WO2008053358A8 - A common gene expression signature in dilated cardiomyopathy - Google Patents

A common gene expression signature in dilated cardiomyopathy Download PDF

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Publication number
WO2008053358A8
WO2008053358A8 PCT/IB2007/004191 IB2007004191W WO2008053358A8 WO 2008053358 A8 WO2008053358 A8 WO 2008053358A8 IB 2007004191 W IB2007004191 W IB 2007004191W WO 2008053358 A8 WO2008053358 A8 WO 2008053358A8
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
dilated cardiomyopathy
expression signature
common gene
cardiomyopathy
Prior art date
Application number
PCT/IB2007/004191
Other languages
French (fr)
Other versions
WO2008053358A2 (en
WO2008053358A3 (en
Inventor
Ruprecht Kuner
Holger Sueltmann
Markus Ruschhaupt
Andreas Buness
Andreas Barth
Michael Nabauer
Annemarie Poustka
Original Assignee
Deutsches Krebsforschungszentrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum filed Critical Deutsches Krebsforschungszentrum
Priority to JP2009521384A priority Critical patent/JP2009544306A/en
Priority to EP07866600A priority patent/EP2046997A2/en
Publication of WO2008053358A2 publication Critical patent/WO2008053358A2/en
Publication of WO2008053358A3 publication Critical patent/WO2008053358A3/en
Publication of WO2008053358A8 publication Critical patent/WO2008053358A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a convenient and highly effective microarray tool and method for diagnosing a cardiomyopathy state, especially dilated cardiomyopathy, in a subject, with a high degree of accuracy.
PCT/IB2007/004191 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy WO2008053358A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009521384A JP2009544306A (en) 2006-07-25 2007-07-24 Common gene expression signature for dilated cardiomyopathy
EP07866600A EP2046997A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83295906P 2006-07-25 2006-07-25
US60/832,959 2006-07-25

Publications (3)

Publication Number Publication Date
WO2008053358A2 WO2008053358A2 (en) 2008-05-08
WO2008053358A3 WO2008053358A3 (en) 2008-11-20
WO2008053358A8 true WO2008053358A8 (en) 2009-08-27

Family

ID=39344668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004191 WO2008053358A2 (en) 2006-07-25 2007-07-24 A common gene expression signature in dilated cardiomyopathy

Country Status (3)

Country Link
EP (1) EP2046997A2 (en)
JP (1) JP2009544306A (en)
WO (1) WO2008053358A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102027374A (en) * 2008-04-30 2011-04-20 霍夫曼-拉罗奇有限公司 Use of SFRP-3 in the assessment of heart failure
CN110506057B (en) 2017-02-17 2023-09-29 百时美施贵宝公司 ALPHA synuclein antibody and application thereof
US20200141948A1 (en) * 2017-06-21 2020-05-07 Korea Research Institute Of Bioscience And Biotechnology Method and kit for diagnosis of muscle weakness-related diseases using blood biomarker
CN113355332B (en) * 2021-07-22 2022-09-06 青岛市妇女儿童医院 HEG1 gene mutant and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610480B1 (en) * 1997-11-10 2003-08-26 Genentech, Inc. Treatment and diagnosis of cardiac hypertrophy
WO2003006687A2 (en) * 2001-07-10 2003-01-23 Medigene Ag Novel target genes for diseases of the heart
WO2003040407A2 (en) * 2001-11-09 2003-05-15 Max-Planck-Gesellschaft Novel markers for cardiopathies
EP1704224A4 (en) * 2003-12-16 2008-03-12 Joshua M Hare Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy

Also Published As

Publication number Publication date
WO2008053358A2 (en) 2008-05-08
WO2008053358A3 (en) 2008-11-20
JP2009544306A (en) 2009-12-17
EP2046997A2 (en) 2009-04-15

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