WO2008114505A1 - Inhibiteur d'eg5 et agent destinés au traitement d'un trouble de la prolifération cellulaire les contenant - Google Patents

Inhibiteur d'eg5 et agent destinés au traitement d'un trouble de la prolifération cellulaire les contenant Download PDF

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Publication number
WO2008114505A1
WO2008114505A1 PCT/JP2008/000617 JP2008000617W WO2008114505A1 WO 2008114505 A1 WO2008114505 A1 WO 2008114505A1 JP 2008000617 W JP2008000617 W JP 2008000617W WO 2008114505 A1 WO2008114505 A1 WO 2008114505A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
agent
treatment
cell proliferative
inhibitor
Prior art date
Application number
PCT/JP2008/000617
Other languages
English (en)
Japanese (ja)
Inventor
Akira Asai
Junichi Sawada
Kenji Matsuno
Naohisa Ogo
Nobutaka Fujii
Shinya Oishi
Original Assignee
Pharma Ip Limited Liability Intermediary Corporations
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Ip Limited Liability Intermediary Corporations filed Critical Pharma Ip Limited Liability Intermediary Corporations
Priority to JP2009505077A priority Critical patent/JPWO2008114505A1/ja
Publication of WO2008114505A1 publication Critical patent/WO2008114505A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un inhibiteur d'Eg5 contenant un dérivé de cystéine représenté par la formule (I) ci-dessous ou un sel pharmacologiquement acceptable de celui-ci en tant qu'un ingrédient actif. La présente invention concerne également un agent destiné au traitement des troubles de la prolifération cellulaire. [formule chimique 1] (I) (Dans la formula, Ar représente un groupe aryle substitué ou non substitué ou un groupe hétérocyclique aromatique substitué ou non substitué ; R1 représente un atome d'hydrogène ou un groupe de protection d'un groupe amino ; et R2 et représente un groupe hydroxy, un groupe alcoxy, un groupe amino, un groupe -NH(CH2)2O(CH2)2NH2 ou équivalents. A cet égard, lorsque Ar est un groupe phényle, R2 est un groupe autre qu'un groupe hydroxy.)
PCT/JP2008/000617 2007-03-16 2008-03-17 Inhibiteur d'eg5 et agent destinés au traitement d'un trouble de la prolifération cellulaire les contenant WO2008114505A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009505077A JPWO2008114505A1 (ja) 2007-03-16 2008-03-17 Ｅｇ５阻害剤および該化合物を含有してなる細胞増殖性疾患治療薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-069487 2007-03-16
JP2007069487 2007-03-16

Publications (1)

Publication Number Publication Date
WO2008114505A1 true WO2008114505A1 (fr) 2008-09-25

Family

ID=39765623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000617 WO2008114505A1 (fr) 2007-03-16 2008-03-17 Inhibiteur d'eg5 et agent destinés au traitement d'un trouble de la prolifération cellulaire les contenant

Country Status (2)

Country Link
JP (1) JPWO2008114505A1 (fr)
WO (1) WO2008114505A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
CN103740648A (zh) * 2013-11-20 2014-04-23 成都正能生物技术有限责任公司 一种纺锤体驱动蛋白(Eg5)单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US9902690B2 (en) 2013-12-27 2018-02-27 Novus International, Inc. Ethoxylated surfactants
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104011A2 (fr) * 2006-03-08 2007-09-13 University Of Maryland, Baltimore Inhibition de protrusion de microtubule dans des cellules cancereuses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104011A2 (fr) * 2006-03-08 2007-09-13 University Of Maryland, Baltimore Inhibition de protrusion de microtubule dans des cellules cancereuses

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEBONIS S. ET AL.: "STRUCTURE-ACTIVITY RELATIONSHIP OF S-TRITYL-L-CYSTEINE ANALOGUES AS INHIBITORS OF THE HUMAN MITOTIC KINESIN EG5", J. MED. CHEM., vol. 51, no. 5, 13 March 2008 (2008-03-13), pages 1115 - 1125 *
KESSEL D. ET AL.: "EFFECTS OF S-(TRITYL)-L-CYSTEINE AND ITS ANALOGS ON CELL SURFACE PROPERTIES OF LEUKEMIA L1210 CELLS", BIOCHEM. PHARMACOL., vol. 25, no. 16, 1976, pages 1893 - 1897, XP023729552, DOI: doi:10.1016/0006-2952(76)90195-7 *
OGO N. ET AL.: "SYNTHESIS AND BIOLOGICAL EVALUATION OF L-CYSTEINE DERIVATIVES AS MITOTIC KINESIN EG5 INHIBITORS", BIOORG. MED. CHEM. LETT., vol. 17, no. 14, 15 July 2007 (2007-07-15), pages 3921 - 3924, XP022119981 *
ZEE-CHENG K.Y. ET AL.: "EXPERIMENTAL ANTILEUKEMIC AGENTS. PREPARATION AND STRUCTURE-ACTIVITY STUDY OF S-TRITYLCYSTEINE AND RELATED COMPOUNDS", J. MED. CHEM., vol. 13, no. 3, 1970, pages 414 - 418, XP002919020 *
ZEE-CHENG K.Y. ET AL.: "STRUCTURAL MODIFICATION OF S-TRITYL-L-CYSTEINE. PREPARATION OF SOME S-(SUBSTITUTED TRITYL)-L-CYSTEINES AND DIPEPTIDES OF TRITYL-L-CYSTEINE", J. MED. CHEM., vol. 15, no. 1, 1972, pages 13 - 16, XP002398931 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
CN103740648A (zh) * 2013-11-20 2014-04-23 成都正能生物技术有限责任公司 一种纺锤体驱动蛋白(Eg5)单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
CN103740648B (zh) * 2013-11-20 2016-08-31 成都汇瑞新元生物科技有限责任公司 一种纺锤体驱动蛋白(Eg5)单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
US9902690B2 (en) 2013-12-27 2018-02-27 Novus International, Inc. Ethoxylated surfactants
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

Also Published As

Publication number Publication date
JPWO2008114505A1 (ja) 2010-07-01

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