WO2008057254A3 - Composés tricycliques servant d'inhibiteurs des métalloprotéases matricielles - Google Patents
Composés tricycliques servant d'inhibiteurs des métalloprotéases matricielles Download PDFInfo
- Publication number
- WO2008057254A3 WO2008057254A3 PCT/US2007/022651 US2007022651W WO2008057254A3 WO 2008057254 A3 WO2008057254 A3 WO 2008057254A3 US 2007022651 W US2007022651 W US 2007022651W WO 2008057254 A3 WO2008057254 A3 WO 2008057254A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- matrix metalloproteinase
- metalloproteinase inhibitors
- tricyclic compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009534660A JP2010507674A (ja) | 2006-10-27 | 2007-10-26 | マトリクスメタロプロテアーゼ阻害剤としての三環式化合物 |
CA002667644A CA2667644A1 (fr) | 2006-10-27 | 2007-10-26 | Composes tricycliques servant d'inhibiteurs des metalloproteases matricielles |
EP07839790A EP2074107A2 (fr) | 2006-10-27 | 2007-10-26 | Composes tricycliques servant d'inhibiteurs des metalloproteases matricielles |
MX2009004289A MX2009004289A (es) | 2006-10-27 | 2007-10-26 | Compuestos triciclicos como inhibidores de metaloproteinasas matriciales. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85478606P | 2006-10-27 | 2006-10-27 | |
US60/854,786 | 2006-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008057254A2 WO2008057254A2 (fr) | 2008-05-15 |
WO2008057254A3 true WO2008057254A3 (fr) | 2009-01-08 |
Family
ID=39166382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/022651 WO2008057254A2 (fr) | 2006-10-27 | 2007-10-26 | Composés tricycliques servant d'inhibiteurs des métalloprotéases matricielles |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2074107A2 (fr) |
JP (1) | JP2010507674A (fr) |
CA (1) | CA2667644A1 (fr) |
MX (1) | MX2009004289A (fr) |
WO (1) | WO2008057254A2 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR066412A1 (es) * | 2007-05-04 | 2009-08-19 | Wyeth Corp | Derivados de dibenzofurano y dibenzotiofeno, composiciones farmaceuticas que los contienen y usos en patologias tales como trastornos oseos, crecimiento de tumores, diabetes y obesidad. |
CA2747670A1 (fr) | 2008-12-19 | 2010-07-15 | Bristol-Myers Squibb Company | Composes carbazole carboxamide utiles comme inhibiteurs de kinases |
US9273021B2 (en) | 2009-02-05 | 2016-03-01 | Trustees Of Boston College | Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof |
FR2949463B1 (fr) | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | Inhibiteurs de mmp |
FR2996003B1 (fr) | 2012-09-25 | 2014-10-17 | Commissariat Energie Atomique | Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active |
BR112015021452A2 (pt) | 2013-03-15 | 2017-07-18 | Monsanto Technology Llc | azóis n-,c-dissubstituídos para controlar pragas de nematódeos |
US9981928B2 (en) | 2013-06-20 | 2018-05-29 | Bayer Cropscience Aktiengesellschaft | Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides |
EP2907512A1 (fr) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibiteurs de MMP-12 en tant qu'agents antiviraux |
US20170107216A1 (en) | 2015-10-19 | 2017-04-20 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
AU2016358100B2 (en) | 2015-11-19 | 2021-05-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
DK3394033T3 (da) | 2015-12-22 | 2021-01-04 | Incyte Corp | Heterocykliske forbindelser som immunmodulatorer |
MA44860A (fr) | 2016-05-06 | 2019-03-13 | Incyte Holdings Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
ES2930092T3 (es) | 2016-07-14 | 2022-12-07 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
EP3504198B1 (fr) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Composés hétérocycliques utilisés comme immunomodulateurs |
US10042251B2 (en) | 2016-09-30 | 2018-08-07 | Rohm And Haas Electronic Materials Llc | Zwitterionic photo-destroyable quenchers |
MA47120A (fr) | 2016-12-22 | 2021-04-28 | Incyte Corp | Dérivés pyridine utilisés en tant qu'immunomodulateurs |
EP3558985B1 (fr) | 2016-12-22 | 2022-09-07 | Incyte Corporation | Dérivés de benzooxazole en tant qu'mmunomodulateurs |
EP3558989B1 (fr) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs |
CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
EP3790877B1 (fr) | 2018-05-11 | 2023-03-01 | Incyte Corporation | Dérivés de tétrahydro-imidazo[4,5-c]pyridine en tant qu'immunomodulateurs de pd-l1 |
TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之鹽 |
TW202126652A (zh) | 2019-09-30 | 2021-07-16 | 美商英塞特公司 | 作為免疫調節劑之吡啶并[3,2—d]嘧啶化合物 |
AU2020385113A1 (en) | 2019-11-11 | 2022-05-19 | Incyte Corporation | Salts and crystalline forms of a PD-1/PD-L1 inhibitor |
WO2022099018A1 (fr) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Procédé de préparation d'un inhibiteur de pd-1/pd-l1 |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
CA3200844A1 (fr) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Processus de fabrication d'un inhibiteur pd-1/pd-l1 ainsi que de ses sels et formes cristallines |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09194481A (ja) * | 1996-01-11 | 1997-07-29 | Eisai Co Ltd | 縮合四環式ヘテロ環誘導体 |
WO1998009957A1 (fr) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Composes et procede destines a l'inhibition de metalloproteases matricielles |
WO1998009934A1 (fr) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Inhibiteurs de metalloproteinases matricielles et leurs utilisations pharmaceutiques |
JPH11246527A (ja) * | 1998-03-02 | 1999-09-14 | Shionogi & Co Ltd | Mmp−8阻害剤 |
EP1233017A1 (fr) * | 2001-02-14 | 2002-08-21 | Warner-Lambert Company | Sulphonamides tricycliques utiles comme inhibiteurs de métalloprotéase matricielle |
US20050027129A1 (en) * | 2003-04-11 | 2005-02-03 | Glenmark Pharmaceuticals, Inc. Usa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
-
2007
- 2007-10-26 WO PCT/US2007/022651 patent/WO2008057254A2/fr active Application Filing
- 2007-10-26 CA CA002667644A patent/CA2667644A1/fr not_active Abandoned
- 2007-10-26 JP JP2009534660A patent/JP2010507674A/ja not_active Withdrawn
- 2007-10-26 MX MX2009004289A patent/MX2009004289A/es unknown
- 2007-10-26 EP EP07839790A patent/EP2074107A2/fr not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09194481A (ja) * | 1996-01-11 | 1997-07-29 | Eisai Co Ltd | 縮合四環式ヘテロ環誘導体 |
WO1998009957A1 (fr) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Composes et procede destines a l'inhibition de metalloproteases matricielles |
WO1998009934A1 (fr) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Inhibiteurs de metalloproteinases matricielles et leurs utilisations pharmaceutiques |
JPH11246527A (ja) * | 1998-03-02 | 1999-09-14 | Shionogi & Co Ltd | Mmp−8阻害剤 |
EP1233017A1 (fr) * | 2001-02-14 | 2002-08-21 | Warner-Lambert Company | Sulphonamides tricycliques utiles comme inhibiteurs de métalloprotéase matricielle |
US20050027129A1 (en) * | 2003-04-11 | 2005-02-03 | Glenmark Pharmaceuticals, Inc. Usa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
Non-Patent Citations (3)
Title |
---|
DATABASE WPI Week 1997, Derwent World Patents Index; AN 1997-431459, XP002500619 * |
DATABASE WPI Week 1999, Derwent World Patents Index; AN 1999-566553, XP002473193 * |
EL-NAGGAR A M ET AL: "Synthesis and biological activity of some new dibenzofuran- and 7-nitrodibenzofuran-2-sulfonyl amino acid derivatives", ACTA PHARMACEUTICA JUGOSLAVICA, SAVEZ FARMACEUTSKIH DRUSTAVA JUGOSLAVIJE, ZAGREB, YU, vol. 35, no. 1, 1 January 1985 (1985-01-01), pages 15 - 22, XP009097421, ISSN: 0001-6667 * |
Also Published As
Publication number | Publication date |
---|---|
JP2010507674A (ja) | 2010-03-11 |
EP2074107A2 (fr) | 2009-07-01 |
WO2008057254A2 (fr) | 2008-05-15 |
MX2009004289A (es) | 2009-05-05 |
CA2667644A1 (fr) | 2008-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008057254A3 (fr) | Composés tricycliques servant d'inhibiteurs des métalloprotéases matricielles | |
MY154895A (en) | Pyrimidine hydrazide compounds as pgds inhibitors | |
NO20082000L (no) | Pyrimidinamidforbindelser som PGDS-inhibitorer | |
WO2006124692A3 (fr) | Inhibiteurs 3-cyanoquinoline de la tpl2 kinase et procedes de production et d'utilisation associes | |
WO2007056167A3 (fr) | (quinazolinyl)phenyl-thiophenyl-sulfonylurees substituees et procedes pour les preparer | |
WO2006002434A3 (fr) | Nouveaux indazole carboxamides et leur utilisation | |
WO2010018113A3 (fr) | Bi-aryle aminotétralines | |
WO2008137816A3 (fr) | Composés tricycliques en tant qu'inhibiteurs de métalloprotéinase matricielle | |
WO2009126530A3 (fr) | Antagonistes du récepteur cgrp | |
WO2010018109A3 (fr) | Aminotétralines substituées | |
WO2011005811A8 (fr) | Polythérapie pour le traitement du diabète | |
WO2012083112A3 (fr) | Inhibiteurs de cyp11b, cyp17 et/ou cyp21 | |
WO2008127682A3 (fr) | Combinaison d'une thérapie anticoagulante à un composé agissant en tant qu'inhibiteur de facteur xa | |
ATE537175T1 (de) | Neue piperazino-dihydrothienopyrimidin-derivate | |
EA200970883A1 (ru) | Индолкарбоксамиды как ингибиторы ikk2 | |
EA200970158A1 (ru) | Производные хинуклидина в качестве антагонистов м3 | |
NZ591914A (en) | Naphthylacetic acids | |
WO2010018112A3 (fr) | Monoaryle aminotétralines | |
NZ599099A (en) | Phenyloxadiazole derivatives as pgds inhibitors | |
WO2006011024A3 (fr) | Nouveaux composes tricycliques utilises dans le traitement de troubles inflammatoires et allergiques, procede de preparation associe, et compositions pharmaceutiques les contenant | |
EA200800183A1 (ru) | Новые производные индолкарбоксамида, содержащая их фармацевтическая композиция и способ лечения | |
WO2008137809A3 (fr) | Sels de [4(-(6-fluoro-7-méthylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phényl]-5-chloro-thiophén-2-yl-sulfonylurée, formes et procédés qui leur sont associés | |
WO2004075840A3 (fr) | Modulateurs selectifs de recepteurs de glucocorticoides non steroidaux | |
TW200640905A (en) | Monopotassium salt of an IκB kinase inhibitor | |
NO20081483L (no) | Kombinasjon av forbindelser som kan brukes ved behandling av respiratoriske sykdommer, spesielt kronisk obstruktiv pulmonaer sykdom (COPD) og astma |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07839790 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007839790 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2009/004289 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref document number: 2009534660 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2667644 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |