WO2009068463A9 - Préparation de dérivés de dihydropyrrole comme intermédiaires - Google Patents

Préparation de dérivés de dihydropyrrole comme intermédiaires Download PDF

Info

Publication number
WO2009068463A9
WO2009068463A9 PCT/EP2008/065820 EP2008065820W WO2009068463A9 WO 2009068463 A9 WO2009068463 A9 WO 2009068463A9 EP 2008065820 W EP2008065820 W EP 2008065820W WO 2009068463 A9 WO2009068463 A9 WO 2009068463A9
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
intermediates
well
isoindole derivatives
formula
Prior art date
Application number
PCT/EP2008/065820
Other languages
English (en)
Other versions
WO2009068463A2 (fr
WO2009068463A3 (fr
Inventor
Christophe Pfleger
Paul Spurr
René Trussardi
Pius Waldmeier
Shaoning Wang
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2008328951A priority Critical patent/AU2008328951B2/en
Priority to BRPI0821102-7A priority patent/BRPI0821102A2/pt
Priority to CA2705950A priority patent/CA2705950A1/fr
Priority to CN2008801175966A priority patent/CN101874019B/zh
Priority to JP2010535334A priority patent/JP5255647B2/ja
Priority to ES08855641T priority patent/ES2378185T3/es
Priority to AT08855641T priority patent/ATE539054T1/de
Priority to EP08855641A priority patent/EP2225202B1/fr
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Priority to KR1020107011606A priority patent/KR101196543B1/ko
Priority to MX2010004669A priority patent/MX2010004669A/es
Publication of WO2009068463A2 publication Critical patent/WO2009068463A2/fr
Publication of WO2009068463A3 publication Critical patent/WO2009068463A3/fr
Publication of WO2009068463A9 publication Critical patent/WO2009068463A9/fr
Priority to IL204936A priority patent/IL204936A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention porte sur un nouveau procédé d'échelle variable de préparation de composés de formule (I) comprenant un nouveau procédé de préparation de l'intermédiaire clé, un dérivé de dihydropyrrole de formule (II) ou un sel de celui-ci.
PCT/EP2008/065820 2007-11-29 2008-11-19 Préparation de dérivés de dihydropyrrole comme intermédiaires WO2009068463A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AT08855641T ATE539054T1 (de) 2007-11-29 2008-11-19 Verfahren zur herstellung von dihydropyrrolderivaten als zwischenprodukte
CA2705950A CA2705950A1 (fr) 2007-11-29 2008-11-19 Preparation de derives de dihydropyrrole comme intermediaires
CN2008801175966A CN101874019B (zh) 2007-11-29 2008-11-19 制备异吲哚衍生物的方法以及制备它们的中间体的方法
JP2010535334A JP5255647B2 (ja) 2007-11-29 2008-11-19 イソインドール誘導体の製造方法およびその中間体の製造方法
ES08855641T ES2378185T3 (es) 2007-11-29 2008-11-19 Preparación de derivados de dihidropirrol como productos intermedios
AU2008328951A AU2008328951B2 (en) 2007-11-29 2008-11-19 Preparation of dihydropyrrol derivatives as intermediates
EP08855641A EP2225202B1 (fr) 2007-11-29 2008-11-19 Préparation de dérivés dihydropyrroles en tant qu' intermédiaires
BRPI0821102-7A BRPI0821102A2 (pt) 2007-11-29 2008-11-19 Preparação de derivados de di-hidropirrol como intermediários
KR1020107011606A KR101196543B1 (ko) 2007-11-29 2008-11-19 아이소인돌 유도체의 제조 방법 및 그의 중간체의 제조 방법
MX2010004669A MX2010004669A (es) 2007-11-29 2008-11-19 Proceso para la preparacion de derivados de isoindol asi como tambien un proceso para la preparacion de sus intermediarios.
IL204936A IL204936A (en) 2007-11-29 2010-04-08 The process of preparing pyrrolo-pyridazine or pyridine is converted

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07121841.6 2007-11-29
EP07121841 2007-11-29

Publications (3)

Publication Number Publication Date
WO2009068463A2 WO2009068463A2 (fr) 2009-06-04
WO2009068463A3 WO2009068463A3 (fr) 2009-09-11
WO2009068463A9 true WO2009068463A9 (fr) 2009-11-12

Family

ID=40551563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/065820 WO2009068463A2 (fr) 2007-11-29 2008-11-19 Préparation de dérivés de dihydropyrrole comme intermédiaires

Country Status (13)

Country Link
US (3) US20090143589A1 (fr)
EP (1) EP2225202B1 (fr)
JP (1) JP5255647B2 (fr)
KR (1) KR101196543B1 (fr)
CN (1) CN101874019B (fr)
AT (1) ATE539054T1 (fr)
AU (1) AU2008328951B2 (fr)
BR (1) BRPI0821102A2 (fr)
CA (1) CA2705950A1 (fr)
ES (1) ES2378185T3 (fr)
IL (1) IL204936A (fr)
MX (1) MX2010004669A (fr)
WO (1) WO2009068463A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20161372A1 (es) 2014-02-03 2017-01-08 Vitae Pharmaceuticals Inc Inhibidores de dihidropirrolopiridina de ror-gamma
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3331876B1 (fr) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulateurs de ror-gamma
MA53943A (fr) 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (fr) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibiteurs de ror gamma
CN111225914B (zh) 2017-07-24 2022-10-11 生命医药有限责任公司 RORγ的抑制剂
CN111448195A (zh) * 2017-09-27 2020-07-24 费多拉制药公司 二氮杂二环辛烷衍生物的晶型及其生产方法
CN111808102B (zh) * 2020-08-03 2021-12-31 南通大学 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
JP2832584B2 (ja) * 1995-03-27 1998-12-09 日本農薬株式会社 カルボン酸エステル類の製造方法
ES2186823T3 (es) * 1996-07-23 2003-05-16 Lonza Ag Procedimiento para la preparacion de esteres del acido piridin-2,3-dicarboxilico.
DE602006010665D1 (en) * 2005-02-07 2010-01-07 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1

Also Published As

Publication number Publication date
WO2009068463A2 (fr) 2009-06-04
BRPI0821102A2 (pt) 2015-06-16
CA2705950A1 (fr) 2009-06-04
KR20100075664A (ko) 2010-07-02
IL204936A (en) 2013-12-31
US20130060038A1 (en) 2013-03-07
JP2011504896A (ja) 2011-02-17
JP5255647B2 (ja) 2013-08-07
US20120041205A1 (en) 2012-02-16
CN101874019A (zh) 2010-10-27
AU2008328951A1 (en) 2009-06-04
IL204936A0 (en) 2010-11-30
MX2010004669A (es) 2010-05-27
ATE539054T1 (de) 2012-01-15
ES2378185T3 (es) 2012-04-09
US20090143589A1 (en) 2009-06-04
EP2225202A2 (fr) 2010-09-08
KR101196543B1 (ko) 2012-11-01
AU2008328951B2 (en) 2012-12-13
EP2225202B1 (fr) 2011-12-28
WO2009068463A3 (fr) 2009-09-11
CN101874019B (zh) 2013-06-12

Similar Documents

Publication Publication Date Title
WO2009068463A3 (fr) Préparation de dérivés de dihydropyrrole comme intermédiaires
AU2008303600A8 (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
WO2009156462A3 (fr) Composés organiques
WO2006122216A3 (fr) Procedes de production de derives phenoliques 4-biphenylylazetidin-2-one
WO2009079008A8 (fr) Benzopyranes et analogues utilisés comme inhibiteurs de la rho kinase
WO2010129918A8 (fr) Promédicaments à base de triptolide
WO2009121939A3 (fr) Composés c-aryl glycosides pour le traitement du diabète et de l'obésité
MX2009008660A (es) Metodo para la preparacion de derivados de trifenilbuteno terapeuticamente valiosos.
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
WO2008155666A3 (fr) Dérivés de pyrimidone hétéroarylamide
WO2006075139A3 (fr) Procede nouveau
WO2008033757A3 (fr) Dérivés d'acétamide 2-(1-oxo-1h-isoquinolin-2-yl)
WO2009039362A3 (fr) Synthèse chirale de diazépinoquinolines
WO2007108011A3 (fr) Procede de preparation de donepezile de grande purete
WO2009062659A3 (fr) Polymorphes d'erdostéine énantiopure
WO2008015133A3 (fr) Procédé de fabrication d'amidrazones
NO20065157L (no) Biotransformasjon av colchicinoidforbindelser
WO2007143014A3 (fr) Méthodes de synthèse de dérivés d'acide glutamique et de leurs intermédiaires
WO2008007391A3 (fr) Procédé amélioré de préparation du valsartan
EP2084168A4 (fr) Processus pour la préparation de composés dialkyldithiophosphiniques hautement purifiés
WO2009152474A3 (fr) Procédé de préparation de dérivés de (3s)-3-amino-n-cyclopropyl-2-hydroxyalcanamide
WO2008006499A3 (fr) Furyl-sulfonylamino(thio)carbonyl-triazoline(thi)ones substituées
WO2008099418A3 (fr) Procédé amélioré de préparation de chlohydrate de bupropion
WO2009057137A3 (fr) Procédé de purification du lévétiracétam
WO2008072257A3 (fr) Procédé de préparation de dérivés de l'indole

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880117596.6

Country of ref document: CN

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08855641

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 204936

Country of ref document: IL

Ref document number: 2008855641

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008328951

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: MX/A/2010/004669

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2008328951

Country of ref document: AU

Date of ref document: 20081119

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2705950

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 20107011606

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2010535334

Country of ref document: JP

Ref document number: 3176/CHENP/2010

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: PI0821102

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20100531