WO2008099136A1 - Mesure de pression et de vitesse d'écoulement en utilisant un dispositif vibrant en porte-à-faux - Google Patents

Mesure de pression et de vitesse d'écoulement en utilisant un dispositif vibrant en porte-à-faux Download PDF

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Publication number
WO2008099136A1
WO2008099136A1 PCT/GB2008/000314 GB2008000314W WO2008099136A1 WO 2008099136 A1 WO2008099136 A1 WO 2008099136A1 GB 2008000314 W GB2008000314 W GB 2008000314W WO 2008099136 A1 WO2008099136 A1 WO 2008099136A1
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WO
WIPO (PCT)
Prior art keywords
cantilever
fluid
channel
measurement apparatus
fluid flow
Prior art date
Application number
PCT/GB2008/000314
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English (en)
Other versions
WO2008099136A8 (fr
Inventor
Georg Haehner
Gennady Lubarsky
Original Assignee
The University Court Of The University Of St Andrews
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Court Of The University Of St Andrews filed Critical The University Court Of The University Of St Andrews
Priority to ES08701983.2T priority Critical patent/ES2502517T3/es
Priority to CA2715504A priority patent/CA2715504C/fr
Priority to US12/527,346 priority patent/US8371184B2/en
Priority to EP08701983.2A priority patent/EP2109760B1/fr
Publication of WO2008099136A1 publication Critical patent/WO2008099136A1/fr
Publication of WO2008099136A8 publication Critical patent/WO2008099136A8/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q30/00—Auxiliary means serving to assist or improve the scanning probe techniques or apparatus, e.g. display or data processing devices
    • G01Q30/08—Means for establishing or regulating a desired environmental condition within a sample chamber
    • G01Q30/12—Fluid environment
    • G01Q30/14—Liquid environment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
    • G01F1/20—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by detection of dynamic effects of the flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/05—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects
    • G01F1/20—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by detection of dynamic effects of the flow
    • G01F1/32—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using mechanical effects by detection of dynamic effects of the flow using swirl flowmeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L9/00—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
    • G01L9/0001—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means
    • G01L9/0008—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means using vibrations
    • G01L9/001—Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means using vibrations of an element not provided for in the following subgroups of G01L9/0008
    • G01L9/0011—Optical excitation or measuring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q40/00—Calibration, e.g. of probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
    • G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
    • G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
    • G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders

Definitions

  • the present invention relates to the characterisation and use of cantilever devices, in particular cantilevers for use in atomic force microscopy.
  • Cantilevered sensing heads are used in Atomic Force Microscopy (AFM) to sense and measure forces between the sensing head and a surface. This generally involves scanning the sensing head across a surface and measuring its deflection. The deflection of the sensing head may be used to investigate the topography of the surface. It can also be used to measure forces acting on the sensing head such as forces exerted on the tip by the surface, electrostatic forces and capillary forces. In order to measure such forces using this technique, it is necessary to know the spring constant of the cantilevered sensing head. Inaccuracies in determination of the spring constant can lead to unacceptable errors in the resulting force measurement.
  • AFM Atomic Force Microscopy
  • the spring constant of cantilevered sensing heads can be measured by a variety of methods including theoretical calculation, applying a known mass to statically deflect the cantilever head, deflecting the cantilevered head with another cantilevered head having a known spring constant and by determination of the resonant frequency either in vacuum or in a static pool of liquid.
  • a summary of prior art calibration methods is given in "Calibration of Atomic Force Microscopy Cantilevers” by J E Sader in “Encyclopaedia of Surface and Colloid Science", published by Marcel Dekker Lie New York [2002] page 846.
  • a measurement device having a cantilever and a fluid flow channel, the cantilever being positioned in the channel so that it projects in a direction parallel to the direction of fluid flow.
  • the measurement device may have means for measuring the frequency of vibration of the cantilever.
  • the means for measuring the vibration frequency of the cantilever may be adapted to measure the resonant frequency of the cantilever.
  • the means for measuring the vibration frequency of the cantilever may include a laser adapted to reflect off the cantilever or a piezoelectric element or be a capacitive sensor.
  • the measurement device may be provided with means of measuring, and/or providing fluid flow at a known, applied pressure and/or pressure drop and/or fluid velocity.
  • the measurement device may be adapted to use that known applied pressure and/or pressure drop and/or fluid velocity in conjunction with at least one measurement of resonant frequency to determine the spring constant of the cantilever. This allows the cantilever to be calibrated without contact between it and a solid weight or other force-applying device. Hence, damage to the cantilever, especially those coated with a bio-film, may be minimised.
  • the measurement device may be adapted to determine the applied pressure and/or pressure drop and/or velocity of the fluid using at least one measurement of resonant frequency.
  • the cantilever may be of any shape known in the art but is preferably rectangular and/or v-shaped.
  • the cantilever may extend from a mount.
  • the cantilever may extend to any length but preferably between 10 and 400 ⁇ m perpendicularly from the mount.
  • the channel may be shaped to provide laminar flow.
  • the walls of the channel may be smooth.
  • the channel may define an opening to receive fluid flow and an opening at which the cantilever meets the mount.
  • the minimal length of the channel between these two openings may correspond to the hydrodynamic entry length L in order to achieve the fully developed velocity profile in the region of cantilever opening.
  • the height of the cavity may be optimized to achieve the maximum of setup sensitivity and depends on the calibration fluid.
  • the width of the channel may depend on the size of the cantilever mount and is variable.
  • the minimum length L to height h ratio of the channel may be obtained from an expression Uh-0.05 Re, with Re the Reynolds number.
  • the fluid may be selected and/or the channel adapted such that the Knudsen number is less than 0.01.
  • the cantilever may be integral with a holder or may be removable there from, with the base adapted to receive the mount and cantilever to form the channel.
  • the cantilever may be part of a sensing head for an atomic force microscope.
  • the cantilever may form a cantilever chip for an atomic force microscope.
  • the holder and/or mount may be substantially rigid such that the channel is substantially rigid.
  • the measurement device may include a cover, adapted to seal with the holder in order to enclose the mount, cantilever and channel within the holder and cover.
  • the cover may be transparent, preferably glass. In this way, if the means for measuring the vibration frequency of the cantilever is a laser, then it may be located outside the measurement device and the laser beam may pass through the cover.
  • the channel may have a fluid inlet and a fluid outlet and the cantilever may be positioned so that it projects towards the fluid outlet.
  • a method for determining the spring constant of a cantilever the method involving positioning the cantilever in a channel adapted to permit fluid flow such that the cantilever extends parallel with the direction of fluid flow in the channel, measuring the resonant frequency of the cantilever at one or more velocities of fluid flow and calculating the spring constant of the cantilever using the measured resonant frequency.
  • the method may involve providing the fluid at a known applied pressure and/or pressure drop and/or fluid velocity. Alternatively, the method may involve measuring applied pressure and/or pressure drop and/or fluid velocity of the fluid.
  • the cantilever may be arranged relative to the fluid flow such that the pressure exerted by the fluid on the cantilever is substantially a static pressure.
  • the length to height ratio of the channel may be greater than 20 and preferably between 20 and 700.
  • the fluid flow may be laminar flow.
  • the fluid flow may be such that the inertial forces exerted by the fluid are negligible.
  • the fluid flow may be such that the Reynolds number (Re) is less than 2000.
  • the cantilever may be the cantilever of an atomic force microscope.
  • the cantilever may form at least part of a cantilever chip of an atomic force microscope.
  • a third aspect of the present invention is a method for determining the velocity of flow of a fluid and the fluid flow rate, including positioning a cantilever in a channel adapted to permit fluid flow such that the cantilever extends parallel with the direction of fluid flow, measuring the resonant frequency of the cantilever and using the measured resonant frequency to determine the velocity of flow of the fluid.
  • the method may further include using a cantilever of known spring constant or determining the spring constant of a cantilever.
  • a fourth aspect of the present invention is a holder adapted to receive an atomic force microscope cantilever chip such that the cantilever chip and/or the holder define a channel for fluid flow and wherein the cantilever is in communication with, and extends parallel to, the channel.
  • the fluid may be a gas or a liquid.
  • the fluid may be nitrogen.
  • Figure 1 shows a cantilever measurement device
  • Figure 2 shows a schematic of the fluid flow through the cantilever measurement device of Figure 1;
  • Figure 3 shows a v-shaped cantilever for use in the cantilever measurement device of Figure 1;
  • Figure 4 shows an example of variation of the amplitude of vibration of the cantilever of Figure 1 on a logarithmic scale against frequency for varying applied fluid pressures
  • Figure 5 shows an example of the variation of resonance shifts ⁇ (f) of the cantilever of Figure 1 measured as a function of the applied pressure Ap together with a best parabolic fit.
  • Figure 1 shows a measurement cell 5 having a brass holder 10 shaped to receive a cantilever chip 15.
  • the holder 10 is provided with a slot 20 having side walls 25, 30 and a base 35, running from one side 40 of the holder 10 to the opposing side 45.
  • the sidewalls 25, 30 of the slot 20 each have steps 50, 55 running along the length of the slot 20 adjacent to the base 35.
  • the steps 50, 55 are such that the cantilever chip 15 may be seated upon them and supported away from the base 35 of the slot in order to define a channel 60 having a flow inlet 65 and outlet 70.
  • the slot 20 is sealed by a glass cover 75, which encloses the cantilever chip 15 within the slot 20.
  • the cantilever chip 15 has a v-shaped cantilever 80 extending from a chip section 85 such that the apex 90 of the cantilever 80 points away from the chip 85.
  • the angle between the cantilever legs is 62°.
  • the holder 10 is shaped and sized such that the cantilever chip 15 can be placed within the slot 20 of the holder such that the cantilever extends parallel with the channel 60 defined by the chip 85 and the holder 10 and points towards the outlet 70 of the channel 60.
  • the cantilever 80 is formed of gold-coated silicon nitride.
  • the channel 60 is sized to have a cross section of lmm wide and 20 ⁇ m high.
  • the chip 85 is sized to give a channel 60 of 3.5mm + 1 in length, where 1 is the length of the cantilever 80. This provides a length to height ratio for the channel of around 180. This high channel length to height ratio ensures that the fluid flow is fully developed by the time that it reaches the cantilever 80.
  • the inlet 65 of the channel 60 is connected to a pressurised nitrogen supply via a valve for adjusting the pressure. Nitrogen provides a cheap, easily accessible fluid having well defined and known parameters.
  • a pressure meter such as a manometer, is used to measure the pressure drop ( ⁇ p) between the inlet 65 and outlet 70.
  • An external laser (not shown) may be used to provide a beam through the glass cover, to be reflected from the cantilever 80 and detected by a split photodiode in order to determine the displacement and thereby the frequency of vibration of the cantilever 80.
  • the measurement device 5 is constructed around an atomic force microscope having the scanner disconnected and removed. The resonance peaks of the fundamental mode noise, thermal noise spectra of the cantilever 80 are recorded using a spectrum analyser (not shown).
  • the initial resonant frequency of the cantilever 80 is measured with the cell filled by nitrogen gas but with no fluid flow through the channel 60. Nitrogen flow is then introduced into the channel by applying pressure at the inlet 65. The applied pressure is then increased, which increases the velocity of nitrogen flow.
  • the resonant frequency of the cantilever 80 is measured at various controlled nitrogen flows. For example, the resonant frequency is measured at ten different levels of pressure drop ( ⁇ p) up to a maximum of 7kPa.
  • ⁇ p pressure drop
  • the cantilever 80 is exposed to each different fluid flow for one minute prior to collecting vibrational frequency data.
  • the spring constant or the velocity of the fluid may be calculated as follows.
  • the fluid flow reaching the cantilever 80 essentially has a velocity profile having a stable parabolic shape, as shown in Figure 2. This velocity profile in the z-direction corresponds to plane Poiseuille flow.
  • the maximum velocity (u 0 ) of the fluid flow in the centre of the channel 60 depends on the static pressure difference (Ap) between the pressure applied at the inlet (p a ppi) and the pressure at the cantilever 80 opening (P ca nt), the viscosity of the fluid ( ⁇ ) and the length (L) and height (K) of the channel 80 such that:
  • Ap static pressure difference
  • p cmt can be expressed in terms of the dynamic pressure according to Bernoulli's law:
  • k p is the cantilever spring constant corresponding to a uniformly distributed surface load. This spring constant differs significantly from the commonly used spring constant k/, which corresponds to an end-loaded cantilever. For cantilevers with common geometries, the relation between these spring constants can be calculated.
  • t is the thickness of the cantilever
  • ⁇ is the angle between the legs of the cantilever
  • 1 is the perpendicular length of the cantilever to the apex 90
  • 1' is the perpendicular length to the inside of the apex of the cantilever.
  • M p (x) pw -x 2 if 0 ⁇ x ⁇ l' cos —
  • du/dz can be determined as follows: duiz) _ h (10) dz (h+ zY
  • the spring constant k p can be determined simply by acquiring the resonance frequency shift as a function of the pressure gradient applied to the channel as follows:
  • Equations (6) or (8) can be applied to translate k p into k / .
  • Resonance curves obtained using the method and apparatus described above were collected at ten differing fluid pressures / velocities, as shown in Figure 4.
  • Figure 5 shows typical resonance shifts A(f) measured as a function of the applied pressure Ap together with the best parabolic fit.
  • the resonance frequencies of three V-shaped cantilevers made from silicon nitride with nominal spring constants of 0.06, 0.12, and 0.32 N/m (Veeco Instruments Inc., NY, USA), and one tipless rectangular cantilever made from silicon with a nominal spring constant of 0.03 N/m (MikroMasch, Estonia) were measured as a function of pressure difference ⁇ p.
  • the method shows exceptional stability and repeatability, with an error in the resonance frequency of less than 1%. Usually five measurements are performed for each experimental condition but in situations of good reproducibility this can be reduced to a minimum of two measurements. Hence, in accordance with the present invention, it has been demonstrated that the spring constant for cantilevers can be determined in-situ and with high precision.
  • the invention does not require deflection of the cantilever by a solid object and minimises damage to the cantilever or any coating on it.
  • the method is fast, simple and reliable.
  • the above measurement cell and method can be adapted to measure the velocity of fluid flow and thus the flow rate by repeating the above procedure and rearranging (12) to determine the peak fluid velocity UQ SLS follows:
  • the device inlet 65 is arranged to accept the fluid flow whose velocity is to be measured. This may be done by locating the measurement device 5 in a fluid flow with the inlet open and facing the oncoming flow, and measuring the cantilever's resonant frequency. This provides a simple, quick and reproducible method for measuring the fluid velocity. Because of the small dimensions possible with the device of the invention, flow measurements can be taken at various points in a flow pattern with minimal disruption to the overall flow. Hence, it is possible to accurately measure micro scale flow velocity as well as bulk flow. Multiple cantilevers 80 or measurement cells 5 may be provided to measure micro scale flow at various sites. It will be further appreciated that this embodiment of the measurement cell and method may be further adapted to provide local anemometry with high precision and up to high speeds.
  • the fluid used is advantageously nitrogen gas, other gasses or liquids may be used, such as air, and water.
  • the configuration described above is preferentially adapted such that the fluid flow channel is an elongated cuboid, having the inlet 65 opposite the outlet 70 and having smooth, rigid sides.
  • other configurations of channel may be used, preferably those that facilitate developed laminar flow of the fluid.
  • the cantilever chip 15 is described as being removable, the cantilever chip 15 may be integral with the holder 10, particularly in the fluid flow velocity measurement embodiment.
  • the cantilever 80 used is a v-shaped cantilever, other shapes of cantilever such as rectangular cantilevers may be used.

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Fluid Mechanics (AREA)
  • Measuring Volume Flow (AREA)
  • Micromachines (AREA)

Abstract

La présente invention concerne un appareil de mesure présentant un porte-à-faux et un canal d'écoulement de fluide, le porte-à-faux étant positionné dans le canal d'une manière telle qu'il fait saillie dans une direction parallèle à la direction d'écoulement du fluide. Dans un procédé associé, le porte-à-faux est positionné dans un canal d'écoulement de fluide d'une manière telle que le porte-à-faux s'étend parallèlement à la direction d'écoulement du fluide dans le canal. Le fluide est amené à s'écouler dans le canal à une vitesse connue. La fréquence de résonance du porte-à-faux est mesurée à une ou plusieurs vitesses d'écoulement du fluide et en calculant la constante de rappel du porte-à-faux à l'aide de la ou des fréquences de résonance mesurées. Si la constante de rappel du porte-à-faux est connue, la mesure de la fréquence de résonance du porte-à-faux est utilisée pour déterminer la vitesse de l'écoulement du fluide.
PCT/GB2008/000314 2007-02-15 2008-01-31 Mesure de pression et de vitesse d'écoulement en utilisant un dispositif vibrant en porte-à-faux WO2008099136A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES08701983.2T ES2502517T3 (es) 2007-02-15 2008-01-31 Medición de velocidad de flujo y de presión usando un dispositivo de viga en voladizo vibratorio
CA2715504A CA2715504C (fr) 2007-02-15 2008-01-31 Mesure de pression et de vitesse d'ecoulement en utilisant un dispositif vibrant en porte-a-faux
US12/527,346 US8371184B2 (en) 2007-02-15 2008-01-31 Flow velocity and pressure measurement using a vibrating cantilever device
EP08701983.2A EP2109760B1 (fr) 2007-02-15 2008-01-31 Mesure de pression et de vitesse d'ecoulement en utilisant un dispositif vibrant en porte-a-faux

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0702965.5A GB0702965D0 (en) 2007-02-15 2007-02-15 Cantilever device and method
GB0702965.5 2007-02-15
GB0709880.9 2007-03-23
GBGB0709880.9A GB0709880D0 (en) 2007-02-15 2007-05-23 Cantilever device and method

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Publication Number Publication Date
WO2008099136A1 true WO2008099136A1 (fr) 2008-08-21
WO2008099136A8 WO2008099136A8 (fr) 2009-10-22

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US (1) US8371184B2 (fr)
EP (2) EP2450687B1 (fr)
CA (1) CA2715504C (fr)
ES (2) ES2502517T3 (fr)
GB (2) GB0702965D0 (fr)
WO (1) WO2008099136A1 (fr)

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US20100071477A1 (en) * 2007-02-15 2010-03-25 Georg Haehner Flow Velocity and Pressure Measurement Using a Vibrating Cantilever Device
RU2645884C1 (ru) * 2016-11-29 2018-02-28 Общество с ограниченной ответственностью Научно-производственное предприятие "Центр перспективных технологий" Проточная жидкостная ячейка для сканирующей зондовой микроскопии
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US10088454B2 (en) 2011-10-18 2018-10-02 Cidra Corporate Services, Inc. Speed of sound and/or density measurement using acoustic impedance
WO2013152302A1 (fr) * 2012-04-05 2013-10-10 Cidra Corporate Services Inc. Mesure de densité et/ou de vitesse du son à l'aide d'impédance acoustique
DE102015000064B3 (de) * 2015-01-12 2016-03-31 Carl Von Ossietzky Universität Oldenburg Vorrichtung und Verfahren zum Bestimmen mindestens eines Parameters einer Strömung eines Fluids und deren Verwendung
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US20060075836A1 (en) * 2004-10-13 2006-04-13 Anis Zribi Pressure sensor and method of operation thereof

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US20100071477A1 (en) * 2007-02-15 2010-03-25 Georg Haehner Flow Velocity and Pressure Measurement Using a Vibrating Cantilever Device
US8371184B2 (en) * 2007-02-15 2013-02-12 The University Court Of The University Of St. Andrews Flow velocity and pressure measurement using a vibrating cantilever device
US10900878B2 (en) 2012-09-17 2021-01-26 University Court Of The University Of St Andrews Torsional and lateral stiffness measurement
RU2645884C1 (ru) * 2016-11-29 2018-02-28 Общество с ограниченной ответственностью Научно-производственное предприятие "Центр перспективных технологий" Проточная жидкостная ячейка для сканирующей зондовой микроскопии

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EP2450687B1 (fr) 2014-05-21
ES2494116T3 (es) 2014-09-15
EP2109760A1 (fr) 2009-10-21
CA2715504C (fr) 2015-08-18
GB0709880D0 (en) 2007-07-04
WO2008099136A8 (fr) 2009-10-22
US8371184B2 (en) 2013-02-12
US20100071477A1 (en) 2010-03-25
ES2502517T3 (es) 2014-10-03

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