WO2008152654A1 - Protéines hybrides du charbon, compositions et leurs applications - Google Patents
Protéines hybrides du charbon, compositions et leurs applications Download PDFInfo
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- WO2008152654A1 WO2008152654A1 PCT/IN2008/000368 IN2008000368W WO2008152654A1 WO 2008152654 A1 WO2008152654 A1 WO 2008152654A1 IN 2008000368 W IN2008000368 W IN 2008000368W WO 2008152654 A1 WO2008152654 A1 WO 2008152654A1
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- protein
- anthrax
- fusion proteins
- recombinant fusion
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- 230000009851 immunogenic response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
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- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Abstract
La présente invention concerne des protéines hybrides recombinées du charbon, des procédés destinés à la préparation de ces protéines et des compositions contenant ces protéines. Plus précisément, les protéines hybrides recombinées de la présente invention comprennent la protéine du facteur oedème (EF), de préférence une protéine du facteur oedème (EF) native ou une protéine du facteur oedème (EFm) mutée ou une protéine du facteur oedème (EFn) tronquée ou, mieux encore, une protéine du facteur oedème (EFn) tronquée et la protéine du facteur létal (LF), de préférence une protéine du facteur létal (LF) native ou une protéine du facteur létal (LFm) mutée ou une protéine du facteur létal (LFn) tronquée ou, mieux encore, une protéine du facteur létal (LFn) tronquée, éventuellement avec un lieur. L'invention concerne également des acides nucléiques codant pour les protéines hybrides de la présente invention. La présente invention concerne également une composition contre une infection par B. anthracis, comprenant la protéine hybride recombinée du charbon mélangée à un antigène protecteur (PA) natif ou adulte ou muté, et éventuellement à un ou plusieurs adjuvants, pouvant être utile comme vaccin thérapeutique et/ou préventif contre le charbon, avant ou après une exposition à la bactérie.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1251DE2007 | 2007-06-11 | ||
| IN1251/DEL/2007 | 2007-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2008152654A1 true WO2008152654A1 (fr) | 2008-12-18 |
Family
ID=40129293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2008/000368 WO2008152654A1 (fr) | 2007-06-11 | 2008-06-11 | Protéines hybrides du charbon, compositions et leurs applications |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2008152654A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520717A (zh) * | 2013-09-02 | 2014-01-22 | 中山大学 | 丙氨酸作为疫苗佐剂的应用 |
| US9616117B2 (en) | 2008-10-02 | 2017-04-11 | Pharmathene, Inc. | Anthrax vaccine formulation and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003048390A1 (fr) * | 2001-12-05 | 2003-06-12 | Rakesh Bhatnagar | Procede de preparation d'un vaccin non toxique contre l'anthrax |
| US20040028695A1 (en) * | 2002-04-12 | 2004-02-12 | Sukjoon Park | Recombinant immunogenic compositions and methods for protecting against lethal infections from Bacillus anthracis |
| WO2008048344A2 (fr) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Antigènes de bacillus anthracis, compositions pour vaccins et procédés connexes |
-
2008
- 2008-06-11 WO PCT/IN2008/000368 patent/WO2008152654A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003048390A1 (fr) * | 2001-12-05 | 2003-06-12 | Rakesh Bhatnagar | Procede de preparation d'un vaccin non toxique contre l'anthrax |
| US20040028695A1 (en) * | 2002-04-12 | 2004-02-12 | Sukjoon Park | Recombinant immunogenic compositions and methods for protecting against lethal infections from Bacillus anthracis |
| WO2008048344A2 (fr) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Antigènes de bacillus anthracis, compositions pour vaccins et procédés connexes |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9616117B2 (en) | 2008-10-02 | 2017-04-11 | Pharmathene, Inc. | Anthrax vaccine formulation and uses thereof |
| CN103520717A (zh) * | 2013-09-02 | 2014-01-22 | 中山大学 | 丙氨酸作为疫苗佐剂的应用 |
| CN103520717B (zh) * | 2013-09-02 | 2015-11-18 | 中山大学 | 丙氨酸作为疫苗佐剂的应用 |
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