WO2008126770A1 - Procédé de production d'un dérivé d'acide triarylcarboxylique - Google Patents

Procédé de production d'un dérivé d'acide triarylcarboxylique Download PDF

Info

Publication number
WO2008126770A1
WO2008126770A1 PCT/JP2008/056708 JP2008056708W WO2008126770A1 WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1 JP 2008056708 W JP2008056708 W JP 2008056708W WO 2008126770 A1 WO2008126770 A1 WO 2008126770A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzene ring
producing
acid derivative
compound
inhibitory effect
Prior art date
Application number
PCT/JP2008/056708
Other languages
English (en)
Japanese (ja)
Inventor
Masaru Hayashi
Hiroyuki Tsuboi
Junji Sato
Tatsuya Sawada
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of WO2008126770A1 publication Critical patent/WO2008126770A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention propose un agent de traitement ou de prévention de l'hyperuricémie, la goutte, les maladies intestinales inflammatoires, la néphropathie diabétique, la rétinite diabétique ou analogue très innovants et très sûrs. Ledit agent présente un excellent effet inhibiteur d'oxydase de xanthine obtenu par procédé de production industriellement utile et de production intermédiaire de celui-ci. Les inventeurs ont effectué des études en profondeur du procédé pour produire un dérivé d'acide triarylcarboxylique, caractérisé en ce qu'il comporte un groupe azole carboxylique substitué et un groupe phényle substitué dans la position para d'un cycle du benzène et, de plus, un groupe cyano sur le cycle du benzène sur la base de la constatation que le composé a un effet inhibiteur d'oxydase de xanthine efficace. En conséquence, lesdits chercheurs ont constaté que le composé peut être efficacement obtenu par un procédé de liaison du groupe d'azole au cycle de benzène, ce qui est la base de la présente invention.
PCT/JP2008/056708 2007-04-05 2008-04-03 Procédé de production d'un dérivé d'acide triarylcarboxylique WO2008126770A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007099936 2007-04-05
JP2007-099936 2007-04-05

Publications (1)

Publication Number Publication Date
WO2008126770A1 true WO2008126770A1 (fr) 2008-10-23

Family

ID=39863870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056708 WO2008126770A1 (fr) 2007-04-05 2008-04-03 Procédé de production d'un dérivé d'acide triarylcarboxylique

Country Status (1)

Country Link
WO (1) WO2008126770A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (fr) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Nouveaux composés efficaces comme inhibiteurs de la xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant
WO2014119681A1 (fr) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 Dérivé d'azole et de benzène
WO2014192977A1 (fr) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 Dérivé de thiazole
WO2016017826A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Inhibiteur de xanthine-oxydase
WO2016017708A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Dérivé de benzène et d'azole et son cristal
WO2016017696A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Cristal de dérivé de benzène et d'azole
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
CN110204493A (zh) * 2019-07-01 2019-09-06 华南理工大学 三环类xor抑制剂及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (fr) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Terphenyles a substitutions laterales cyano et fluoro
JPH04327586A (ja) * 1991-03-08 1992-11-17 Merck & Co Inc アンギオテンシンｉｉ拮抗薬としての酸性官能基を有する複素環化合物
WO2007043457A1 (fr) * 2005-10-07 2007-04-19 Astellas Pharma Inc. Dérivé de l'acide triarylcarboxylique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989003821A1 (fr) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Terphenyles a substitutions laterales cyano et fluoro
JPH04327586A (ja) * 1991-03-08 1992-11-17 Merck & Co Inc アンギオテンシンｉｉ拮抗薬としての酸性官能基を有する複素環化合物
WO2007043457A1 (fr) * 2005-10-07 2007-04-19 Astellas Pharma Inc. Dérivé de l'acide triarylcarboxylique

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043568A2 (fr) 2009-10-07 2011-04-14 Lg Life Sciences Ltd. Nouveaux composés efficaces comme inhibiteurs de la xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant
WO2014119681A1 (fr) * 2013-01-31 2014-08-07 帝人ファーマ株式会社 Dérivé d'azole et de benzène
JP5734532B2 (ja) * 2013-01-31 2015-06-17 帝人ファーマ株式会社 アゾールベンゼン誘導体
KR20150112955A (ko) * 2013-01-31 2015-10-07 데이진 화-마 가부시키가이샤 아졸벤젠 유도체
KR102199258B1 (ko) 2013-01-31 2021-01-06 데이진 화-마 가부시키가이샤 아졸벤젠 유도체
RU2641891C2 (ru) * 2013-01-31 2018-01-23 Тейдзин Фарма Лимитед Азоловые производные бензола
US9388174B2 (en) 2013-01-31 2016-07-12 Teijin Pharma Limited Azole benzene derivative
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
WO2014192977A1 (fr) * 2013-05-31 2014-12-04 帝人ファーマ株式会社 Dérivé de thiazole
JPWO2016017696A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 アゾールベンゼン誘導体の結晶
US10179780B2 (en) 2014-07-30 2019-01-15 Teijin Pharma Limited Azole benzene derivative and crystalline form thereof
JPWO2016017708A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 アゾールベンゼン誘導体およびその結晶
WO2016017696A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Cristal de dérivé de benzène et d'azole
JPWO2016017826A1 (ja) * 2014-07-30 2017-04-27 帝人ファーマ株式会社 キサンチンオキシダーゼ阻害薬
CN106661014A (zh) * 2014-07-30 2017-05-10 帝人制药株式会社 唑苯衍生物及其晶体
US9815826B2 (en) 2014-07-30 2017-11-14 Teijin Pharma Limited Crystal of azole benzene derivative
WO2016017708A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Dérivé de benzène et d'azole et son cristal
RU2675854C2 (ru) * 2014-07-30 2018-12-25 Тейдзин Фарма Лимитед Кристаллическая форма азолбензольного производного
CN106536519A (zh) * 2014-07-30 2017-03-22 帝人制药株式会社 唑苯衍生物的晶体
US10301300B2 (en) 2014-07-30 2019-05-28 Teijin Limited Xanthine oxidase inhibitor
WO2016017826A1 (fr) * 2014-07-30 2016-02-04 帝人ファーマ株式会社 Inhibiteur de xanthine-oxydase
AU2015297489B2 (en) * 2014-07-30 2019-09-19 Teijin Limited Crystal of azole benzene derivative
RU2701515C2 (ru) * 2014-07-30 2019-09-27 Тейдзин Фарма Лимитед Производное азолобензола и его кристаллическая форма
CN110204493A (zh) * 2019-07-01 2019-09-06 华南理工大学 三环类xor抑制剂及其制备方法和应用
WO2021000527A1 (fr) * 2019-07-01 2021-01-07 华南理工大学 Inhibiteur de xor tricyclique, son procédé de préparation et son utilisation
CN110204493B (zh) * 2019-07-01 2021-05-14 华南理工大学 三环类xor抑制剂及其制备方法和应用

Similar Documents

Publication Publication Date Title
WO2008126770A1 (fr) Procédé de production d'un dérivé d'acide triarylcarboxylique
EP1932832A4 (fr) Dérivé de l'acide triarylcarboxylique
WO2008048990A3 (fr) Procédés d'obtention de compositions anti-oxydantes macro-moléculaires
WO2009139817A3 (fr) Produit pharmaceutique cristallin et ses procédés de préparation et d'utilisation
WO2009145456A3 (fr) Dérivés hétérocycliques
WO2007085895A3 (fr) Inhibiteurs fap
WO2006092213A8 (fr) Pyrazolylcarboxanilides
WO2008055814A3 (fr) Procédé de préparation de la (s)-4-fluorométhyl-dihydro-furan-2-one
WO2011043568A3 (fr) Nouveaux composés efficaces comme inhibiteurs de la xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant
WO2006113919A3 (fr) Preparation et utilisation de derives de l'acide aryle alkyle dans le traitement de l'obesite
WO2010093191A3 (fr) Nouveaux composés efficaces en tant qu'inhibiteurs de xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant
WO2008110314A8 (fr) Fluoroalkylphénylamidines et leur utilisation comme fongicides
WO2006122216A3 (fr) Procedes de production de derives phenoliques 4-biphenylylazetidin-2-one
TW200738693A (en) Substituted biaryls, process for their manufacture and use thereof as medicaments
WO2009068463A9 (fr) Préparation de dérivés de dihydropyrrole comme intermédiaires
MY146084A (en) Benzyl amines, a process for their production and their use as anti-inflammatory agents
WO2009074247A8 (fr) Nouveaux dérivés d'amide d'acide 2-arylthiazole-4-carboxylique, leur préparation et leur utilisation en tant que médicament
WO2009098612A3 (fr) Forme polymorphe
IL187746A0 (en) Process for the production of benzoimidazole derivatives as intermediates for the preparation of tricyclic benzimidazole compounds
WO2009062659A3 (fr) Polymorphes d'erdostéine énantiopure
NO20073440L (no) Prosess for fremstilling av candesartan
WO2008035360A3 (fr) Nouvelles formes cristallines
ATE442371T1 (de) Víllig lísungsmittelfreie cefotetan säure und verfahren zu ihrer herstellung.
WO2008015133A3 (fr) Procédé de fabrication d'amidrazones
WO2008041176A3 (fr) Procédé de préparation de la forme i et de la forme ii du ritonavir

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08739815

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08739815

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP