WO2008131858A3 - Verwendung acyclisch substituierter furopyrimidin-derivate zur behandlung der pulmonalen arteriellen hypertonie - Google Patents

Verwendung acyclisch substituierter furopyrimidin-derivate zur behandlung der pulmonalen arteriellen hypertonie Download PDF

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Publication number
WO2008131858A3
WO2008131858A3 PCT/EP2008/003007 EP2008003007W WO2008131858A3 WO 2008131858 A3 WO2008131858 A3 WO 2008131858A3 EP 2008003007 W EP2008003007 W EP 2008003007W WO 2008131858 A3 WO2008131858 A3 WO 2008131858A3
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WO
WIPO (PCT)
Prior art keywords
pulmonary arterial
hypertonia
treating pulmonary
derivatives
acyclically
Prior art date
Application number
PCT/EP2008/003007
Other languages
English (en)
French (fr)
Other versions
WO2008131858A2 (de
Inventor
Thomas Lampe
Eva-Maria Becker
Raimund Kast
Hartmut Beck
Mario Jeske
Joachim Schuhmacher
Friederike Stoll
Martina Klein
Metin Akbaba
Andreas Knorr
Johannes-Peter Stasch
Lars Baerfacker
Alexander Hillisch
Gunter Karig
Mark Meininghaus
Karl-Heinz Schlemmer
Rudolf Schohe-Loop
Original Assignee
Bayer Schering Pharma Ag
Thomas Lampe
Eva-Maria Becker
Raimund Kast
Hartmut Beck
Mario Jeske
Joachim Schuhmacher
Friederike Stoll
Martina Klein
Metin Akbaba
Andreas Knorr
Johannes-Peter Stasch
Lars Baerfacker
Alexander Hillisch
Gunter Karig
Mark Meininghaus
Karl-Heinz Schlemmer
Rudolf Schohe-Loop
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Thomas Lampe, Eva-Maria Becker, Raimund Kast, Hartmut Beck, Mario Jeske, Joachim Schuhmacher, Friederike Stoll, Martina Klein, Metin Akbaba, Andreas Knorr, Johannes-Peter Stasch, Lars Baerfacker, Alexander Hillisch, Gunter Karig, Mark Meininghaus, Karl-Heinz Schlemmer, Rudolf Schohe-Loop filed Critical Bayer Schering Pharma Ag
Priority to CA002685128A priority Critical patent/CA2685128A1/en
Publication of WO2008131858A2 publication Critical patent/WO2008131858A2/de
Publication of WO2008131858A3 publication Critical patent/WO2008131858A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Anmeldung betrifft die Verwendung von acyclisch substituierten Furopyrimidin- Derivaten der Formel (I) zur Behandlung und/oder Prophylaxe der pulmonalen arteriellen Hypertonie und anderer Formen der pulmonalen Hypertonie sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe der pulmonalen arteriellen Hypertonie und anderer Formen der pulmonalen Hypertonie.
PCT/EP2008/003007 2007-04-26 2008-04-16 Verwendung acyclisch substituierter furopyrimidin-derivate zur behandlung der pulmonalen arteriellen hypertonie WO2008131858A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002685128A CA2685128A1 (en) 2007-04-26 2008-04-16 Use of acyclically substituted furopyrimidine derivatives for treating pulmonary arterial hypertonia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007019691A DE102007019691A1 (de) 2007-04-26 2007-04-26 Verwendung von acyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie
DE102007019691.3 2007-04-26

Publications (2)

Publication Number Publication Date
WO2008131858A2 WO2008131858A2 (de) 2008-11-06
WO2008131858A3 true WO2008131858A3 (de) 2009-07-16

Family

ID=39777459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/003007 WO2008131858A2 (de) 2007-04-26 2008-04-16 Verwendung acyclisch substituierter furopyrimidin-derivate zur behandlung der pulmonalen arteriellen hypertonie

Country Status (3)

Country Link
CA (1) CA2685128A1 (de)
DE (1) DE102007019691A1 (de)
WO (1) WO2008131858A2 (de)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1817146A1 (de) * 1968-01-05 1969-11-27 Pfizer & Co C 4-Aminofuro[2,3-d]pyrimidine und deren Verwendung als Relaxantien fuer glatte Muskeln
EP1018514A1 (de) * 1998-07-22 2000-07-12 Suntory Limited Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten
WO2000075145A1 (en) * 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
EP1132093A1 (de) * 1999-09-17 2001-09-12 Suntory Limited Vorbeugungsmittel oder heilmittel gegen myokarditis, dilatierte kardiomyopathie und herzinsuffiziens, die nf-kappa b inhibitoren als aktiven bestandteil enthalten
WO2002092603A1 (en) * 2001-05-14 2002-11-21 Novartis Ag Oxazolo-and furopyrimidines and their use in medicaments against tumors
WO2003022852A2 (en) * 2001-09-11 2003-03-20 Smithkline Beecham Corporation Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
WO2005092896A1 (en) * 2004-03-12 2005-10-06 Korea Institute Of Science And Technology Compound for inhibiting tyrosine kinase activity of ddr2 protein
WO2005121149A1 (en) * 2004-06-10 2005-12-22 Xention Discovery Limited Furanopyrimidine compounds effective as potassium channel inhibitors
WO2006004658A2 (en) * 2004-06-29 2006-01-12 Amgen Inc. Furanopyrimidines
WO2007079862A1 (de) * 2005-12-21 2007-07-19 Bayer Healthcare Ag Neue, acyclisch substituierte furopyrimidin-derivate und ihre verwendung zur behandlung von kardiovaskulären erkrankungen

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10141212A1 (de) 2001-08-22 2003-03-06 Bayer Ag Neue 4-Aminofuropyrimidine und ihre Verwendung
JP4486817B2 (ja) 2001-12-20 2010-06-23 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト １，４−ジヒドロ−１，４−ジフェニルピリジン誘導体
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
GB0219896D0 (en) 2002-08-27 2002-10-02 Bayer Ag Dihydropyridine derivatives
AU2003293356A1 (en) 2002-08-27 2004-03-19 Bayer Healthcare Ag Dihydropyridinone derivatives as hne inhibitors
EP1546113B1 (de) 2002-09-10 2013-05-01 Bayer Intellectual Property GmbH Pyrimidinonderivate als therapeutische mittel gegen aktute und chronische entzündliche, ischämische und verändernde prozesse
EP1539710B1 (de) 2002-09-10 2010-10-27 Bayer Schering Pharma Aktiengesellschaft Heterocyclische derivate
ATE516285T1 (de) 2004-02-19 2011-07-15 Bayer Schering Pharma Ag Dihydropyridinonderivate
ES2428503T3 (es) 2004-02-26 2013-11-08 Bayer Intellectual Property Gmbh 1,4-Diaril-dihidropirimidin-2-onas y su uso como inhibidores de elastasa de neutrófilos humanos
CA2557271C (en) 2004-02-26 2012-08-21 Bayer Healthcare Ag 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1817146A1 (de) * 1968-01-05 1969-11-27 Pfizer & Co C 4-Aminofuro[2,3-d]pyrimidine und deren Verwendung als Relaxantien fuer glatte Muskeln
EP1018514A1 (de) * 1998-07-22 2000-07-12 Suntory Limited Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten
WO2000075145A1 (en) * 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
EP1132093A1 (de) * 1999-09-17 2001-09-12 Suntory Limited Vorbeugungsmittel oder heilmittel gegen myokarditis, dilatierte kardiomyopathie und herzinsuffiziens, die nf-kappa b inhibitoren als aktiven bestandteil enthalten
WO2002092603A1 (en) * 2001-05-14 2002-11-21 Novartis Ag Oxazolo-and furopyrimidines and their use in medicaments against tumors
WO2003022852A2 (en) * 2001-09-11 2003-03-20 Smithkline Beecham Corporation Furo-and thienopyrimidine derivatives as angiogenesis inhibitors
WO2005092896A1 (en) * 2004-03-12 2005-10-06 Korea Institute Of Science And Technology Compound for inhibiting tyrosine kinase activity of ddr2 protein
WO2005121149A1 (en) * 2004-06-10 2005-12-22 Xention Discovery Limited Furanopyrimidine compounds effective as potassium channel inhibitors
WO2006004658A2 (en) * 2004-06-29 2006-01-12 Amgen Inc. Furanopyrimidines
WO2007079862A1 (de) * 2005-12-21 2007-07-19 Bayer Healthcare Ag Neue, acyclisch substituierte furopyrimidin-derivate und ihre verwendung zur behandlung von kardiovaskulären erkrankungen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; November 2002 (2002-11-01), GALIÈ NAZZARENO ET AL: "Emerging medical therapies for pulmonary arterial hypertension.", XP002528176, Database accession no. NLM12525997 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2006 (2006-09-01), BRESSER PAUL ET AL: "Medical therapies for chronic thromboembolic pulmonary hypertension: an evolving treatment paradigm.", XP002528177, Database accession no. NLM16963540 *
PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY SEP 2006, vol. 3, no. 7, September 2006 (2006-09-01), pages 594 - 600, ISSN: 1546-3222 *
PROGRESS IN CARDIOVASCULAR DISEASES 2002 NOV-DEC, vol. 45, no. 3, November 2002 (2002-11-01), pages 213 - 224, ISSN: 0033-0620 *

Also Published As

Publication number Publication date
WO2008131858A2 (de) 2008-11-06
DE102007019691A1 (de) 2008-10-30
CA2685128A1 (en) 2008-11-06

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