WO2008090944A1 - スピロ環化合物 - Google Patents
スピロ環化合物 Download PDFInfo
- Publication number
- WO2008090944A1 WO2008090944A1 PCT/JP2008/050949 JP2008050949W WO2008090944A1 WO 2008090944 A1 WO2008090944 A1 WO 2008090944A1 JP 2008050949 W JP2008050949 W JP 2008050949W WO 2008090944 A1 WO2008090944 A1 WO 2008090944A1
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- Prior art keywords
- ring
- membered
- aromatic heterocyclic
- spiro
- nitrogenated
- Prior art date
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- A61P9/12—Antihypertensives
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
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- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
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- Endocrinology (AREA)
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- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
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- Pregnancy & Childbirth (AREA)
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Abstract
本発明は、アセチル-CoAカルボキシラーゼ(ACC)阻害作用を有し、肥満症、糖尿病、高血圧症、高脂血症、心不全、糖尿病性合併症、メタボリックシンドローム、筋肉減少症、または癌等の予防・治療に有用であり、かつ優れた薬効を有する式(I)で表される化合物またはその塩を提供するものである。 [式中、R1は、水素原子または置換基を;環Pは、置換されていてもよい6員の含窒素芳香族複素環を;環Qは、さらに置換されていてもよい5ないし7員の含窒素非芳香族複素環を; 環Rは、さらに置換されていてもよく、縮合していてもよい5ないし7員の芳香環を示す。]
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08703778A EP2128163A1 (en) | 2007-01-25 | 2008-01-24 | Spiro-ring compound |
US12/449,084 US20100093777A1 (en) | 2007-01-25 | 2008-01-24 | Spiro-ring compound |
JP2008555099A JPWO2008090944A1 (ja) | 2007-01-25 | 2008-01-24 | スピロ環化合物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007015593 | 2007-01-25 | ||
JP2007-015593 | 2007-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008090944A1 true WO2008090944A1 (ja) | 2008-07-31 |
Family
ID=39644518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/050949 WO2008090944A1 (ja) | 2007-01-25 | 2008-01-24 | スピロ環化合物 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100093777A1 (ja) |
EP (1) | EP2128163A1 (ja) |
JP (1) | JPWO2008090944A1 (ja) |
WO (1) | WO2008090944A1 (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010050445A1 (ja) | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
CN102267995A (zh) * | 2010-06-04 | 2011-12-07 | 艾琪康医药科技(上海)有限公司 | 一种制备二氮杂螺环化合物的方法 |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
EP2398320A1 (en) * | 2009-02-19 | 2011-12-28 | Vanderbilt University | Amidobipiperidinecarboxylate m1 allosteric agonists, analogs and derivatives thereof, and methods of making and using same |
EP2567959A1 (en) | 2011-09-12 | 2013-03-13 | Sanofi | 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JP2013525262A (ja) * | 2010-04-27 | 2013-06-20 | 武田薬品工業株式会社 | 二環性化合物 |
WO2015036892A1 (en) | 2013-09-12 | 2015-03-19 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
WO2017144341A1 (de) | 2016-02-23 | 2017-08-31 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109608460A (zh) * | 2018-12-17 | 2019-04-12 | 上海合全药业股份有限公司 | 一种1,10-二氧亚基-2,7-二氮杂螺[4.5]癸烷-7-甲酸叔丁酯的合成方法 |
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Family Cites Families (1)
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DE3522638A1 (de) * | 1985-06-25 | 1987-01-08 | Diamalt Ag | Neue somatostatin-derivate |
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2008
- 2008-01-24 EP EP08703778A patent/EP2128163A1/en not_active Withdrawn
- 2008-01-24 US US12/449,084 patent/US20100093777A1/en not_active Abandoned
- 2008-01-24 WO PCT/JP2008/050949 patent/WO2008090944A1/ja active Application Filing
- 2008-01-24 JP JP2008555099A patent/JPWO2008090944A1/ja not_active Withdrawn
Patent Citations (19)
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WO1997010224A1 (en) | 1995-09-13 | 1997-03-20 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
WO2001014372A2 (en) | 1999-08-25 | 2001-03-01 | Takeda Chemical Industries, Ltd. | Oxazole and thiazole derivatives as neurotrophin production/secretion promoting agent |
WO2001082925A1 (fr) | 2000-04-28 | 2001-11-08 | Takeda Chemical Industries, Ltd. | Antagonistes de l'hormone concentrant la melanine |
WO2001087834A1 (fr) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Antagoniste de l'hormone de concentration de la melanine |
JP2003533509A (ja) * | 2000-05-19 | 2003-11-11 | メルク シャープ エンド ドーム リミテッド | シクロヘキサン誘導体および治療薬としてのその使用 |
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US20100093777A1 (en) | 2010-04-15 |
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