WO2009007334A3 - Transdermal therapeutic systems which contain the substance anastrozole - Google Patents

Transdermal therapeutic systems which contain the substance anastrozole Download PDF

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Publication number
WO2009007334A3
WO2009007334A3 PCT/EP2008/058743 EP2008058743W WO2009007334A3 WO 2009007334 A3 WO2009007334 A3 WO 2009007334A3 EP 2008058743 W EP2008058743 W EP 2008058743W WO 2009007334 A3 WO2009007334 A3 WO 2009007334A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
anastrozole
transdermal therapeutic
contain
layer
Prior art date
Application number
PCT/EP2008/058743
Other languages
German (de)
French (fr)
Other versions
WO2009007334A2 (en
Inventor
Christian Braetter
Original Assignee
Christian Braetter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christian Braetter filed Critical Christian Braetter
Priority to EP08774817A priority Critical patent/EP2178523A2/en
Publication of WO2009007334A2 publication Critical patent/WO2009007334A2/en
Publication of WO2009007334A3 publication Critical patent/WO2009007334A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a transdermal therapeutic system (TTS) which comprises a back layer impermeable to the substance, an adhesive layer (layer holding the substance) which contains an adhesive component and the substance anastrozole or the physiologically acceptable hydrate thereof, solvate or salt dissolved in a concentration of 0.1% (m/m) to 30% (m/m), relative to the weight of the adhesive layer, and a removable layer in contact with the skin which is removed before application of the TTS. The invention likewise relates to the use of said TTS.
PCT/EP2008/058743 2007-07-10 2008-07-07 Transdermal therapeutic systems which contain the substance anastrozole WO2009007334A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08774817A EP2178523A2 (en) 2007-07-10 2008-07-07 Transdermal therapeutic systems which contain the substance anastrozole

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200710032468 DE102007032468A1 (en) 2007-07-10 2007-07-10 Transdermal therapeutic systems containing the active substance anastrozole
DE102007032468.7 2007-07-10

Publications (2)

Publication Number Publication Date
WO2009007334A2 WO2009007334A2 (en) 2009-01-15
WO2009007334A3 true WO2009007334A3 (en) 2009-03-12

Family

ID=40121449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/058743 WO2009007334A2 (en) 2007-07-10 2008-07-07 Transdermal therapeutic systems which contain the substance anastrozole

Country Status (3)

Country Link
EP (1) EP2178523A2 (en)
DE (1) DE102007032468A1 (en)
WO (1) WO2009007334A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010046464A1 (en) 2009-03-19 2011-04-21 Amw Gmbh Transdermal system, useful for indicating breast cancer in postmenopausal women, comprises aromatase inhibitor, drug-impermeable skin protective layer, reservoir, optional drug-permeable membrane and a carrier for reservoir or membrane
DE102010026883A1 (en) 2010-03-11 2011-12-15 Amw Gmbh Transdermal system useful e.g. for indication of breast cancer with progesterone-receptor positive status, comprises e.g. aromatase inhibitor, active substance puller protection layer, active substance reservoir
WO2017054151A1 (en) * 2015-09-30 2017-04-06 徐静 Patch for external application containing anastrozole and use thereof
DE102019110398A1 (en) * 2019-04-18 2020-10-22 Amw Gmbh Transdermal delivery system with aromatase inhibitor
DE102019110397A1 (en) * 2019-04-18 2020-10-22 Amw Gmbh Transdermal delivery system with aromatase inhibitor in a supersaturated matrix

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
WO2002017928A2 (en) * 2000-08-30 2002-03-07 Lts Lohman Therapie-Systeme Ag Transdermal therapeutic system for releasing exemestane
CN1927190A (en) * 2006-09-28 2007-03-14 哈尔滨健迪医药技术有限公司 Letrozole transdermal drug administration plaster and its preparation method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE505635C2 (en) 1995-11-28 1997-09-22 Aga Ab Method and apparatus for adding an odorant to a gas piping system
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
EP0943333A1 (en) 1998-03-18 1999-09-22 S.W. Patentverwertungs GmbH Medicament for the prevention and/or treatment of breast cancer comprising an inhibitor of estrogen synthesis
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
AU2001262378A1 (en) * 2000-07-10 2002-02-13 Hormos Medical Corporation Method for treating cryptorchidism
ES2299730T3 (en) * 2002-07-12 2008-06-01 Pantarhei Bioscience B.V. PHARMACEUTICAL COMPOSITION THAT INCLUDES STETROL DERIVATIVES FOR USE IN CANCER THERAPY.
US20060189670A1 (en) * 2005-02-22 2006-08-24 Glenmark Pharmaceuticals Limited Process for the preparation of anastrozole and intermediates thereof
US20090215731A1 (en) * 2005-10-19 2009-08-27 Chavah Pty Ltd. Reduction of Side Effects From Aromatase Inhibitors Used for Treating Breast Cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
WO2002017928A2 (en) * 2000-08-30 2002-03-07 Lts Lohman Therapie-Systeme Ag Transdermal therapeutic system for releasing exemestane
CN1927190A (en) * 2006-09-28 2007-03-14 哈尔滨健迪医药技术有限公司 Letrozole transdermal drug administration plaster and its preparation method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUZDAR AMAN U; ROBERTSON JOHN F R; EIERMANN WOLFGANG; NABHOLTZ JEAN-MARC: "An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.", CANCER, vol. 95, no. 9, 1 November 2002 (2002-11-01), United States, pages 2006 - 2016, XP002510617 *
DATABASE EPODOC EUROPEAN PATENT OFFICE, THE HAGUE, NL; XP002510618 *
SIPE ET AL: "A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins", FERTILITY AND STERILITY, ELSEVIER SCIENCE INC, NEW YORK, NY, US, vol. 86, no. 6, 22 November 2006 (2006-11-22), pages 1676 - 1681, XP005776229, ISSN: 0015-0282 *

Also Published As

Publication number Publication date
DE102007032468A1 (en) 2009-01-15
EP2178523A2 (en) 2010-04-28
WO2009007334A2 (en) 2009-01-15

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