WO2008049919A3 - Inhibiteurs de kinase - Google Patents
Inhibiteurs de kinase Download PDFInfo
- Publication number
- WO2008049919A3 WO2008049919A3 PCT/EP2007/061542 EP2007061542W WO2008049919A3 WO 2008049919 A3 WO2008049919 A3 WO 2008049919A3 EP 2007061542 W EP2007061542 W EP 2007061542W WO 2008049919 A3 WO2008049919 A3 WO 2008049919A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitors
- kinase inhibitors
- rho kinase
- relates
- present
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne de nouveaux inhibiteurs des kinases de la famille AGC, en particulier des composés de formule (I) ou (II), ou un stéréoisomère, un tautomère, un racémique, un métabolite, un pro ou pré-médicament, un sel, un hydrate ou un solvate de ceux-ci, dans lesquelles R1, R2, R4, R5, R7, R8, q s, L et Y ont le sens défini dans les revendications. La présente invention concerne en particulier des inhibiteurs de la ROCK, des compositions, en particulier des produits pharmaceutiques, comprenant de tels inhibiteurs et des utilisations de tels inhibiteurs pour le traitement et la prophylaxie de maladies.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85444506P | 2006-10-26 | 2006-10-26 | |
US60/854,445 | 2006-10-26 | ||
EP06447116 | 2006-10-26 | ||
EP06447116.2 | 2006-10-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008049919A2 WO2008049919A2 (fr) | 2008-05-02 |
WO2008049919A3 true WO2008049919A3 (fr) | 2008-07-03 |
Family
ID=39149206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/061542 WO2008049919A2 (fr) | 2006-10-26 | 2007-10-26 | Inhibiteurs de kinase |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008049919A2 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096569B2 (en) | 2008-07-25 | 2015-08-04 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
CN107903250A (zh) * | 2017-12-31 | 2018-04-13 | 佛山市赛维斯医药科技有限公司 | 一种含吡啶和硝基噻吩结构的化合物、制备方法及其用途 |
CN107915717A (zh) * | 2017-12-31 | 2018-04-17 | 佛山市赛维斯医药科技有限公司 | 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途 |
CN107935986A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途 |
CN107935987A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途 |
CN108047193A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途 |
CN108047194A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途 |
CN108047214A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 一种含吡啶和硝基噻吩结构化合物及其用途 |
CN108191820A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 一种含异丙胺和噻吩酰胺类结构的化合物 |
US11590123B2 (en) | 2016-08-31 | 2023-02-28 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7470787B2 (en) | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
EP2526948A1 (fr) | 2006-09-20 | 2012-11-28 | Aerie Pharmaceuticals, Inc. | Inhibiteurs de la RHO-kinase |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
EP3053913B1 (fr) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Inhibiteurs à double mécanisme pour le traitement d'une maladie |
EP2332917B1 (fr) * | 2009-11-11 | 2012-08-01 | Sygnis Bioscience GmbH & Co. KG | Composés pour l'inhibition de kinase PIM et pour le traitement des tumeurs |
US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
KR20140023356A (ko) * | 2011-04-18 | 2014-02-26 | 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 | 기체 포획 방법 |
GB201107223D0 (en) | 2011-04-29 | 2011-06-15 | Amakem Nv | Novel rock inhibitors |
US9394296B2 (en) * | 2012-01-09 | 2016-07-19 | X-Chem, Inc. | Tryptoline derivatives having kinase inhibitory activity and uses thereof |
JP6509747B2 (ja) * | 2013-03-04 | 2019-05-08 | ヘルス・サイエンシズ・ノース・リサーチ・インスティチュート | キノリンスルホニル誘導体及びそれらの使用 |
US20140275160A1 (en) | 2013-03-15 | 2014-09-18 | Aerie Pharmaceuticals, Inc. | Combination therapy |
WO2016003450A1 (fr) * | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Inhibiteurs de pkc-epsilon |
US10662183B2 (en) | 2014-11-07 | 2020-05-26 | The Regents Of The University Of Michigan | Inhibitors of myocardin-related transcription factor and serum response factor (MRTF/SRF)-mediated gene transcription and methods for use of the same |
AU2015414743B2 (en) | 2015-11-17 | 2019-07-18 | Alcon Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
EP3609871A4 (fr) | 2017-03-31 | 2021-01-06 | Aerie Pharmaceuticals, Inc. | Composés d'amide aryl cyclopropyl-amino-isoquinolinyl |
US10800745B2 (en) * | 2017-08-18 | 2020-10-13 | Purdue Research Foundation | Methods for 1,4-diazo n-heterocycle synthesis |
CN108129453A (zh) * | 2017-12-31 | 2018-06-08 | 佛山市赛维斯医药科技有限公司 | 一种含甲基萘和丙二醇噻吩酰胺类结构的rock抑制剂 |
CN108129451A (zh) * | 2017-12-31 | 2018-06-08 | 佛山市赛维斯医药科技有限公司 | 含丙二醇噻吩酰胺类化合物、制备方法及其用途 |
CN108129450A (zh) * | 2017-12-31 | 2018-06-08 | 佛山市赛维斯医药科技有限公司 | 含烷氧噻吩酰胺和甲基萘结构的化合物、制备方法及其用途 |
CN108129448A (zh) * | 2017-12-31 | 2018-06-08 | 佛山市赛维斯医药科技有限公司 | 噻吩酰胺类rock抑制剂、制备方法及其用途 |
CN107973776A (zh) * | 2017-12-31 | 2018-05-01 | 佛山市赛维斯医药科技有限公司 | 一种噻吩酰胺类结构化合物及其用途 |
CN108033954A (zh) * | 2017-12-31 | 2018-05-15 | 佛山市赛维斯医药科技有限公司 | 一种含吡啶结构的化合物、制备方法及其用途 |
CN108148042A (zh) * | 2017-12-31 | 2018-06-12 | 佛山市赛维斯医药科技有限公司 | 一类噻吩酰胺rock抑制剂、制备方法及其用途 |
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CN108047192A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 甲噻吩酰胺类结构化合物、其制备方法及用途 |
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CN108101885A (zh) * | 2017-12-31 | 2018-06-01 | 佛山市赛维斯医药科技有限公司 | 含异丙胺和硝基噻吩酰胺类结构化合物、其制备方法及用途 |
CN108218829A (zh) * | 2017-12-31 | 2018-06-29 | 佛山市赛维斯医药科技有限公司 | 一种噻吩酰胺类rock抑制剂、制备方法及其用途 |
CN107936003A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 一类含吡啶和噻吩结构的化合物、制备方法及其用途 |
CN108047215A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 含吡啶结构的化合物、制备方法及其用途 |
CN108191819A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 异丙胺噻吩酰胺类结构化合物、其制备方法及用途 |
CN108047195A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 一种含丙二醇腈基噻吩酰胺类化合物及其用途 |
CN108047197A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 硝基噻吩酰胺rock抑制剂、制备方法及其用途 |
CN108101884A (zh) * | 2017-12-31 | 2018-06-01 | 佛山市赛维斯医药科技有限公司 | 含噻吩酰胺结构衍生物、制备方法及其用途 |
CN107973777A (zh) * | 2017-12-31 | 2018-05-01 | 佛山市赛维斯医药科技有限公司 | 一种含甲基萘和丙二醇噻吩酰胺类rock抑制剂及其用途 |
CN108558823A (zh) * | 2017-12-31 | 2018-09-21 | 佛山市赛维斯医药科技有限公司 | 一类腈基噻吩酰胺rock抑制剂、制备方法及其用途 |
CN108084149A (zh) * | 2017-12-31 | 2018-05-29 | 佛山市赛维斯医药科技有限公司 | 含异丙基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途 |
CA3110661A1 (fr) | 2018-08-29 | 2020-03-05 | University Of Massachusetts | Inhibition de proteines kinases pour traiter la maladie de friedreich |
CA3112391A1 (fr) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Composes d'amide aryl cyclopropyl-amino-isoquinolinyl |
Citations (6)
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WO1993005014A1 (fr) * | 1991-09-05 | 1993-03-18 | Pharno-Wedropharm Gmbh | Derives aromatiques de sulfamide, leur utilisation en tant qu'inhibiteurs d'enzymes et compositions pharmaceutiques les contenant |
WO2004092164A1 (fr) * | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Derives amines cycliques et leur utilisation dans le traitement de troubles lies a l'inflammation induits par la bradykinine |
WO2005035503A1 (fr) * | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | Nouveau derive isoquinoline |
EP1541559A1 (fr) * | 2002-07-22 | 2005-06-15 | Asahi Kasei Pharma Corporation | Derive d'isoquinoline 5-substituee |
WO2005080394A1 (fr) * | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | Derives de piperidine substitues en position 4 |
US20050222127A1 (en) * | 2004-03-30 | 2005-10-06 | Alcon, Inc. | Use of Rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance |
-
2007
- 2007-10-26 WO PCT/EP2007/061542 patent/WO2008049919A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993005014A1 (fr) * | 1991-09-05 | 1993-03-18 | Pharno-Wedropharm Gmbh | Derives aromatiques de sulfamide, leur utilisation en tant qu'inhibiteurs d'enzymes et compositions pharmaceutiques les contenant |
EP1541559A1 (fr) * | 2002-07-22 | 2005-06-15 | Asahi Kasei Pharma Corporation | Derive d'isoquinoline 5-substituee |
WO2004092164A1 (fr) * | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Derives amines cycliques et leur utilisation dans le traitement de troubles lies a l'inflammation induits par la bradykinine |
WO2005035503A1 (fr) * | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | Nouveau derive isoquinoline |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096569B2 (en) | 2008-07-25 | 2015-08-04 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US11590123B2 (en) | 2016-08-31 | 2023-02-28 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
CN107903250A (zh) * | 2017-12-31 | 2018-04-13 | 佛山市赛维斯医药科技有限公司 | 一种含吡啶和硝基噻吩结构的化合物、制备方法及其用途 |
CN107915717A (zh) * | 2017-12-31 | 2018-04-17 | 佛山市赛维斯医药科技有限公司 | 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途 |
CN107935986A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途 |
CN107935987A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途 |
CN108047193A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途 |
CN108047194A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途 |
CN108047214A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 一种含吡啶和硝基噻吩结构化合物及其用途 |
CN108191820A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 一种含异丙胺和噻吩酰胺类结构的化合物 |
Also Published As
Publication number | Publication date |
---|---|
WO2008049919A2 (fr) | 2008-05-02 |
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