IL202083A0 - Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system - Google Patents

Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system

Info

Publication number
IL202083A0
IL202083A0 IL202083A IL20208309A IL202083A0 IL 202083 A0 IL202083 A0 IL 202083A0 IL 202083 A IL202083 A IL 202083A IL 20208309 A IL20208309 A IL 20208309A IL 202083 A0 IL202083 A0 IL 202083A0
Authority
IL
Israel
Prior art keywords
methods
pharmaceutical compositions
nervous system
central nervous
therapeutic compounds
Prior art date
Application number
IL202083A
Original Assignee
Healthpartners Res Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Healthpartners Res Foundation filed Critical Healthpartners Res Foundation
Publication of IL202083A0 publication Critical patent/IL202083A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2006—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
IL202083A 2007-06-08 2009-11-12 Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system IL202083A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94269607P 2007-06-08 2007-06-08
PCT/US2008/066033 WO2008154337A1 (en) 2007-06-08 2008-06-06 Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system
US12/134,385 US9808509B2 (en) 2007-06-08 2008-06-06 Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system

Publications (1)

Publication Number Publication Date
IL202083A0 true IL202083A0 (en) 2010-06-16

Family

ID=40096080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL202083A IL202083A0 (en) 2007-06-08 2009-11-12 Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system

Country Status (6)

Country Link
US (2) US9808509B2 (en)
EP (1) EP2152240A4 (en)
JP (1) JP2011504163A (en)
CA (1) CA2687505C (en)
IL (1) IL202083A0 (en)
WO (1) WO2008154337A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100383A2 (en) 2008-02-07 2009-08-13 University Of Washington Circumferential aerosol device
JP5863650B2 (en) 2009-07-27 2016-02-16 ノシセプタ エルエルシー Method for treating pain
FR2948809B1 (en) * 2009-07-31 2012-08-17 St Microelectronics Rousset LOW POWER SELF-MINUTE READING AMPLIFIER
US8592485B2 (en) * 2010-06-17 2013-11-26 Healthpartners Research Foundation Methods and pharmaceutical compositions for treating the animal central nervous system for psychiatric disorders
RU2728583C2 (en) 2011-03-03 2020-07-30 Импел Ньюрофарма Инк. Device for nasal drug delivery
EP3851142A1 (en) 2011-05-09 2021-07-21 Impel NeuroPharma Inc. Nozzles for nasal drug delivery
US8609088B2 (en) 2011-05-10 2013-12-17 Regents Of The University Of Minnesota Intranasal delivery of therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases
US20130336928A1 (en) * 2012-06-18 2013-12-19 Healthpartners Research & Education Methods and pharmaceutical compositions for treatment of central nervous system disorders with therapeutic agent(s) in patients with concurrent non-cns condition(s) or disorders contraindicating systemic administration of the therapeutic agent(s)
ES2880399T3 (en) 2012-07-27 2021-11-24 Neurodyn Life Sciences Inc Improved cerebral bioavailability of galantamine through selected formulations and transmucosal administration of lipophilic prodrugs
CN104507461A (en) * 2012-07-27 2015-04-08 神经动力生命科学公司 Enhanced brain bioavailability of galantamine by selected formulations and transmucosal administration of lipophilic prodrugs
ES2442242B1 (en) * 2012-08-09 2014-11-25 Biotechnology Institute, I Mas D, S.L. Composition with growth factors intended for intranasal treatment of a neurodegenerative disease or other pathology of the central nervous system, and its manufacturing method.
PT2961426T (en) 2013-02-26 2019-12-09 Baxalta Inc Treatment of central nervous system disorders by intranasal administration of immunoglobulin g
US10279012B2 (en) * 2013-03-11 2019-05-07 Healthpartners Research & Education Methods of treating and preventing social communication disorder in patients by intranasal administration of insulin
WO2014159878A2 (en) 2013-03-13 2014-10-02 Regents Of The University Of California Intranasal administration of guanidinylated aminoglycosides
WO2014169272A1 (en) 2013-04-12 2014-10-16 Icahn School Of Medicine At Mount Sinai Method for treating post-traumatic stress disorder
JP2016520378A (en) 2013-04-28 2016-07-14 インペル ニューロファーマ インコーポレイテッド Medical unit dose container
KR20220119187A (en) 2013-05-15 2022-08-26 리젠츠 오브 더 유니버시티 오브 미네소타 Adeno-associated virus mediated gene transfer to the central nervous system
US10314911B2 (en) * 2014-04-08 2019-06-11 Healthpartners Research & Education Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
SI3242676T1 (en) 2015-01-07 2024-02-29 Tonix Pharma Limited Magnesium-containing oxytocin formulations and methods of use
MX2018002895A (en) 2015-09-10 2018-07-06 Impel Neuropharma Inc In-line nasal delivery device.
BR112018071156A2 (en) 2016-04-15 2019-03-12 The Trustees Of The University Of Pennsylvania gene therapy to treat mucopolysaccharidosis type ii
US10449230B2 (en) 2016-10-06 2019-10-22 The Regents Of The University Of California Polymyxin derived cell penetrating scaffolds
EP3684938A1 (en) 2017-09-22 2020-07-29 The Trustees of the University of Pennsylvania Gene therapy for treating mucopolysaccharidosis type ii
JP2021503988A (en) 2017-11-21 2021-02-15 インペル ニューロファーマ インコーポレイテッド Intranasal device with inlet interface
JP7191099B2 (en) 2017-11-21 2022-12-16 インペル ファーマシューティカルズ インコーポレイテッド intranasal device with dip tube
BR112020013750A8 (en) 2018-01-05 2022-10-18 Impel Neuropharma Inc INTRANASAL DISPENSE OF OLANZAPINE BY PRECISION OLFATIVE DEVICE
US20190209463A1 (en) 2018-01-05 2019-07-11 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
JP2021532098A (en) 2018-07-19 2021-11-25 インペル ニューロファーマ インコーポレイテッド Respiratory tract delivery of levodopa and dopa decarboxylase inhibitors for the treatment of Parkinson's disease
BR112021013244A8 (en) 2019-01-03 2022-10-18 Impel Neuropharma Inc NASAL DRUG DELIVERY DEVICE
EP3969085A4 (en) 2019-05-17 2023-06-21 Impel Pharmaceuticals Inc. Single-use nasal delivery device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2989437A (en) * 1955-06-08 1961-06-20 Upjohn Co Anti-inflammatory and anti-bacterial decongestant nasal spray compositions
US5624898A (en) * 1989-12-05 1997-04-29 Ramsey Foundation Method for administering neurologic agents to the brain
US5855907A (en) 1997-03-24 1999-01-05 Peyman; Gholam A. Method of treatment of migraine
US20010053775A1 (en) * 1998-01-30 2001-12-20 Matthias Seidel Nasal solutions
US7534866B2 (en) 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
US7112566B1 (en) * 1999-09-17 2006-09-26 The Regents Of The University Of California Systemic administration of Hypocretin-1
CA2393688A1 (en) * 1999-12-09 2001-06-14 Chiron Corporation Method for administering a cytokine to the central nervous system and the lymphatic system
JP2005524649A (en) * 2002-02-25 2005-08-18 カイロン コーポレーション Intranasal administration of MC4-R agonist
US7071172B2 (en) * 2002-04-30 2006-07-04 The University Of North Carolina At Chapel Hill Secretion signal vectors
US7491695B2 (en) 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
US7618615B2 (en) * 2004-08-13 2009-11-17 Healthpartners Research Foundation Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
US7776312B2 (en) 2004-08-13 2010-08-17 Healthpartners Research Foundation Method of treating Alzheimer's disease comprising administering deferoxamine (DFO) to the upper one-third of the nasal cavity
US20090317377A1 (en) 2005-08-26 2009-12-24 Yeomans David C Therapy procedure for drug delivery for trigeminal pain

Also Published As

Publication number Publication date
CA2687505C (en) 2013-10-08
US20180125940A1 (en) 2018-05-10
EP2152240A1 (en) 2010-02-17
US9808509B2 (en) 2017-11-07
CA2687505A1 (en) 2008-12-18
EP2152240A4 (en) 2012-05-09
US10098928B2 (en) 2018-10-16
WO2008154337A1 (en) 2008-12-18
JP2011504163A (en) 2011-02-03
US20080305077A1 (en) 2008-12-11

Similar Documents

Publication Publication Date Title
IL202083A0 (en) Pharmaceutical compositions and methods for enhancing targeting of therapeutic compounds to the central nervous system
SG10201401661RA (en) Multicycle compounds and pharmaceutical compositions useful for the treatment of neurological disorders
PT2482812T (en) Therapeutic uses of pharmaceutical compositions
ZA201100034B (en) Pharmaceutical compositions for treatment of parkinson's disease
HK1211889A1 (en) Therapeutic use of diaminophenothiazines
EP2291157A4 (en) Compositions and methods for the transdermal delivery of pharmaceutical compounds
IL193727A0 (en) Dosage forms for administering combinations of drugs
EP2152316A4 (en) Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system
HK1147767A1 (en) Compositions and methods for the therapy and diagnosis of influenza
ZA200905962B (en) Combination therapy for treatment of immune disorders
EP2207802A4 (en) Intranasal administration of active agents to the central nervous system
EP2268140A4 (en) Novel compounds advantageous in the treatment of central nervous system diseases and disorders
HK1141447A1 (en) Pharmaceutical composition for the treatment of proliferative diseases
ZA201200944B (en) Pharmaceutical compositions for the treatment of cancer and other diseases or disorders
EP2114415A4 (en) Methods and compounds for the targeted delivery of agents to bone for interaction therewith
PL385972A1 (en) Pharmaceutical composition for therapy of parodonthium deseases
IL206435A0 (en) Therapeutic regimens for the treatment of immunoinflammatory disorders
PL2331092T3 (en) Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
EP2222295A4 (en) Pharmaceutical composition for treatment and prevention of kidney diseases
EP2203174A4 (en) Therapeutic regimens for the treatment of immunoinflammatory disorders
PT2344166E (en) Pharmaceutical composition for the treatment of gastrointestinal irritation disorders
EP2578206A4 (en) Pharmaceutical composition for the treatment of disorders of the lower section of the urogenital system
EP2329824A4 (en) Novel pharmaceutical composition for treatment of nociceptive pain
IL209804A0 (en) Pharmaceutical compositions for treatment of parkinson's disease
GB0715256D0 (en) Benzylthiazolypiperazine derivatives for the treatment of neuro degenerative diseases