WO2008101374A2 - 眼压监护装置 - Google Patents

眼压监护装置 Download PDF

Info

Publication number
WO2008101374A2
WO2008101374A2 PCT/CN2007/002278 CN2007002278W WO2008101374A2 WO 2008101374 A2 WO2008101374 A2 WO 2008101374A2 CN 2007002278 W CN2007002278 W CN 2007002278W WO 2008101374 A2 WO2008101374 A2 WO 2008101374A2
Authority
WO
WIPO (PCT)
Prior art keywords
intraocular pressure
coil
eyeball
magnetic
magnetic field
Prior art date
Application number
PCT/CN2007/002278
Other languages
English (en)
French (fr)
Other versions
WO2008101374A3 (zh
Inventor
Jialiang Zhao
Jianfa Wang
Xueqiao Wang
Original Assignee
Tianjin Suowei Electronic Technology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Suowei Electronic Technology Co., Ltd. filed Critical Tianjin Suowei Electronic Technology Co., Ltd.
Publication of WO2008101374A2 publication Critical patent/WO2008101374A2/zh
Publication of WO2008101374A3 publication Critical patent/WO2008101374A3/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers

Definitions

  • Intraocular pressure monitoring device Intraocular pressure monitoring device
  • the present invention relates to an intraocular pressure monitoring device, and more particularly to an intraocular pressure monitoring device using a magnetic vibration sensor and a resonance principle. Background technique
  • intraocular pressure monitoring is of great significance for the diagnosis and treatment of glaucoma.
  • the device capable of monitoring intraocular pressure for 24 hours is an urgently needed device for the diagnosis and medical research of glaucoma.
  • intraocular pressure monitoring devices implantable, patched, and resonant. The description is as follows:
  • the passive sensor changes the capacitance of the RF coil by the pressure of the aqueous water, thereby changing the resonant frequency of the RF coil, and the resonant frequency can be obtained by the external excitation coil to obtain the intraocular pressure.
  • method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitor recorder US6579235, Joseph L. Abita etc, 2000.
  • the active sensor transmits intraocular pressure data to an external receiver by implanting a built-in signal processing and data transmission chip through RF power.
  • Intraocular pressure monitoring/measuring apparatus and method (US6193656, Robert E. Jeffries etc, 1999).
  • the second type SMD type of intraocular pressure monitor through the contact lens or other device, the sensor is attached to the surface of the cornea, by measuring the curvature of the cornea (US2004186366), tension (US5251627) or hardness (US5179953, US4922913AK US5179953) To get intraocular pressure data.
  • the third category: Resonance This type of intraocular pressure monitor can cause changes in the resonance frequency of the eyeball according to changes in intraocular pressure. For an infinitely thin spherical shell, the resonant frequency is proportional to the square root of the intraocular pressure.
  • Such tonometers actuate the eyeball by means of audio sonic excitation or mechanical hammer excitation, and obtain intraocular pressure by measuring the resonance frequency of the cornea or fundus.
  • the main difference is the way of picking up.
  • fiber pick-up US5375595
  • laser interference pick-up US2004046937
  • ultrasonic Doppler pick-up US6030343
  • capacitor pick-up Choen Zenghan, resonant non-contact tonometer design discussion, China Medical Devices Magazine, 1989 Volume 13, Number 1, pl3 ⁇ 16
  • mechanical contact pick-up US6800061, US2003187343
  • the implantable intraocular pressure monitor has the highest accuracy, but it must be implanted in the patient's anterior chamber, only for cataract patients who need to be implanted in the lens.
  • the patch sensor is greatly affected by the radius of curvature of the cornea, the thickness of the cornea, and the elastic modulus of the cornea.
  • the type of intraocular pressure monitor needs to apply the sensor to the corneal surface through a large pre-tightening force, or needs to be customized.
  • Contact lenses that are closely matched to the patient's corneal surface are more restrictive to the patient's daily activities during monitoring and are difficult to monitor for long periods of time.
  • Resonance type IOP monitors have reported that the method of picking up is affected by distance and eyelids.
  • the technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a novel intraocular pressure monitoring device, which has non-implantation, is insensitive to eye movement, has small pressure on the eyeball, and can be continuously monitored for 24 hours.
  • the basic idea of adopting the technical solution of the present invention is: an intraocular pressure monitoring device,
  • the tonometer is characterized in that: the ocular pressure monitoring device comprises a spectacle frame, a magnetic vibrator and a processing module, wherein the spectacle frame is provided with a coil that is energized to generate an induced magnetic field; and the magnetic vibrator is excited by an external magnetic field and closely adheres to the eyeball.
  • the processing module Invigorating the eyeball vibration, simultaneously following the eyeball vibration, and generating an induced electromotive force in the coil in the eyeglass frame; the processing module generates a signal to cause an induced magnetic field in the inner frame of the eyeglass frame, and measures the induced electromotive force by the magnetic induction principle to obtain the vibration of the eyeball Information, thereby obtaining the resonance frequency of the cornea, and then acquiring the intraocular pressure.
  • the invention combines the characteristics of the patch type and the resonance type intraocular pressure monitor, and the magnetic vibrator is clamped on the cornea in the contact lens, and the magnetic vibrator is excited by the external magnetic field to urge the eyeball to vibrate, and the vibration of the eyeball drives the vibrator to vibrate.
  • the vibrator vibration in turn causes a disturbance of the external magnetic field, thereby generating a corresponding induced electromotive force in the induction coil.
  • the corneal vibration information can be acquired by detecting the induced electromotive force, and the resonance frequency can be extracted therefrom to obtain the intraocular pressure.
  • the magnon is placed in the center of the two contact lenses by a thin magnetic ring to form a "sandwich" structure that can be assembled into a contact lens by ultrasonic welding or bonding.
  • the contact lens with the embedded magnetic ring is similar to the conventional contact lens and can be worn directly on the patient's cornea.
  • the processing module of the present invention mainly comprises an analog signal processing module, a high-speed logic processing unit, a low-power single-chip microcomputer and a wireless transmission module, and is powered by a rechargeable battery, wherein the analog signal processing module comprises a signal for generating a bias magnetic field and an excitation magnetic field.
  • the processing module can be disposed on a corner frame of the eyeglass frame.
  • the excitation coil is a measuring coil at the same time, and the vibration of the magnetic vibrator generates an induced electromotive force in the excitation coil, and the induced electromotive force generated by the magnetic vibration vibration can be extracted by the processing of the subsequent circuit.
  • the magnetic vibrator needs to be in close contact with the cornea during the measurement process.
  • the present invention compresses the magnetic ring against the cornea by generating a bias magnetic field by the excitation coil.
  • the invention extracts the induced electromotive force generated by the magnon in the excitation coil through the Wheatstone bridge.
  • L2 is the excitation coil and the measurement coil
  • L1 is the compensation coil
  • the two constitute one bridge arm
  • R1 and R2 constitute the other bridge arm.
  • V 2 ⁇ ⁇ ⁇ (V 0 - V) + AV
  • the patient's heartbeat also causes the eyeball to vibrate, so the invention can also simultaneously measure the heartbeat frequency, that is, the heartbeat frequency of the patient can also be obtained according to the amplitude spectrum of the ball vibration.
  • the intraocular pressure monitoring device of the invention does not need to be implanted in the anterior chamber first, has a simple structure and is convenient for more patients; secondly, it is insensitive to eye movement and has small pressure on the eyeball, so that the patient is more comfortable to use, and the night monitoring can be performed. It enables the continuity of monitoring and better monitors the patient's intraocular pressure.
  • FIG. 1 is a schematic view showing the working principle of an intraocular pressure monitoring device according to the present invention
  • FIG. 2 is a schematic view showing the assembled structure of a magnetic vibrator according to the present invention
  • FIG. 4 is a waveform diagram of the excitation signal according to the present invention
  • 5 is a measurement bridge diagram of the present invention
  • FIG. 6 is a flow chart of the operation of the present invention
  • FIG. 7 is a frequency spectrum diagram of eyeball vibration under excitation conditions of the present invention.
  • Figure 8 is a block diagram of the system of the present invention.
  • the intraocular pressure monitoring device of the present invention comprises an eyeglass frame 6, a magnetic vibrator 4 and a processing module.
  • the eyeglass frame 6 is placed in front of the eye, the processing module 7 is disposed on the eyeglass frame 62 at a position close to the eyeglass frame 61, and the magnetic vibrator 4 is mounted on the eyeball 5.
  • the eyeglass frame 6 is electrically connected to generate an induction.
  • the magnetic vibrator 4 is excited by an external magnetic field to abut the eyeball 5 and oscillates the eyeball 5 to vibrate, simultaneously vibrating the eyeball 5, and generating an induced electromotive force in the coil in the spectacle frame 6; the processing module 7 generates The signal is such that the coil in the spectacle frame 6 generates an induced magnetic field, and the induced electromotive force is measured by the principle of magnetic induction, and the vibration information of the eyeball 5 is acquired, thereby obtaining the resonance frequency of the cornea, and then acquiring the intraocular pressure.
  • the magnetic vibrator 4 in the form of a contact lens is worn on the surface of the eyeball 5.
  • the patient wears a pair of eyeglass frames 6, in which an excitation and measuring coil, a measuring coil and an excitation coil are embedded.
  • the excitation signal generated by the processing module 7 is supplied to the coils in the spectacle frame 6.
  • the coil generates an exciting magnetic field a acting on the magnetic ring in the magnetron 4.
  • the magnon 4 incites the eyeball 5 to be concentrically vibrated.
  • the vibration of the eyeball 5 drives the magnetron 4 to vibrate, and the vibration of the magnetron 4 disturbs the magnetic field of the excitation coil, generating an induced electromotive force in the excitation coil.
  • the processing module 7 detects the induced electromotive force in the excitation coil by a specific method including subsequent circuit processing such as bridge, signal amplification, filtering, etc. (see FIGS. 5 and 8) to acquire the vibration information of the eyeball 5.
  • the information is subjected to FFT analysis to obtain the amplitude spectrum of the eyeball vibration (see Fig. 7).
  • At least the heartbeat frequency f of the patient and the resonance frequency f of the eyeball can be obtained from the amplitude spectrum.
  • the mathematical expression of the excitation signal generated by the processing module 7 described above is as follows:
  • the voltage required to generate the bias magnetic field is the amplitude of the excitation signal at each frequency point, where ⁇ is the frequency of the excitation signal, ⁇ is the phase, and is randomly distributed between [0, 2] as shown in Figure 4.
  • the voltage for generating the bias magnetic field in this embodiment is 4V
  • the voltage for generating the excitation signal is from 1 to 1000 Hz
  • the interval is 1 ⁇
  • the amplitude of each frequency is 0. IV
  • the phases are randomly distributed in a normal state.
  • the induced electromotive force generated in the excitation coil is as follows: Among them, L2 is the excitation coil and the measurement coil, L1 is the compensation coil, and the two constitute one bridge arm, and R1 and R2 constitute the other bridge arm. As shown in Fig. 5, it is a bridge for detecting the induced electromotive force.
  • the excitation and sensing coil L1 is wound with an enameled wire having a diameter of 0.01 mm, a total of 100 inches, and a diameter of 30 cm.
  • the compensation coil L2 is also wound with an enamel wire of 0.01 mm diameter, 10 ⁇ in total, and 1 cm in diameter, placed in the processing module (7). In order to reduce the mutual interference between the two, L1 and L2 are vertically distributed.
  • R1 takes 100 ⁇ ⁇ and R2 is a variable resistor.
  • the excitation signal is applied to the bridge, and R2 is adjusted to balance the bridge.
  • the values in the figure need to be determined according to the specific circuit, not a certain value.
  • FIG 2 shows the way in which the magnetic vibrators are assembled.
  • the magnon 4 is composed of an upper contact lens 1, a magnetic ring 2 and a lower contact lens 3.
  • the magnon is worn in the same way as a normal soft contact lens, and it fits on the eyeball (see Figure 3).
  • the two contact lenses 1, 3 can be customized and have a recess 22 in which the magnetic ring 2 is accommodated.
  • the existing soft contact lens can be directly assembled into a "sandwich" structure contact lens by ultrasonic welding or bonding.
  • the lower contact lens 3 must be thinner than the upper contact lens 1.
  • the thickness of the lower contact lens 3 is taken as 0.1 brain, and the thickness of the upper contact lens 1 is taken as 0. 8 let.
  • Magnetic ring 2 The light-transmitting hole having a thickness of 0. 5 mm, an outer diameter of 8 mra and an inner diameter of 6 mm is made of a neodymium-iron-boron permanent magnet material.
  • Figure 6 is a flow chart of the intraocular pressure monitor of the present invention. The system performs measurement every hour or less, and the excitation signal is applied for about 10 s in a single measurement.
  • the pre-tightening magnetic field described in the figure is the bias magnetic field generated by the bias voltage through the excitation coil, in order to magnetically The ring is pressed against the cornea.
  • Figure 7 is a spectrum of acquired eye vibration amplitudes.
  • the signal extraction, amplification, and spectral analysis of the bridge can at least obtain the heartbeat frequency and the eye resonance frequency of the patient, so the present invention can also be used to measure the heartbeat frequency of the patient at the same time.
  • Figure 8 is a system frame diagram, in which the part inside the large frame is the processing module 7, which includes analog signal processing, high-speed logic processing unit (using Altera's EP1C3T144C8), low-power single-chip microcomputer (using MS's MSP430F149), and wireless transmission module. Powered by a rechargeable battery.
  • the analog signal processing module consists of two parts, input and output. The output channel is used to generate a bias magnetic field signal and an excitation signal.
  • the MCU sends the pre-designed bias signal and offset signal data to the FPGA, and the FPGA sends it to the DA through the high-speed logic, and sends it to the excitation coil after the power amplifier.
  • the input channel is used to acquire the vibration signal generated by the magnetron 4.
  • the vibration signal is converted into a differential voltage by the bridge shown in FIG. 5, and then differentially amplified to enter the band pass filter.
  • the passband of the bandpass filter is 40 ⁇ 1 ⁇ , retaining the heartbeat frequency and the eyeball resonance frequency, removing the low frequency signal caused by the natural flutter of the eyeball and the chirp frequency signal caused by the eyelid vibration, and then the FPGA filters the signal through AD ⁇ Collected into the FPGA.
  • the fast FFT transform is implemented in the FPGA.
  • the amplitude spectrum shown in Figure 7 can be obtained. Then the FPGA sends 1024 points of spectrum data to the MCU, and the MCU resonance frequency f is obtained after processing by the MCU. . And the heartbeat frequency f, then the intraocular pressure can be obtained by the formula, where k is the calibration parameter.
  • the module 7 can be stored in the internal MCU, and can transmit data to the data center through the wireless module during a monitoring period or during the monitoring process.
  • the intraocular pressure monitoring device of the invention does not need to be implanted in the anterior chamber first, has a simple structure and is convenient for more patients; secondly, it is insensitive to eye movement and has small pressure on the eyeball, so that the patient is more comfortable to use, and the night monitoring can be performed. It enables the continuity of monitoring and better monitors the patient's intraocular pressure.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)

Description

眼压监护装置 技术领域
本发明涉及一种眼压监护装置， 尤其是一种通过使用磁振动传感器和共振原理 的眼压监护装置。 背景技术
目前眼压监护对于青光眼的诊断和治疗具有重大意义， 尤其是能够对眼压进行 24小时监护的装置更是青光眼的诊断和医学研究迫切需要的设备。 目前公知的眼压监护装置主要有以下三种类型： 植入式、 贴片式和共振式。 其 说明如下： 第一类： 植入式 ' 该类眼压监护仪将一枚传感器植入前房内， 通过传感器直接传感房水压强。 传 感器分为被动传感器和主动传感器两类。 被动传感器通过房水压强改变射频线圈的电容， 从而改变射频线圈共振频率， 通过外部激励线圈能够获取该共振频率，从而获取眼内压。具体内容见" method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder" (US6579235, Joseph L. Abita etc, 2000)。 主动传感器通过植入一枚内置信号处理和数据传输芯片， 通过射频供电， 将眼 压数据传输给外部接收器。 具体 内 容见 " intraocular pressure monitoring/measuring apparatus and method" (US6193656, Robert E. Jeffries etc, 1999)。 第二类： 贴片式 该类眼压监护仪通过角膜接触镜或者其他装置， 将传感器贴在角膜表面， 通过 测量角膜的曲率变化 (US2004186366)、 张力 (US5251627)或者硬度 (US5179953、 US4922913AK US5179953)来获取眼压数据。 第三类： 共振式 该类眼压监护仪通过依据眼内压的变化会引起眼球共振频率的变化。 对于一个 无限薄的球壳， 其共振频率与眼压的平方根成正比。 该类眼压计通过音频声波激励 或者机械锤激励等方式策动眼球， 通过测量角膜或者眼底的共振频率来获取眼压。 其主要区别在于拾振的方式。 主要有光纤拾振（US5375595)、 激光干涉拾振 (US2004046937) , 超声多普勒拾振 (US6030343)、 电容拾振（陈曾汉， 共振式非接触 眼压计设计探讨， 中国医疗器械杂志， 1989年第 13卷第 1期， pl3〜16)和机械接 触拾振（US6800061、 US2003187343)等方式。 上述三类眼压监护装置均具有各自的优点， 但都具有一定的缺陷， 阻碍了其 在临床上的广泛应用。 其中植入式眼压监护仪精度最高， 但是它必须植入病人的前房内， 只适用需要 植入晶状体的白内障患者。 贴片式传感器受角膜的曲率半径、 角膜厚度、 角膜弹性模量影响较大， 并且该 类眼压监护仪均需要将传感器通过较大的预紧力将传感器紧贴于角膜表面， 或者需 要定制与患者角膜表面严密配合的角膜接触镜， 在监护期间对病人的日常活动限制 较多， 并且难于长时间监护。 共振式眼压监护仪已有报道的拾振方式均对受到距离和眼睑的影响。 如通过光 纤拾振、 激光干涉拾振、 电容拾振和机械接触式拾振均不能在眼睑闭合的情况下测 量共振信号， 而超声多普勒在眼睑闭合时则难于区分服睑的振动和服球振动的信 号。 因此该类眼压监护仪难于实现夜间监护。 研发一种非植入、 对眼球运动不敏感、 对眼球压迫小、 可晚间监护的眼压监护 仪是青光眼诊断和治疗中急需且长期未能研发出来的设备。 发明内容 本发明要解决的技术问题 E于克服现有技术的不足， 提供一种新型的眼压监护 装置， 具有非植入、 对眼球运动不敏感、 对眼球压迫小、 可 24 小时连续监护等优 点。 为解决上述技术问题，本发明采用技术方案的基本构思是：一种眼压监护装置， 其特征在于： 所述的眼压监护装置包括眼镜框、 磁振子和处理模块， 所述的眼镜框 内设有通电可产生感应磁场的线圈； 所述的磁振子通过外部磁场激励紧贴眼球并策 动眼球振动， 同时跟随眼球振动， 并在眼镜框内的线圈内产生感应电动势； 所述的 处理模块产生信号以使得眼镜框内线圈产生感应磁场， 并通过磁感应原理测量感应 电动势， 获取眼球的振动信息， 从而获取眼角膜的共振频率， 进而获取眼压。 本发明结合贴片式和共振式眼压监护仪的特点， 它将磁振子夹在角膜接触镜内 贴在角膜上， 通过外部磁场激励磁振子策动眼球振动， 同时眼球的振动带动磁振子 振动， 磁振子振动又会引起外部磁场的扰动， 从而在感应线圈中产生相应的感应电 动势。 通过检测感应电动势能够获取角膜振动信息， 并可从中提取共振频率， 从而 获取眼压。 磁振子是将一薄磁环置于两片角膜接触镜中央， 形成一种 "三明治"结构， 通 过超声波焊接或者粘接的方式能将该 "三明治"结构装配成角膜接触镜。 内嵌磁环 的角膜接触镜和普通角膜接触镜使用方法类似， 可以直接佩戴于患者角膜上。 为了 不影响患者正常视力，磁环中间需要预留一定直径的透光孔， 比如直径为 6mm的孔。 激励磁场通过一个线圈产生， 该线圈置于一眼镜框的眼镜边框内。 通过不同大 小、 频率和方向的电流可对磁振子产生不同大小、 频率和方向的力。 本发明所述的处理模块主要包括模拟信号处理模块、 高速逻辑处理单元、 低功 耗单片机及无线传输模块， 使用充电电池供电， 其中， 模拟信号处理模块包括用于 产生偏置磁场信号和激励磁场信号输出部分和用来获取磁振子所产生振动信号的 输入部分。 该处理模块可设于眼镜框的角架上。 ' 激励线圈同时为测量线圈， 磁振子的振动在激励线圈内产生感应电动势， 通过 后续电路的处理能够将由磁振动振动产生的感应电动势提取出来。 为了保证激振和测振的准确性， 磁振子在测量过程中需要紧贴于角膜上。 本发 明通过激励线圈产生偏置磁场将磁环压紧在角膜上。 为了准确捕获共振频率和提髙 信噪比， 激励磁场为多正弦组合磁场， 它通过一组多正弦组合电压信号通过激励线 圈产生。 因此加在激励线圈上的电压为激励电压和偏置电压的组合， 其数学表达式 如下： v = v。+∑vfc cos(iy¾t + 0¾) 其中 为产生偏置磁场所需的电压， 为各个频率点的激励信号幅值， 为 激励信号的频率， Φ 为相位， 在 [0， 2 it ]之间按正态随机分布。 本发明通过惠斯通电桥提取磁振子在激励线圈内产生的感应电动势。 其中， L2 为激励线圈和测量线圈， L1为补偿线圈， 两者构成一条桥臂， R1和 R2构成另一条 桥臂。 则：
V2 = ~~ ^ ~ (V0 - V) + AV
L7 + ω∑.
IL oL,
满足 ?2 + Rx ω∑2 +
V2 - VX = V—— x AF = "2 χ AF ^
2 1 Rz + Rx R2 + R{
本发明通过对采集到的磁振子在激励线圈内产生的感应电动势进行 FFT变换求 取共振峰， 即得到幅值频谱， 再经单片机处理后获取眼球共振频率 f， 通过公式卩= k * f2获取眼压， 其中的 k为标定参数。 在测量眼压的过程中， 患者的心跳也会造成眼球的振动， 因此该发明也可以同 时实现心跳频率的测量，即，根据服球振动的幅值频谱还可以获取患者的心跳频率。 采用上述技术方案后， 本发明与现有技术相比具有以下有益效果。
本发明所述的眼压监护装置首先无需植入前房内， 结构简单， 方便于更多的患 者； 其次对眼球运动不敏感、 对眼球压迫小， 使得患者使用更舒适， 另外可晚间监 护， 使得其实现了监护的连续性， 更好的监护患者眼压。
下面结合附图对本发明的具体实施方式作进一步详细的描述。
附图说明 图 1为本发明所述的眼压监护装置的工作原理示意图； 图 2为本发明所述的磁振子的组装结构示意图； 图 3为本发明所述的带内嵌磁环的角膜接触镜紧贴眼球的配戴方式示意图； 图 4为本发明所述的激励信号的波形图； 图 5为本发明所述的测量电桥图； 图 6为本发明所述的工作流程图； 图 7为本发明在激励条件下眼球振动的幅值频谱图。 图 8为本发明所述的系统框架图。
附图中： 1、 上角膜接触镜； 2、 磁环； 21、 透光孔； 22、 凹槽； 3、 下角膜接 触镜； 4、 磁振子； 5、 眼球； 6、 眼镜框； 61、 眼镜边框； 62、 眼镜脚架； 7、 处理 模块； a、 激励磁场； b、 扰动磁场； c、 振动方向； f。、 心跳频率； 、 眼球共振频 率。 具体实施方式
如图 1所示，本发明所述的眼压监护装置， 包括眼镜框 6、磁振子 4和处理模块
7， 眼镜框 6置于眼睛前面， 处理模块 7设于眼镜脚架 62上靠近眼镜边框 61的位 置，磁振子 4配戴于眼球 5上，所述的眼镜框 6内设有通电可产生感应磁场的线圈； 所述的磁振子 4通过外部磁场激励紧贴眼球 5并策动眼球 5振动， 同时跟随眼球 5 振动， 并在眼镜框 6内的线圈内产生感应电动势； 所述的处理模块 7产生信号以使 得眼镜框 6内线圈产生感应磁场， 并通过磁感应原理测量感应电动势， 获取眼球 5 的振动信息， 从而获取眼角膜的共振频率， 进而获取眼压。 图 1中将角膜接触镜形式的磁振子 4佩戴于眼球 5表面， 类似于戴隐形眼镜， 患者再佩戴一副眼镜框 6， 在眼镜框的内部嵌有激励和测量线圈， 测量线圈和激励 线圈为同一个线圈， 处理模块 7产生的激励信号输送给眼镜框 6内的线圈。 线圈产 生激励磁场 a作用在磁振子 4内的磁环上。 磁振子 4策动眼球 5作同心振动。 眼球 5的振动反过来带动磁振子 4振动， 磁振子 4的振动会扰动激励线圈的磁场， 在激 励线圈内产生感应电动势。 处理模块 7通过特定的方法检测激励线圈内的感应电动 势， 该特定的方法包括电桥、 信号放大、 滤波等后续电路处理（参阅图 5和图 8〉 ， 从而获取眼球 5振动信息。 对眼球振动信息进行 FFT分析得到眼球振动的幅值频谱 (参阅图 7 )，从幅值频谱中至少可以获取患者的心跳频率 f。和眼球的共振频率 f,。 对共振频率进行查表处理， 通过公式 = /c * ;2获取眼压。其中的 k为标定参数， 可 以得到患者的眼压值。 上述中处理模块 7产生的激励信号其数学表达式如下:
Figure imgf000008_0001
其中 v。为产生偏置磁场所需的电压， 为各个频率点的激励信号幅值， ^为 激励信号的频率， Φ 为相位， 在 [0, 2 ]之间按正态随机分布， 如图 4所示，为本 发明所述的激励信号的波形图，本实施例中产生偏置磁场的电压为 4V，产生激励信 号的电压从 l〜1000Hz， 间隔 1Ηζ， 每个频率的幅值均为 0. IV， 相位按照正态随机 分布。
在激励线圈内产生的感应电动势如下：
Figure imgf000008_0002
Figure imgf000008_0003
其中， L2为激励线圈和测量线圈， L1为补偿线圈， 两者构成一条桥臂， R1和 R2构成另一条桥臂， 如图 5所示,是用于检测感应电动势的电桥。 激励和传感线圈 L1采用直径 0. 01mm的漆包线绕制， 共 100匝， 直径 30cm。 补偿线圈 L2的也采用 0. 01mm直径的漆包线绕制， 共 10匝， 直径 lcm， 置于处理模块 (7)内。 为了降低两 者的相互干扰， L1与 L2成垂直分布。 为了保持电桥平衡， R1取 100Κ Ω , R2为可 变电阻。在无磁振子 (4)和外部磁场干扰的情况下， 对电桥施加激励信号， 调整 R2， 使电桥平衡， 图中的数值需要依照具体的电路而定， 不是一个确定值。
图 2是磁振子的组装方式。 磁振子 4由一片上角膜接触镜 1、 磁环 2和一片下 角膜接触镜 3组成。 磁振子的佩戴方式与普通的软性角膜接触镜佩戴方法一样， 贴 合于眼球上（参阅图 3 ) 。两片角膜接触镜 1、 3可以定制， 并在其中留有容纳磁环 2的凹槽 22。 也可以直接使用现有的软性角膜接触镜， 通过超声波焊接或者粘接的 方法组装成一片 "三明治"结构的角膜接触镜。 为了保证角膜接触镜的具有一定的 刚度而且不需要施加较大的预载力， 下角膜接触镜 3必须薄于上角膜接触镜 1。 本 实施例中下角膜接触镜 3厚度取 0. 1腦， 上角膜接触镜 1厚度取 0· 8讓。 磁环 2的 厚度为 0. 5mm,外径 8mra，内径为 6mm的透光孔，采用铷铁硼永磁材料。 图 6为本发明的眼压监护仪的工作流程。 系统每隔 1个小时或者更短的时间进 行一次测量， 单次测量施加激励信号 10s左右， 图中所述的预紧磁场是偏置电压通 过激励线圈产生的偏置磁场， 目的是为了将磁环压紧在角膜上。 图 7为获取的眼球振动幅值频谱。 通过电桥对信号进行提取、 放大、 谱分析至 少可以获取患者的心跳频率和眼球共振频率， 所以本发明也可以同时用于测量患者 心跳频率。 图 8为系统框架图， 其中大框内的部分为处理模块 7， 其中包含模拟信号处理、 高速逻辑处理单元 （使用 altera 的 EP1C3T144C8 ) ，低功耗单片机（使用 Ti 的 MSP430F149)以及无线传输模块， 使用充电电池供电。 模拟信号处理模块包含输入和输出两部分。 其中输出通道用于产生偏置磁场信 号和激励信号。单片机将预先设计好的偏置信号和偏置信号数据送给 FPGA， 由 FPGA 通过高速逻辑送给 DA， 经过功放之后送给激励线圈。输入通道用来获取磁振子 4所 产生的振动信号。 通过图 5所示的电桥将振动信号转换为差分电压， 再经过差分放 大进入带通滤波器。带通滤波器的通频带为 40Ηζ〜1ΚΗζ， 保留心跳频率和眼球共振 频率， 去由于眼球自然颤振引起的低频信号和由于眼睑振动引起的髙频信号， 随后 FPGA通过 AD将滤波后的信号釆集到 FPGA内部。 快速 FFT变换在 FPGA内部实现， 经过 1024点的 FFT变换后可获得如图 7所示 的幅值频谱， 随后 FPGA将 1024点的频谱数据送入单片机， 经单片机进行处理之后 获取到眼球共振频率 f。和心跳频率 f,， 于是可以通过公式 获取眼压， 其 中的 k为标定参数。 另外， 模块 7获取眼压之后， 可存于单片机内部， 并可以在完成一个监护周期 或者在监护过程中将数据通过无线模块传输给数据中心。 本发明所述的眼压监护装置首先无需植入前房内， 结构简单， 方便于更多的患 者； 其次对眼球运动不敏感、 对眼球压迫小， 使得患者使用更舒适， 另外可晚间监 护， 使得其实现了监护的连续性， 更好的监护患者眼压。

Claims

权利要求书
1、 一种眼压监护装置， 其特征在于： 所述的眼压监护装置包括眼镜框、 磁振 子和处理模块， 所述的眼镜框内设有通电可产生感应磁场的线圈； 所述的磁振子通 过外部磁场激励紧贴眼球并策动眼球振动， 同时跟随眼球振动， 并在眼镜框内的线 圈内产生感应电动势； 所述的处理模块产生信号以使得眼镜框内的线圈产生感应磁 场， 并通过磁感应原理测量感应电动势， 获取眼球的振动信息， 从而获取眼角膜的 共振频率， 进而获取眼压。
2、 根据权利要求 1 所述的一种眼压监护装置， 其特征在于： 所述的磁振子是 由上、 下角膜接触镜和磁环组成， 磁环置于上、 下角膜接触镜之间对应设有的凹槽 内， 呈 "三明治"式的压合结构， 磁振子形状为可扣在眼球上的球冠曲面形状。
3、 根据权利要求 2所述的一种眼压监护装置， 其特征在于： 所述的下角膜接 触镜厚度小于上角膜接触镜厚度， 磁环呈环形中间为一透光孔， 凹槽分别对应设于 上角膜接触镜的下表面和下角膜接触镜的上表面。
4、 根据权利要求 1 所述的一种眼压监护装置， 其特征在于： 所述的线圈为激 励线圈和测量线圈，设于眼镜框的眼镜边框内，激励线圈和测量线圈共用一个线圈。
5、 根据权利要求 1或 4所述的一种眼压监护装置， 其特征在于： 于所述的激 励线圈施加直流电压产生偏置磁场， 使用该偏置磁场将磁振子压紧在眼球表面。
6、 根据权利要求 1或 4所述的一种眼压监护装置， 其特征在于： 于所述的激 励线圈施加一组多正弦组合电压信号产生多正弦组合激励磁场， 使用该激励磁场作 用于磁振子策动眼球作同心振动。
7、 根据权利要求 1 所述的一种眼压监护装置， 其特征在于： 所述的处理模块 主要包括模拟信号处理模块、 高速逻辑处理单元、 低功耗单片机及无线传输模块， 使用充电电池供电， 其中， 模拟信号处理模块包括用于产生偏置磁场信号和激励磁 场信号输出部分和用来获取磁振子所产生振动信号的输入部分。
8、 根据权利要求 1或 7所述的一种眼压监护装置， 其特征在于： 所述的磁振 子振动信号在线圈中所产生的感应电动势可使用电桥的方式测量， 感应电动势进行 FFT变换求取共振峰， 即得到幅值频谱， 经单片机处理后获取眼球共振频率 f， 通 过公式 P = k * f2获取眼压， 其中的 k为标定参数。
9、 根据权利要求 8 所述的一种眼压监护装置， 其特征在于： 所述的眼压监护 装置根据眼球振动的幅值频谱还可以获取患者的心跳频率。
PCT/CN2007/002278 2007-01-23 2007-07-27 眼压监护装置 WO2008101374A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2007100036605A CN100448391C (zh) 2007-01-23 2007-01-23 眼压监护装置
CN200710003660.5 2007-01-23

Publications (2)

Publication Number Publication Date
WO2008101374A2 true WO2008101374A2 (zh) 2008-08-28
WO2008101374A3 WO2008101374A3 (zh) 2009-08-27

Family

ID=38257374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/002278 WO2008101374A2 (zh) 2007-01-23 2007-07-27 眼压监护装置

Country Status (2)

Country Link
CN (1) CN100448391C (zh)
WO (1) WO2008101374A2 (zh)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145409A2 (en) * 2008-08-29 2008-12-04 Phonak Ag Hearing instrument and method for providing hearing assistance to a user
US7845235B2 (en) 2007-11-06 2010-12-07 Costin Sandu Non-invasive system and method for measuring vacuum pressure in a fluid
US9247877B2 (en) 2010-10-20 2016-02-02 University Of Dundee Device for monitoring intraocular pressure
CN113867006A (zh) * 2021-09-28 2021-12-31 电子科技大学 一种基于γ-Fe2O3@NiO磁性氧化物纳米片的柔性多功能角膜接触镜
CN113974553A (zh) * 2021-12-28 2022-01-28 广东麦特维逊医学研究发展有限公司 一种眼压测量装置及其工作方法
US11406415B2 (en) 2012-06-11 2022-08-09 Tenex Health, Inc. Systems and methods for tissue treatment
US11457937B2 (en) 2014-09-02 2022-10-04 Tenex Health, Inc. Subcutaneous wound debridement

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG181956A1 (en) * 2010-01-05 2012-08-30 Sensimed Sa Intraocular pressure monitoring device
CN101822528B (zh) * 2010-05-13 2011-06-29 华中科技大学 一种眼压检测装置
CN103181750B (zh) * 2012-12-21 2015-08-26 苏州苜蓿园电子有限公司 佩戴式眼压计及其测定眼压的方法
CN104473615B (zh) * 2014-11-11 2015-12-09 华中科技大学 一种基于光纤光栅的24小时眼压监测传感器
CN106821305A (zh) * 2017-03-23 2017-06-13 清华大学 一种眼压监测装置
CN112603258B (zh) * 2020-12-08 2022-03-25 南京大学 一种眼压监测智能隐形眼镜
CN113331785B (zh) * 2021-05-12 2024-08-06 清华大学 一种无线压平式眼压监测系统
CN113712539B (zh) * 2021-08-31 2023-11-14 刘宏图 一种儿童智能健康眼镜

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209021A (en) * 1977-12-22 1980-06-24 J. D. Moller Optische Werke Gmbh Apparatus for generating and measurement of defined forces for medical appliances
CN2296693Y (zh) * 1997-07-14 1998-11-11 河南省眼科研究所 轻便式电子眼压描记仪
US5840041A (en) * 1994-09-16 1998-11-24 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Device for measuring the mechanical properties of biological tissue
US6093147A (en) * 1999-02-22 2000-07-25 Kontiola; Antti Apparatus for measuring intraocular pressure
CN1372447A (zh) * 1999-08-31 2002-10-02 生物谐振器公司 由测量频率特性的改变确定眼内压力的方法和设备

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100889166B1 (ko) * 2001-03-30 2009-03-16 각코호진 와세다다이가쿠 안압 측정을 위한 방법 및 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209021A (en) * 1977-12-22 1980-06-24 J. D. Moller Optische Werke Gmbh Apparatus for generating and measurement of defined forces for medical appliances
US5840041A (en) * 1994-09-16 1998-11-24 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Device for measuring the mechanical properties of biological tissue
CN2296693Y (zh) * 1997-07-14 1998-11-11 河南省眼科研究所 轻便式电子眼压描记仪
US6093147A (en) * 1999-02-22 2000-07-25 Kontiola; Antti Apparatus for measuring intraocular pressure
CN1372447A (zh) * 1999-08-31 2002-10-02 生物谐振器公司 由测量频率特性的改变确定眼内压力的方法和设备

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7845235B2 (en) 2007-11-06 2010-12-07 Costin Sandu Non-invasive system and method for measuring vacuum pressure in a fluid
WO2008145409A2 (en) * 2008-08-29 2008-12-04 Phonak Ag Hearing instrument and method for providing hearing assistance to a user
WO2008145409A3 (en) * 2008-08-29 2009-09-11 Phonak Ag Hearing instrument and method for providing hearing assistance to a user
US9247877B2 (en) 2010-10-20 2016-02-02 University Of Dundee Device for monitoring intraocular pressure
US11406415B2 (en) 2012-06-11 2022-08-09 Tenex Health, Inc. Systems and methods for tissue treatment
US11457937B2 (en) 2014-09-02 2022-10-04 Tenex Health, Inc. Subcutaneous wound debridement
CN113867006A (zh) * 2021-09-28 2021-12-31 电子科技大学 一种基于γ-Fe2O3@NiO磁性氧化物纳米片的柔性多功能角膜接触镜
CN113867006B (zh) * 2021-09-28 2023-04-28 电子科技大学 一种基于γ-Fe2O3@NiO磁性氧化物纳米片的柔性多功能角膜接触镜
CN113974553A (zh) * 2021-12-28 2022-01-28 广东麦特维逊医学研究发展有限公司 一种眼压测量装置及其工作方法
CN113974553B (zh) * 2021-12-28 2022-04-01 广东麦特维逊医学研究发展有限公司 一种眼压测量装置及其工作方法

Also Published As

Publication number Publication date
WO2008101374A3 (zh) 2009-08-27
CN100448391C (zh) 2009-01-07
CN100998496A (zh) 2007-07-18

Similar Documents

Publication Publication Date Title
WO2008101374A2 (zh) 眼压监护装置
US9247877B2 (en) Device for monitoring intraocular pressure
Katuri et al. Intraocular pressure monitoring sensors
US6579235B1 (en) Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder
AU741461B2 (en) A tonometer system for measuring intraocular pressure by applanation and/or indentation
US6213943B1 (en) Apparatus for signal transmission and detection using a contact device for physical measurement on the eye
US6193656B1 (en) Intraocular pressure monitoring/measuring apparatus and method
US20090076367A1 (en) Monitoring Intraocular Pressure
CN104644149B (zh) 带有视网膜血管形成监测系统的眼科镜片
JP2004528146A (ja) 眼の内圧を測定するための装置および方法
US20230029042A1 (en) Wearable system for the ear
US20120289810A1 (en) Pressure monitor
Sun et al. Eye-tracking monitoring based on PMUT arrays
CN112603258B (zh) 一种眼压监测智能隐形眼镜
US20210282669A1 (en) System and method for monitoring eye blink mechanics
CN211674231U (zh) 睡眠感测系统
CN209048114U (zh) 一种新型医用智能手环
CN113331785A (zh) 一种无线压平式眼压监测系统
JP5962226B2 (ja) 眼球生体情報収集装置および眼球生体情報収集方法
CN220876746U (zh) 一种眼内压测量装置
US20230380685A1 (en) Wearable and non-contact intraocular pressure (iop) measurement and monitoring system
JPH0737104U (ja) 脈波検出装置
CN117017206A (zh) 一种眼内压测量装置
AU9728601A (en) A tonometer system for measuring intraocular pressure by applanation and/or indentation
MXPA99002157A (en) A tonometer system for measuring intraocular pressure by applanation and/or indentation

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07785193

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07785193

Country of ref document: EP

Kind code of ref document: A2