WO2009007861A1 - Défibrillateur implantable haute fréquence - Google Patents

Défibrillateur implantable haute fréquence Download PDF

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Publication number
WO2009007861A1
WO2009007861A1 PCT/IB2008/051822 IB2008051822W WO2009007861A1 WO 2009007861 A1 WO2009007861 A1 WO 2009007861A1 IB 2008051822 W IB2008051822 W IB 2008051822W WO 2009007861 A1 WO2009007861 A1 WO 2009007861A1
Authority
WO
WIPO (PCT)
Prior art keywords
defibrillator
implantable
stimulation
coil
energy
Prior art date
Application number
PCT/IB2008/051822
Other languages
English (en)
Inventor
Vakeriy Khursenko
Original Assignee
Chamed Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chamed Srl filed Critical Chamed Srl
Priority to EP08776407A priority Critical patent/EP2167190A1/fr
Publication of WO2009007861A1 publication Critical patent/WO2009007861A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/378—Electrical supply
    • A61N1/3787—Electrical supply from an external energy source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39—Heart defibrillators
    • A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39—Heart defibrillators
    • A61N1/3975—Power supply

Definitions

  • the present invention relates to a defibrillator having an internal implantable component and an external coupled component equipped with output radio-frequency (RF) antenna.
  • RF radio-frequency
  • Defibrillator technology is based on that of the pacemaker, which was invented some twenty years before. Precisely on account of the advantages obtained in the field of pacemakers, the defibrillator has been able to evolve with a surprising rapidity from 1980 to the present day. The first implantation of a defibrillator in a human being was performed in 1980. Before then patients affected by arrhythmias were treated with pharmacological therapy, which is able to reduce the incidence of arrhythmic phenomena, but not to interrupt them in the case where they arise.
  • the internal cardiac defibrillator is usually constituted by a generator implanted subcutaneously and by one or more electro-catheters positioned in the cardiac chambers, capable of detecting, interpreting and storing the intrinsic electrical activity of the heart and, if need be, of supplying stimulations (antibradycardial therapy) or electric shocks (antitachycardial therapy).
  • the implantable cardiac defibrillator is the only device capable of recognizing a malignant ventricular tachyarrhythmia and of providing automatically an immediate electrical therapy in patients running the risk of sudden cardiac death.
  • On the basis of the stimulation modalities there may be distinguished single-chamber, dual-chamber, and biventricular (three-chamber) ICDs.
  • Single-chamber devices which were the first to be launched on the market and are still in use, have a single electrode implanted in the right ventricle with functions of stimulation and registration (pacing/sensing) of the activity of a cardiac chamber.
  • Dual-chamber ICDs require the implantation of two electrodes, one in the atrium and one in the ventricle, and enable stimulation, analysis, and classification of both the ventricular rhythm and the atrial rhythm.
  • the presence of an electrocatheter in the right atrium enables more precise classification of the cardiac rhythms and, in some models, also interruption of some forms of supraventricular tachycardia, such as for example atrial flutter.
  • the various models produced by the various manufacturers differ from one another substantially on the basis of programmability, algorithms and parameters of stimulation and of storage of data.
  • Biventricular ICDs unite in a single device a biventricular pacemaker and a defibrillator.
  • the function of biventricular pacemaker is obtained through the insertion of an electrode in the coronary sinus capable of stimulating the left ventricle.
  • an electrode in the coronary sinus capable of stimulating the left ventricle.
  • it enables atrial-ventricular re- synchronization and re-synchronization between the right ventricle and the left ventricle, with an improvement in the contractile function of the heart.
  • These ICDs are indicated in the therapy of congestional cardiac decompensation.
  • the main aim of the present invention is consequently to provide an implantable system of very small dimensions that will enable atrial defibrillation and will be simple to manage by the operator both as regards its encumbrance and as regards its optimized and more immediate functionality.
  • Figure 2 illustrates an external apparatus with RF output antenna.
  • the implantable defibrillator according to the present invention consequently comprises:
  • an implantable RF coil 10 equipped with a circuit 30 for generating the stimulation signal and with a stimulation electrode 20; and - an external apparatus 2 with RF output antenna coupled to the coil 10 for transmission of the desired type of stimulation.
  • the stimulation electrode is directed in the atrium for a low-energy defibrillation, of between 5 and 10 joule.
  • Said coil will receive the energy transmitted by the external apparatus ( Figure 2) reconstructing the modality of low-energy atrial defibrillation.
  • the reception coil 10 is equipped with a stimulation-signal-forming circuit 30, thanks to which said signal is sent to the stimulation electrode 20.
  • the second component is constituted by the external apparatus with RF output antenna 1 that can be coupled with the implanted one ( Figure 1), to which it is possible to transmit the desired type of stimulation.
  • the apparatus may set the functions that are deemed necessary so as to be able to perform interventions of atrial defibrillation.
  • the apparatus can operate either asynchronously or synchronously with the QRS signals detected on the patient.
  • Said apparatus is also equipped with an input for ECG.
  • the present device with the simple implantation of a coil with one stimulation electrode a universal instrument of intervention is obtained that is not perceived by the patient but has a wide application for the cardiologist, who will be able to intervene and defibrillate the atrium in all the cases in which a low-energy atrial defibrillation is able to solve a particular situation.
  • the present RF internal defibrillator hence transfers the possibility of intervention to the external operator, who, by analysing the cardiac activity of a patient, will be able to choose the mode of intervention verifying in real time the outcome of the intervention.

Abstract

La présente invention concerne un défibrillateur ayant un composant interne implantable et un composant externe couplé équipé d'une antenne de sortie haute fréquence (RF). Les fonctions de défibrillation atriale sont obtenues avec une connexion haute fréquence offrant au cardiologue un instrument d'intervention à faible puissance très fonctionnel, qui n'est pas invasif et qui est facile à appliquer.
PCT/IB2008/051822 2007-07-07 2008-05-08 Défibrillateur implantable haute fréquence WO2009007861A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08776407A EP2167190A1 (fr) 2007-07-07 2008-05-08 Défibrillateur implantable haute fréquence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007022063.6 2007-07-07
DE102007022063 2007-07-07

Publications (1)

Publication Number Publication Date
WO2009007861A1 true WO2009007861A1 (fr) 2009-01-15

Family

ID=39768897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/051822 WO2009007861A1 (fr) 2007-07-07 2008-05-08 Défibrillateur implantable haute fréquence

Country Status (3)

Country Link
EP (1) EP2167190A1 (fr)
DE (1) DE202007018529U1 (fr)
WO (1) WO2009007861A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2520332A1 (fr) * 2011-05-05 2012-11-07 Magnetic Pacing Technologies GmbH Dispositif de stimulation implantable pour défribilisation et stimulation
US8321021B2 (en) 2006-01-13 2012-11-27 Universität Duisburg-Essen Stimulation system, in particular a cardiac pacemaker
WO2012147061A3 (fr) * 2011-04-27 2012-12-27 University Of Ulster Défibrillateur et procédé associé
US8399624B1 (en) 2009-06-25 2013-03-19 Esbatech, An Alcon Biomedical Research Unit Llc Acceptor framework for CDR grafting
WO2020025564A1 (fr) 2018-07-31 2020-02-06 Heidelberg Pharma Research Gmbh Anticorps humanisés dirigés contre psma
WO2021255217A1 (fr) 2020-06-19 2021-12-23 Heidelberg Pharma Research Gmbh Amatoxine et conjugués d'amatoxine destinés à être utilisés dans l'inhibition de la réplication de virus à arn
DE102020128677A1 (de) 2020-10-30 2022-05-05 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Körperschaft des öffentlichen Rechts Ein neues Target zur Behandlung der Nierenfibrose
WO2022096604A1 (fr) 2020-11-04 2022-05-12 Heidelberg Pharma Research Gmbh Composition comprenant une combinaison d'un inhibiteur de point de contrôle immunitaire et d'un conjugué anticorps-amatoxine pour une utilisation dans le traitement du cancer
WO2022194988A2 (fr) 2021-03-19 2022-09-22 Heidelberg Pharma Research Gmbh Conjugués d'anticorps d'amatoxine spécifiques de lymphocytes b
WO2023247607A1 (fr) 2022-06-21 2023-12-28 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Fatp2 dans les lymphocytes t en tant que molécule cible pour le traitement de l'arthrite juvénile idiopathique chez les enfants

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2297037A (en) * 1995-01-19 1996-07-24 Vascor Inc Transcutaneous energy and information transmission apparatus
DE19703737A1 (de) * 1997-02-01 1998-08-06 Michael R Dipl Phys Bedrich Implantierbares telemetrisches Reizsystem
US6058328A (en) * 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
US6070590A (en) * 1998-02-12 2000-06-06 Pacesetter, Inc. Method of using electrical energy to produce temporary conduction block for defibrillation and cardioversion
WO2000067843A1 (fr) * 1999-05-06 2000-11-16 Uutech Limited Defibrillation cardiaque

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2297037A (en) * 1995-01-19 1996-07-24 Vascor Inc Transcutaneous energy and information transmission apparatus
US6058328A (en) * 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
DE19703737A1 (de) * 1997-02-01 1998-08-06 Michael R Dipl Phys Bedrich Implantierbares telemetrisches Reizsystem
US6070590A (en) * 1998-02-12 2000-06-06 Pacesetter, Inc. Method of using electrical energy to produce temporary conduction block for defibrillation and cardioversion
WO2000067843A1 (fr) * 1999-05-06 2000-11-16 Uutech Limited Defibrillation cardiaque

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8321021B2 (en) 2006-01-13 2012-11-27 Universität Duisburg-Essen Stimulation system, in particular a cardiac pacemaker
US9403903B2 (en) 2009-06-25 2016-08-02 Esbatech, An Alcon Biomedical Research Unit Llc Acceptor framework for CDR grafting
US8399624B1 (en) 2009-06-25 2013-03-19 Esbatech, An Alcon Biomedical Research Unit Llc Acceptor framework for CDR grafting
US9409979B2 (en) 2009-06-25 2016-08-09 ESTABECH, an Alcon Biomedical Research Unit LLC Acceptor framework for CDR grafting
US8399625B1 (en) 2009-06-25 2013-03-19 ESBATech, an Alcon Biomedical Research Unit, LLC Acceptor framework for CDR grafting
US9994645B2 (en) 2009-06-25 2018-06-12 ESBATech—a Novartis Company LLC Acceptor framework for CDR grafting
US9005924B2 (en) 2009-06-25 2015-04-14 Esbatech Acceptor framework for CDR grafting
US9051366B2 (en) 2009-06-25 2015-06-09 Esbatech Acceptor framework for CDR grafting
WO2012147061A3 (fr) * 2011-04-27 2012-12-27 University Of Ulster Défibrillateur et procédé associé
WO2012150000A3 (fr) * 2011-05-05 2013-08-22 Magnetic Pacing Technologies Gmbh Dispositif de stimulation implantable pour défibrillation et entraînement
EP2520332A1 (fr) * 2011-05-05 2012-11-07 Magnetic Pacing Technologies GmbH Dispositif de stimulation implantable pour défribilisation et stimulation
WO2020025564A1 (fr) 2018-07-31 2020-02-06 Heidelberg Pharma Research Gmbh Anticorps humanisés dirigés contre psma
WO2021255217A1 (fr) 2020-06-19 2021-12-23 Heidelberg Pharma Research Gmbh Amatoxine et conjugués d'amatoxine destinés à être utilisés dans l'inhibition de la réplication de virus à arn
DE102020128677A1 (de) 2020-10-30 2022-05-05 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Körperschaft des öffentlichen Rechts Ein neues Target zur Behandlung der Nierenfibrose
WO2022090434A1 (fr) 2020-10-30 2022-05-05 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Nouvelle cible pour le traitement de la fibrose rénale
WO2022096604A1 (fr) 2020-11-04 2022-05-12 Heidelberg Pharma Research Gmbh Composition comprenant une combinaison d'un inhibiteur de point de contrôle immunitaire et d'un conjugué anticorps-amatoxine pour une utilisation dans le traitement du cancer
WO2022194988A2 (fr) 2021-03-19 2022-09-22 Heidelberg Pharma Research Gmbh Conjugués d'anticorps d'amatoxine spécifiques de lymphocytes b
WO2023247607A1 (fr) 2022-06-21 2023-12-28 Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen Fatp2 dans les lymphocytes t en tant que molécule cible pour le traitement de l'arthrite juvénile idiopathique chez les enfants

Also Published As

Publication number Publication date
EP2167190A1 (fr) 2010-03-31
DE202007018529U1 (de) 2008-12-04

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