WO2008153042A1 - 抗腫瘍剤 - Google Patents

抗腫瘍剤 Download PDF

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Publication number
WO2008153042A1
WO2008153042A1 PCT/JP2008/060651 JP2008060651W WO2008153042A1 WO 2008153042 A1 WO2008153042 A1 WO 2008153042A1 JP 2008060651 W JP2008060651 W JP 2008060651W WO 2008153042 A1 WO2008153042 A1 WO 2008153042A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituent
hydrogen atom
tumor agent
aryl
prodrug
Prior art date
Application number
PCT/JP2008/060651
Other languages
English (en)
French (fr)
Inventor
Shinji Nara
Yuuki Hirata
Toshikazu Saitoh
Kazuhiko Kato
Kimihisa Ueno
Ryuichiro Nakai
Asae Igarashi
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of WO2008153042A1 publication Critical patent/WO2008153042A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

式（I） ［式中、R1は置換基を有していてもよいアリール等を表し、 R2はシアノ等を表し、R3は水素原子を表し、R4は水素原子、置換基を有していてもよい低級アルカノイル等を表し、R5は置換基を有していてもよいアリールまたは置換基を有していてもよい芳香族複素環基を表し、Xは-NR9-（式中、R9は水素原子、置換基を有していてもよい低級アルキルまたは置換基を有していてもよい低級アルコキシカルボニルを表す）または-S(O)n-（式中、nは0から2の整数を表す）を表す］で表されるピラゾール誘導体もしくはそのプロドラッグまたはその薬学的に許容される塩を有効成分として含有する抗腫瘍剤等を提供する。
PCT/JP2008/060651 2007-06-11 2008-06-11 抗腫瘍剤 WO2008153042A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007153800 2007-06-11
JP2007-153800 2007-06-11

Publications (1)

Publication Number Publication Date
WO2008153042A1 true WO2008153042A1 (ja) 2008-12-18

Family

ID=40129647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060651 WO2008153042A1 (ja) 2007-06-11 2008-06-11 抗腫瘍剤

Country Status (2)

Country Link
TW (1) TW200911240A (ja)
WO (1) WO2008153042A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529891A (ja) * 2008-07-31 2011-12-15 メルク・シャープ・エンド・ドーム・コーポレイション Ｊａｎｕｓキナーゼの阻害剤
EP2467142A2 (en) * 2009-08-17 2012-06-27 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
WO2014053450A1 (de) 2012-10-02 2014-04-10 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2015031036A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
WO2015041887A2 (en) 2013-09-18 2015-03-26 Milliken & Company Laundry care composition comprising carboxylate dye
WO2015042086A1 (en) 2013-09-18 2015-03-26 The Procter & Gamble Company Laundry care composition comprising carboxylate dye
WO2015150300A1 (de) 2014-04-02 2015-10-08 Bayer Cropscience Ag N-(1-(hetero)aryl-1h-pyrazol-4-yl)-(hetero)arylamid-derivate und ihre verwendung als schädlingsbekämpfungsmittel
JP2016037462A (ja) * 2014-08-07 2016-03-22 長谷川香料株式会社 ソラノンの製造方法およびその合成中間体
US9878987B2 (en) 2014-05-13 2018-01-30 Memorial Sloan Kettering Cancer Center HSP70 modulators and methods for making and using the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD267044A1 (de) * 1987-12-01 1989-04-19 Univ Rostock Verfahren zur herstellung von pyrazolderivaten
JPH0348243A (ja) * 1989-07-17 1991-03-01 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
JPH11514991A (ja) * 1995-09-29 1999-12-21 ジー．ディー．サール アンド カンパニー 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物
JP2000509035A (ja) * 1996-04-24 2000-07-18 セルテック セラピューティックス リミテッド プロテインチロシンキナーゼｐ５６ｉｃｋの選択的インヒビターとして有用な５―アミノピラゾール化合物
JP2002502380A (ja) * 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼ阻害剤としてのピラゾール誘導体
JP2003500401A (ja) * 1999-05-19 2003-01-07 ファイザー・プロダクツ・インク 抗がん剤として有用な複素環式誘導体
JP2006505512A (ja) * 2002-07-24 2006-02-16 キューエルティー インコーポレーティッド ピラゾリルベンゾチアゾール誘導体および治療薬としてのそれらの使用法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD267044A1 (de) * 1987-12-01 1989-04-19 Univ Rostock Verfahren zur herstellung von pyrazolderivaten
JPH0348243A (ja) * 1989-07-17 1991-03-01 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
JPH11514991A (ja) * 1995-09-29 1999-12-21 ジー．ディー．サール アンド カンパニー 動物医療で使用するための置換ピラゾリルベンゼンスルホンアミド化合物
JP2000509035A (ja) * 1996-04-24 2000-07-18 セルテック セラピューティックス リミテッド プロテインチロシンキナーゼｐ５６ｉｃｋの選択的インヒビターとして有用な５―アミノピラゾール化合物
JP2002502380A (ja) * 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼ阻害剤としてのピラゾール誘導体
JP2003500401A (ja) * 1999-05-19 2003-01-07 ファイザー・プロダクツ・インク 抗がん剤として有用な複素環式誘導体
JP2006505512A (ja) * 2002-07-24 2006-02-16 キューエルティー インコーポレーティッド ピラゾリルベンゾチアゾール誘導体および治療薬としてのそれらの使用法

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* Cited by examiner, † Cited by third party
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ELGEMEIE G.H. ET AL.: "Synthesis of benzimidazole ketene N,S-acetals and their reactions with nucleophiles", SYNTHETIC COMMUNICATIONS, vol. 33, no. 4, 2003, pages 555 - 562 *
FATHALLA O.A. ET AL.: "Facile synthesis of fused pyrazolo[1,5-a]pyridimines, pyrazolo[1,5-a]triazines, and N-sulphonamidopyrazoles as antiinflammatory", ACTA POLONIAE PHARMACEUTICA, vol. 60, no. 1, 2003, pages 51 - 60 *
KLUGE R. ET AL.: "Free radical reactions of N-heterocyclic compounds. XIV. Oxidative cyclization of anilinopyrazoles to pyrazolo[1,5-a]benzimidazoles", CHEMISCHE BERICHTE, vol. 127, no. 9, 1994, pages 1729 - 1733 *
PERUMAL R. ET AL.: "Synthesis of 3-substituted N-substituted phenyl pyrazolo[3,4-d]pyrimidin-4-ones as antimicrobial agents", INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15, no. 4, 2006, pages 413 - 414, XP008096899 *
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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011529891A (ja) * 2008-07-31 2011-12-15 メルク・シャープ・エンド・ドーム・コーポレイション Ｊａｎｕｓキナーゼの阻害剤
US10052325B2 (en) 2009-08-17 2018-08-21 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
EP3205647A3 (en) * 2009-08-17 2017-09-27 Memorial Sloan-Kettering Cancer Center 2-(pyrimidin-5-yl)-thiopyrimidine derivatives as hsp70 and hsc70 modulators for the treatment of proliferative disorders
US10758538B2 (en) 2009-08-17 2020-09-01 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
EP2467142A2 (en) * 2009-08-17 2012-06-27 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
US9567318B2 (en) 2009-08-17 2017-02-14 Memorial Sloan-Kettering Cancer Center Substituted pyrimidine compounds and uses thereof
EP2467142A4 (en) * 2009-08-17 2013-03-06 Sloan Kettering Inst Cancer THERMAL SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING AND USING SAME
WO2014053450A1 (de) 2012-10-02 2014-04-10 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2015031036A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
US9884865B2 (en) 2013-08-26 2018-02-06 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
US11180502B2 (en) 2013-08-26 2021-11-23 Purdue Pharma L.P. Azaspiro[4.5]decane derivatives and use thereof
JP2019031531A (ja) * 2013-08-26 2019-02-28 パーデュー、ファーマ、リミテッド、パートナーシップ アザスピロ［４．５］デカン誘導体及びその使用
CN105612152A (zh) * 2013-08-26 2016-05-25 普渡制药公司 氮杂螺[4.5]癸烷衍生物及其用途
WO2015041887A2 (en) 2013-09-18 2015-03-26 Milliken & Company Laundry care composition comprising carboxylate dye
EP3339377A1 (en) 2013-09-18 2018-06-27 Milliken & Company Laundry care composition comprising carboxylate dye
WO2015042086A1 (en) 2013-09-18 2015-03-26 The Procter & Gamble Company Laundry care composition comprising carboxylate dye
EP4047058A1 (en) 2013-09-18 2022-08-24 Milliken & Company Laundry care composition comprising a carboxylate dye
WO2015150300A1 (de) 2014-04-02 2015-10-08 Bayer Cropscience Ag N-(1-(hetero)aryl-1h-pyrazol-4-yl)-(hetero)arylamid-derivate und ihre verwendung als schädlingsbekämpfungsmittel
US10160729B2 (en) 2014-05-13 2018-12-25 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same
US10647683B2 (en) 2014-05-13 2020-05-12 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same
US9878987B2 (en) 2014-05-13 2018-01-30 Memorial Sloan Kettering Cancer Center HSP70 modulators and methods for making and using the same
JP2016037462A (ja) * 2014-08-07 2016-03-22 長谷川香料株式会社 ソラノンの製造方法およびその合成中間体

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