WO2005107467A3 - Compositions including opioids and methods of their use in treating pain - Google Patents

Compositions including opioids and methods of their use in treating pain Download PDF

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Publication number
WO2005107467A3
WO2005107467A3 PCT/US2005/015044 US2005015044W WO2005107467A3 WO 2005107467 A3 WO2005107467 A3 WO 2005107467A3 US 2005015044 W US2005015044 W US 2005015044W WO 2005107467 A3 WO2005107467 A3 WO 2005107467A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions including
treating pain
drug
including opioids
Prior art date
Application number
PCT/US2005/015044
Other languages
French (fr)
Other versions
WO2005107467A2 (en
Inventor
Harry Jefferson Leighton
David Borsook
Stephen Ashley Lawton
Original Assignee
Descartes Therapeutics Inc
Harry Jefferson Leighton
David Borsook
Stephen Ashley Lawton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Descartes Therapeutics Inc, Harry Jefferson Leighton, David Borsook, Stephen Ashley Lawton filed Critical Descartes Therapeutics Inc
Publication of WO2005107467A2 publication Critical patent/WO2005107467A2/en
Publication of WO2005107467A3 publication Critical patent/WO2005107467A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention features compositions for treatment of pain or nociception and methods of their use. The compositions include the combination of two or more drugs, such as an opioid (e.g., delta, kappa, or mu), a non-steroidal anti-inflammatory drug (NSAID) or acetaminophen, and a dopaminergic agent. These drug combinations may be administered alone (i.e., treatment is accomplished using a composition that consists of or consists essentially of the drug combination itself), or the drug combinations may be administered in conjunction with yet additional compounds.
PCT/US2005/015044 2004-05-03 2005-04-29 Compositions including opioids and methods of their use in treating pain WO2005107467A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56753904P 2004-05-03 2004-05-03
US60/567,539 2004-05-03
US58453404P 2004-07-01 2004-07-01
US60/584,534 2004-07-01

Publications (2)

Publication Number Publication Date
WO2005107467A2 WO2005107467A2 (en) 2005-11-17
WO2005107467A3 true WO2005107467A3 (en) 2006-04-13

Family

ID=35320674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/015044 WO2005107467A2 (en) 2004-05-03 2005-04-29 Compositions including opioids and methods of their use in treating pain

Country Status (1)

Country Link
WO (1) WO2005107467A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911751B2 (en) 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
US8946220B2 (en) 2011-03-03 2015-02-03 Purdue Research Foundation Compositions and uses thereof to ameliorate pain
AU2014306759B2 (en) 2013-08-12 2018-04-26 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US20150352099A1 (en) * 2014-06-04 2015-12-10 Mentinova Inc. Compositions and Methods of Reducing Sedation
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US20160106737A1 (en) 2014-10-20 2016-04-21 Pharmaceutical Manufacturing Research Services, Inc. Extended Release Abuse Deterrent Liquid Fill Dosage Form
US20170143681A1 (en) * 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
WO2020227646A1 (en) * 2019-05-09 2020-11-12 Apkarian Technologies Llc Methods and compositions for treating pain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127352A (en) * 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127352A (en) * 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER, vol. 33, no. 2, 1974, pages 358 - 363 *
DATABASE EMBASE [online] MINTON J.P.: "The response of breast cancer patients with bone pain to L dopa", XP002994724, Database accession no. 1975078914 *

Also Published As

Publication number Publication date
WO2005107467A2 (en) 2005-11-17

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