WO2009008412A1 - 放射線治療後における泌尿器の晩期有害反応の発症予測用ｄｎａチップ、及びこれを用いた放射線治療後における泌尿器の晩期有害反応の発症予測方法 - Google Patents

放射線治療後における泌尿器の晩期有害反応の発症予測用ｄｎａチップ、及びこれを用いた放射線治療後における泌尿器の晩期有害反応の発症予測方法 Download PDF

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Publication number
WO2009008412A1
WO2009008412A1 PCT/JP2008/062297 JP2008062297W WO2009008412A1 WO 2009008412 A1 WO2009008412 A1 WO 2009008412A1 JP 2008062297 W JP2008062297 W JP 2008062297W WO 2009008412 A1 WO2009008412 A1 WO 2009008412A1
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WO
WIPO (PCT)
Prior art keywords
adverse reaction
radiation therapy
urinary organ
occurrence
prediction
Prior art date
Application number
PCT/JP2008/062297
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English (en)
French (fr)
Inventor
Takashi Imai
Mayumi Iwakawa
Eisei Oda
Original Assignee
National Institute Of Radiological Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Radiological Sciences filed Critical National Institute Of Radiological Sciences
Priority to US12/452,500 priority Critical patent/US20100130376A1/en
Priority to JP2009522644A priority patent/JP4974091B2/ja
Publication of WO2009008412A1 publication Critical patent/WO2009008412A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Ｃ－イオンＲＴ後における泌尿器の晩期有害反応の発症を予測するためのＤＮＡチップ及び予測方法を提供する。ＤＮＡチップは、ＤＮＡプローブを保持するための保持手段と、前記保持手段に保持された複数の遺伝子マーカーとを有する。予測方法は、遺伝子マーカーと、測定対象から調製した標識ＤＮＡとをハイブリダイズさせる第１ステップと、遺伝子マーカーとハイブリダイズさせた標識ＤＮＡの両対立遺伝子の塩基を特定する第２ステップと、特定した標識ＤＮＡの両対立遺伝子の塩基の組み合わせが特定の場合にリスク遺伝子型と判定し、当該リスク遺伝子型の数が３つ以上であれば放射線治療後における泌尿器の晩期有害反応が発症し易いと予測し、２つ以下であれば放射線治療後における泌尿器の晩期有害反応が発症し難いと予測する第３ステップとを含む。本発明によれば、放射線治療後における泌尿器の晩期有害反応となるか否かを予測することが可能となる。
PCT/JP2008/062297 2007-07-06 2008-07-07 放射線治療後における泌尿器の晩期有害反応の発症予測用ｄｎａチップ、及びこれを用いた放射線治療後における泌尿器の晩期有害反応の発症予測方法 WO2009008412A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/452,500 US20100130376A1 (en) 2007-07-06 2008-07-07 Dna chip for prediction of occurrence of late adverse reaction in urinary organ after radiotherapy, and method for prediction of occurrence of late adverse reaction in urinary organ after radio therapy using the same
JP2009522644A JP4974091B2 (ja) 2007-07-06 2008-07-07 放射線治療後における泌尿器の晩期有害反応の発症予測用ｄｎａチップ、及びこれを用いた放射線治療後における泌尿器の晩期有害反応の発症予測方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92966207P 2007-07-06 2007-07-06
US60/929,662 2007-07-06

Publications (1)

Publication Number Publication Date
WO2009008412A1 true WO2009008412A1 (ja) 2009-01-15

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Application Number Title Priority Date Filing Date
PCT/JP2008/062297 WO2009008412A1 (ja) 2007-07-06 2008-07-07 放射線治療後における泌尿器の晩期有害反応の発症予測用ｄｎａチップ、及びこれを用いた放射線治療後における泌尿器の晩期有害反応の発症予測方法

Country Status (3)

Country Link
US (1) US20100130376A1 (ja)
JP (1) JP4974091B2 (ja)
WO (1) WO2009008412A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015128435A (ja) * 2009-10-19 2015-07-16 ロスタクオ・ソシエタ・ペル・アチオニＲＯＳＴＡＱＵＯ Ｓ．ｐ．Ａ． 心血管状態の薬理ゲノミクス治療のための方法およびシステム

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JP2007116905A (ja) * 2005-10-24 2007-05-17 Natl Inst Of Radiological Sciences 放射線治療における副作用発症予測用ポリヌクレオチドおよび放射線治療における副作用発症予測方法

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US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US20020028455A1 (en) * 2000-05-03 2002-03-07 Laibinis Paul E. Methods and reagents for assembling molecules on solid supports
US20040210400A1 (en) * 2003-01-27 2004-10-21 Perlegen Sciences, Inc. Analysis methods for individual genotyping

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JP2007116905A (ja) * 2005-10-24 2007-05-17 Natl Inst Of Radiological Sciences 放射線治療における副作用発症予測用ポリヌクレオチドおよび放射線治療における副作用発症予測方法

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APOSTOLOPOULOS J. ET AL.: "Identification and characterization of a novel family of mammalian ependymin-related proteins (MERPs) in hematopoietic, nonhematopoietic, and malignant tissues", DNA CELL BIOL., vol. 20, 2001, pages 625 - 635 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015128435A (ja) * 2009-10-19 2015-07-16 ロスタクオ・ソシエタ・ペル・アチオニＲＯＳＴＡＱＵＯ Ｓ．ｐ．Ａ． 心血管状態の薬理ゲノミクス治療のための方法およびシステム

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Publication number Publication date
US20100130376A1 (en) 2010-05-27
JPWO2009008412A1 (ja) 2010-09-09
JP4974091B2 (ja) 2012-07-11

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