WO2008048970A8 - Synthetic antibodies - Google Patents

Synthetic antibodies Download PDF

Info

Publication number
WO2008048970A8
WO2008048970A8 PCT/US2007/081536 US2007081536W WO2008048970A8 WO 2008048970 A8 WO2008048970 A8 WO 2008048970A8 US 2007081536 W US2007081536 W US 2007081536W WO 2008048970 A8 WO2008048970 A8 WO 2008048970A8
Authority
WO
WIPO (PCT)
Prior art keywords
synthetic antibodies
methods
antibodies
reagents
present invention
Prior art date
Application number
PCT/US2007/081536
Other languages
French (fr)
Other versions
WO2008048970A2 (en
WO2008048970A3 (en
Inventor
Stephen Albert Johnston
Neal Woodbury
John C Chaput
Chris W Diehnelt
Hao Yan
Original Assignee
Univ Arizona
Stephen Albert Johnston
Neal Woodbury
John C Chaput
Chris W Diehnelt
Hao Yan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US85204006P priority Critical
Priority to US60/852,040 priority
Priority to US97544207P priority
Priority to US60/975,442 priority
Application filed by Univ Arizona, Stephen Albert Johnston, Neal Woodbury, John C Chaput, Chris W Diehnelt, Hao Yan filed Critical Univ Arizona
Publication of WO2008048970A2 publication Critical patent/WO2008048970A2/en
Publication of WO2008048970A3 publication Critical patent/WO2008048970A3/en
Publication of WO2008048970A8 publication Critical patent/WO2008048970A8/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/14Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL CHEMISTRY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.
PCT/US2007/081536 2006-10-16 2007-10-16 Synthetic antibodies WO2008048970A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US85204006P true 2006-10-16 2006-10-16
US60/852,040 2006-10-16
US97544207P true 2007-09-26 2007-09-26
US60/975,442 2007-09-26

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2009533482A JP2010507099A (en) 2006-10-16 2007-10-16 Synthetic antibodies
CA002666507A CA2666507A1 (en) 2006-10-16 2007-10-16 Synthetic antibodies
EP07844320A EP2076614A4 (en) 2006-10-16 2007-10-16 Synthetic antibodies
US12/445,923 US20110143953A1 (en) 2006-10-16 2007-10-16 Synthetic Antibodies
US14/198,316 US9863938B2 (en) 2006-10-16 2014-03-05 Synthetic antibodies

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US12/445,923 A-371-Of-International US20110143953A1 (en) 2006-10-16 2007-10-16 Synthetic Antibodies
US44592310A A-371-Of-International 2010-11-23 2010-11-23
US14/198,316 Division US9863938B2 (en) 2006-10-16 2014-03-05 Synthetic antibodies
US14/198,316 Continuation US9863938B2 (en) 2006-10-16 2014-03-05 Synthetic antibodies

Publications (3)

Publication Number Publication Date
WO2008048970A2 WO2008048970A2 (en) 2008-04-24
WO2008048970A3 WO2008048970A3 (en) 2008-08-21
WO2008048970A8 true WO2008048970A8 (en) 2009-05-28

Family

ID=39314793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/081536 WO2008048970A2 (en) 2006-10-16 2007-10-16 Synthetic antibodies

Country Status (5)

Country Link
US (2) US20110143953A1 (en)
EP (1) EP2076614A4 (en)
JP (1) JP2010507099A (en)
CA (1) CA2666507A1 (en)
WO (1) WO2008048970A2 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU748939B2 (en) * 1997-02-20 2002-06-13 Regents Of The University Of California, The Plasmon resonant particles, methods and apparatus
CN102007145A (en) 2008-02-14 2011-04-06 百时美施贵宝公司 Targeted therapeutics based on engineered proteins that bind egfr
GB0805608D0 (en) * 2008-03-28 2008-04-30 Sec Dep For Environment Food & Detection method
AR071874A1 (en) * 2008-05-22 2010-07-21 Squibb Bristol Myers Co Frame domain proteins based multivalent fibronectin
TWI496582B (en) 2008-11-24 2015-08-21 Squibb Bristol Myers Co Bispecific egfr/igfir binding molecules
WO2010111299A2 (en) * 2009-03-24 2010-09-30 The Arizona Board Of Regents A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Synthetic antibodies
EP2438444A1 (en) 2009-06-02 2012-04-11 The Board of Regents of The University of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
EP2443459B1 (en) * 2009-06-19 2018-12-26 The Arizona Board of Regents, A Body Corporate Of the State of Arizona acting for and on behalf Of Arizona State University Compound arrays for sample profiling
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
WO2011029008A2 (en) * 2009-09-04 2011-03-10 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Synbodies to akt1
TW201138808A (en) 2010-05-03 2011-11-16 Squibb Bristol Myers Co Serum albumin binding molecules
ES2573108T3 (en) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Based scaffold proteins fibronectin having improved stability
CN103384681B (en) * 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 Binding agent
KR20140063577A (en) 2011-06-30 2014-05-27 피라말 이미징 에스에이 Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine
EP2540710A1 (en) 2011-06-30 2013-01-02 Bayer Schering Pharma Aktiengesellschaft New precursors for direct radiosynthesis of protected derivatives of O-([18F]Fluoromethyl) tyrosine
US9309298B2 (en) 2011-11-02 2016-04-12 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Anti-bacterial polypeptides and pathogen specific synthetic antibodies
WO2013119845A1 (en) * 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
CN107817348A (en) * 2012-09-05 2018-03-20 亚利桑那州评议委员会,亚利桑那州法人团体,代理和代表亚利桑那州立大学 Methods for discovering therapeutic targets
US20150241420A1 (en) * 2012-09-05 2015-08-27 Arizona Board of Regents, Body Corp. of the State of Arizona, acting for and on behalf of Arizona S Methods for discovering therapeutic targets
WO2014083474A1 (en) * 2012-11-30 2014-06-05 Koninklijke Philips N.V. Capture particle for selectively binding a target molecule
US10006919B2 (en) 2013-03-15 2018-06-26 Arizona Board Of Regents On Behalf Of Arizona State University Peptide array quality control
US9970932B2 (en) 2013-03-15 2018-05-15 Arizona Board Of Regents On Behalf Of Arizona State University Non-covalent patterned chemical features and use thereof in MALDI-based quality control
US10011649B2 (en) 2013-08-26 2018-07-03 Arizona Board Of Regents On Behalf Of Arizona State University High affinity synbodies for influenza
US9757472B2 (en) * 2014-07-28 2017-09-12 Arizona Board Of Regents On Behalf Of Arizona State University Proteas stabilized antibacterial peptides for S. aureus
US10125167B2 (en) 2015-12-04 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Compositions and methods for treating MRSA infections and for sensitizing MRSA to beta-lactam antibiotics

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
EP1958962A3 (en) * 1997-06-12 2013-05-01 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
US6087103A (en) * 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
AT340870T (en) * 1998-04-03 2006-10-15 Compound Therapeutics Inc Addressable protein arrays
US6255469B1 (en) * 1998-05-06 2001-07-03 New York University Periodic two and three dimensional nucleic acid structures
US6818418B1 (en) * 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
CN1654956A (en) * 2000-05-04 2005-08-17 耶鲁大学 High density protein arrays for screening of protein activity
US20040175756A1 (en) * 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
US20050089932A1 (en) * 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding
US20030157561A1 (en) * 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
US20050053973A1 (en) * 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20050048512A1 (en) * 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20060223114A1 (en) * 2001-04-26 2006-10-05 Avidia Research Institute Protein scaffolds and uses thereof
AU2002256371B2 (en) * 2001-04-26 2008-01-10 Amgen Mountain View Inc. Combinatorial libraries of monomer domains
EP1556506A1 (en) * 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US7034941B2 (en) * 2003-06-26 2006-04-25 Eastman Kodak Company Color detection using spectroscopic imaging and processing in random array of microspheres
AU2003903295A0 (en) 2003-06-30 2003-07-10 Raustech Pty Ltd Substrate for combinatorial chemistry
WO2005040229A2 (en) * 2003-10-24 2005-05-06 Avidia, Inc. Ldl receptor class a and egf domain monomers and multimers
WO2006033972A2 (en) * 2004-09-15 2006-03-30 Protometrix, Inc. Protein arrays and methods of use thereof
AU2005307789A1 (en) * 2004-11-16 2006-05-26 Avidia Research Institute Protein scaffolds and uses thereof
WO2006124644A2 (en) 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays

Also Published As

Publication number Publication date
EP2076614A2 (en) 2009-07-08
WO2008048970A2 (en) 2008-04-24
EP2076614A4 (en) 2012-07-04
US20140221253A1 (en) 2014-08-07
CA2666507A1 (en) 2008-04-24
JP2010507099A (en) 2010-03-04
US9863938B2 (en) 2018-01-09
WO2008048970A3 (en) 2008-08-21
US20110143953A1 (en) 2011-06-16

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