MX2013004747A - Marcadores de gen de sangre periferica para el diagnostico temprano de la enfermedad de parkinson. - Google Patents

Marcadores de gen de sangre periferica para el diagnostico temprano de la enfermedad de parkinson.

Info

Publication number
MX2013004747A
MX2013004747A MX2013004747A MX2013004747A MX2013004747A MX 2013004747 A MX2013004747 A MX 2013004747A MX 2013004747 A MX2013004747 A MX 2013004747A MX 2013004747 A MX2013004747 A MX 2013004747A MX 2013004747 A MX2013004747 A MX 2013004747A
Authority
MX
Mexico
Prior art keywords
parkinson
disease
peripheral blood
early diagnosis
gene markers
Prior art date
Application number
MX2013004747A
Other languages
English (en)
Inventor
Moussa B H Youdim
Silvia A Mandel
Peter Riederer
Jose M Rabey
Leonid Molochnikov
Edna Gruenblatt
Original Assignee
Leonid Molochnikov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leonid Molochnikov filed Critical Leonid Molochnikov
Publication of MX2013004747A publication Critical patent/MX2013004747A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con el uso de perfiles para marcadores de riesgo molecular para el diagnóstico de la enfermedad de Parkinson; en particular, la invención proporciona métodos para el diagnóstico de la enfermedad de Parkinson en un individuo utilizando ciertos perfiles establecidos con base en los niveles de expresión de ciertos genes, que en conjunto forman un panel génico, en la sangre periférica de dicho individuo, así como los kits para llevar a cabo estos métodos; el perfil abarca ALDH1A1.
MX2013004747A 2010-10-26 2011-10-26 Marcadores de gen de sangre periferica para el diagnostico temprano de la enfermedad de parkinson. MX2013004747A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40678210P 2010-10-26 2010-10-26
PCT/IL2011/000830 WO2012056451A2 (en) 2010-10-26 2011-10-26 Peripheral blood gene markers for early diagnosis of parkinson's disease

Publications (1)

Publication Number Publication Date
MX2013004747A true MX2013004747A (es) 2013-11-20

Family

ID=45217594

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004747A MX2013004747A (es) 2010-10-26 2011-10-26 Marcadores de gen de sangre periferica para el diagnostico temprano de la enfermedad de parkinson.

Country Status (7)

Country Link
US (1) US20130217028A1 (es)
EP (1) EP2633078B1 (es)
AU (1) AU2011322108A1 (es)
BR (1) BR112013010069A2 (es)
CA (1) CA2815896A1 (es)
MX (1) MX2013004747A (es)
WO (1) WO2012056451A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7779039B2 (en) 2004-04-02 2010-08-17 Salesforce.Com, Inc. Custom entities and fields in a multi-tenant database system
WO2007030796A2 (en) 2005-09-09 2007-03-15 Salesforce.Com, Inc. Systems and methods for exporting, publishing, browsing and installing on-demand applications in a multi-tenant database environment
CN104984363B (zh) * 2015-07-31 2017-12-26 固安博健生物技术有限公司 Zmym1在制备帕金森诊疗试剂中的应用
WO2018202740A1 (en) 2017-05-04 2018-11-08 Universitat De Barcelona Method for predicting early onset and severity of levodopa induced dyskinesia (lid) in subjects diagnosed of parkinson disease (pd)
WO2019092715A1 (en) * 2017-11-08 2019-05-16 Bio Shai Ltd. Methods for prognosis or treatment of parkinson's disease
WO2019217807A2 (en) * 2018-05-10 2019-11-14 Integrated Nano-Technologies, Inc. Systems and methods for determining risk or diagnosis of a neurodegenerative disease
US20220081715A1 (en) 2019-01-17 2022-03-17 Katholieke Universiteit Leuven mRNA-BASED BIOMARKERS FOR ANTIBODY-MEDIATED TRANSPLANT REJECTION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1711632A4 (en) * 2004-01-19 2009-03-11 Technion Res & Dev Foundation DIAGNOSTIC TEST FOR PARKINSON

Also Published As

Publication number Publication date
BR112013010069A2 (pt) 2016-08-02
AU2011322108A1 (en) 2013-05-30
WO2012056451A9 (en) 2013-06-13
US20130217028A1 (en) 2013-08-22
EP2633078B1 (en) 2018-06-13
WO2012056451A2 (en) 2012-05-03
WO2012056451A3 (en) 2012-07-05
EP2633078A2 (en) 2013-09-04
CA2815896A1 (en) 2012-05-03

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