WO2008143729A3 - Macrolide compounds and methods of making and using the same - Google Patents

Macrolide compounds and methods of making and using the same Download PDF

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Publication number
WO2008143729A3
WO2008143729A3 PCT/US2008/002718 US2008002718W WO2008143729A3 WO 2008143729 A3 WO2008143729 A3 WO 2008143729A3 US 2008002718 W US2008002718 W US 2008002718W WO 2008143729 A3 WO2008143729 A3 WO 2008143729A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
macrolide compounds
compounds
Prior art date
Application number
PCT/US2008/002718
Other languages
French (fr)
Other versions
WO2008143729A2 (en
Inventor
Shili Chen
Ashoke Bhattacharjee
Erin M Duffy
Original Assignee
Rib X Pharmaceuticals Inc
Shili Chen
Ashoke Bhattacharjee
Erin M Duffy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc, Shili Chen, Ashoke Bhattacharjee, Erin M Duffy filed Critical Rib X Pharmaceuticals Inc
Publication of WO2008143729A2 publication Critical patent/WO2008143729A2/en
Publication of WO2008143729A3 publication Critical patent/WO2008143729A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides a family of branched amide containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory, and prokinetic agents.
PCT/US2008/002718 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same WO2008143729A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90435507P 2007-02-28 2007-02-28
US90439607P 2007-02-28 2007-02-28
US90435107P 2007-02-28 2007-02-28
US90439207P 2007-02-28 2007-02-28
US90439507P 2007-02-28 2007-02-28
US60/904,351 2007-02-28
US60/904,392 2007-02-28
US60/904,395 2007-02-28
US60/904,355 2007-02-28
US60/904,396 2007-02-28

Publications (2)

Publication Number Publication Date
WO2008143729A2 WO2008143729A2 (en) 2008-11-27
WO2008143729A3 true WO2008143729A3 (en) 2009-05-14

Family

ID=39433908

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2008/002718 WO2008143729A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002716 WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002717 WO2008106226A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002732 WO2008143730A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002658 WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Family Applications After (5)

Application Number Title Priority Date Filing Date
PCT/US2008/002716 WO2008106225A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002717 WO2008106226A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002715 WO2008106224A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002732 WO2008143730A2 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same
PCT/US2008/002658 WO2008106204A1 (en) 2007-02-28 2008-02-28 Macrolide compounds and methods of making and using the same

Country Status (1)

Country Link
WO (6) WO2008143729A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103998419A (en) * 2011-10-17 2014-08-20 佐蒂斯有限责任公司 Novel phenicol antibacterials

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JP2011026260A (en) * 2009-07-28 2011-02-10 Central Glass Co Ltd Protected 2-fluoropropylamine having leaving group at 3-position or protected n-alkyl-2-fluoropropylamine having leaving group at 3-position
US8865662B2 (en) 2009-08-13 2014-10-21 Basilea Pharmaceutica Ag Macrolides and their use
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN102725274A (en) 2009-10-16 2012-10-10 Rib-X制药公司 Antimicrobial compounds and methods of making and using the same
EP3868377A1 (en) 2009-11-13 2021-08-25 Receptos Llc Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
KR101781233B1 (en) 2009-11-13 2017-09-22 셀진 인터내셔널 Ii 에스에이알엘 Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
CN101735149B (en) * 2009-11-30 2012-04-18 玉溪市维和生物技术有限责任公司 Macro-cyclic amide compound with antibacterial and anti-tumour activities, preparation method thereof and application thereof
AR085286A1 (en) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd MACROLIDO DERIVATIVE REPLACED IN POSITION C-4
WO2012125832A2 (en) * 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
WO2013001088A1 (en) 2011-06-30 2013-01-03 Piramal Imaging Sa Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine
JP5857008B2 (en) * 2012-08-20 2016-02-10 大正製薬株式会社 Medicament containing C-4 ″ substituted macrolide derivative
JP2016529325A (en) 2013-09-09 2016-09-23 メリンタ セラピューティクス，インコーポレイテッド Antimicrobial compounds and methods for their production and use
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
MX2017011616A (en) 2015-03-11 2018-04-11 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same.
CN105153020A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for aromatic azide
CN105001118A (en) * 2015-07-20 2015-10-28 湖南华腾制药有限公司 Method for preparing iodine-containing azido compound
CN105152966A (en) * 2015-07-20 2015-12-16 湖南华腾制药有限公司 Preparation method for azide
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
CN106562943B (en) * 2016-11-09 2019-07-16 济南市儿童医院 Memantine and its application in the drug of preparation treatment Acinetobacter bauamnnii infection
WO2018191682A1 (en) * 2017-04-15 2018-10-18 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
WO2018193117A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018193125A1 (en) * 2017-04-20 2018-10-25 Novintum Biotechnology Gmbh Azithromycin derivatives containing a phosphonium ion as anticancer agents
CN108727445B (en) * 2018-06-29 2021-06-11 宜昌东阳光生化制药有限公司 Synthesis method of azithromycin impurity F
CN115724823B (en) * 2021-08-27 2023-11-24 中国科学院大连化学物理研究所 Method for preparing dihydrothiophene derivative
CN115745823B (en) * 2022-11-03 2024-02-23 武夷学院 Preparation method and application of compound
CN116574014A (en) * 2023-05-25 2023-08-11 山东锐顺药业有限公司 Preparation method of zolmitriptan intermediate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051855A2 (en) * 2000-12-01 2002-07-04 Kosan Biosciences, Inc. Motilide compounds
WO2004013153A2 (en) * 2002-08-01 2004-02-12 Zambon Group S.P.A. Macrolide compounds endowed with antiinflammatory activity
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

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DE69824201T2 (en) * 1997-10-16 2005-09-22 Pliva - Istrazivacki Institut D.O.O. NEW 9A AZALIDE
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6992069B2 (en) * 2002-04-30 2006-01-31 Yu-Gui Gu Tricyclic macrolide antibacterial compounds
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
US20050250713A1 (en) * 2004-04-26 2005-11-10 Bin Zhu 11,12-Cyclic thiocarbamate macrolide antibacterial agents
WO2007025089A2 (en) * 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
WO2007025284A1 (en) * 2005-08-24 2007-03-01 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051855A2 (en) * 2000-12-01 2002-07-04 Kosan Biosciences, Inc. Motilide compounds
WO2004013153A2 (en) * 2002-08-01 2004-02-12 Zambon Group S.P.A. Macrolide compounds endowed with antiinflammatory activity
WO2005085266A2 (en) * 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103998419A (en) * 2011-10-17 2014-08-20 佐蒂斯有限责任公司 Novel phenicol antibacterials

Also Published As

Publication number Publication date
WO2008143729A2 (en) 2008-11-27
WO2008143730A2 (en) 2008-11-27
WO2008106226A3 (en) 2008-11-20
WO2008106225A1 (en) 2008-09-04
WO2008106204A1 (en) 2008-09-04
WO2008143730A3 (en) 2009-05-28
WO2008106226A2 (en) 2008-09-04
WO2008106224A1 (en) 2008-09-04

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