WO2009011613A1

WO2009011613A1 - Composition for washing the nasal cavity, rhinopharynx and the mouth cavity

Info

Publication number: WO2009011613A1
Application number: PCT/RU2008/000427
Authority: WO
Inventors: Anton Evgenyevich Suprun
Original assignee: Anton Evgenyevich Suprun
Priority date: 2007-07-18
Filing date: 2008-07-02
Publication date: 2009-01-22
Also published as: RU2342937C1

Abstract

The invention relates to the chemical and pharmaceutical industry, in particular to agents for washing the nasal cavity, rhinopharynx and the mouth cavity. The inventive composition for washing the nasal cavity, rhinopharynx and the mouth cavity contains mineral salt, carnallite, sodium bicarbonate, a dry wild rose extract and a dry licorice extract at the following component ratio (in % by weight): 70.0 mineral salt, 25.0 carnallite, 2.0 sodium bicarbonate, 1.5 dry wild rose extract and 1.5 dry licorice extract. The use of the composition in the form of a solution improves the nasal mucosa and rhinopharynx nutrition by means of useful microelements of K, Na, Mg and Cl. Moreover, it reduces the nasal mucosa and rhinopharynx irritation and contributed in the mucosa reparation in the case of different types of rhinitis, rhinopharingitis (infectious, allergic and atrophic).

Description

DESCRIPTION OF THE INVENTION

COMPOSITION FOR RINSING THE NOSE CAVITY, NOSOPHALUS AND

Oral cavity

The invention relates to the pharmaceutical industry, in particular to substances intended for washing the nasal cavity, nasopharynx and oral cavity.

A known composition for washing the nasal cavity in the form of a solution of sodium chloride, baking soda with the addition of vegetable edible oil and an antiseptic, which used propolis tincture or rotokan, or liquid chamomile extract. [Patent RU JV ° 2220710, cl. 7 A61L9 / 08. 11/01/1999].

A disadvantage of the known composition is the limited number of minerals with a sedative and analgesic effect, which reduces the effectiveness of the known composition. In addition, the implementation of the composition for washing the nasal cavity in the form of a solution containing more than 90% water, causes a large volume of the composition and complicates its storage and transportation, which limits the convenience of its use.

A known complex for washing the nose in the form of a powder, including sea salt l, 6 g, baking soda 0.2 g, licorice dry extract 0.1 g, rosehip dry extract 0.1 g. (FS JY ° 22 a 2005 / 1672-05 dated 05.05.2005).

A disadvantage of the known composition is the presence of an insoluble precipitate formed during the dissolution of the powder in water, as well as the presence of man-caused, man-made, radioactive and bacterial contamination of "salt."

The present invention is the creation of an effective tool that can be used for various diseases of the nose and nasopharynx based on pure minerals.

The problem is solved as follows.

A composition for washing the nasal cavity, nasopharynx and oral cavity is proposed, including halite, carnallite, baking soda, dry rosehip extract and dry licorice extract with the following components in total wt.%:

SUBSTITUTE SHEET (RULE 26) halite 70.0 carnallite 25.0 baking soda 2.0 dry rosehip extract 1.5 dry licorice extract 1.5

The composition for washing the nasal cavity, nasopharynx and oral cavity in the form of a dry powder helps to increase the convenience of its use, by increasing its compactness, leading to the facilitation of its storage and transportation.

Supply of the proposed composition with natural yellow carnallite minerals and the use of natural halite minerals as sodium chloride helps to increase its effectiveness by supplementing with minerals that have a sedative and analgesic effect and creating the necessary concentration of trace elements.

The supply of the composition for washing the nasal cavity, nasopharynx and oral cavity with dry plant extracts of licorice and rose hips, which have anti-inflammatory properties and complement the proposed composition with multivitamins, contributes to its effectiveness.

The proposed composition for washing the nasal cavity, nasopharynx and oral cavity can be used as follows.

Immediately before use, 2 g (for adults) or 1 g (for children) of the dry powder of the proposed composition are dissolved in 240 ml or 120 ml of warm (34-36 ° C) distilled or boiled clean drinking water, respectively.

The solution is ready to use and can be used to rinse the nasal cavity, nasopharynx and / or rinse the oral cavity.

Ingredients: halite 70%, carnallite 25%, baking soda 2%, dry plant rosehip extract 1.5%, dry plant licorice extract 1.5%.

The product is a mixture of pure minerals halite, carnallite, soda, rosehip extract, licorice extract.

SUBSTITUTE SHEET (RULE 26) The product includes magnesium, sodium, potassium chlorides and is characterized in that it contains pure carnallite as magnesium chloride and potassium halite as pure sodium chloride.

The product also contains rosehip extract, licorice extract, which are related to multivitamin raw materials. Rosehip extracts in its composition contain salts of potassium (23 mg%), sodium (5%), calcium (26 mg%), magnesium (8 mg%), phosphorus (8 mg%), iron (11.5%), and also contains ascorbic acid, carotene, vitamins B2, Kl.

Licorice extract contains flavonoids (up to 4.3%) - liquiquirithigenin, isoliquirithigenin, neoliquirithin, neoisoliquirithin, liquiquirithin, isoliquirithin, isouraloside, draloside, globroside, lacrazide; carbohydrates - glucose and sucrose (up to 15.6%), pentose (up to 13.2%), starch (up to 24.5%), pentin (up to 4.6%); organic acids (up to 4.6%) - tartaric, citric, fumaric, oxalic, malic, succinic; triterpenoids - glycerizinic acid (22.2%); Acitosterol, alkaloids, coumarins, tannins (up to 9.46%), in addition, contains: macroelements (mg / g) - K - 0.08, Cu - 0.2, Zn - 0.13, Fe - 0.7; trace elements (μg / g) - Mn - 0.08, Cu - 02, Zn - 0.13, Co - 0.03, Cr - 0.04, Al - 0.51, V - 0.29, Se - 17 , 1, Ni - 0.23, Sr - 0.54, Pb - 0.02, 1 - 0.09, B - 60; concentrate Fe, Se.

The chemical formula of the product, without plant extracts

Pg ^• (NaCiuAg + Pc ^• (KMgCl ₃ 6H ₂ O) / Ac + Ps ^• (NaHCO ₃ ) / Ac

where, Pg - [%], wt.% halite mineral in the mixture;

Pc - [%], wt.% Channelite mineral in the mixture;

Ps - [%], wt.% Soda in the mixture;

Ar, Ak, and Ac are the atomic weights of halite (NaCl) and carnallite (KMgCl ₃ OH ₂ O), soda (NaHCO ₃ ), respectively.

Mass% of halite is Pg = 70 wt.%, Mass% of soda is

Ps = 2 wt.%, And mass% of carnallite Pk = macc. 25%.

Knowing the atomic weights of each of the elements, it is easy to calculate the atomic weights of chemically pure halite and carnallite minerals:

Ar = 58,433

SUBSTITUTE SHEET (RULE 26) Ak = 277.862

Ac = 84.001

The chemical formula of the product:

[70 (NaCl)] / 58,433 + [25 (KMgCl ₃ ^• 6H ₂ O)] / 277,862 + [2 (NaHCO ₃ )] / 84,001 or after dividing the numerator by the denominator in each of the terms we obtain the final chemical formula of the chemical pure means

1.2 (NaCl) + 0.09 (KMgCl ₃ ^• 6H ₂ O) + 0.024 (NaHCO ₃ )

The solution of the proposed tool has high and significant physiological effects due to the specified ratio of macro- and microelements contained in salts and plant extracts of bioflavonoids and other biologically active substances of plant origin.

The value of the ion content in the proposed tool, calculated by the formula with plant extracts

SUBSTITUTE SHEET (RULE 26) The effectiveness of the proposed composition for washing the nasal cavity, nasopharynx and oral cavity can be confirmed by the following data.

For a month, in the ENT department of the Municipal Institution “HPB” of Balashikha District, a solution with neutral PH of dry powder containing a mixture of natural minerals carnallite and halite, baking soda and licorice and rosehip extract was used in 63 patients. The control group included other inpatients and outpatients with similar diagnoses.

Children:

- with purulent adenoiditis - 13 patients (with additional therapy and after anemization of the nasal passages in the first 2 days before the procedure);

- with purulent adenoiditis, tonsillitis - 2 patients (with infectious mononucleosis);

- with acute purulent sinusitis or exacerbation of the chronic process - 16 patients (of which 6 patients underwent additional treatment, but without maxillary sinus punctures, and 10 patients in combination with punctures);

- with chronic rhinitis - 5 patients (treated only with a solution).

Adults:

- with chronic rhinitis - 3 pregnant women (only by washing with a solution);

- with exacerbation of chronic sinusitis - 1 pregnant (in combination with punctures); - with additional treatment - 5 patients;

- with purulent sinusitis - 10 patients (with additional treatment);

- with bronchial asthma - 8 patients (after polypectomy of the nose).

Total: preschoolers from 2 years old - 25, schoolchildren - 11, adults - 27.

For children, the volume of fluid per procedure is 100 ml. + 2 g of dry powder, the treatment period is from 3 to 10 days.

Subjectively sick and objective doctors noted an improvement in nasal breathing at 30% by day 3, in 70% by 4-5 days, in the control group by 10 days.

Conclusion: a solution with a neutral PH of a dry powder containing a mixture of natural materials carnallite and halite, baking soda and licorice and rosehip extract is convenient to use in a hospital, at home, especially in small and often ill children, patients with increased nervous

SUBSTITUTE SHEET (RULE 26) excitability, due to the impossibility of their treatment with punctures and washing according to Proets. This procedure does not cause pain, fear and the use of anesthetics and can be used in pregnant women.

The composition is a mixture of pure minerals of halite, carnallite and soda without the use of any additives and reagents.

When the product is dissolved in water, a solution is obtained that has more advantageous distinctive features from physiological solutions, mineral healing waters, solutions of any sea and therapeutic salts, as well as from the natural water of the Sea of Oceans.

The healing properties of the composition of the product can be explained by the fact that the solution obtained during preparation is close not only to the composition of sea water, but also to the composition of human blood plasma. This determines the effectiveness of the solution of the proposed drug on the mucous membrane in various diseases of the nose and nasopharynx.

The composition contains a number of vital trace elements, sulfur-containing gases.

The aqueous solution of the product, in comparison with natural seawater, has a full correspondence in the concentration of sodium and chlorine ions, a decrease in magnesium ions in comparison with potassium ions, which makes it closer to the composition of human blood plasma, and a multiple decrease in calcium content (Ca ²⁺ ) and sulfates (SO ₄ ^{2 "} ) allows you to avoid the main all" salt "- the presence of insoluble sediment.

The use of pure halite, carnallite and soda minerals containing trace elements of potassium, sodium, magnesium in the indicated proportions allows to obtain a solution that is close in composition to human blood plasma, which makes it possible to carry out the nutrition process of the nasal mucosa and nasopharynx of blood with deficient trace elements.

Clinical testing of the composition in the form of a solution showed:

1. The solution improves the nutrition of the mucous membranes of the nasopharynx due to active biological substances and micronutrients;

2. The presence in the solution of plant extracts containing zinc and selenium ions, contributing to the production of lysozyme, interferons and

SUBSTITUTE SHEET (RULE 26) immunoglobulins, restores local immunity of the nasal mucosa and paranasal sinuses;

3. The presence of glyceric acid in licorice extract stimulates the production of interferon, gives the solution antiviral activity;

4. The presence of flavonoids in the solution helps to reduce the fragility of capillaries and has an anti-inflammatory effect;

5. The solution is a tool that promotes the healing of wounds of the nasal mucosa and nasopharynx, as well as in the postoperative period;

6. The ascorbic acid contained in the solution promotes tissue regeneration, increases the stability and protective reactions of the nasal mucosa and nasopharynx.

7. The solution contains practically no insoluble precipitate;

8. Unlike seawater, natural water bodies do not contain man-made and man-made, radioactive as well as bacterial contaminants.

SUBSTITUTE SHEET (RULE 26)

Claims

The formula of the invention, the composition for washing the nasal cavity, nasopharynx and oral cavity

1. Composition for washing the nasal cavity, nasopharynx and oral cavity, including halite, carnallite, baking soda, dry rosehip extract and dry licorice extract with the following components in total wt.%:

halite 70.0 carnallite 25.0 baking soda 2.0 dry rosehip extract 1.5 dry licorice extract 1.5

SUBSTITUTE SHEET (RULE 26)