WO2008145074A3 - Secuencias de ácido nucleico y aminoácidos, y vacuna para el control de infestaciones por ectoparásitos en peces - Google Patents

Secuencias de ácido nucleico y aminoácidos, y vacuna para el control de infestaciones por ectoparásitos en peces Download PDF

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Publication number
WO2008145074A3
WO2008145074A3 PCT/CU2008/000003 CU2008000003W WO2008145074A3 WO 2008145074 A3 WO2008145074 A3 WO 2008145074A3 CU 2008000003 W CU2008000003 W CU 2008000003W WO 2008145074 A3 WO2008145074 A3 WO 2008145074A3
Authority
WO
WIPO (PCT)
Prior art keywords
fish
vaccine
amino acid
nucleic acid
acid sequences
Prior art date
Application number
PCT/CU2008/000003
Other languages
English (en)
French (fr)
Other versions
WO2008145074A2 (es
Inventor
Gonzalez Yamila Carpio
Garcia Mario Pablo Estrada
Original Assignee
Ct Ingenieria Genetica Biotech
Gonzalez Yamila Carpio
Garcia Mario Pablo Estrada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech, Gonzalez Yamila Carpio, Garcia Mario Pablo Estrada filed Critical Ct Ingenieria Genetica Biotech
Priority to US12/601,974 priority Critical patent/US9034338B2/en
Priority to EP08757900.9A priority patent/EP2168978B1/en
Priority to DK08757900.9T priority patent/DK2168978T3/da
Priority to CA2688587A priority patent/CA2688587C/en
Publication of WO2008145074A2 publication Critical patent/WO2008145074A2/es
Publication of WO2008145074A3 publication Critical patent/WO2008145074A3/es
Priority to US13/859,314 priority patent/US9034339B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención está relacionada con el aislamiento y clonaje de un gen, la obtención por vía recombinante de Ia proteína para Ia cual codifica, y el empleo de dicho antígeno en una preparación vacunal como proteína purificada y/o ADN desnudo, para inducir respuesta inmune en organismos acuáticos contra las diferentes especies de ectoparásitos, entre ellos los conocidos por piojos de mar, y los patógenos asociados a estas infestaciones. Las preparaciones vacunales, administradas por vía oral, por baños de inmersión o por inyección, demostraron su efectividad al producir respuesta inmune humoral de tipo IgM, y disminuir el número de parásitos por pez en los peces vacunados.
PCT/CU2008/000003 2007-05-31 2008-05-30 Secuencias de ácido nucleico y aminoácidos, y vacuna para el control de infestaciones por ectoparásitos en peces WO2008145074A2 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/601,974 US9034338B2 (en) 2007-05-31 2008-05-30 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish
EP08757900.9A EP2168978B1 (en) 2007-05-31 2008-05-30 Amino acid and nucleic acid sequences and vaccine to control ectoparasite infestations in fish
DK08757900.9T DK2168978T3 (da) 2007-05-31 2008-05-30 Aminosyre- og nukleinsyresekvenser og vaccine til bekæmpelse af ektoparasitinfestationer hos fisk
CA2688587A CA2688587C (en) 2007-05-31 2008-05-30 My32 nucleic acid and amino acid sequences, and vaccine to control sea lice infestations in fish
US13/859,314 US9034339B2 (en) 2007-05-31 2013-04-09 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU20070124A CU23634A1 (es) 2007-05-31 2007-05-31 Secuencias de ácido nucleico y aminoácidos, y vacuna para el control de infestaciones por ectoparásitos en peces
CU2007-0124 2007-05-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/601,974 A-371-Of-International US9034338B2 (en) 2007-05-31 2008-05-30 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish
US13/859,314 Continuation-In-Part US9034339B2 (en) 2007-05-31 2013-04-09 Nucleic acid and amino acid sequences, and vaccine for the control of ectoparasite infestations in fish

Publications (2)

Publication Number Publication Date
WO2008145074A2 WO2008145074A2 (es) 2008-12-04
WO2008145074A3 true WO2008145074A3 (es) 2009-01-29

Family

ID=39736946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2008/000003 WO2008145074A2 (es) 2007-05-31 2008-05-30 Secuencias de ácido nucleico y aminoácidos, y vacuna para el control de infestaciones por ectoparásitos en peces

Country Status (8)

Country Link
US (2) US9034338B2 (es)
EP (2) EP2168978B1 (es)
CA (1) CA2688587C (es)
CL (1) CL2008001596A1 (es)
CU (1) CU23634A1 (es)
DK (1) DK2168978T3 (es)
TR (1) TR201909448T4 (es)
WO (1) WO2008145074A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23919B1 (es) * 2010-09-28 2013-07-31 Ct De Ingeniería Genética Y Biotecnología Composición vacunal para el control de las infestaciones por ectoparásitos
CA3033759C (en) * 2016-08-17 2022-06-14 Pharmaq As Sea lice vaccine
GB201902425D0 (en) * 2019-02-22 2019-04-10 Benchmark Animal Health Ltd Sea lice antigens and vaccines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006010265A1 (en) * 2004-07-28 2006-02-02 National Research Council Of Canada Recombinant vaccines against caligid copepods (sea lice) and antigen sequences thereof
US20060234905A1 (en) * 2002-01-24 2006-10-19 Estrada Garcia Mario P Method of stimulating growth and resistance to diseases of aquatic organisms
WO2006127322A2 (en) * 2005-05-26 2006-11-30 Eli Lilly And Company Improved fish production
WO2007039599A1 (en) * 2005-10-05 2007-04-12 Intervet International B.V. Novel sea lice vaccine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438200B1 (en) 1990-01-16 2002-07-17 Centro De Ingenieria Genetica Y Biotecnologia Method for the expression of heterologous genes in the yeast Pichia pastoris, expression vectors and transformed microorganisms

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234905A1 (en) * 2002-01-24 2006-10-19 Estrada Garcia Mario P Method of stimulating growth and resistance to diseases of aquatic organisms
WO2006010265A1 (en) * 2004-07-28 2006-02-02 National Research Council Of Canada Recombinant vaccines against caligid copepods (sea lice) and antigen sequences thereof
WO2006127322A2 (en) * 2005-05-26 2006-11-30 Eli Lilly And Company Improved fish production
WO2007039599A1 (en) * 2005-10-05 2007-04-12 Intervet International B.V. Novel sea lice vaccine

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALMAZAN C ET AL: "Characterization of three Ixodes scapularis cDNAs protective against tick infestations", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 23, no. 35, 15 August 2005 (2005-08-15), pages 4403 - 4416, XP004973242, ISSN: 0264-410X *
DATABASE UniProt [online] 19 July 2005 (2005-07-19), "SubName: Full=Chromosome 14 SCAF15003, whole genome shotgun sequence.; Flags: Fragment;", XP002504096, retrieved from EBI accession no. UNIPROT:Q4RQX3 Database accession no. Q4RQX3 *
GONZALEZ LAURA ET AL: "Life cycle of Caligus rogercresseyi, (Copepoda: Caligidae) parasite of Chilean reared salmonids.", AQUACULTURE, vol. 220, no. 1-4, 14 April 2003 (2003-04-14), pages 101 - 117, XP002504095, ISSN: 0044-8486 *
JAILLON O ET AL: "GENOME DUPLICATION IN THE TELEOST FISH TETRAODON NIGROVIRIDIS REVEALS THE EARLY VERTEBRATE PROTO-KARYOTYPE", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 431, 21 October 2004 (2004-10-21), pages 946 - 957, XP008040820, ISSN: 0028-0836 *
JOSÉ DE LA FUENTE ET AL: "RNA interference screening in ticks for identification of protective antigens", PARASITOLOGY RESEARCH ; FOUNDED AS ZEITSCHRIFT FÜR PARASITENKUNDE, SPRINGER, BERLIN, DE, vol. 96, no. 3, 1 June 2005 (2005-06-01), pages 137 - 141, XP019345609, ISSN: 1432-1955 *
KVAMME B O ET AL: "The cloning and characterisation of full-length trypsins from the salmon louse Lepeophtheirus salmonis", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 136, no. 2, 1 August 2004 (2004-08-01), pages 303 - 307, XP004582678, ISSN: 0166-6851 *
LABUS MARIE B ET AL: "IDENTIFICATION AND EXPRESSION OF ANTIGENS FROM LEPEOPHTHEIRUS SALMONIS FOR USE IN VACCINATION TRIALS", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 24, no. 2, 18 December 1995 (1995-12-18), pages 254S, XP009078712, ISSN: 0300-5127 *
RAYNARD R S ET AL: "Development of a vaccine for the control of sea lice (Lepeophtheirus salmonis and caligus elongatus) in atlantic salmon (salmo salar)", ICES COUNCIL MEETING PAPERS, XX, XX, vol. 22, no. 30, 1 September 1994 (1994-09-01), pages 1 - 6, XP008090049 *
RAYNARD ROBERT S ET AL: "Development of vaccines against sea lice", PEST MANAGEMENT SCIENCE, WILEY & SONS, BOGNOR REGIS, GB, vol. 58, no. 6, 1 June 2002 (2002-06-01), pages 569 - 575, XP002419573, ISSN: 1526-498X *

Also Published As

Publication number Publication date
TR201909448T4 (tr) 2019-07-22
EP2168978A2 (en) 2010-03-31
US9034339B2 (en) 2015-05-19
WO2008145074A2 (es) 2008-12-04
US20130280290A1 (en) 2013-10-24
CA2688587A1 (en) 2008-12-04
DK2168978T3 (da) 2019-07-15
CU23634A1 (es) 2011-02-24
EP3263594A1 (en) 2018-01-03
CA2688587C (en) 2019-05-07
EP2168978B1 (en) 2019-05-01
US9034338B2 (en) 2015-05-19
CL2008001596A1 (es) 2009-09-25
US20100221271A1 (en) 2010-09-02

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