WO2008117796A1 - Nouveaux dérivés de mutiline - Google Patents

Nouveaux dérivés de mutiline Download PDF

Info

Publication number
WO2008117796A1
WO2008117796A1 PCT/JP2008/055566 JP2008055566W WO2008117796A1 WO 2008117796 A1 WO2008117796 A1 WO 2008117796A1 JP 2008055566 W JP2008055566 W JP 2008055566W WO 2008117796 A1 WO2008117796 A1 WO 2008117796A1
Authority
WO
WIPO (PCT)
Prior art keywords
general formula
amino
mutilin derivatives
lower alkyl
protecting group
Prior art date
Application number
PCT/JP2008/055566
Other languages
English (en)
Japanese (ja)
Inventor
Yoshimi Hirokawa
Shiro Kato
Hironori Kinoshita
Tomoyuki Tanaka
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Publication of WO2008117796A1 publication Critical patent/WO2008117796A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des dérivés de mutiline représentés par la formule générale (I) qui sont utiles comme agents antimicrobiens contre les bactéries multirésistantes aux antibiotiques; et des intermédiaires pour leur production. Dans la formule générale (I), R1 représente un vinyle ou équivalent; P1 représente H, un groupe protecteur de la fonction hydroxyle, ou équivalent; R2 et R3 représentent chacun H ou équivalent; G représente un alkylène de faible poids moléculaire; A représente une liaison simple ou équivalent; Q1 représente un hétérocycle saturé; R4 et R5 représentent chacun H, un alkyle de faible poids moléculaire, ou équivalent; et W est un groupe représenté par la formule générale (W-1), un groupe protecteur de la fonction amino, ou H; Dans la formule générale (W-1), B représente -CO- ou équivalent; X représente un alkylène de faible poids moléculaire ou équivalent; Z1 représente CH ou équivalent; Z2, Z3 et Z4 représentent chacun N ou équivalent; et Y1 et Y2 représentent chacun H, un amino, un groupe représenté par la formule générale (Y-1), ou équivalent; et dans la formule générale (Y-1), Q2 représente un hétérocycle saturé; et R7 et R8 représentent chacun H, un alkyle de faible poids moléculaire, ou équivalents.
PCT/JP2008/055566 2007-03-28 2008-03-25 Nouveaux dérivés de mutiline WO2008117796A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007085971 2007-03-28
JP2007-085971 2007-03-28

Publications (1)

Publication Number Publication Date
WO2008117796A1 true WO2008117796A1 (fr) 2008-10-02

Family

ID=39788530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055566 WO2008117796A1 (fr) 2007-03-28 2008-03-25 Nouveaux dérivés de mutiline

Country Status (1)

Country Link
WO (1) WO2008117796A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011125684A1 (fr) * 2010-03-31 2011-10-13 Jsr株式会社 Composition de résine sensible au rayonnement, procédé de formation de motif de résine photosensible, polymère et composé
CN102372717A (zh) * 2010-08-20 2012-03-14 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
US8182842B1 (en) 2010-11-10 2012-05-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria
CN102924390A (zh) * 2012-09-07 2013-02-13 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN103265442A (zh) * 2013-06-05 2013-08-28 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
CN105837530A (zh) * 2016-04-18 2016-08-10 华南农业大学 一种具有哌嗪侧链的截短侧耳素衍生物及其制备方法和用途
US9585886B2 (en) 2010-12-16 2017-03-07 Calchan Limited ASK1 inhibiting pyrrolopyrimidine derivatives
US9701628B2 (en) 2014-01-22 2017-07-11 Nabriva Therapeutics Ag 12-epi pleuromutilins
CN108484424A (zh) * 2018-04-08 2018-09-04 中国农业科学院兰州畜牧与兽药研究所 侧链含有季铵盐基团的截短侧耳素类衍生物及其用途
US10111875B2 (en) 2010-08-20 2018-10-30 Hutchinson Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN109195608A (zh) * 2016-03-02 2019-01-11 比尔及梅琳达盖茨基金会 含硼小分子
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
CN110467603A (zh) * 2019-07-08 2019-11-19 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN111793044A (zh) * 2020-07-21 2020-10-20 西华大学 哌嗪脲截短侧耳素衍生物及其用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278674A (en) * 1971-10-05 1981-07-14 Sandoz Ltd. Substituted 14-desoxy-mutilin compositions
WO1999021855A1 (fr) * 1997-10-29 1999-05-06 Smithkline Beecham P.L.C. Derives de pleuromutiline utilises comme agents antimicrobiens
WO2000007974A1 (fr) * 1998-08-05 2000-02-17 Smithkline Beecham P.L.C. Derives de 2-fluoro mutiline
WO2000037074A1 (fr) * 1998-12-18 2000-06-29 Smithkline Beecham Plc Derives de 14-ester mutilin a activite antibacterienne
WO2002030929A1 (fr) * 2000-10-10 2002-04-18 Smithkline Beecham P.L.C. Nouveaux derives de pleuromutiline
WO2002038528A1 (fr) * 2000-11-11 2002-05-16 Smithkline Beecham P.L.C. Derives de pleuromutiline possedant une activite antimicrobienne
WO2007037518A1 (fr) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. Derive de mutiline et composition pharmaceutique la contenant

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278674A (en) * 1971-10-05 1981-07-14 Sandoz Ltd. Substituted 14-desoxy-mutilin compositions
WO1999021855A1 (fr) * 1997-10-29 1999-05-06 Smithkline Beecham P.L.C. Derives de pleuromutiline utilises comme agents antimicrobiens
WO2000007974A1 (fr) * 1998-08-05 2000-02-17 Smithkline Beecham P.L.C. Derives de 2-fluoro mutiline
WO2000037074A1 (fr) * 1998-12-18 2000-06-29 Smithkline Beecham Plc Derives de 14-ester mutilin a activite antibacterienne
WO2002030929A1 (fr) * 2000-10-10 2002-04-18 Smithkline Beecham P.L.C. Nouveaux derives de pleuromutiline
WO2002038528A1 (fr) * 2000-11-11 2002-05-16 Smithkline Beecham P.L.C. Derives de pleuromutiline possedant une activite antimicrobienne
WO2007037518A1 (fr) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. Derive de mutiline et composition pharmaceutique la contenant

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2011125684A1 (ja) * 2010-03-31 2013-07-08 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
WO2011125684A1 (fr) * 2010-03-31 2011-10-13 Jsr株式会社 Composition de résine sensible au rayonnement, procédé de formation de motif de résine photosensible, polymère et composé
JP5655855B2 (ja) * 2010-03-31 2015-01-21 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法、重合体及び化合物
US10369153B2 (en) 2010-08-20 2019-08-06 Hutchison Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN102372717B (zh) * 2010-08-20 2014-06-18 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
US10111875B2 (en) 2010-08-20 2018-10-30 Hutchinson Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
CN102372717A (zh) * 2010-08-20 2012-03-14 和记黄埔医药（上海）有限公司 吡咯并嘧啶类化合物及其用途
US8182842B1 (en) 2010-11-10 2012-05-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria
US9585886B2 (en) 2010-12-16 2017-03-07 Calchan Limited ASK1 inhibiting pyrrolopyrimidine derivatives
CN102924390A (zh) * 2012-09-07 2013-02-13 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN102924390B (zh) * 2012-09-07 2014-12-31 苏州康润医药有限公司 1,5-二氮杂环辛烷-1-甲酸叔丁酯的合成方法
CN103265442A (zh) * 2013-06-05 2013-08-28 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
CN103265442B (zh) * 2013-06-05 2017-02-08 北京理工大学 一类新型截短侧耳素衍生物及其制备方法和抗肿瘤用途
US9701628B2 (en) 2014-01-22 2017-07-11 Nabriva Therapeutics Ag 12-epi pleuromutilins
US10189841B2 (en) 2015-11-20 2019-01-29 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US10399980B2 (en) 2015-11-20 2019-09-03 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
US11161848B2 (en) 2015-11-20 2021-11-02 Forma Therapeutics, Inc. Purinones as ubiquitin-specific protease 1 inhibitors
CN109195608A (zh) * 2016-03-02 2019-01-11 比尔及梅琳达盖茨基金会 含硼小分子
CN105837530A (zh) * 2016-04-18 2016-08-10 华南农业大学 一种具有哌嗪侧链的截短侧耳素衍生物及其制备方法和用途
CN108484424A (zh) * 2018-04-08 2018-09-04 中国农业科学院兰州畜牧与兽药研究所 侧链含有季铵盐基团的截短侧耳素类衍生物及其用途
CN110467603A (zh) * 2019-07-08 2019-11-19 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN110467603B (zh) * 2019-07-08 2021-05-11 华南农业大学 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用
CN111793044A (zh) * 2020-07-21 2020-10-20 西华大学 哌嗪脲截短侧耳素衍生物及其用途
CN111793044B (zh) * 2020-07-21 2022-05-10 西华大学 哌嗪脲截短侧耳素衍生物及其用途

Similar Documents

Publication Publication Date Title
WO2008117796A1 (fr) Nouveaux dérivés de mutiline
GEP20125505B (en) Fungicidal azocylic amides
RS53839B1 (en) SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1
MY159364A (en) Fungicidal pyrazoles
MX2010005109A (es) Compuestos herbicidas.
MX2010007974A (es) Amidas fungicidas.
WO2008071918A8 (fr) Dérivés de pyrido-pyrazine utiles en tant que composés herbicides
TN2011000400A1 (en) Inhibitors of beta-secretase
EP1852434A4 (fr) Dérivé de carbamoylpyridone bicyclique ayant une activité d'inhibition de la vih intégrase
WO2007079186A3 (fr) Inhibiteurs de la cetp
WO2007084914A3 (fr) Pyrimidines substituees par un groupe phenoxy en tant qu'antagonistes des recepteurs d’adenosine
WO2011004162A3 (fr) Composés utilisés en tant que médicaments
MX2009012082A (es) Compuestos de ariloazol-2-il cianoetilamino, metodo para prepararlos y metodo para utilizarlos.
TW200642683A (en) Heterocyclic compound
RS54618B1 (en) NEW S-NITROZOGLUTATION REDUCTASE INHIBITORS
MX2009007482A (es) Agentes antiparasitarios.
MX2008014908A (es) Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
TW201144305A (en) Fungicidal oximes and hydrazones
NO20092279L (no) Makrocyklisk factor VIIa inhibitorer anvendbare som antikoagulanter
MX2011008176A (es) Derivados de 3,3'-espiroindolinona como agentes anticancerigenos.
UA100291C2 (uk) Фунгіцидні похідні n-циклоалкіл-n-біфенілметилкарбоксаміду
MX2009008756A (es) Compuesto macrociclico.
WO2011061452A3 (fr) Précurseurs biscarbonates, leur procédé de préparation et leurs utilisations
JO2413B1 (en) Benzoxazine derivatives and their use
MX2012007223A (es) Carboxamidas fungicidas 2-(ariloxi biciclicas).

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08722776

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08722776

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP