WO2008139539A1 - バラシクロビルの製造方法 - Google Patents

バラシクロビルの製造方法 Download PDF

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Publication number
WO2008139539A1
WO2008139539A1 PCT/JP2007/059261 JP2007059261W WO2008139539A1 WO 2008139539 A1 WO2008139539 A1 WO 2008139539A1 JP 2007059261 W JP2007059261 W JP 2007059261W WO 2008139539 A1 WO2008139539 A1 WO 2008139539A1
Authority
WO
WIPO (PCT)
Prior art keywords
valacyclovir
represented
formula
protected
alkyl group
Prior art date
Application number
PCT/JP2007/059261
Other languages
English (en)
French (fr)
Inventor
Satoji Takahashi
Tatsuya Ishikawa
Hirofumi Okuno
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to PCT/JP2007/059261 priority Critical patent/WO2008139539A1/ja
Priority to JP2009513882A priority patent/JP5152180B2/ja
Publication of WO2008139539A1 publication Critical patent/WO2008139539A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Abstract

　化学的及び光学的に高純度のバラシクロビルを効率的に得ることのできる製造方法を提供する。 　式（２）で表されるアシクロビルと、式（１）（式中、Ｒ１はアルキル基、アリール基又はアルコキシル基を示し、Ｒ２は水素原子又はアルキル基を示し、Ｒ３はアルキル基を示す。）で表されるＮ－保護バリンの有機アミン塩を、又は該Ｎ－保護バリンのアルカリ金属塩もしくはアルカリ土類金属塩を中和し、縮合剤存在下に縮合反応させ、式（３）で表されるＮ－保護バラシクロビルを得、次いで脱保護することを含む、式（４）で表されるバラシクロビル又はその塩の製造方法。 （式中の各記号は、明細書中と同義を示す。）
PCT/JP2007/059261 2007-04-27 2007-04-27 バラシクロビルの製造方法 WO2008139539A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2007/059261 WO2008139539A1 (ja) 2007-04-27 2007-04-27 バラシクロビルの製造方法
JP2009513882A JP5152180B2 (ja) 2007-04-27 2007-04-27 バラシクロビルの製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/059261 WO2008139539A1 (ja) 2007-04-27 2007-04-27 バラシクロビルの製造方法

Publications (1)

Publication Number Publication Date
WO2008139539A1 true WO2008139539A1 (ja) 2008-11-20

Family

ID=40001775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/059261 WO2008139539A1 (ja) 2007-04-27 2007-04-27 バラシクロビルの製造方法

Country Status (2)

Country Link
JP (1) JP5152180B2 (ja)
WO (1) WO2008139539A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787027A (zh) * 2010-03-19 2010-07-28 常州康丽制药有限公司 高纯度cbz-伐昔洛韦的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04108768A (ja) * 1990-08-30 1992-04-09 Kyowa Hakko Kogyo Co Ltd アミノ酸エステルの製造法
WO1998003553A1 (en) * 1996-07-18 1998-01-29 Industriale Chimica S.R.L. Process of preparation of valacyclovir and relevant intermediates
JPH10195075A (ja) * 1997-01-17 1998-07-28 Ajinomoto Co Inc Ｚ−バラシクロビルの製造方法
JP2005508993A (ja) * 2001-11-14 2005-04-07 テバ ファーマシューティカル インダストリーズ リミティド バラシクロビルの合成及び精製

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04108768A (ja) * 1990-08-30 1992-04-09 Kyowa Hakko Kogyo Co Ltd アミノ酸エステルの製造法
WO1998003553A1 (en) * 1996-07-18 1998-01-29 Industriale Chimica S.R.L. Process of preparation of valacyclovir and relevant intermediates
JPH10195075A (ja) * 1997-01-17 1998-07-28 Ajinomoto Co Inc Ｚ−バラシクロビルの製造方法
JP2005508993A (ja) * 2001-11-14 2005-04-07 テバ ファーマシューティカル インダストリーズ リミティド バラシクロビルの合成及び精製

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BALOG A. ET AL.: "Peptides. XV. The use of beta-dicarbonyl N-protected asparagine and glutamine in peptide synthesis", REVUE ROUMAINE DE CHIMIE, vol. 19, no. 4, 1974, pages 689 - 699, XP003024079 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101787027A (zh) * 2010-03-19 2010-07-28 常州康丽制药有限公司 高纯度cbz-伐昔洛韦的制备方法
CN101787027B (zh) * 2010-03-19 2011-12-14 常州康丽制药有限公司 高纯度cbz-伐昔洛韦的制备方法

Also Published As

Publication number Publication date
JP5152180B2 (ja) 2013-02-27
JPWO2008139539A1 (ja) 2010-07-29

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