WO2008106226A3 - Macrolide compounds and methods of making and using the same - Google Patents

Macrolide compounds and methods of making and using the same Download PDF

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Publication number
WO2008106226A3
WO2008106226A3 PCT/US2008/002717 US2008002717W WO2008106226A3 WO 2008106226 A3 WO2008106226 A3 WO 2008106226A3 US 2008002717 W US2008002717 W US 2008002717W WO 2008106226 A3 WO2008106226 A3 WO 2008106226A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
macrolide compounds
compounds
Prior art date
Application number
PCT/US2008/002717
Other languages
French (fr)
Other versions
WO2008106226A2 (en
Inventor
Erin M Duffy
Ashoke Bhattacharjee
Zoltan F Kanyo
Jacek G Martynow
Hardwin O'dowd
Yuanqing Tang
Yusheng Wu
Original Assignee
Rib X Pharmaceuticals Inc
Erin M Duffy
Ashoke Bhattacharjee
Zoltan F Kanyo
Jacek G Martynow
Hardwin O'dowd
Yuanqing Tang
Yusheng Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc, Erin M Duffy, Ashoke Bhattacharjee, Zoltan F Kanyo, Jacek G Martynow, Hardwin O'dowd, Yuanqing Tang, Yusheng Wu filed Critical Rib X Pharmaceuticals Inc
Publication of WO2008106226A2 publication Critical patent/WO2008106226A2/en
Publication of WO2008106226A3 publication Critical patent/WO2008106226A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
PCT/US2008/002717 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same WO2008106226A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90439507P 2007-02-28 2007-02-28
US90439607P 2007-02-28 2007-02-28
US90435507P 2007-02-28 2007-02-28
US90435107P 2007-02-28 2007-02-28
US90439207P 2007-02-28 2007-02-28
US60/904,395 2007-02-28
US60/904,392 2007-02-28
US60/904,355 2007-02-28
US60/904,351 2007-02-28
US60/904,396 2007-02-28

Publications (2)

Publication Number Publication Date
WO2008106226A2 WO2008106226A2 (en) 2008-09-04
WO2008106226A3 true WO2008106226A3 (en) 2008-11-20

Family

ID=39433908

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2008/002718 WO2008143729A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002716 WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002658 WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002732 WO2008143730A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002717 WO2008106226A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Family Applications Before (5)

Application Number Title Priority Date Filing Date
PCT/US2008/002718 WO2008143729A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002716 WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002658 WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002732 WO2008143730A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Country Status (1)

Country Link
WO (6) WO2008143729A2 (en)

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Publication number Priority date Publication date Assignee Title
JP2011026260A (en) * 2009-07-28 2011-02-10 Central Glass Co Ltd Protected 2-fluoropropylamine having leaving group at 3-position or protected n-alkyl-2-fluoropropylamine having leaving group at 3-position
JP5662445B2 (en) * 2009-08-13 2015-01-28 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ New macrolides and their use
NZ599289A (en) 2009-10-16 2014-11-28 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
EP2488502A4 (en) 2009-10-16 2013-05-15 Rib X Pharmaceuticals Inc Antimicrobial compounds and methods of making and using the same
LT3406142T (en) 2009-11-13 2021-06-10 Receptos Llc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
JP5988379B2 (en) 2009-11-13 2016-09-07 レセプトス エルエルシー Sphingosine-1-phosphate receptor modulator and asymmetric synthesis method
CN101735149B (en) 2009-11-30 2012-04-18 玉溪市维和生物技术有限责任公司 Macro-cyclic amide compound with antibacterial and anti-tumour activities, preparation method thereof and application thereof
AR085286A1 (en) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd MACROLIDO DERIVATIVE REPLACED IN POSITION C-4
SG193424A1 (en) * 2011-03-15 2013-10-30 Rib X Pharmaceuticals Inc Antimicrobial agents
WO2012158550A2 (en) 2011-05-13 2012-11-22 Receptos, Inc. Selective heterocyclic sphingosine 1 phosphate receptor modulators
EP2751087A1 (en) 2011-06-30 2014-07-09 Piramal Imaging SA Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl)tyrosine
EP2768798A1 (en) * 2011-10-17 2014-08-27 Zoetis LLC Novel phenicol antibacterials
JP5857008B2 (en) * 2012-08-20 2016-02-10 大正製薬株式会社 Medicament containing C-4 ″ substituted macrolide derivative
JP2016529325A (en) 2013-09-09 2016-09-23 メリンタ セラピューティクス，インコーポレイテッド Antimicrobial compounds and methods for their production and use
SG11201601654TA (en) 2013-09-09 2016-04-28 Melinta Therapeutics Inc Antimicrobial compunds and methods of making and using the same
SG11201707346RA (en) 2015-03-11 2017-10-30 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same
CN105152966A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for azide
CN105153020A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for aromatic azide
CN105001118A (en) * 2015-07-20 2015-10-28 湖南华腾制药有限公司 Method for preparing iodine-containing azido compound
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
CN106562943B (en) * 2016-11-09 2019-07-16 济南市儿童医院 Memantine and its application in the drug of preparation treatment Acinetobacter bauamnnii infection
WO2018191682A1 (en) * 2017-04-15 2018-10-18 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
EP3612544B1 (en) * 2017-04-20 2022-11-23 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
US11560395B2 (en) * 2017-04-20 2023-01-24 Rising Tide Foundation Azithromycin derivatives containing a phosphonium ion as anticancer agents
CN108727445B (en) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 Synthesis method of azithromycin impurity F
CN115724823B (en) * 2021-08-27 2023-11-24 中国科学院大连化学物理研究所 Method for preparing dihydrothiophene derivative
CN115745823B (en) * 2022-11-03 2024-02-23 武夷学院 Preparation method and application of compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

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KR100554549B1 (en) * 1997-10-16 2006-03-03 플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
CA2429709A1 (en) * 2000-12-01 2002-07-04 Gary Ashley Motilide compounds
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6992069B2 (en) * 2002-04-30 2006-01-31 Yu-Gui Gu Tricyclic macrolide antibacterial compounds
ITMI20021726A1 (en) * 2002-08-01 2004-02-02 Zambon Spa MACROLIDS WITH ANTI-INFLAMMATORY ACTIVITY.
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Novel antibacterial agents
WO2005121160A2 (en) * 2004-04-26 2005-12-22 Johnson & Johnson Pharmaceutical Research & Development 11, 12 cyclic thiocarbamate macrolide antibacterial agents
JP2009506063A (en) * 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Triazole compounds and methods for making and using the same
EP1928893A2 (en) * 2005-08-24 2008-06-11 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

Also Published As

Publication number Publication date
WO2008106225A1 (en) 2008-09-04
WO2008106204A1 (en) 2008-09-04
WO2008106224A1 (en) 2008-09-04
WO2008143729A3 (en) 2009-05-14
WO2008106226A2 (en) 2008-09-04
WO2008143730A2 (en) 2008-11-27
WO2008143729A2 (en) 2008-11-27
WO2008143730A3 (en) 2009-05-28

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