WO2008053358A3 - A common gene expression signature in dilated cardiomyopathy - Google Patents

A common gene expression signature in dilated cardiomyopathy Download PDF

Info

Publication number
WO2008053358A3
WO2008053358A3 PCT/IB2007/004191 IB2007004191W WO2008053358A3 WO 2008053358 A3 WO2008053358 A3 WO 2008053358A3 IB 2007004191 W IB2007004191 W IB 2007004191W WO 2008053358 A3 WO2008053358 A3 WO 2008053358A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
dilated cardiomyopathy
expression signature
common gene
cardiomyopathy
Prior art date
Application number
PCT/IB2007/004191
Other languages
French (fr)
Other versions
WO2008053358A2 (en
WO2008053358A8 (en
Inventor
Ruprecht Kuner
Holger Sueltmann
Markus Ruschhaupt
Andreas Buness
Andreas Barth
Michael Nabauer
Annemarie Poustka
Original Assignee
Deutsches Krebsforsch
Ruprecht Kuner
Holger Sueltmann
Markus Ruschhaupt
Andreas Buness
Andreas Barth
Michael Nabauer
Annemarie Poustka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Ruprecht Kuner, Holger Sueltmann, Markus Ruschhaupt, Andreas Buness, Andreas Barth, Michael Nabauer, Annemarie Poustka filed Critical Deutsches Krebsforsch
Priority to EP07866600A priority Critical patent/EP2046997A2/en
Priority to JP2009521384A priority patent/JP2009544306A/en
Publication of WO2008053358A2 publication Critical patent/WO2008053358A2/en
Publication of WO2008053358A3 publication Critical patent/WO2008053358A3/en
Publication of WO2008053358A8 publication Critical patent/WO2008053358A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a convenient and highly effective microarray tool and method for diagnosing a cardiomyopathy state, especially dilated cardiomyopathy, in a subject, with a high degree of accuracy.
PCT/IB2007/004191 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy WO2008053358A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07866600A EP2046997A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy
JP2009521384A JP2009544306A (en) 2006-07-25 2007-07-24 Common gene expression signature for dilated cardiomyopathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83295906P 2006-07-25 2006-07-25
US60/832,959 2006-07-25

Publications (3)

Publication Number Publication Date
WO2008053358A2 WO2008053358A2 (en) 2008-05-08
WO2008053358A3 true WO2008053358A3 (en) 2008-11-20
WO2008053358A8 WO2008053358A8 (en) 2009-08-27

Family

ID=39344668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004191 WO2008053358A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy

Country Status (3)

Country Link
EP (1) EP2046997A2 (en)
JP (1) JP2009544306A (en)
WO (1) WO2008053358A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102027374A (en) * 2008-04-30 2011-04-20 霍夫曼-拉罗奇有限公司 Use of SFRP-3 in the assessment of heart failure
CN110506057B (en) 2017-02-17 2023-09-29 百时美施贵宝公司 ALPHA synuclein antibody and application thereof
CN110809718A (en) * 2017-06-21 2020-02-18 韩国生命工学研究院 Method and kit for diagnosing muscle weakness-related diseases using blood biomarkers
CN113355332B (en) * 2021-07-22 2022-09-06 青岛市妇女儿童医院 HEG1 gene mutant and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
WO2003040407A2 (en) * 2001-11-09 2003-05-15 Max-Planck-Gesellschaft Novel markers for cardiopathies
WO2005060656A2 (en) * 2003-12-16 2005-07-07 Hare Joshua M Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024571A2 (en) * 1997-11-10 1999-05-20 Curagen Corporation Differentially expressed genes in cardiac hypertrophy and their uses in treatment and diagnosis
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
WO2003040407A2 (en) * 2001-11-09 2003-05-15 Max-Planck-Gesellschaft Novel markers for cardiopathies
WO2005060656A2 (en) * 2003-12-16 2005-07-07 Hare Joshua M Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy
US20050158756A1 (en) * 2003-12-16 2005-07-21 Joshua Hare Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Affimetrix GeneChip Human Genome U133 Array Set HG-U133A", GEO,, 1 January 1900 (1900-01-01), XP002254749 *
BOHELER ET AL: "Gene expression in cardiac hypertrophy", DS IN CARDIOVASCULAR MEDICINE, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 2, no. 5, 1 September 1992 (1992-09-01), pages 176 - 182, XP002096139, ISSN: 1050-1738 *
HWANG JUEY-JEN ET AL: "Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure", PHYSIOLOGICAL GENOMICS, vol. 10, October 2002 (2002-10-01), pages 31 - 44, XP002488465, ISSN: 1094-8341 *
TAN F-L ET AL: "The gene expression fingerprint of human heart failure", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 99, no. 17, 20 August 2002 (2002-08-20), pages 11387 - 11392, XP002970100, ISSN: 0027-8424 *
YUNG C K ET AL: "Gene expression profiles in end-stage human idiopathic dilated cardiomyopathy: altered expression of apoptotic and cytoskeletal genes", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 83, no. 2, 1 February 2004 (2004-02-01), pages 281 - 297, XP004482956, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
WO2008053358A2 (en) 2008-05-08
JP2009544306A (en) 2009-12-17
EP2046997A2 (en) 2009-04-15
WO2008053358A8 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
EP1903478A3 (en) Methods and systems for defining, identifying and learning geometric features
WO2008048970A8 (en) Synthetic antibodies
WO2007008276A3 (en) Turnover probes and use thereof for nucleic acid detection
WO2008086282A3 (en) Methods and systems for using electrical information for a device being fabricated on a wafer to perform one or more defect-related functions
WO2008005321A3 (en) Systems and methods for real-time pcr
WO2010019414A3 (en) Detecting nucleic acid
WO2011044298A3 (en) Systems and methods for establishing an environmental representation
WO2007082154A3 (en) B7-h1 and b7-h4 in cancer
WO2007047408A3 (en) Promac signature application
BRPI0717416A2 (en) METHOD FOR PERFORMING A HIGH PRODUCTIVITY COMPLEX IMMUNOASON, AND
WO2008070269A3 (en) Methods, software and systems for imaging
EP1764351A3 (en) Silicon based substrate with hafnium silicate containing barrier layer
WO2009140039A3 (en) Synthetic antibodies
WO2009155502A3 (en) Computer-implemented methods, computer-readable media, and systems for determining one or more characteristics of a wafer
AU2007266218B2 (en) Biomarkers for diagnosing multiple sclerosis, and methods thereof
WO2007126548A3 (en) Adaptive mission profiling
WO2008014495A3 (en) Genomics based targeted advertising
WO2009037600A3 (en) Solid substrate with surface bound molecules and methods for producing and using the same
WO2007132397A3 (en) Up-scaling
EP2021313A4 (en) Biomarkers for diagnosing multiple sclerosis, and methods thereof
MX2012004403A (en) End member, gas spring assembly and method.
WO2008034622A3 (en) A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
WO2008053358A8 (en) A common gene expression signature in dilated cardiomyopathy
WO2009103061A3 (en) Methods and compositions for identifying, diagnosing, and treating neuroblastoma
WO2008133705A3 (en) Assays and devices for identifying pathogens

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07866600

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009521384

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007866600

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU