WO2008096769A1 - 置換されたセルコスポラミド誘導体を含有する医薬 - Google Patents

置換されたセルコスポラミド誘導体を含有する医薬 Download PDF

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WO2008096769A1
WO2008096769A1 PCT/JP2008/051906 JP2008051906W WO2008096769A1 WO 2008096769 A1 WO2008096769 A1 WO 2008096769A1 JP 2008051906 W JP2008051906 W JP 2008051906W WO 2008096769 A1 WO2008096769 A1 WO 2008096769A1
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alkyl
pharmaceutical compositions
hydrogen
compositions containing
containing substituted
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French (fr)
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Kazushi Araki
Masanori Kuroha
Tsuneaki Ogata
Weiyong Sun
Kenji Wakabayashi
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Daiichi Sankyo Company, Limited
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    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

　本発明は、一般式（Ｉ） ［式中、Ｘは、酸素原子等を示し、Ｒ1 は、水素原子又はＣ１−Ｃ６アルキル基を示し、Ｒ２は、水素原子、Ｃ１−Ｃ６アルキル基等を示し、Ｒ３は、水素原子又はＣ１−Ｃ６アルキル基を示し、Ｒ４は、置換基群ａから独立に選択される１乃至５個の基で置換されていてもよいＣ６−Ｃ１０アリール基等を示し、ｎは、１、２又は３を示し、置換基群ａは、ハロゲン原子、Ｃ１−Ｃ６アルキル基、Ｃ１−Ｃ６ハロゲン化アルキル基等を示す。］で表されるセルコスポラミド誘導体、その薬理上許容される塩又はそのエステルを有効成分として含有するＰＰＡＲγ活性化剤／モジュレーター、及び、ＰＰＡＲγが介在する疾病の治療及び/又は発症を予防する製薬的組成物に関する。
PCT/JP2008/051906 2007-02-08 2008-02-06 置換されたセルコスポラミド誘導体を含有する医薬 WO2008096769A1 (ja)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
DE102010015123A1 (de) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
EP3436152A4 (en) * 2016-03-31 2019-12-25 South Australian Health and Medical Research Institute Limited METHOD FOR INHIBITING STATES ASSOCIATED WITH A FAT-RICH DIET

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
DE102010015123A1 (de) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
EP3436152A4 (en) * 2016-03-31 2019-12-25 South Australian Health and Medical Research Institute Limited METHOD FOR INHIBITING STATES ASSOCIATED WITH A FAT-RICH DIET

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