WO2005118610A3 - Macrocyclic compounds and methods of making and using the same - Google Patents

Macrocyclic compounds and methods of making and using the same

Info

Publication number
WO2005118610A3
WO2005118610A3 PCT/US2005/018733 US2005018733W WO2005118610A3 WO 2005118610 A3 WO2005118610 A3 WO 2005118610A3 US 2005018733 W US2005018733 W US 2005018733W WO 2005118610 A3 WO2005118610 A3 WO 2005118610A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
macrocyclic compounds
compounds
Prior art date
Application number
PCT/US2005/018733
Other languages
French (fr)
Other versions
WO2005118610A2 (en
Inventor
Yi Chen
Jay J Farmer
Joyce A Sutcliffe
Ashoke Bhattacharjee
Original Assignee
Rib X Pharmaceuticals Inc
Yi Chen
Jay J Farmer
Joyce A Sutcliffe
Ashoke Bhattacharjee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/006082 external-priority patent/WO2005085266A2/en
Application filed by Rib X Pharmaceuticals Inc, Yi Chen, Jay J Farmer, Joyce A Sutcliffe, Ashoke Bhattacharjee filed Critical Rib X Pharmaceuticals Inc
Publication of WO2005118610A2 publication Critical patent/WO2005118610A2/en
Publication of WO2005118610A3 publication Critical patent/WO2005118610A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
PCT/US2005/018733 2004-06-01 2005-05-27 Macrocyclic compounds and methods of making and using the same WO2005118610A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57594904P 2004-06-01 2004-06-01
US60/575,949 2004-06-01
PCT/US2005/006082 WO2005085266A2 (en) 2004-02-27 2005-02-25 Macrocyclic compounds and methods of making and using the same
USPCT/US2005/006082 2005-02-25

Publications (2)

Publication Number Publication Date
WO2005118610A2 WO2005118610A2 (en) 2005-12-15
WO2005118610A3 true WO2005118610A3 (en) 2006-10-19

Family

ID=35463422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018733 WO2005118610A2 (en) 2004-06-01 2005-05-27 Macrocyclic compounds and methods of making and using the same

Country Status (1)

Country Link
WO (1) WO2005118610A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5383037B2 (en) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Macrocyclic compounds and methods of making and using them
US7247617B2 (en) 2004-07-13 2007-07-24 Kosan Biosciences Incorporated Sixteen-member macrolide antiinfective agents
US8470985B2 (en) * 2005-08-24 2013-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
US8278281B2 (en) 2005-08-24 2012-10-02 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
US9593140B2 (en) * 2011-11-25 2017-03-14 Bayer Intellectual Property Gmbh Antibacterial tylosin derivatives and methods for their preparation
EA201500699A1 (en) * 2012-12-24 2015-12-30 Рамот Эт Тель-Авив Юниверсити Лтд. AGENTS FOR THE TREATMENT OF GENETIC DISEASES ARISING AS A RESULT OF NONSENS-MUTATIONS, AND METHODS OF IDENTIFICATION OF THESE AGENTS
AU2014270353B2 (en) 2013-05-23 2018-09-20 Elanco Animal Health Gmbh Tylosin derivatives and method for preparation thereof
WO2015198329A1 (en) 2014-06-25 2015-12-30 Bio Blast Pharma Ltd. Injectable formulations for intrathecal administration of antibiotic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003011882A1 (en) * 2001-07-27 2003-02-13 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
WO2004029066A2 (en) * 2002-09-26 2004-04-08 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003011882A1 (en) * 2001-07-27 2003-02-13 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
WO2004029066A2 (en) * 2002-09-26 2004-04-08 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PHAN, LY T. ET AL: "Synthesis and Antibacterial Activity of a Novel Class of 4'-Substituted 16-Membered Ring Macrolides Derived from Tylosin", JOURNAL OF MEDICINAL CHEMISTRY , 47(12), 2965-2968 CODEN: JMCMAR; ISSN: 0022-2623, 2004, XP002376518 *
SANO, HIROSHI ET AL: "Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4'''-de-N-methylspiramycin I and their N-substituted derivatives", JOURNAL OF ANTIBIOTICS , 38(2), 186-96 CODEN: JANTAJ; ISSN: 0021-8820, 1985, XP009064961 *

Also Published As

Publication number Publication date
WO2005118610A2 (en) 2005-12-15

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