-10-15 Smith & Nephew Plc Medical dressing
USRE46289E1 (en) 2010-10-15 2017-01-31 Smith & Nephew Plc Medical dressing
USRE48282E1 (en) 2010-10-15 2020-10-27 Smith & Nephew Plc Medical dressing
USRE49227E1 (en) 2010-10-15 2022-10-04 Smith & Nephew Plc Medical dressing
USRE46778E1 (en) 2010-10-15 2018-04-10 Smith & Nephew Plc Medical dressing
US10231874B2 (en) 2010-11-08 2019-03-19 Smith & Nephew Plc Wound dressing and method of treatment
US11510819B2 (en) 2011-07-14 2022-11-29 Smith & Nephew Plc Wound dressing and method of treatment
USRE48535E1 (en) 2011-07-14 2021-04-27 Smith & Nephew Plc Wound dressing and method of treatment
WO2013053410A1 (fr) * 2011-10-13 2013-04-18 Carl Freudenberg Kg Non-tissé à pouvoir gonflant élevé
USRE47100E1 (en) 2012-05-15 2018-10-30 Smith & Nephew Plc Medical dressing
USD806256S1 (en) 2012-05-23 2017-12-26 Smith & Nephew Plc Medical dressing
USD820990S1 (en) 2012-05-23 2018-06-19 Smith & Nephew Plc Medical dressing
USD866756S1 (en) 2012-05-23 2019-11-12 Smith & Nephew Plc Flexible port used to connect a wound dressing to a source of negative pressure
US11559437B2 (en) 2016-10-28 2023-01-24 Smith & Nephew Plc Multi-layered wound dressing and method of manufacture
CN114126673A (zh) * 2019-08-22 2022-03-01 T.J.史密夫及内修有限公司 吸收性部件

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