WO2008105476A1 - 概日リズム遺伝子および時計モチーフ - Google Patents

概日リズム遺伝子および時計モチーフ Download PDF

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Publication number
WO2008105476A1
WO2008105476A1 PCT/JP2008/053448 JP2008053448W WO2008105476A1 WO 2008105476 A1 WO2008105476 A1 WO 2008105476A1 JP 2008053448 W JP2008053448 W JP 2008053448W WO 2008105476 A1 WO2008105476 A1 WO 2008105476A1
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WO
WIPO (PCT)
Prior art keywords
circadian rhythm
motif
clock
pharmaceutical composition
cartilage
Prior art date
Application number
PCT/JP2008/053448
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English (en)
French (fr)
Inventor
Yukio Kato
Takeshi Kawamoto
Taichi Ueshima
Mitsuhide Noshiro
Osamu Gotoh
Original Assignee
Hiroshima University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hiroshima University filed Critical Hiroshima University
Publication of WO2008105476A1 publication Critical patent/WO2008105476A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

概日リズム障害（例えば、軟骨・骨概日リズム障害）の診断マーカーとして使用可能な薬学的組成物を提供すること、および、時間治療のための薬学的組成物を提供することを本発明の課題とする。本発明に従って、軟骨・骨概日リズム障害の診断マーカーとして使用可能な複数の遺伝子が同定されることによって、軟骨・骨概日リズム障害およびその他の概日リズム障害の診断マーカーとして使用可能な薬学的組成物が提供された。また、本発明に従って、概日リズムに関連する時計モチーフを同定することによって、時間治療のための薬学的組成物が提供された。
PCT/JP2008/053448 2007-02-27 2008-02-27 概日リズム遺伝子および時計モチーフ WO2008105476A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007048189 2007-02-27
JP2007-048189 2007-02-27

Publications (1)

Publication Number Publication Date
WO2008105476A1 true WO2008105476A1 (ja) 2008-09-04

Family

ID=39721300

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053448 WO2008105476A1 (ja) 2007-02-27 2008-02-27 概日リズム遺伝子および時計モチーフ

Country Status (1)

Country Link
WO (1) WO2008105476A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336355A1 (en) * 2008-10-16 2011-06-22 Sony Corporation Biological rhythm prediction method
WO2013054846A1 (ja) * 2011-10-11 2013-04-18 日清食品ホールディングス株式会社 哺乳動物細胞を用いた変異原性試験法
CN113368244A (zh) * 2021-08-04 2021-09-10 华中科技大学同济医学院附属协和医院 Bmal1基因在制备检测治疗软骨发育不全疾病产品中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATO Y. ET AL.: "Nankotsu. Hone no Gaijitsu Rhythm", CLINICAL CALCIUM, vol. 16, 2006, pages 118 - 125 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336355A1 (en) * 2008-10-16 2011-06-22 Sony Corporation Biological rhythm prediction method
EP2336355A4 (en) * 2008-10-16 2012-06-06 Sony Corp METHOD FOR PREDICTING A BIOLOGICAL RHYTHM
WO2013054846A1 (ja) * 2011-10-11 2013-04-18 日清食品ホールディングス株式会社 哺乳動物細胞を用いた変異原性試験法
JPWO2013054846A1 (ja) * 2011-10-11 2015-03-30 日清食品ホールディングス株式会社 哺乳動物細胞を用いた変異原性試験法
CN113368244A (zh) * 2021-08-04 2021-09-10 华中科技大学同济医学院附属协和医院 Bmal1基因在制备检测治疗软骨发育不全疾病产品中的应用

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