WO2008105493A1 - 光学活性アミノ酸の製造方法 - Google Patents

光学活性アミノ酸の製造方法 Download PDF

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Publication number
WO2008105493A1
WO2008105493A1 PCT/JP2008/053508 JP2008053508W WO2008105493A1 WO 2008105493 A1 WO2008105493 A1 WO 2008105493A1 JP 2008053508 W JP2008053508 W JP 2008053508W WO 2008105493 A1 WO2008105493 A1 WO 2008105493A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
acid amide
aminonitrile
optically active
biocatalyst
Prior art date
Application number
PCT/JP2008/053508
Other languages
English (en)
French (fr)
Inventor
Akinori Tanaka
Ryuji Hasemi
Yasuhisa Asano
Original Assignee
Mitsubishi Gas Chemical Company, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Gas Chemical Company, Inc. filed Critical Mitsubishi Gas Chemical Company, Inc.
Priority to US12/529,050 priority Critical patent/US20100105111A1/en
Priority to JP2009501294A priority patent/JPWO2008105493A1/ja
Priority to EP08712079A priority patent/EP2130925A4/en
Publication of WO2008105493A1 publication Critical patent/WO2008105493A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

【課題】 　食品や飼料、農薬、工業用薬品、化粧品や医薬品等の合成中間体等として有用であり、有機合成における光学分割剤やキラルビルディングブロック剤としても重要な光学活性アミノ酸を、簡便かつ経済的に製造できる工業的に実施可能な方法を提供する。 【解決手段】 　Ｄ－アミノニトリルとＬ－アミノニトリルの混合物からなるアミノニトリルに、両アミノニトリルの各々をＤ－アミノ酸アミドとＬ－アミノ酸アミドに変換する活性を有する新たに分離した<>ロドコッカス</>属に属する微生物由来の生体触媒と、Ｄ－アミノ酸アミドとＬ－アミノ酸アミドを互いにラセミ化する活性を有する生体触媒と、Ｄ－アミノ酸アミドとＬ－アミノ酸アミドの何れか一方を対応のＤ－アミノ酸またはＬ－アミノ酸に変換する活性を有する生体触媒を作用させる。
PCT/JP2008/053508 2007-02-28 2008-02-28 光学活性アミノ酸の製造方法 WO2008105493A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/529,050 US20100105111A1 (en) 2007-02-28 2008-02-28 Method for production of optically active amino acid
JP2009501294A JPWO2008105493A1 (ja) 2007-02-28 2008-02-28 光学活性アミノ酸の製造方法
EP08712079A EP2130925A4 (en) 2007-02-28 2008-02-28 PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINO ACID

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007049301 2007-02-28
JP2007-049301 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105493A1 true WO2008105493A1 (ja) 2008-09-04

Family

ID=39721317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053508 WO2008105493A1 (ja) 2007-02-28 2008-02-28 光学活性アミノ酸の製造方法

Country Status (4)

Country Link
US (1) US20100105111A1 (ja)
EP (1) EP2130925A4 (ja)
JP (1) JPWO2008105493A1 (ja)
WO (1) WO2008105493A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9717403B2 (en) 2008-12-05 2017-08-01 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63500004A (ja) 1985-06-11 1988-01-07 ノボ　インダストリ　アクテイ−ゼルスカブ 光学活性な有機化合物の調整方法
JPH0231694A (ja) 1988-04-08 1990-02-01 Idemitsu Kosan Co Ltd 光学活性なα‐アミノ酸及び／又はα‐アミノアミドの製造法
JPH03500484A (ja) 1988-05-06 1991-02-07 シエーリング　アクチエンゲゼルシヤフト Ｌ‐アミノ酸およびアミノ酸アミドの製造方法
JPH0316118B2 (ja) 1979-01-24 1991-03-04 Anbaaru Ajansu Nashionaru Do Barorizashion Do Ra Rusherushu
JPH0720432B2 (ja) 1988-03-09 1995-03-08 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造方法
JPH0724590B2 (ja) 1988-03-08 1995-03-22 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造法
JP2670838B2 (ja) 1988-03-08 1997-10-29 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造方法
JP2864277B2 (ja) 1989-06-15 1999-03-03 株式会社ジャパンエナジー 光学活性アミノ酸類の製造方法
JP2003225094A (ja) 2001-12-06 2003-08-12 Degussa Ag Ｖａｒｉｏｖｏｒａｘ由来のＤ−アミダーゼ、それをコードする遺伝子、そのような核酸を含有するプラスミド、ベクターおよび微生物、ハイブリダイズする核酸、核酸を製造するためのプライマー、改良されたｒｅｃ−アミダーゼ、コードｒｅｃ−アミダーゼおよび核酸の製法、Ｄ−アミダーゼおよび核酸の使用、ならびに全細胞触媒
WO2005093080A2 (de) * 2004-03-20 2005-10-06 Degussa Ag Nitrilhydratase aus rhodococcus
WO2006008872A1 (ja) * 2004-07-22 2006-01-26 Mitsubishi Gas Chemical Company, Inc. Ｌ体アミノ酸アミド不斉加水分解酵素及びそれをコードするｄｎａ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001296653A1 (en) * 2000-10-04 2002-04-15 Maxygen, Inc. Enantioselective production of amino carboxylic acids

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0316118B2 (ja) 1979-01-24 1991-03-04 Anbaaru Ajansu Nashionaru Do Barorizashion Do Ra Rusherushu
JPS63500004A (ja) 1985-06-11 1988-01-07 ノボ　インダストリ　アクテイ−ゼルスカブ 光学活性な有機化合物の調整方法
JPH0724590B2 (ja) 1988-03-08 1995-03-22 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造法
JP2670838B2 (ja) 1988-03-08 1997-10-29 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造方法
JPH0720432B2 (ja) 1988-03-09 1995-03-08 株式会社ジャパンエナジー Ｌ―α―アミノ酸類の製造方法
JPH0231694A (ja) 1988-04-08 1990-02-01 Idemitsu Kosan Co Ltd 光学活性なα‐アミノ酸及び／又はα‐アミノアミドの製造法
JPH03500484A (ja) 1988-05-06 1991-02-07 シエーリング　アクチエンゲゼルシヤフト Ｌ‐アミノ酸およびアミノ酸アミドの製造方法
JP2864277B2 (ja) 1989-06-15 1999-03-03 株式会社ジャパンエナジー 光学活性アミノ酸類の製造方法
JP2003225094A (ja) 2001-12-06 2003-08-12 Degussa Ag Ｖａｒｉｏｖｏｒａｘ由来のＤ−アミダーゼ、それをコードする遺伝子、そのような核酸を含有するプラスミド、ベクターおよび微生物、ハイブリダイズする核酸、核酸を製造するためのプライマー、改良されたｒｅｃ−アミダーゼ、コードｒｅｃ−アミダーゼおよび核酸の製法、Ｄ−アミダーゼおよび核酸の使用、ならびに全細胞触媒
WO2005093080A2 (de) * 2004-03-20 2005-10-06 Degussa Ag Nitrilhydratase aus rhodococcus
WO2006008872A1 (ja) * 2004-07-22 2006-01-26 Mitsubishi Gas Chemical Company, Inc. Ｌ体アミノ酸アミド不斉加水分解酵素及びそれをコードするｄｎａ

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ASANO A. ET AL.: "Dynamic kinetic resolution of amino acid amide catalyzed by D-aminopeptidase and alpha-amino-epsiloncaprolactam racemase", J. AM. CHEM. SOC., vol. 127, 2005, pages 7696 - 7697, XP008112084 *
ASANO Y.: "Dynamic na Kogaku Bunkatsu ni yoru Aminonitrile Oyobi Amino Acid Amide kara no Kogaku Kassei Amino Acid no Gosei", 30TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN . DAI 80 KAI THE JAPANESE BIOCHEMICAL SOCIETY TAIKAI GODO TAIKAI KOEN YOSHISHU, 25 November 2007 (2007-11-25), pages 117 + ABSTR. NO. 1W10-12, XP003021970 *
J. ORG. CHEM., vol. 55, 1990, pages 5567 - 5571
KOMEDA H. ET AL.: "L: -Stereoselective amino acid amidase with broad substrate specificity from Brevundimonas diminuta: characterization of a new member of the leucine aminopeptidase family", APPL. MICROBIOL. BIOTECHNOL., vol. 70, no. 4, 2006, pages 412 - 421, XP019332125 *
YASUHISA ASANO, J. MOL. CATAL. B: ENZYMATIC, vol. 36, 2005, pages 22 - 29

Also Published As

Publication number Publication date
US20100105111A1 (en) 2010-04-29
EP2130925A4 (en) 2011-06-01
EP2130925A1 (en) 2009-12-09
JPWO2008105493A1 (ja) 2010-06-03

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