WO2008081580A1 - 環状ホスファチジン酸誘導体を含む鎮痛剤 - Google Patents
環状ホスファチジン酸誘導体を含む鎮痛剤 Download PDFInfo
- Publication number
- WO2008081580A1 WO2008081580A1 PCT/JP2007/001463 JP2007001463W WO2008081580A1 WO 2008081580 A1 WO2008081580 A1 WO 2008081580A1 JP 2007001463 W JP2007001463 W JP 2007001463W WO 2008081580 A1 WO2008081580 A1 WO 2008081580A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analgesic agent
- acid derivative
- phosphatidic acid
- cyclic phosphatidic
- analgesic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002672534A CA2672534A1 (en) | 2006-12-28 | 2007-12-25 | Analgesic agent comprising cyclic phosphatidic acid derivative |
CN200780045798XA CN101610775B (zh) | 2006-12-28 | 2007-12-25 | 含有环状磷脂酸衍生物的镇痛剂 |
EP07849882A EP2098237B1 (en) | 2006-12-28 | 2007-12-25 | Analgesic agent comprising cyclic phosphatidic acid derivative |
JP2008552022A JP5077893B2 (ja) | 2006-12-28 | 2007-12-25 | 環状ホスファチジン酸誘導体を含む鎮痛剤 |
US12/447,566 US20090326256A1 (en) | 2006-12-28 | 2007-12-25 | Analgesic agent comprising cyclic phosphatidic acid derivative |
US12/907,666 US8017597B2 (en) | 2006-12-28 | 2010-10-19 | Analgesic agent comprising cyclic phosphatidic acid derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006-353642 | 2006-12-28 | ||
JP2006353642 | 2006-12-28 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/447,566 A-371-Of-International US20090326256A1 (en) | 2006-12-28 | 2007-12-25 | Analgesic agent comprising cyclic phosphatidic acid derivative |
US12/907,666 Division US8017597B2 (en) | 2006-12-28 | 2010-10-19 | Analgesic agent comprising cyclic phosphatidic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008081580A1 true WO2008081580A1 (ja) | 2008-07-10 |
Family
ID=39588269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2007/001463 WO2008081580A1 (ja) | 2006-12-28 | 2007-12-25 | 環状ホスファチジン酸誘導体を含む鎮痛剤 |
Country Status (7)
Country | Link |
---|---|
US (2) | US20090326256A1 (ja) |
EP (1) | EP2098237B1 (ja) |
JP (1) | JP5077893B2 (ja) |
KR (1) | KR20090097943A (ja) |
CN (1) | CN101610775B (ja) |
CA (1) | CA2672534A1 (ja) |
WO (1) | WO2008081580A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014115885A1 (ja) | 2013-01-28 | 2014-07-31 | 国立大学法人お茶の水女子大学 | 脱髄疾患治療薬 |
WO2021100847A1 (ja) | 2019-11-22 | 2021-05-27 | 国立大学法人お茶の水女子大学 | カルバリゾホスファチジン酸 |
US11958876B2 (en) | 2019-12-23 | 2024-04-16 | Otsuka Chemical Co., Ltd. | Carbacyclic phosphatidic acid compound |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2098237B1 (en) | 2006-12-28 | 2012-08-29 | Ochanomizu University | Analgesic agent comprising cyclic phosphatidic acid derivative |
JP5465815B2 (ja) * | 2011-11-11 | 2014-04-09 | Sansho株式会社 | 関節症治療剤 |
JP6074411B2 (ja) * | 2012-04-27 | 2017-02-01 | Sansho株式会社 | 育毛剤 |
EP3492479A3 (en) | 2014-08-12 | 2019-10-02 | Otsuka Chemical Co., Ltd. | Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05230088A (ja) | 1991-09-30 | 1993-09-07 | Mitsubishi Kasei Corp | 新規生理活性物質及びその製造法 |
JPH07149772A (ja) | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | タンパク質リン酸化酵素cの活性促進剤 |
JPH07258278A (ja) | 1994-03-18 | 1995-10-09 | Sagami Chem Res Center | 1−O−アシルグリセロール−2,3−ホスフェート誘導体を有効成分とするDNAポリメラーゼαの阻害剤 |
JPH0925235A (ja) | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | 1−o−アシルグリセロール−2,3−ホスフェート誘導体を有効成分とするがん転移抑制剤 |
JP2001178489A (ja) | 1999-12-24 | 2001-07-03 | Kimiko Murofushi | 環状ホスファチジン酸の製造法 |
JP2002308778A (ja) * | 2001-04-13 | 2002-10-23 | Gencom Co | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 |
JP2002308779A (ja) * | 2001-04-13 | 2002-10-23 | Gencom Co | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び/又は生存の促進のための薬剤 |
JP2002540146A (ja) * | 1999-03-25 | 2002-11-26 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 神経細胞分化を促進するための環状グリセロリン酸とその類似体を含む医薬組成物 |
WO2002094286A1 (fr) | 2001-05-21 | 2002-11-28 | Gencom Corporation | Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques |
JP2004010582A (ja) | 2002-06-11 | 2004-01-15 | Gencom Co | カルバ環状ホスファチジン酸誘導体 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060025132A (ko) * | 2003-04-11 | 2006-03-20 | 더 유니버시티 오브 테네시 리서치 파운데이션 | 리소포스파티드산 유사체 및 신생내막 형성의 저해 |
EP2098237B1 (en) | 2006-12-28 | 2012-08-29 | Ochanomizu University | Analgesic agent comprising cyclic phosphatidic acid derivative |
-
2007
- 2007-12-25 EP EP07849882A patent/EP2098237B1/en active Active
- 2007-12-25 CA CA002672534A patent/CA2672534A1/en not_active Abandoned
- 2007-12-25 CN CN200780045798XA patent/CN101610775B/zh active Active
- 2007-12-25 KR KR1020097015380A patent/KR20090097943A/ko not_active Application Discontinuation
- 2007-12-25 US US12/447,566 patent/US20090326256A1/en not_active Abandoned
- 2007-12-25 WO PCT/JP2007/001463 patent/WO2008081580A1/ja active Application Filing
- 2007-12-25 JP JP2008552022A patent/JP5077893B2/ja active Active
-
2010
- 2010-10-19 US US12/907,666 patent/US8017597B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05230088A (ja) | 1991-09-30 | 1993-09-07 | Mitsubishi Kasei Corp | 新規生理活性物質及びその製造法 |
JPH07149772A (ja) | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | タンパク質リン酸化酵素cの活性促進剤 |
JPH07258278A (ja) | 1994-03-18 | 1995-10-09 | Sagami Chem Res Center | 1−O−アシルグリセロール−2,3−ホスフェート誘導体を有効成分とするDNAポリメラーゼαの阻害剤 |
JPH0925235A (ja) | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | 1−o−アシルグリセロール−2,3−ホスフェート誘導体を有効成分とするがん転移抑制剤 |
JP2002540146A (ja) * | 1999-03-25 | 2002-11-26 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 神経細胞分化を促進するための環状グリセロリン酸とその類似体を含む医薬組成物 |
JP2001178489A (ja) | 1999-12-24 | 2001-07-03 | Kimiko Murofushi | 環状ホスファチジン酸の製造法 |
JP2002308778A (ja) * | 2001-04-13 | 2002-10-23 | Gencom Co | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 |
JP2002308779A (ja) * | 2001-04-13 | 2002-10-23 | Gencom Co | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び/又は生存の促進のための薬剤 |
WO2002094286A1 (fr) | 2001-05-21 | 2002-11-28 | Gencom Corporation | Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques |
JP2004010582A (ja) | 2002-06-11 | 2004-01-15 | Gencom Co | カルバ環状ホスファチジン酸誘導体 |
Non-Patent Citations (9)
Title |
---|
"The Pharmaceutical Society of Japan, The 23rd Symposium of Advancement of Reaction and Synthesis", SYNTHESIS AND PHYSIOLOGICAL EFFECTS OF CYCLIC PHOSPHATIDIC ACID AND CARBA DERIVATIVE, 17 November 1997 (1997-11-17), pages 101 - 104 |
KOBAYASHI, S. ET AL., TETRAHEDRON LETT., vol. 34, 1993, pages 4047 - 4050 |
KOBAYASHI, S. ET AL., TETRAHEDRON LETTERS, vol. 34, 1993, pages 4047 - 4050 |
KOBAYASHI, T. ET AL., LIFE SCI., vol. 65, 1999, pages 2185 - 2191 |
MURAKAMI-MUROFUSHI, K. ET AL., BIOCHEM. BIOPHYS. ACTA, vol. 1258, 1995, pages 57 - 60 |
MURAKAMI-MUROFUSHI, K. ET AL., J. BIOL. CHEM., vol. 267, 1992, pages 21512 - 21517 |
SATO ET AL., J AUTON NERV SYST, vol. 4, 1981, pages 231 |
See also references of EP2098237A4 |
UCHIDA ET AL., NEUROSCI LETT, vol. 269, 1999, pages 161 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014115885A1 (ja) | 2013-01-28 | 2014-07-31 | 国立大学法人お茶の水女子大学 | 脱髄疾患治療薬 |
US10413559B2 (en) | 2013-01-28 | 2019-09-17 | Ochanomizu University | Method for treating demyelinating disease |
WO2021100847A1 (ja) | 2019-11-22 | 2021-05-27 | 国立大学法人お茶の水女子大学 | カルバリゾホスファチジン酸 |
US11958876B2 (en) | 2019-12-23 | 2024-04-16 | Otsuka Chemical Co., Ltd. | Carbacyclic phosphatidic acid compound |
Also Published As
Publication number | Publication date |
---|---|
JP5077893B2 (ja) | 2012-11-21 |
US8017597B2 (en) | 2011-09-13 |
JPWO2008081580A1 (ja) | 2010-04-30 |
US20110086820A1 (en) | 2011-04-14 |
CN101610775A (zh) | 2009-12-23 |
CN101610775B (zh) | 2012-12-12 |
EP2098237A1 (en) | 2009-09-09 |
EP2098237B1 (en) | 2012-08-29 |
EP2098237A4 (en) | 2010-02-24 |
CA2672534A1 (en) | 2008-07-10 |
US20090326256A1 (en) | 2009-12-31 |
KR20090097943A (ko) | 2009-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008081580A1 (ja) | 環状ホスファチジン酸誘導体を含む鎮痛剤 | |
WO2007115305A3 (en) | Oral dosage forms including an antiplatelet agent and an acid inhibitor | |
WO2010031825A3 (en) | Methods and compositions for the treatment of cancer | |
WO2011061330A3 (de) | Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe | |
WO2008148074A3 (en) | Inhibitors of mtor and methods of treatment using same | |
TNSN08178A1 (en) | Triazolopyridine derivatives as inhibitors of lipases and phospholipases | |
EP2349279A4 (en) | ALDEHYDE DEHYDROGENASE MODULATORS AND METHOD OF USE THEREOF | |
WO2010042163A3 (en) | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders | |
WO2011012816A3 (fr) | Formulation pharmaceutique | |
RS53574B1 (en) | PYROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS | |
WO2007142752A3 (en) | Polymer-bioceramic composite implantable medical devices | |
WO2007087431A3 (en) | Sublingual fentanyl spray | |
WO2009064388A3 (en) | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders | |
WO2007023243A3 (en) | Cleavage of antifolate compounds | |
WO2008036206A3 (en) | Copolymer-bioceramic composite implantable medical devices | |
EP2045253A4 (en) | alpha-amino acid derivative and pharmaceutical agent containing it as an active ingredient | |
WO2007098964A3 (en) | Pyrrazole derivatives as sigma receptors antagonists | |
WO2007070517A3 (en) | Fexofenadine suspension formulation | |
WO2007090661A3 (en) | Active substance combination comprising azolylcarbinol compounds | |
WO2008046865A3 (en) | Long-term feed - elderly | |
WO2009060952A1 (ja) | 新規製剤 | |
WO2009003719A3 (en) | Indane-amine derivatives, their preparation and use as medicaments | |
WO2011142731A3 (en) | Formulations comprising a third generation cephalosporin and clavulanic acid | |
WO2007104485A3 (de) | Substituierte imidazo[2,1-b]thiazol-verbindungen und ihre verwendung zur herstellung von arzneimitteln | |
WO2011017306A3 (en) | Targeting therapeutic agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200780045798.X Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07849882 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008552022 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007849882 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2672534 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020097015380 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 4458/CHENP/2009 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12447566 Country of ref document: US |