WO2009015799A3 - Détection de la résistance au platine - Google Patents

Détection de la résistance au platine Download PDF

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Publication number
WO2009015799A3
WO2009015799A3 PCT/EP2008/005965 EP2008005965W WO2009015799A3 WO 2009015799 A3 WO2009015799 A3 WO 2009015799A3 EP 2008005965 W EP2008005965 W EP 2008005965W WO 2009015799 A3 WO2009015799 A3 WO 2009015799A3
Authority
WO
WIPO (PCT)
Prior art keywords
platinum
detection
platinum resistance
patient
sensitive
Prior art date
Application number
PCT/EP2008/005965
Other languages
German (de)
English (en)
Other versions
WO2009015799A2 (fr
Inventor
Michael Bonin
Jessica Hoffmann
Michael Walter
Olaf Riess
Hans Neubauer
Tanja Fehm
Erich Solomayer
Diethelm Wallwiener
Karl Sotlar
Original Assignee
Univ Eberhard Karls
Michael Bonin
Jessica Hoffmann
Michael Walter
Olaf Riess
Hans Neubauer
Tanja Fehm
Erich Solomayer
Diethelm Wallwiener
Karl Sotlar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Eberhard Karls, Michael Bonin, Jessica Hoffmann, Michael Walter, Olaf Riess, Hans Neubauer, Tanja Fehm, Erich Solomayer, Diethelm Wallwiener, Karl Sotlar filed Critical Univ Eberhard Karls
Publication of WO2009015799A2 publication Critical patent/WO2009015799A2/fr
Publication of WO2009015799A3 publication Critical patent/WO2009015799A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un procédé servant à classer un patient comme sensible ou résistant au platine, l'utilisation du profil d'expression d'un sous-groupe de gènes pour classer un patient comme sensible ou résistant au platine, ainsi qu'un procédé pour l'identification de gènes informatifs permettant de classer un patient comme sensible ou résistant au platine.
PCT/EP2008/005965 2007-07-27 2008-07-21 Détection de la résistance au platine WO2009015799A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200710036404 DE102007036404A1 (de) 2007-07-27 2007-07-27 Nachweis der Platinresistenz
DE102007036404.2 2007-07-27

Publications (2)

Publication Number Publication Date
WO2009015799A2 WO2009015799A2 (fr) 2009-02-05
WO2009015799A3 true WO2009015799A3 (fr) 2009-06-11

Family

ID=40104652

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/005965 WO2009015799A2 (fr) 2007-07-27 2008-07-21 Détection de la résistance au platine

Country Status (2)

Country Link
DE (1) DE102007036404A1 (fr)
WO (1) WO2009015799A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060019268A1 (en) * 2004-03-26 2006-01-26 Research Development Foundation Molecular markers of cisplatin resistance in cancer and uses thereof
US20060094012A1 (en) * 2002-07-31 2006-05-04 University Of Southern California Polymorphisms for predicting disease and treatment outcome

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060094012A1 (en) * 2002-07-31 2006-05-04 University Of Southern California Polymorphisms for predicting disease and treatment outcome
US20060019268A1 (en) * 2004-03-26 2006-01-26 Research Development Foundation Molecular markers of cisplatin resistance in cancer and uses thereof

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
AGARWAL ET AL: "Expression profiling and individualisation of treatment for ovarian cancer", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 6, no. 4, 1 August 2006 (2006-08-01), pages 345 - 349, XP005539061, ISSN: 1471-4892 *
BERNARDINI M ET AL: "HIGH-RESOLUTION MAPPING OF GENOMIC IMBALANCE AND IDENTIFICATION OF GENE EXPRESSION PROFILES ASSOCAITED WITH DIFFERENTIAL CHEMOTHERAPY RESPONSE IN SEROUS EPITHELIAL OVARIAN CANCER", NEOPLASIA, DOYMA, BARCELONA, ES, vol. 7, no. 6, 1 June 2005 (2005-06-01), pages 603 - 613, XP008068059, ISSN: 0212-9787 *
CHEN Z ET AL: "CORRELATION OF CISPLATIN SENSITIVITY WITH DIFFERENTIAL ALTERATION OF EGFR EXPRESSION IN HEAD AND NECK CANCER CELLS", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS, vol. 20, no. 2A, 1 March 2000 (2000-03-01), pages 899 - 902, XP009012770, ISSN: 0250-7005 *
DAHL EDGAR ET AL: "Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 JUL 2006, vol. 12, no. 13, 1 July 2006 (2006-07-01), pages 3950 - 3960, XP002508551, ISSN: 1078-0432 *
DE SMET F ET AL: "Predicting the clinical behavior of ovarian cancer from gene expression profiles.", INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER : OFFICIAL JOURNAL OF THE INTERNATIONAL GYNECOLOGICAL CANCER SOCIETY 2006 JAN-FEB, vol. 16 Suppl 1, January 2006 (2006-01-01), pages 147 - 151, XP002508552, ISSN: 1048-891X *
DRESSMAN HOLLY K ET AL: "An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 FEB 2007, vol. 25, no. 5, 10 February 2007 (2007-02-10), pages 517 - 525, XP002519673, ISSN: 1527-7755 *
FEHRMANN RUDOLF S N ET AL: "Profiling studies in ovarian cancer: a review.", THE ONCOLOGIST AUG 2007, vol. 12, no. 8, August 2007 (2007-08-01), pages 960 - 966, XP002519672, ISSN: 1083-7159 *
HELLEMAN JOZIEN ET AL: "Molecular profiling of platinum resistant ovarian cancer.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 APR 2006, vol. 118, no. 8, 15 April 2006 (2006-04-15), pages 1963 - 1971, XP002519674, ISSN: 0020-7136 *
KOMATSU MASAAKI ET AL: "Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers.", MOLECULAR CANCER THERAPEUTICS MAR 2006, vol. 5, no. 3, March 2006 (2006-03-01), pages 767 - 775, XP002519676, ISSN: 1535-7163 *
MACLEOD KENNETH ET AL: "Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer", CANCER RESEARCH, vol. 65, no. 15, August 2005 (2005-08-01), pages 6789 - 6800, XP002519751, ISSN: 0008-5472 *
PETERS DAVID ET AL: "Genome-wide transcriptional analysis of carboplatin response in chemosensitive and chemoresistant ovarian cancer cells.", MOLECULAR CANCER THERAPEUTICS OCT 2005, vol. 4, no. 10, October 2005 (2005-10-01), pages 1605 - 1616, XP002519675, ISSN: 1535-7163 *
RICHARDSON ET AL: "Drug resistance in ovarian cancer: The emerging importance of gene transcription and spatio-temporal regulation of resistance", DRUG RESISTANCE UPDATES, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 8, no. 5, 1 October 2005 (2005-10-01), pages 311 - 321, XP005182400, ISSN: 1368-7646 *
ROBERTS D ET AL: "Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells", BRITISH JOURNAL OF CANCER, vol. 92, no. 6, 28 March 2005 (2005-03-28), pages 1149 - 1158, XP002519671, ISSN: 0007-0920 *
TAKEUCHI ET AL: "Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase", GENE, ELSEVIER, AMSTERDAM, NL, vol. 399, no. 2, 2 June 2007 (2007-06-02), pages 174 - 180, XP022190607, ISSN: 0378-1119 *

Also Published As

Publication number Publication date
DE102007036404A1 (de) 2009-01-29
WO2009015799A2 (fr) 2009-02-05

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