WO2009015799A3 - Detection of platinum resistance - Google Patents
Detection of platinum resistance Download PDFInfo
- Publication number
- WO2009015799A3 WO2009015799A3 PCT/EP2008/005965 EP2008005965W WO2009015799A3 WO 2009015799 A3 WO2009015799 A3 WO 2009015799A3 EP 2008005965 W EP2008005965 W EP 2008005965W WO 2009015799 A3 WO2009015799 A3 WO 2009015799A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- platinum
- detection
- platinum resistance
- patient
- sensitive
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
The invention relates to a method for classifying a patient as platinum-sensitive or platinum-resistant, the use of the expression profile of a subgroup of genes for classifying a patient as platinum-sensitive or platinum-resistant, and a method for identifying informative genes in order to be able to classify a patient as platinum-sensitive or platinum-resistant.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007036404.2 | 2007-07-27 | ||
DE200710036404 DE102007036404A1 (en) | 2007-07-27 | 2007-07-27 | Detection of platinum resistance |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009015799A2 WO2009015799A2 (en) | 2009-02-05 |
WO2009015799A3 true WO2009015799A3 (en) | 2009-06-11 |
Family
ID=40104652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/005965 WO2009015799A2 (en) | 2007-07-27 | 2008-07-21 | Detection of platinum resistance |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102007036404A1 (en) |
WO (1) | WO2009015799A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060019268A1 (en) * | 2004-03-26 | 2006-01-26 | Research Development Foundation | Molecular markers of cisplatin resistance in cancer and uses thereof |
US20060094012A1 (en) * | 2002-07-31 | 2006-05-04 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
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2007
- 2007-07-27 DE DE200710036404 patent/DE102007036404A1/en not_active Ceased
-
2008
- 2008-07-21 WO PCT/EP2008/005965 patent/WO2009015799A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060094012A1 (en) * | 2002-07-31 | 2006-05-04 | University Of Southern California | Polymorphisms for predicting disease and treatment outcome |
US20060019268A1 (en) * | 2004-03-26 | 2006-01-26 | Research Development Foundation | Molecular markers of cisplatin resistance in cancer and uses thereof |
Non-Patent Citations (14)
Title |
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AGARWAL ET AL: "Expression profiling and individualisation of treatment for ovarian cancer", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 6, no. 4, 1 August 2006 (2006-08-01), pages 345 - 349, XP005539061, ISSN: 1471-4892 * |
BERNARDINI M ET AL: "HIGH-RESOLUTION MAPPING OF GENOMIC IMBALANCE AND IDENTIFICATION OF GENE EXPRESSION PROFILES ASSOCAITED WITH DIFFERENTIAL CHEMOTHERAPY RESPONSE IN SEROUS EPITHELIAL OVARIAN CANCER", NEOPLASIA, DOYMA, BARCELONA, ES, vol. 7, no. 6, 1 June 2005 (2005-06-01), pages 603 - 613, XP008068059, ISSN: 0212-9787 * |
CHEN Z ET AL: "CORRELATION OF CISPLATIN SENSITIVITY WITH DIFFERENTIAL ALTERATION OF EGFR EXPRESSION IN HEAD AND NECK CANCER CELLS", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS, vol. 20, no. 2A, 1 March 2000 (2000-03-01), pages 899 - 902, XP009012770, ISSN: 0250-7005 * |
DAHL EDGAR ET AL: "Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 JUL 2006, vol. 12, no. 13, 1 July 2006 (2006-07-01), pages 3950 - 3960, XP002508551, ISSN: 1078-0432 * |
DE SMET F ET AL: "Predicting the clinical behavior of ovarian cancer from gene expression profiles.", INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER : OFFICIAL JOURNAL OF THE INTERNATIONAL GYNECOLOGICAL CANCER SOCIETY 2006 JAN-FEB, vol. 16 Suppl 1, January 2006 (2006-01-01), pages 147 - 151, XP002508552, ISSN: 1048-891X * |
DRESSMAN HOLLY K ET AL: "An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 10 FEB 2007, vol. 25, no. 5, 10 February 2007 (2007-02-10), pages 517 - 525, XP002519673, ISSN: 1527-7755 * |
FEHRMANN RUDOLF S N ET AL: "Profiling studies in ovarian cancer: a review.", THE ONCOLOGIST AUG 2007, vol. 12, no. 8, August 2007 (2007-08-01), pages 960 - 966, XP002519672, ISSN: 1083-7159 * |
HELLEMAN JOZIEN ET AL: "Molecular profiling of platinum resistant ovarian cancer.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 15 APR 2006, vol. 118, no. 8, 15 April 2006 (2006-04-15), pages 1963 - 1971, XP002519674, ISSN: 0020-7136 * |
KOMATSU MASAAKI ET AL: "Prediction of individual response to platinum/paclitaxel combination using novel marker genes in ovarian cancers.", MOLECULAR CANCER THERAPEUTICS MAR 2006, vol. 5, no. 3, March 2006 (2006-03-01), pages 767 - 775, XP002519676, ISSN: 1535-7163 * |
MACLEOD KENNETH ET AL: "Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer", CANCER RESEARCH, vol. 65, no. 15, August 2005 (2005-08-01), pages 6789 - 6800, XP002519751, ISSN: 0008-5472 * |
PETERS DAVID ET AL: "Genome-wide transcriptional analysis of carboplatin response in chemosensitive and chemoresistant ovarian cancer cells.", MOLECULAR CANCER THERAPEUTICS OCT 2005, vol. 4, no. 10, October 2005 (2005-10-01), pages 1605 - 1616, XP002519675, ISSN: 1535-7163 * |
RICHARDSON ET AL: "Drug resistance in ovarian cancer: The emerging importance of gene transcription and spatio-temporal regulation of resistance", DRUG RESISTANCE UPDATES, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 8, no. 5, 1 October 2005 (2005-10-01), pages 311 - 321, XP005182400, ISSN: 1368-7646 * |
ROBERTS D ET AL: "Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells", BRITISH JOURNAL OF CANCER, vol. 92, no. 6, 28 March 2005 (2005-03-28), pages 1149 - 1158, XP002519671, ISSN: 0007-0920 * |
TAKEUCHI ET AL: "Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase", GENE, ELSEVIER, AMSTERDAM, NL, vol. 399, no. 2, 2 June 2007 (2007-06-02), pages 174 - 180, XP022190607, ISSN: 0378-1119 * |
Also Published As
Publication number | Publication date |
---|---|
DE102007036404A1 (en) | 2009-01-29 |
WO2009015799A2 (en) | 2009-02-05 |
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