WO2008129270A3 - Compositions comprising anti-inflammatory compounds - Google Patents

Compositions comprising anti-inflammatory compounds Download PDF

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Publication number
WO2008129270A3
WO2008129270A3 PCT/GB2008/001373 GB2008001373W WO2008129270A3 WO 2008129270 A3 WO2008129270 A3 WO 2008129270A3 GB 2008001373 W GB2008001373 W GB 2008001373W WO 2008129270 A3 WO2008129270 A3 WO 2008129270A3
Authority
WO
WIPO (PCT)
Prior art keywords
formulation
nsaid
compositions
composition
inflammatory compounds
Prior art date
Application number
PCT/GB2008/001373
Other languages
French (fr)
Other versions
WO2008129270A2 (en
Inventor
Robert Damms
Humphery-Smith Ian
Original Assignee
Renaissance Pharma Ltd
Biosystems Informatics Inst
Robert Damms
Humphery-Smith Ian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renaissance Pharma Ltd, Biosystems Informatics Inst, Robert Damms, Humphery-Smith Ian filed Critical Renaissance Pharma Ltd
Publication of WO2008129270A2 publication Critical patent/WO2008129270A2/en
Publication of WO2008129270A3 publication Critical patent/WO2008129270A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention provides compositions for providing an effective therapeutic effect at lower drug dosages. A composition of the invention comprises a first formulation of a non-steroidal anti-inflammatory compound (NSAID) and a second formulation of the same NSAID, wherein the dosage amount of the NSAID in the first formulation is higher than that of the second formulation, and wherein the second formulation is a pulsed release formulation which, on administration of the composition, releases the NSAID at a time interval of greater than 12 minutes after the release of the NSAID of the first formulation.
PCT/GB2008/001373 2007-04-18 2008-04-18 Compositions comprising anti-inflammatory compounds WO2008129270A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0707489.1 2007-04-18
GBGB0707489.1A GB0707489D0 (en) 2007-04-18 2007-04-18 Compounds

Publications (2)

Publication Number Publication Date
WO2008129270A2 WO2008129270A2 (en) 2008-10-30
WO2008129270A3 true WO2008129270A3 (en) 2008-12-18

Family

ID=38116947

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/001373 WO2008129270A2 (en) 2007-04-18 2008-04-18 Compositions comprising anti-inflammatory compounds

Country Status (2)

Country Link
GB (1) GB0707489D0 (en)
WO (1) WO2008129270A2 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1276089A (en) * 1968-08-23 1972-06-01 Pfizer Ltd Pharmaceutical preparations
US4025613A (en) * 1971-07-19 1977-05-24 Richard G. Powers Timed-release aspirin
EP0105065A1 (en) * 1982-10-05 1984-04-11 Kishan Narain Mathur A pharmaceutical composition for pain relief
EP0239361A1 (en) * 1986-03-27 1987-09-30 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
EP0411590A2 (en) * 1989-08-02 1991-02-06 ARNOLD, John David Method and preparation for reducing risk of myocardial infarction
GB2306109A (en) * 1997-02-07 1997-04-30 John Wright A zinc containing composition for treating the common cold
WO2001037813A2 (en) * 1999-11-24 2001-05-31 Lts Lohmann Therapie-Systeme Ag Multilayer preparation for a controlled, pulsed release of active substances
WO2006049978A1 (en) * 2004-10-28 2006-05-11 Novartis Ag Composition comprising acetaminophen, caffeine and optionally aspirin together with an alkiline agent fr enhanced absorption

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1276089A (en) * 1968-08-23 1972-06-01 Pfizer Ltd Pharmaceutical preparations
US4025613A (en) * 1971-07-19 1977-05-24 Richard G. Powers Timed-release aspirin
EP0105065A1 (en) * 1982-10-05 1984-04-11 Kishan Narain Mathur A pharmaceutical composition for pain relief
EP0239361A1 (en) * 1986-03-27 1987-09-30 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
EP0411590A2 (en) * 1989-08-02 1991-02-06 ARNOLD, John David Method and preparation for reducing risk of myocardial infarction
GB2306109A (en) * 1997-02-07 1997-04-30 John Wright A zinc containing composition for treating the common cold
WO2001037813A2 (en) * 1999-11-24 2001-05-31 Lts Lohmann Therapie-Systeme Ag Multilayer preparation for a controlled, pulsed release of active substances
WO2006049978A1 (en) * 2004-10-28 2006-05-11 Novartis Ag Composition comprising acetaminophen, caffeine and optionally aspirin together with an alkiline agent fr enhanced absorption

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CATELLA-LAWSON F ET AL: "CYCLOOXYGENASE INHIBITORS AND THE ANTIPLATELET EFFECTS OF ASPIRIN", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, vol. 345, no. 25, 20 December 2001 (2001-12-20), pages 1809 - 1817, XP001118002, ISSN: 0028-4793 *

Also Published As

Publication number Publication date
WO2008129270A2 (en) 2008-10-30
GB0707489D0 (en) 2007-05-23

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