WO2009010871A3 - Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine - Google Patents
Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine Download PDFInfo
- Publication number
- WO2009010871A3 WO2009010871A3 PCT/IB2008/002243 IB2008002243W WO2009010871A3 WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3 IB 2008002243 W IB2008002243 W IB 2008002243W WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antagonists
- adenosine
- receptor
- compounds
- pyrazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne de nouveaux composés de formule (I). X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am et Bn sont définis dans les revendications de l'invention. Les composés de l'invention sont des antagonistes des récepteurs de l'adénosine de sous-type A3 qui servent à traiter les troubles modulés par les récepteurs A3. L'invention concerne également des compositions pharmaceutiques associées et un procédé d'utilisation de tels composés mis en oeuvre dans la fabrication de médicaments, ainsi qu'un procédé d'utilisation de tels composés visant à prévenir et à traiter des maladies dans lesquelles A3 est impliqué.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0713687A GB0713687D0 (en) | 2007-07-13 | 2007-07-13 | New compounds 1 |
GB0713687.2 | 2007-07-13 | ||
GB0723344A GB0723344D0 (en) | 2007-11-28 | 2007-11-28 | Novel compounds 3 |
GB0723344.8 | 2007-11-28 | ||
GB0803103.1 | 2008-02-20 | ||
GB0803103A GB0803103D0 (en) | 2008-02-20 | 2008-02-20 | Novel compounds 3 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009010871A2 WO2009010871A2 (fr) | 2009-01-22 |
WO2009010871A3 true WO2009010871A3 (fr) | 2009-03-12 |
Family
ID=40089928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2008/002243 WO2009010871A2 (fr) | 2007-07-13 | 2008-07-11 | Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009010871A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9233956B2 (en) | 2008-05-06 | 2016-01-12 | Novartis Ag | Benzene sulfonamide thiazole and oxazole compounds |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0900388D0 (en) | 2009-01-12 | 2009-02-11 | Addex Pharmaceuticals Sa | New compounds |
GB201000655D0 (en) | 2010-01-15 | 2010-03-03 | Addex Pharmaceuticals Sa | New compounds 2 |
WO2012068196A1 (fr) * | 2010-11-18 | 2012-05-24 | Janssen Pharmaceutica Nv | Inhibiteurs bis-hétéroaryles de l'activation pro-métalloprotéinases de matrice |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
CN103351339A (zh) * | 2013-07-12 | 2013-10-16 | 雅本化学股份有限公司 | 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法 |
GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
WO2017054112A1 (fr) * | 2015-09-28 | 2017-04-06 | 常州市卜弋科研化工有限公司 | Procédé de préparation d'acide 3-fluoroalkyl-1-méthylpyrazole-4-carboxylique |
GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
WO2017185061A1 (fr) | 2016-04-21 | 2017-10-26 | Astrocyte Pharmaceuticals, Inc. | Composés et procédés pour traiter des états neurologiques et cardiovasculaires |
JP2019515938A (ja) * | 2016-05-10 | 2019-06-13 | ソルヴェイ(ソシエテ アノニム) | 3−(ハロアルキルまたはホルミル)−1h−ピラゾール−4−カルボン酸またはエステルを含む組成物、その製造、およびカルボキサミド調製のためのその使用 |
ES2676535B1 (es) * | 2017-01-20 | 2019-04-29 | Palobiofarma Sl | Moduladores de los receptores a3 de adenosina |
JPWO2018180943A1 (ja) * | 2017-03-27 | 2020-02-06 | Agc株式会社 | ハロゲン含有ピラゾールカルボン酸及びその中間体の製造方法 |
CN108017584B (zh) * | 2017-06-20 | 2021-03-23 | 南开大学 | A3腺苷受体的小分子拮抗剂 |
JP7311855B2 (ja) * | 2018-02-09 | 2023-07-20 | アストロサイト ファーマシューティカルズ, インコーポレイテッド | 嗜癖および関連する障害を処置するための化合物および方法 |
WO2020106773A1 (fr) * | 2018-11-19 | 2020-05-28 | Saint Louis University | Traitement du syndrome du côlon irritable |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンa3拮抗剤 |
WO2001064674A1 (fr) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | Derives de thiazolyle 2,4-disubstitue |
WO2007071348A1 (fr) * | 2005-12-19 | 2007-06-28 | F. Hoffmann-La Roche Ag | Dérivés d’aminopyrazole de type isoquinoléine, leur fabrication et application en tant qu'agents pharmaceutiques pour le traitement du cancer |
WO2007076473A2 (fr) * | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Urees pyrimidinyloxy substituees utiles comme inhibiteurs des proteines kinases |
-
2008
- 2008-07-11 WO PCT/IB2008/002243 patent/WO2009010871A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンa3拮抗剤 |
WO2001064674A1 (fr) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | Derives de thiazolyle 2,4-disubstitue |
WO2007071348A1 (fr) * | 2005-12-19 | 2007-06-28 | F. Hoffmann-La Roche Ag | Dérivés d’aminopyrazole de type isoquinoléine, leur fabrication et application en tant qu'agents pharmaceutiques pour le traitement du cancer |
WO2007076473A2 (fr) * | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Urees pyrimidinyloxy substituees utiles comme inhibiteurs des proteines kinases |
Non-Patent Citations (7)
Title |
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DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHELKE, S. N. ET AL: "Synthesis of pyrazolyltriazoles and thiadiazoles by conventional and non-conventional methods", XP002507912, retrieved from STN Database accession no. 2006:1282971 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507907, retrieved from STN Database accession no. 255828-23-0 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507908, retrieved from STN Database accession no. 255828-22-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507909, retrieved from STN Database accession no. 255828-21-8 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507910, retrieved from STN Database accession no. 255828-20-7 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507911, retrieved from STN Database accession no. 255828-19-4 * |
ORIENTAL JOURNAL OF CHEMISTRY , 22(2), 369-374 CODEN: OJCHEG; ISSN: 0970-020X, 2006 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9233956B2 (en) | 2008-05-06 | 2016-01-12 | Novartis Ag | Benzene sulfonamide thiazole and oxazole compounds |
Also Published As
Publication number | Publication date |
---|---|
WO2009010871A2 (fr) | 2009-01-22 |
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